Alterations of ROBO1/DUTT1 and ROBO2 loci in early dysplastic lesions of head and neck: Clinical and prognostic implications

Human Genetics

Volumn 125, Issue 2, 2009, Pages 189-198

  Ghosh, Susmita ^a   Ghosh, Amlan ^a   Maiti, Guru Prasad ^a   Alam, Neyaz ^a   Roy, Anup ^b   Roychoudhury, Susanta ^c   Panda, Chinmay Kumar ^a  

^a CHITTARANJAN NATIONAL CANCER INSTITUTE   (India)

^b MEDICAL COLLEGE AND HOSPITAL   (India)

^c INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; MESSENGER RNA; PROTEIN DUTT1; PROTEIN ROBO1; PROTEIN ROBO2; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ADULT; ARTICLE; CANCER CELL CULTURE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DNA METHYLATION; DYSPLASIA; EARLY DIAGNOSIS; FEMALE; GENE DELETION; GENE EXPRESSION; GENE LOCUS; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUTH CANCER; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; SQUAMOUS CELL CARCINOMA; TOBACCO DEPENDENCE; UPREGULATION;

ADULT; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 3; DNA METHYLATION; FEMALE; GENE DELETION; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; PROGNOSIS; RECEPTORS, IMMUNOLOGIC; RNA, UNTRANSLATED; SURVIVAL ANALYSIS;

NICOTIANA TABACUM;

EID: 60549093720     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-008-0610-9     Document Type: Article

References (30)

1. Angeloni D, ter Elst A, Wei MH et al (2006) Analysis of a new homozygous deletion in the tumor suppressor region at 3p12.3 reveals two novel intronic noncoding RNA genes. Genes Chrom Cancer 45:676-691
2. Anitha A, Nakamura K, Yamada K (2008) Genetic analyses of Roundabout (ROBO) axon guidance receptors in autism. Am J Med Genet B Neuropsychiatr Genet 147B(7):1019-1027
3. Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96:795-806
4. Burbee DG, Forgacs E, Zöchbauer-Müller S et al (2001) Epigenetic Inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst 93(9):691-699
5. Chakraborty SB, Dasgupta S, Roy A et al (2003) Differential deletions in 3p is associated with the development of head and neck squamous cell carcinoma from Indian patients. Cancer Genet Cytogenet 145:1-9
6. Dallol A, Forgacs E, Martinez A et al (2002) Tumor specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers. Oncogene 21:3020-3028
7. Dasgupta S, Mukherjee N, Roy S et al (2002) Mapping of candidate tumor suppressor genes' loci on human chromosome 3 in head, neck squamous cell carcinoma of Indian patient population. Oral Oncol 38:6-15
8. Fricke C, Lee JS, Geiger-Rudolph S, Bonhoeffer F, Chien CB (2001) Astray, a zebrafish roundabout homolog required for retinal axon guidance. Science 292:507-510
9. Ha PK, Benoit NE, Yochem R et al (2003) A transcriptional progression model for head and neck cancer. Clin Cancer Res 9:3058-3064
10. Harmer MH (1978) UICC TNM classification of malignant tumors, 3rd edn. Union Internationale Contre le Cancer (UICC), Geneva, pp 7892-7896
11. Herman JG, Jeremy R, Graff JR, Myöhänen S, Nelkin BD, Baylin SB (1996) Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93:9821-9826
12. Hossain A, Kuo MT, Saunders GF (2006) Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol 26(21):8191-8201
13. Ichimura K, Bolin MB, Goike HM, Schmidt EE, Moshref A, Collins VP (2000) Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities. Cancer Res 60:417-424
14. Ito H, Funahashi S, Yamauchi N et al (2006) Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. Clin cancer Res 12(11):3257-3264
15. Koch WM, Lango M, Sewell D, Zahurak M, Sidransky D (1999) Head and neck cancer in nonsmokers: A distinct clinical and molecular entity. Laryngoscope 109:1544-1551
16. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods 25:402-408
17. Loginov VI, Malyukova AV, Seryogin YA et al (2004) Methylation of the promoter region of the RASSF1A candidate tumor suppressor gene in primary epithelial tumors. Mol Biol 38(4):654-667
18. Long H, Sabatier C, Ma L et al (2004) Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron 42:213-223
19. Lovell M, Lott ST, Wong P, El-Naggar A, Tucker S, Killary AM (1999) The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation. Cancer Res 59:2182-2189
20. Ordonez BP, Beauchemin M, Jordan RCK (2006) Molecular biology of squamous cell carcinoma of the head and neck. J Clin Pathol 59:445-453
21. Perrone F, Suardi S, Dagrada G, Bossi P, Locati L, Pilotti S (2006) Molecular and cytogenetic subgroups of oropharyngeal squamous cell carcinoma. Clin Cancer Res 12(22):6643-6651
22. Rabbits P, Bergh J, Douglas J, Collins F, Waters J (1990) A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma. Genes Chrom Cancer 2:231-238
23. Stein E, Tessier-Lavigne M (2001) Hierarchical organization of guidance receptors: Silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science (Wash DC) 291:1928-1938
24. Sundarsean V, Chung G, Heppell-Parton A et al (1998) Homozygous deletions at 3p12 in breast and lung cancer. Oncogene 17:1723-1729
25. Tripathi A, Dasgupta S, Roy A et al (2003) Sequential deletions in both Arms of Chromosome 9 are associated with the development of head and neck squamous cell carcinoma in Indian patients. J Exp Clin Cancer Res 22(3):289-297
26. Uzawa N, Yoshida MA, Oshimaura M, Ikeuchi T (1995) Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell mediated chromosome transfer. Oncogene 11:1997-2004
27. Wong K, Park HT, Wu JY, Rao Y (2002) Slit proteins: Molecular guidance cues for cells ranging from neurons to leukocytes. Curr Opin Genet Dev 12:583-591
28. Wong K, Ren XR, Haung YZ et al (2001) Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107:209-221
29. Xian J, Aitchison A, Bobrow L et al (2004) Targeted disruption of the 3p12 gene, DUTT1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Cancer Res 64:6432-6437
30. Zabarovsky ER, Lerman MI, Minna JD (2002) Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 21:6915-6935