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Volumn 2, Issue 2, 2009, Pages 129-143

A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge

Author keywords

[No Author keywords available]

Indexed keywords

CD8+ T LYMPHOCYTE PEPTIDE EPITOPE VACCINE; LIPOPEPTIDE; PALMITIC ACID; PEPTIDE VACCINE; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 60549095850     PISSN: 19330219     EISSN: None     Source Type: Journal    
DOI: 10.1038/mi.2008.81     Document Type: Article
Times cited : (103)

References (98)
  • 1
    • 23744464502 scopus 로고    scopus 로고
    • Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs
    • Yoneyama, H. et al. Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs. J. Exp. Med. 202, 425-435 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 425-435
    • Yoneyama, H.1
  • 2
    • 0026561504 scopus 로고
    • Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens
    • Tigges, M.A. et al. Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens. J. Virol. 66, 1622-1634 (1992).
    • (1992) J. Virol , vol.66 , pp. 1622-1634
    • Tigges, M.A.1
  • 3
    • 0027408266 scopus 로고
    • Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes
    • Koelle, D.M. et al. Herpes simplex virus infection of human fibroblasts and keratinocytes inhibits recognition by cloned CD8+ cytotoxic T lymphocytes. J. Clin. Invest. 91, 961-968 (1993).
    • (1993) J. Clin. Invest , vol.91 , pp. 961-968
    • Koelle, D.M.1
  • 5
    • 32544452998 scopus 로고    scopus 로고
    • Vaccines for herpes simplex virus infections
    • Koelle, D.M. Vaccines for herpes simplex virus infections. Curr. Opin. Investig. Drugs 7, 136-141 (2006).
    • (2006) Curr. Opin. Investig. Drugs , vol.7 , pp. 136-141
    • Koelle, D.M.1
  • 6
    • 0036239761 scopus 로고    scopus 로고
    • Immunization for protection of the reproductive tract: A review
    • Russell, M.W. Immunization for protection of the reproductive tract: A review. Am. J. Reprod. Immunol. 47, 265-268 (2002).
    • (2002) Am. J. Reprod. Immunol , vol.47 , pp. 265-268
    • Russell, M.W.1
  • 7
    • 0033523873 scopus 로고    scopus 로고
    • A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group
    • Langenberg, A.G., Corey, L., Ashley, R.L., Leong, W.P. & Straus, S.E. A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group. N. Engl. J. Med. 341 1432-1438 (1999).
    • (1999) N. Engl. J. Med , vol.341 , pp. 1432-1438
    • Langenberg, A.G.1    Corey, L.2    Ashley, R.L.3    Leong, W.P.4    Straus, S.E.5
  • 8
    • 3042667015 scopus 로고    scopus 로고
    • Genital herpes and human immunodeficiency virus: Double trouble
    • Celum, C., Levine, R., Weaver, M. & Wald, A. Genital herpes and human immunodeficiency virus: Double trouble. Bull. World Heafth Organ. 82, 447-453 (2004).
    • (2004) Bull. World Heafth Organ , vol.82 , pp. 447-453
    • Celum, C.1    Levine, R.2    Weaver, M.3    Wald, A.4
  • 9
    • 38149074165 scopus 로고    scopus 로고
    • The genital tract immune milieu: An important determinant of HIV susceptibility and secondary transmission
    • Kaul, R. et al. The genital tract immune milieu: An important determinant of HIV susceptibility and secondary transmission. J. Reprod. Immunol. 77, 32-40 (2008).
    • (2008) J. Reprod. Immunol , vol.77 , pp. 32-40
    • Kaul, R.1
  • 10
    • 29844454067 scopus 로고    scopus 로고
    • Role of mucosal immunity in preventing genital herpes infection
    • MasCasullo, V., Fam, E., Keller, M.J. & Herold, B.C. Role of mucosal immunity in preventing genital herpes infection. Viral. Immunol. 18, 595-606 (2005).
    • (2005) Viral. Immunol , vol.18 , pp. 595-606
    • MasCasullo, V.1    Fam, E.2    Keller, M.J.3    Herold, B.C.4
  • 11
    • 1242328735 scopus 로고    scopus 로고
    • Efficacy of genital T cell responses to herpes simplex virus type 2 resulting from immunization of the nasal mucosa
    • Milligan, G.N., Dudley-McClain, K.L., Chu, C.F. & Young, C.G. Efficacy of genital T cell responses to herpes simplex virus type 2 resulting from immunization of the nasal mucosa. Virology 318, 507-515 (2004).
    • (2004) Virology , vol.318 , pp. 507-515
    • Milligan, G.N.1    Dudley-McClain, K.L.2    Chu, C.F.3    Young, C.G.4
  • 12
    • 3843066750 scopus 로고    scopus 로고
    • Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2
    • Kwant, A. & Rosenthal, K.L. Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2. Vaccine 22, 3098-3104 (2004).
    • (2004) Vaccine , vol.22 , pp. 3098-3104
    • Kwant, A.1    Rosenthal, K.L.2
  • 13
    • 0036150480 scopus 로고    scopus 로고
    • Systemic and mucosal immune responses in mice after rectal and vaginal immunization with HIV-DNA vaccine
    • Hamajima, K. et al. Systemic and mucosal immune responses in mice after rectal and vaginal immunization with HIV-DNA vaccine. Clin. Immunol. 102, 12-18 (2002).
    • (2002) Clin. Immunol , vol.102 , pp. 12-18
    • Hamajima, K.1
  • 14
    • 0031899819 scopus 로고    scopus 로고
    • Long-term immunity and protection against herpes simplex virus type 2 in the murine female genital tract after mucosal but not systemic immunization
    • Gallichan, W.S. & Rosenthal, K.L. Long-term immunity and protection against herpes simplex virus type 2 in the murine female genital tract after mucosal but not systemic immunization. J. Infect Dis. 177 1155-1161 (1998).
    • (1998) J. Infect Dis , vol.177 , pp. 1155-1161
    • Gallichan, W.S.1    Rosenthal, K.L.2
  • 15
    • 0033936513 scopus 로고    scopus 로고
    • Immunogenicity evaluation of DNA vaccines that target guinea pig cytomegalovirus proteins glycoprotein B and UL83
    • Schleiss, M.R., Bourne, N., Jensen, N.J., Bravo, F. & Bernstein, D.I. Immunogenicity evaluation of DNA vaccines that target guinea pig cytomegalovirus proteins glycoprotein B and UL83. Viral. Immunol. 13, 155-167 (2000).
    • (2000) Viral. Immunol , vol.13 , pp. 155-167
    • Schleiss, M.R.1    Bourne, N.2    Jensen, N.J.3    Bravo, F.4    Bernstein, D.I.5
  • 16
    • 2442517281 scopus 로고    scopus 로고
    • Induction of HIV immunity in the genital tract after intranasal delivery of a MVA vector: Enhanced immunogenicity after DNA prime-modified vaccinia virus Ankara boost immunization schedule
    • Gherardi, M.M., Perez-Jimenez, E., Najera, J.L. & Esteban, M. Induction of HIV immunity in the genital tract after intranasal delivery of a MVA vector: Enhanced immunogenicity after DNA prime-modified vaccinia virus Ankara boost immunization schedule. J. Immunol. 172, 6209-6220 (2004).
    • (2004) J. Immunol , vol.172 , pp. 6209-6220
    • Gherardi, M.M.1    Perez-Jimenez, E.2    Najera, J.L.3    Esteban, M.4
  • 17
    • 33646744394 scopus 로고    scopus 로고
    • Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes
    • Tengvall, S., Lundqvist, A., Eisenberg, R.J,, Cohen, G.H. & Harandi, A.M. Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes. J. Virol. 80, 5283-5291 (2006).
    • (2006) J. Virol , vol.80 , pp. 5283-5291
    • Tengvall, S.1    Lundqvist, A.2    Eisenberg, R.J.3    Cohen, G.H.4    Harandi, A.M.5
  • 18
    • 0031251985 scopus 로고    scopus 로고
    • Challenges for vaccination against sexually-transmitted diseases: Induction and long-term maintenance of mucosal immune responses in the female genital tract
    • Rosenthal, K.L. & Gallichan, W.S. Challenges for vaccination against sexually-transmitted diseases: Induction and long-term maintenance of mucosal immune responses in the female genital tract. Semin. Immunol. 9, 303-314 (1997).
    • (1997) Semin. Immunol , vol.9 , pp. 303-314
    • Rosenthal, K.L.1    Gallichan, W.S.2
  • 19
    • 2942573369 scopus 로고    scopus 로고
    • Molecular adjuvants for mucosal immunity
    • Toka, E.N,, Pack, C.D. & Rouse, B.T. Molecular adjuvants for mucosal immunity. Immunol. Rev. 199, 100-112 (2004).
    • (2004) Immunol. Rev , vol.199 , pp. 100-112
    • Toka, E.N.1    Pack, C.D.2    Rouse, B.T.3
  • 20
    • 4344573865 scopus 로고    scopus 로고
    • Clinical trials of prophylactic and therapeutic herpes simplex virus vaccines
    • Stanberry, L.R. Clinical trials of prophylactic and therapeutic herpes simplex virus vaccines. Herpes 11 (Suppl 3),161A-169A (2004).
    • (2004) Herpes , vol.11 , Issue.SUPPL. 3
    • Stanberry, L.R.1
  • 21
    • 17444394873 scopus 로고    scopus 로고
    • Immunologic uniqueness of the genital tract: Challenge for vaccine development
    • Mestecky, J., Moldoveanu, Z. & Russell, M.W. Immunologic uniqueness of the genital tract: Challenge for vaccine development. Am. J. Reprod. Immunol. 53, 208-214 (2005).
    • (2005) Am. J. Reprod. Immunol , vol.53 , pp. 208-214
    • Mestecky, J.1    Moldoveanu, Z.2    Russell, M.W.3
  • 22
    • 24744434585 scopus 로고    scopus 로고
    • Human male genital tract secretions: Both mucosal and systemic immune compartments contribute to the humoral immunity
    • Moldoveanu, Z., Huang, W.O., Kulhavy, R., Pate, M.S. & Mestecky, J. Human male genital tract secretions: Both mucosal and systemic immune compartments contribute to the humoral immunity. J. Immunol. 175, 4127-4136 (2005).
    • (2005) J. Immunol , vol.175 , pp. 4127-4136
    • Moldoveanu, Z.1    Huang, W.O.2    Kulhavy, R.3    Pate, M.S.4    Mestecky, J.5
  • 23
    • 37349041656 scopus 로고    scopus 로고
    • The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection
    • Gill, N., Davies, E.J. & Ashkar, A.A. The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection. Am. J. Reprod. Immunol. 59, 35-43 (2008).
    • (2008) Am. J. Reprod. Immunol , vol.59 , pp. 35-43
    • Gill, N.1    Davies, E.J.2    Ashkar, A.A.3
  • 24
    • 39149137535 scopus 로고    scopus 로고
    • Quantification and comparison of toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia
    • Herbst-Kralovetz, M.M. et al. Quantification and comparison of toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia. Am. J. Reprod. Immunol. 59, 212-224 (2008).
    • (2008) Am. J. Reprod. Immunol , vol.59 , pp. 212-224
    • Herbst-Kralovetz, M.M.1
  • 25
    • 33646241763 scopus 로고    scopus 로고
    • Effect of toll-like receptor (TLR) agonists on TLR and microbicide expression in uterine and vaginal tissues of the mouse
    • Soboll, G., Schaefer, T.M. & Wira, O. R. Effect of toll-like receptor (TLR) agonists on TLR and microbicide expression in uterine and vaginal tissues of the mouse. Am. J. Reprod. Immunol. 55, 434-446 (2006).
    • (2006) Am. J. Reprod. Immunol , vol.55 , pp. 434-446
    • Soboll, G.1    Schaefer, T.M.2    Wira, O.R.3
  • 26
    • 18944372566 scopus 로고    scopus 로고
    • Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis
    • Zariffard, M.R. et al. Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis. J. Infect. M. 191, 1913-1921 (2005).
    • (2005) J. Infect. M , vol.191 , pp. 1913-1921
    • Zariffard, M.R.1
  • 27
    • 33751566350 scopus 로고    scopus 로고
    • Cutting edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ
    • Lund, J.M., Linehan, M.M., Iijima, N. & Iwasaki, A. Cutting edge: plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. J. Immunol. 177, 7510-7514 (2006).
    • (2006) J. Immunol , vol.177 , pp. 7510-7514
    • Lund, J.M.1    Linehan, M.M.2    Iijima, N.3    Iwasaki, A.4
  • 28
    • 0036499128 scopus 로고    scopus 로고
    • Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling
    • Fichorova, R.N., Cronin, A.O., Lien, E., Anderson, D.J. & Ingalls, R.R. Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling. J. Immunol. 168, 2424-2432 (2002).
    • (2002) J. Immunol , vol.168 , pp. 2424-2432
    • Fichorova, R.N.1    Cronin, A.O.2    Lien, E.3    Anderson, D.J.4    Ingalls, R.R.5
  • 29
    • 0036241804 scopus 로고    scopus 로고
    • Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses
    • BenMohamed, L., Krishnan, R., Auge, C., Primus, J.F. & Diamond, D.J. Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses. Immunology 106, 113-121 (2002).
    • (2002) Immunology , vol.106 , pp. 113-121
    • BenMohamed, L.1    Krishnan, R.2    Auge, C.3    Primus, J.F.4    Diamond, D.J.5
  • 30
    • 0036687165 scopus 로고    scopus 로고
    • Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant
    • BenMohamed, L. et al. Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant. Eur. J. Immunol. 32, 2274-2281 (2002).
    • (2002) Eur. J. Immunol , vol.32 , pp. 2274-2281
    • BenMohamed, L.1
  • 31
    • 32844467862 scopus 로고    scopus 로고
    • Efficient systemic and mucosal responses against the HIV-1 Tat protein by prime/boost vaccination using the lipopeptide MALP-2 as adjuvant
    • Borsutzky, S. et al. Efficient systemic and mucosal responses against the HIV-1 Tat protein by prime/boost vaccination using the lipopeptide MALP-2 as adjuvant. Vaccine 24, 2049-2056 (2006).
    • (2006) Vaccine , vol.24 , pp. 2049-2056
    • Borsutzky, S.1
  • 32
    • 85185097034 scopus 로고    scopus 로고
    • Batz1off, M.R., Hartas, J., Zeng, W., Jackson, D.C. & Good, M.F. Intranasal vaccination with a lipopeptide containing a conformationally constrained conserved minimal peptide, a universal T cell epitope, and a self-adjuvanting lipid protects mice from group a streptococcus challenge and reduces throat colonization. J. Infect. Dis. 194 325-330 (2006).
    • Batz1off, M.R., Hartas, J., Zeng, W., Jackson, D.C. & Good, M.F. Intranasal vaccination with a lipopeptide containing a conformationally constrained conserved minimal peptide, a universal T cell epitope, and a self-adjuvanting lipid protects mice from group a streptococcus challenge and reduces throat colonization. J. Infect. Dis. 194 325-330 (2006).
  • 33
    • 9244235974 scopus 로고    scopus 로고
    • Lipopeptide epitopes extended by Ne-Palmitoyl lysine moiety increases uptake and maturation of dendritic cell through a toll-like receptor 2 pathway and triggers a Th1-dependent protective immunity
    • Zhu, X., Ramos, T.V., Gras-Masse, H., Kaplan, B.E. & BenMohamed, L. Lipopeptide epitopes extended by Ne-Palmitoyl lysine moiety increases uptake and maturation of dendritic cell through a toll-like receptor 2 pathway and triggers a Th1-dependent protective immunity, Eur. J. Immunol. 34, 1142-1149 (2004).
    • (2004) Eur. J. Immunol , vol.34 , pp. 1142-1149
    • Zhu, X.1    Ramos, T.V.2    Gras-Masse, H.3    Kaplan, B.E.4    BenMohamed, L.5
  • 34
    • 29744451544 scopus 로고    scopus 로고
    • Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection
    • Zhang, X. et al. Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection. J. Virol. 79, 15289-15301 (2005).
    • (2005) J. Virol , vol.79 , pp. 15289-15301
    • Zhang, X.1
  • 35
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat. Immunol. 2 675-660 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 675-660
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 36
    • 42949087990 scopus 로고    scopus 로고
    • Importance of myeloiel differentiation factor 88 in innate and acquired immune protection against genital herpes infection in mice
    • Tengvall, S. & Harandi, A.M. Importance of myeloiel differentiation factor 88 in innate and acquired immune protection against genital herpes infection in mice. J. Reprod. Immunol. 78, 49-57 (2008).
    • (2008) J. Reprod. Immunol , vol.78 , pp. 49-57
    • Tengvall, S.1    Harandi, A.M.2
  • 37
    • 0033812637 scopus 로고    scopus 로고
    • Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: Dependence on HLA class II restricted T-(H) response
    • BenMohamed, L. et al. Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: Dependence on HLA class II restricted T-(H) response. Hum. Immunol. 61, 764-779 (2000).
    • (2000) Hum. Immunol , vol.61 , pp. 764-779
    • BenMohamed, L.1
  • 38
    • 85185112420 scopus 로고    scopus 로고
    • Belyakov, I. M. et al. Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge Proc. Natl. Acad. Sci. USA 95, 1709-1714 (1998).
    • Belyakov, I. M. et al. Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge Proc. Natl. Acad. Sci. USA 95, 1709-1714 (1998).
  • 39
    • 0035284751 scopus 로고    scopus 로고
    • Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract
    • Gallichan, W. S. et al. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J. Immunol. 166, 3451-3457 (2001).
    • (2001) J. Immunol , vol.166 , pp. 3451-3457
    • Gallichan, W.S.1
  • 40
    • 0036644724 scopus 로고    scopus 로고
    • Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: Influence of the menstrual cycle
    • Kozlowski, P. A. et al. Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: Influence of the menstrual cycle. J. Immunol. 169 566-574 (2002).
    • (2002) J. Immunol , vol.169 , pp. 566-574
    • Kozlowski, P.A.1
  • 41
    • 34447263785 scopus 로고    scopus 로고
    • Functional Foxp3+ CD4+CD25(Bright+) "natural" regulatory T Cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection
    • Nesburn, A. B. et al. Functional Foxp3+ CD4+CD25(Bright+) "natural" regulatory T Cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection. J. Virol. 81, 6911-6919 (2007).
    • (2007) J. Virol , vol.81 , pp. 6911-6919
    • Nesburn, A.B.1
  • 42
    • 0032526588 scopus 로고    scopus 로고
    • Role of mucosal immunity in herpes simplex virus infection
    • Kuklin, N. A., Daheshia, M., Chun, S. & Rouse, B. T. Role of mucosal immunity in herpes simplex virus infection. J. Immunol. 160, 5998-6003 (1998).
    • (1998) J. Immunol , vol.160 , pp. 5998-6003
    • Kuklin, N.A.1    Daheshia, M.2    Chun, S.3    Rouse, B.T.4
  • 43
    • 0033050319 scopus 로고    scopus 로고
    • Intranasal delivery of recombinant parvovirus-like particles elicits cytotoxic T-cell and neutralizing antibody responses
    • Sedlik, C. et al. Intranasal delivery of recombinant parvovirus-like particles elicits cytotoxic T-cell and neutralizing antibody responses. J. Virol. 73, 2739-2744 (1999).
    • (1999) J. Virol , vol.73 , pp. 2739-2744
    • Sedlik, C.1
  • 44
    • 28444491927 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotide augments HSV-2 glycoprotein D DNA vaccine efficacy to generate T helper 1 response and subsequent protection against primary genital herpes infection in mice
    • Tengvall, S., Josefsson, A., Holmgren, J. & Harandi, A. M. CpG oligodeoxynucleotide augments HSV-2 glycoprotein D DNA vaccine efficacy to generate T helper 1 response and subsequent protection against primary genital herpes infection in mice. J. Reprod. Immunol. 68, 53-69 (2005).
    • (2005) J. Reprod. Immunol , vol.68 , pp. 53-69
    • Tengvall, S.1    Josefsson, A.2    Holmgren, J.3    Harandi, A.M.4
  • 45
    • 34548293833 scopus 로고    scopus 로고
    • Recent advances with TLR2-targeting lipopeptide-based vaccines
    • Eriksson, E. M. & Jackson, D. C. Recent advances with TLR2-targeting lipopeptide-based vaccines. Curr. Protein Pept. Sci. 8, 412-417 (2007).
    • (2007) Curr. Protein Pept. Sci , vol.8 , pp. 412-417
    • Eriksson, E.M.1    Jackson, D.C.2
  • 46
    • 34447293406 scopus 로고    scopus 로고
    • Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system
    • Nesburn, A. B. et al. Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system. Ocul. Surf. 4, 178-187 (2006).
    • (2006) Ocul. Surf , vol.4 , pp. 178-187
    • Nesburn, A.B.1
  • 47
    • 33646365642 scopus 로고    scopus 로고
    • Clinical safety of HIV lipopeptides used as vaccines in healthy volunteers and HIV-infected adults
    • Durier, C. et al. Clinical safety of HIV lipopeptides used as vaccines in healthy volunteers and HIV-infected adults. AIDS 20 1039-1049 (2006).
    • (2006) AIDS , vol.20 , pp. 1039-1049
    • Durier, C.1
  • 48
    • 41549111496 scopus 로고    scopus 로고
    • Self-adjuvanting lipopeptide vaccines
    • Moyle, P. M. & Toth, I. Self-adjuvanting lipopeptide vaccines. Curr. Med. Chem. 15, 506-516 (2008).
    • (2008) Curr. Med. Chem , vol.15 , pp. 506-516
    • Moyle, P.M.1    Toth, I.2
  • 49
    • 18644372395 scopus 로고    scopus 로고
    • The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells
    • Borsutzky, S. et al. The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells. J. Immunol. 174, 6308-6313 (2005).
    • (2005) J. Immunol , vol.174 , pp. 6308-6313
    • Borsutzky, S.1
  • 50
    • 0042890384 scopus 로고    scopus 로고
    • Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity
    • BenMohamed, L. et al. Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity. J. Virol. 77, 9463-9473 (2003).
    • (2003) J. Virol , vol.77 , pp. 9463-9473
    • BenMohamed, L.1
  • 51
    • 0032516771 scopus 로고    scopus 로고
    • Increased levels of IFN-gamma in the trigeminal ganglion correlate with protection against HSV-1-induced encephalitis following subcutaneous administration with androstenediol
    • Carr, D. J. Increased levels of IFN-gamma in the trigeminal ganglion correlate with protection against HSV-1-induced encephalitis following subcutaneous administration with androstenediol. J. Neuroimmunol. 89, 160-167 (1998).
    • (1998) J. Neuroimmunol , vol.89 , pp. 160-167
    • Carr, D.J.1
  • 52
    • 10444280011 scopus 로고    scopus 로고
    • Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant
    • Nesburn, A. B. et al. Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant. Vaccine 23, 873-883 (2005).
    • (2005) Vaccine , vol.23 , pp. 873-883
    • Nesburn, A.B.1
  • 53
    • 0033979991 scopus 로고    scopus 로고
    • Limited antibody-dependent cellular cytotoxicity antibody response induced by a herpes simplex virus type 2 subunit vaccine
    • Kohl, S. et al. Limited antibody-dependent cellular cytotoxicity antibody response induced by a herpes simplex virus type 2 subunit vaccine. J. Infect. Dis. 181, 335-339 (2000).
    • (2000) J. Infect. Dis , vol.181 , pp. 335-339
    • Kohl, S.1
  • 54
    • 17544405251 scopus 로고    scopus 로고
    • Long-term specific immune responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccine: Characterization of CD8+-T-cell epitopes recognized
    • Gahery-Segard, H. et al. Long-term specific immune responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccine: Characterization of CD8+-T-cell epitopes recognized. J. Virol. 77, 11220-11231 (2003).
    • (2003) J. Virol , vol.77 , pp. 11220-11231
    • Gahery-Segard, H.1
  • 55
    • 0033710323 scopus 로고    scopus 로고
    • Protection against plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liverstage antigen 3
    • Daubersies, P. et al. Protection against plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liverstage antigen 3. Nat. Med. 6, 1258-1263 (2000).
    • (2000) Nat. Med , vol.6 , pp. 1258-1263
    • Daubersies, P.1
  • 56
    • 0032526336 scopus 로고    scopus 로고
    • T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2
    • Milligan, G.N., Bernstein, D.I. & Bourne, N. T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2. J. Immunol. 160, 6093-6100 (1998).
    • (1998) J. Immunol , vol.160 , pp. 6093-6100
    • Milligan, G.N.1    Bernstein, D.I.2    Bourne, N.3
  • 57
    • 0029000226 scopus 로고
    • A recombinant glycoprotein vaccine for herpes simplex virus type 2: Safety and immunogenicity [corrected]
    • Langenberg, A.G. et al. A recombinant glycoprotein vaccine for herpes simplex virus type 2: Safety and immunogenicity [corrected]. Ann. Intern. Med. 122, 889-898 (1995).
    • (1995) Ann. Intern. Med , vol.122 , pp. 889-898
    • Langenberg, A.G.1
  • 58
    • 0142182273 scopus 로고    scopus 로고
    • Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge
    • Sajic, D et al. Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge. J. Med. Virol. 71, 561-568 (2003).
    • (2003) J. Med. Virol , vol.71 , pp. 561-568
    • Sajic, D.1
  • 59
    • 0036827534 scopus 로고    scopus 로고
    • Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection
    • Pyles, R.B. et al. Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection. J. Virol. 76, 11387-11396 (2002).
    • (2002) J. Virol , vol.76 , pp. 11387-11396
    • Pyles, R.B.1
  • 60
    • 0037108812 scopus 로고    scopus 로고
    • Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge
    • Dumais, N., Patrick, A., Moss, R.B., Davis, H.L. & Rosenthal, K.L. Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge. J. Infect. Dis. 186 1098-1105 (2002).
    • (2002) J. Infect. Dis , vol.186 , pp. 1098-1105
    • Dumais, N.1    Patrick, A.2    Moss, R.B.3    Davis, H.L.4    Rosenthal, K.L.5
  • 61
    • 17144383586 scopus 로고    scopus 로고
    • Novel conjugates of epitope fusion peptides with CpG-ODN display enhanced immunogenicity and HIV recognition
    • Daftarian, P. et al. Novel conjugates of epitope fusion peptides with CpG-ODN display enhanced immunogenicity and HIV recognition. Vaccine 23, 3453-3468 (2005).
    • (2005) Vaccine , vol.23 , pp. 3453-3468
    • Daftarian, P.1
  • 62
    • 0038745486 scopus 로고    scopus 로고
    • Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade
    • Davila, E., Kennedy, R. & Celis, E. Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res. 63, 3281-3288 (2003).
    • (2003) Cancer Res , vol.63 , pp. 3281-3288
    • Davila, E.1    Kennedy, R.2    Celis, E.3
  • 63
    • 3342994925 scopus 로고    scopus 로고
    • Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides
    • BenMohamed, L., Thomas, A. & Druilhe, P. Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides. Infect. Immun. 72, 4376-4384 (2004).
    • (2004) Infect. Immun , vol.72 , pp. 4376-4384
    • BenMohamed, L.1    Thomas, A.2    Druilhe, P.3
  • 64
    • 0034659607 scopus 로고    scopus 로고
    • High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules
    • BenMohamed, L. et al. High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules. Vaccine 18, 2843-2855 (2000).
    • (2000) Vaccine , vol.18 , pp. 2843-2855
    • BenMohamed, L.1
  • 65
    • 0030959609 scopus 로고    scopus 로고
    • Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees
    • BenMohamed, L. et al. Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees. Eur. J. Immunol. 27, 1242-1253 (1997).
    • (1997) Eur. J. Immunol , vol.27 , pp. 1242-1253
    • BenMohamed, L.1
  • 66
    • 34247250669 scopus 로고    scopus 로고
    • HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+/CD8+ T cells in humans after lipopeptide vaccination
    • Gahery, H. et al. HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+/CD8+ T cells in humans after lipopeptide vaccination. AIDS Res. Hum. Retroviruses 23, 427-437 (2007).
    • (2007) AIDS Res. Hum. Retroviruses , vol.23 , pp. 427-437
    • Gahery, H.1
  • 67
    • 33745969130 scopus 로고    scopus 로고
    • New CD4+ and CD8+ T cell responses induced in chronically HIV type-1-infected patients after immunizations with an HIV type 1 lipopeptide vaccine
    • Gahery, H. et al. New CD4+ and CD8+ T cell responses induced in chronically HIV type-1-infected patients after immunizations with an HIV type 1 lipopeptide vaccine. AIDS Res. Hum. Retroviruses 22, 684-694 (2006).
    • (2006) AIDS Res. Hum. Retroviruses , vol.22 , pp. 684-694
    • Gahery, H.1
  • 68
    • 56449115358 scopus 로고    scopus 로고
    • Asymptomatic human CD4+ cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B
    • Chentoufi, A.A. et al. Asymptomatic human CD4+ cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B. J. Virol. 82, 11792-11802 (2008).
    • (2008) J. Virol , vol.82 , pp. 11792-11802
    • Chentoufi, A.A.1
  • 69
    • 33746256898 scopus 로고    scopus 로고
    • TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation
    • Cottalorda, A. et al. TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation. Eur. J. Immunol. 36, 1684-1693 (2006).
    • (2006) Eur. J. Immunol , vol.36 , pp. 1684-1693
    • Cottalorda, A.1
  • 70
    • 0037455066 scopus 로고    scopus 로고
    • Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2
    • Zhao, X. et al. Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J. Exp. Med. 197, 153-162 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 153-162
    • Zhao, X.1
  • 71
    • 35748930569 scopus 로고    scopus 로고
    • Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines
    • Bettahi, I. et al. Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines. Invest. Ophthalmol. Vis. Sci. 48, 4643-4653 (2007).
    • (2007) Invest. Ophthalmol. Vis. Sci , vol.48 , pp. 4643-4653
    • Bettahi, I.1
  • 72
    • 33745930525 scopus 로고    scopus 로고
    • Protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized Th1 immune response
    • Bettahi, I., Zhang, X., Afifi, R.E. & BenMohamed, L. Protective immunity to genital herpes simplex virus type 1 and type 2 provided by self-adjuvanting lipopeptides that drive dendritic cell maturation and elicit a polarized Th1 immune response. Viral Immunol. 19, 220-236 (2006).
    • (2006) Viral Immunol , vol.19 , pp. 220-236
    • Bettahi, I.1    Zhang, X.2    Afifi, R.E.3    BenMohamed, L.4
  • 73
    • 40449086460 scopus 로고    scopus 로고
    • HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D
    • Chentoufi, A.A. et al. HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D. J. Immunol. 180, 426-437 (2008).
    • (2008) J. Immunol , vol.180 , pp. 426-437
    • Chentoufi, A.A.1
  • 74
    • 0034667879 scopus 로고    scopus 로고
    • Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2
    • Tsunobuchi, H. et al. Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2. J. Immunol. 165, 4552-4560 (2000).
    • (2000) J. Immunol , vol.165 , pp. 4552-4560
    • Tsunobuchi, H.1
  • 75
    • 0037150481 scopus 로고    scopus 로고
    • Development of HSV-specific CD4+ Th1 responses and CD8+ cytotoxic T lymphocytes with antiviral activity by vaccination with the HSV-2 mutant ICP10DeltaPK
    • Gyotoku, T., Ono, F. & Aurelian, L. Development of HSV-specific CD4+ Th1 responses and CD8+ cytotoxic T lymphocytes with antiviral activity by vaccination with the HSV-2 mutant ICP10DeltaPK. Vaccine 20, 2796-2807 (2002).
    • (2002) Vaccine , vol.20 , pp. 2796-2807
    • Gyotoku, T.1    Ono, F.2    Aurelian, L.3
  • 76
    • 58749094126 scopus 로고    scopus 로고
    • Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects
    • Kim, M. et al. Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects. J. Immunol. 181, 6604-6615 (2008).
    • (2008) J. Immunol , vol.181 , pp. 6604-6615
    • Kim, M.1
  • 77
    • 43749114944 scopus 로고    scopus 로고
    • Replication-defective virus vaccine-induced protection of mice from genital herpes simplex virus 2 requires CD4 T cells
    • Morrison, L.A. Replication-defective virus vaccine-induced protection of mice from genital herpes simplex virus 2 requires CD4 T cells. Virology 376, 205-210(2008).
    • (2008) Virology , vol.376 , pp. 205-210
    • Morrison, L.A.1
  • 78
    • 0031849580 scopus 로고    scopus 로고
    • Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpeslesions
    • Koelle, D.M., Frank, J.M., Johnson, M.L. & Kwok, W.W. Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpeslesions. J. Virol. 72, 7476-7483 (1998).
    • (1998) J. Virol , vol.72 , pp. 7476-7483
    • Koelle, D.M.1    Frank, J.M.2    Johnson, M.L.3    Kwok, W.W.4
  • 79
    • 0001585502 scopus 로고    scopus 로고
    • Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
    • Koelle, D.M. et al. Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes. J. Clin. Invest. 101, 1500-1508 (1998).
    • (1998) J. Clin. Invest , vol.101 , pp. 1500-1508
    • Koelle, D.M.1
  • 80
    • 0028321460 scopus 로고
    • Herpes simplex virus type 2 infection of heterosexual men attending a sexual health centre
    • Bassett, I. et al. Herpes simplex virus type 2 infection of heterosexual men attending a sexual health centre. Med. J. Aust. 160, 697-700 (1994).
    • (1994) Med. J. Aust , vol.160 , pp. 697-700
    • Bassett, I.1
  • 81
    • 0017640450 scopus 로고
    • The natural history of recurren herpes simplex labialis: Implications for antiviral therapy
    • Spruance, S.L. et al. The natural history of recurren herpes simplex labialis: Implications for antiviral therapy. N. Engl. J. Med. 297, 69-75 (1977).
    • (1977) N. Engl. J. Med , vol.297 , pp. 69-75
    • Spruance, S.L.1
  • 82
    • 0031985087 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 glycoproteins gB, gC and gD are major targets for CD4 T-lymphocyte cytotoxicity in HLA-DR expressing human epidermal keratinocytes
    • Mikloska, Z. & Cunningham, A.L. Herpes simplex virus type 1 glycoproteins gB, gC and gD are major targets for CD4 T-lymphocyte cytotoxicity in HLA-DR expressing human epidermal keratinocytes. J. Gen. Virol. 79 (Part 2), 353-361 (1998).
    • (1998) J. Gen. Virol , vol.79 , Issue.PART 2 , pp. 353-361
    • Mikloska, Z.1    Cunningham, A.L.2
  • 83
    • 0026603770 scopus 로고
    • Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes
    • Koelle, D.M., Benedetti, J., Langenberg, A. & Corey, L. Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes. Ann. Intern. Med. 116, 433-437 (1992).
    • (1992) Ann. Intern. Med , vol.116 , pp. 433-437
    • Koelle, D.M.1    Benedetti, J.2    Langenberg, A.3    Corey, L.4
  • 84
    • 0024260950 scopus 로고
    • Herpes simplex virus (HSV)-specific proliferative and cytotoxic T-cell responses in humans immunized with an HSV type 2 glycoprotein subunit vaccine
    • Zarling, J.M., Moran, P.A., Brewer, L., Ashley, R. & Corey, L. Herpes simplex virus (HSV)-specific proliferative and cytotoxic T-cell responses in humans immunized with an HSV type 2 glycoprotein subunit vaccine. J. Virol. 62, 4481-4485 (1988).
    • (1988) J. Virol , vol.62 , pp. 4481-4485
    • Zarling, J.M.1    Moran, P.A.2    Brewer, L.3    Ashley, R.4    Corey, L.5
  • 85
    • 0022589085 scopus 로고
    • Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. IV. Recognition and activation by cloned glycoproteins gB and gD
    • Zarling, J.M. et al. Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. IV. Recognition and activation by cloned glycoproteins gB and gD. J. Immunol. 136 4669-4673 (1986).
    • (1986) J. Immunol , vol.136 , pp. 4669-4673
    • Zarling, J.M.1
  • 86
    • 0028301850 scopus 로고
    • Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions
    • Koelle, D.M. et al. Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions. J. Virol. 68, 2803-2810 (1994).
    • (1994) J. Virol , vol.68 , pp. 2803-2810
    • Koelle, D.M.1
  • 87
    • 15844412990 scopus 로고    scopus 로고
    • Homing in on the cellular immune response to HSV-2 in humans
    • Koelle, D.M., Gonzalez, J.C. & Johnson, A.S. Homing in on the cellular immune response to HSV-2 in humans. Am. J. Reprod. Immunol. 53 172-181 (2005).
    • (2005) Am. J. Reprod. Immunol , vol.53 , pp. 172-181
    • Koelle, D.M.1    Gonzalez, J.C.2    Johnson, A.S.3
  • 88
    • 85185103889 scopus 로고    scopus 로고
    • B Koelle, D.M., Schomogyi, M. & Corey, L. Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection. J. Infect. Dis. 182, 662-670 (2000).
    • B Koelle, D.M., Schomogyi, M. & Corey, L. Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection. J. Infect. Dis. 182, 662-670 (2000).
  • 89
    • 85185116557 scopus 로고    scopus 로고
    • Koelle, D.M., Schomogyi, M., McClurkan, C., Reymond, S.N. & Chen, H.B. CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: Comparison with responses to tegument and envelope glycoproteins. J. Virol. 74, 11422-11425 (2000).
    • Koelle, D.M., Schomogyi, M., McClurkan, C., Reymond, S.N. & Chen, H.B. CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: Comparison with responses to tegument and envelope glycoproteins. J. Virol. 74, 11422-11425 (2000).
  • 90
    • 4043126793 scopus 로고    scopus 로고
    • Immunity to latent viral infection: Many skirmishes but few fatalities
    • Khanna, K.M., Lepisto, A.J. & Hendricks, R.L. Immunity to latent viral infection: Many skirmishes but few fatalities. Trends Immunol. 25, 230-234(2004).
    • (2004) Trends Immunol , vol.25 , pp. 230-234
    • Khanna, K.M.1    Lepisto, A.J.2    Hendricks, R.L.3
  • 91
    • 0347364689 scopus 로고    scopus 로고
    • Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation
    • van Lint, A. et al. Herpes simplex virus-specific CD8+ T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. J. Immunol. 172, 392-397 (2004).
    • (2004) J. Immunol , vol.172 , pp. 392-397
    • van Lint, A.1
  • 92
    • 0026554713 scopus 로고
    • Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: Implications for the fate of virally infected neurons
    • Simmons, A. & Tscharke, D.C. Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: Implications for the fate of virally infected neurons. J. Exp. Med. 175, 1337-1344 (1992).
    • (1992) J. Exp. Med , vol.175 , pp. 1337-1344
    • Simmons, A.1    Tscharke, D.C.2
  • 93
    • 1842611841 scopus 로고    scopus 로고
    • T-cell-mediated mechanisms involved in resolution of genital herpes simplex virus type 2 (HSV-2) infection of mice
    • Milligan, G.N., Dudley-McClain, K.L., Young, C.G. & Chu, C.F. T-cell-mediated mechanisms involved in resolution of genital herpes simplex virus type 2 (HSV-2) infection of mice. J. Reprod. Immunol. 61, 115-127 (2004).
    • (2004) J. Reprod. Immunol , vol.61 , pp. 115-127
    • Milligan, G.N.1    Dudley-McClain, K.L.2    Young, C.G.3    Chu, C.F.4
  • 94
    • 0037223705 scopus 로고    scopus 로고
    • A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection
    • Harandi, A.M., Eriksson, K. & Holmgren, J. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J. Virol. 77, 953-962 (2003).
    • (2003) J. Virol , vol.77 , pp. 953-962
    • Harandi, A.M.1    Eriksson, K.2    Holmgren, J.3
  • 95
    • 0034094033 scopus 로고    scopus 로고
    • Both CD4+ and CD8+ T cells are invotved in protection against HSV-1 induced corneal scarring
    • Ghiasi, H., Cai, S., Perng, G.C., Nesburn, A.B. & Wechsler, S.L. Both CD4+ and CD8+ T cells are invotved in protection against HSV-1 induced corneal scarring. Br. J. Ophthalmol. 84, 408-412 (2000).
    • (2000) Br. J. Ophthalmol , vol.84 , pp. 408-412
    • Ghiasi, H.1    Cai, S.2    Perng, G.C.3    Nesburn, A.B.4    Wechsler, S.L.5
  • 96
    • 0028351268 scopus 로고
    • A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2
    • Parr, M.B. et al. A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2. Lab. Invest 70, 369-380 (1994).
    • (1994) Lab. Invest , vol.70 , pp. 369-380
    • Parr, M.B.1
  • 97
    • 0141682084 scopus 로고    scopus 로고
    • Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2
    • Gillgrass, A.E., Ashkar, A.A., Rosenthal, K.L. & Kaushic, C. Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2. J. Virol. 77, 9845-9851 (2003).
    • (2003) J. Virol , vol.77 , pp. 9845-9851
    • Gillgrass, A.E.1    Ashkar, A.A.2    Rosenthal, K.L.3    Kaushic, C.4
  • 98
    • 85185123890 scopus 로고    scopus 로고
    • Suvas, S., Kumaraguru, U., Pack, C.D., Lee, S. & Rouse, B.T. CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J. Exp. Med. 198, 889-901 (2003).
    • Suvas, S., Kumaraguru, U., Pack, C.D., Lee, S. & Rouse, B.T. CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J. Exp. Med. 198, 889-901 (2003).


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