Methylation of the promoter region of the RASSF1A gene, a candidate tumor suppressor, in primary epithelial tumors

Molekulyarnaya Biologiya

Volumn 38, Issue 4, 2004, Pages 654-667

  Loginov, V I ^a   Malyukova, A V ^a   Seryogin, Yu A ^a   Hodyrev, D S ^a   Kazubskaya, T P ^b   Ermilova, V D ^b   Garkavtseva, R F ^b   Kisselev, L L ^c   Zabarovsky, E R ^c,d   Braga, E A ^a  

^a STATE RESEARCH INSTITUTE OF GENETICS AND SELECTION OF INDUSTRIAL MICROORGANISMS   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; DNA; RASSF1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CANCER INHIBITION; CPG ISLAND; EPITHELIUM TUMOR; GENOMICS; METHYLATION; PROMOTER REGION; ALLELE; CHEMISTRY; DNA METHYLATION; GENETICS; HUMAN; HYDROLYSIS; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; NEOPLASM; NUCLEOTIDE SEQUENCE;

ALLELES; BASE SEQUENCE; CPG ISLANDS; DNA; DNA METHYLATION; HUMANS; HYDROLYSIS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; NEOPLASMS; PROMOTER REGIONS (GENETICS); TUMOR SUPPRESSOR PROTEINS;

EID: 16644371431     PISSN: 00268984     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Attwood J.T., Yung R.L., Richardson B.C. 2002. DNA methylation and the regulation of gene transcription. Cell Mol. Life Sci. 59, 241-257.
2. Jain P.K. 2003. Epigenetics: the role of methylation in the mechanism of action of tumor suppressor genes. Ann. N.Y. Acad. Sci. 983, 71-83.
3. Bird A. 2002. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21.
4. Prokhortchouk E., Hendrich B. 2002. Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs? Oncogene. 21, 5394-5399.
5. Zabarovsky E.R., Lerman M.I., Minna J.D. 2002. Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene. 21, 6915-6935.
6. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. 2000. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. Cancer Res. 60, 6116-6133.
7. Kaneda A., Takai D., Kaminishi M., Okochi E., Ushijima T. 2003. Methylation-sensitive representational difference analysis and its application to cancer research. Ann. N.Y. Acad. Sci. 983, 131-141.
8. Patel A., Groopman J.D., Umar A. 2003. DNA methylation as a cancer-specific biomarker. From molecules to populations. Ann. N.Y. Acad. Sci. 983, 286-297.
9. Szyf M. 2003. Targeting DNA methylation in cancer. Ageing Res. Rev. 2, 299-328.
10. Dammann R., Li C., Yoon J.H., Chin P.L., Bates S., Pfeifer G.P. 2000. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nature Genet. 25, 315-319.
11. Dreijerink K., Braga E., Kuzmin I., Geil L., Duh F.M., Angeloni D., Zbar B., Lerman M.I., Stanbridge E.J., Minna J.D., Protopopov A., Li J., Kashuba V., Klein G., Zabarovsky E.R. 2001. The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis. Proc. Natl. Acad. Sci. USA. 98, 7504-7509.
12. Burbee D.G., Forgacs E., Zochbauer-Muller S., Shivakumar L., Fong K., Gao B., Randle D., Kondo M., Virmani A., Bader S., Sekido Y., Latif F., Milchgrub S., Toyooka S., Gazdar A.F., Lerman M.I., Zabarovsky E., White M., Minna J.D. 2001. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J. Natl. Cancer Inst. 93, 691-699.
13. Pfeifer G.P., Yoon J.-H., Liu L., Tommasi S., Wilczynski Sh.P., Dammann R. 2002. Methylation of the RASSF1A gene in human cancers. Biol. Chem. 383, 907-914.
14. Dammann R., Schagdarsurengin U., Strunnikova M., Rastetter M., Seidel C., Liu L., Tommasi S., Pfeifer G.P. 2003. Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis. Histol, Histopathol. 18, 665-677.
15. Tomizawa Y., Kohno T., Kondo H., Otsuka A., Nishioka M., Niki T., Yamada T., Maeshima A., Yoshimura K., Saito R., Minna J.D., Yokota J. 2002. Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma. Clin. Cancer Res. 8, 2362-2368.
16. International histological classification of tumours. Histological typing of kidney tumours. World Health Organization. Second ed. Springer-Verlag Berlin Heidelberg, Germany. 1998.
17. International histological classification of tumours. 2. Histological typing of breast tumours. World Health Organization. Second ed. Geneva. 1981.
18. International histological classification of tumours. Histological typing of ovarian tumours. World Health Organization. Second ed. Springer-Verlag Berlin Heidelberg, Germany. 1999.
19. Grimberg J., Nawoschik S., Belluscio L., McKee R., Turck A., Eisenberg A. 1989. A simple and efficient non-organic procedure for the isolation of genomic DNA from blood. Nucleic Acids Res. 17, 8390.
20. Sambrook J., Fritsch E., Maniatis T. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor N.Y.: Cold Spring Harbor Laboratory Press.
21. Clark S.J., Harrison J., Paul C.L., Frommer M. 1994. High sensitivity mapping of methylated cytosines. Nucleic Acids Res. 22, 2990-2997.
22. Herman J.G., Graff J.R., Myöhänen S., Nelkin B.D., Baylin S.B. 1996. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA. 93, 9821-9826.
23. Ivanova T., Petrenko A., Gritsko T., Vinokourova S., Eshilev E., Kobzeva V., Kisseljov F., Kisseljova N.P. 2002. Methylation and silencing of the retinoic acid receptor-β2 gene in cervical cancer. BMC Cancer. 2, 4 (el.).
24. Li Z., Meng Z.H., Chandrasekaran R., Kuo W.L., Collins C.C., Gray J.W., Dairkee S.H. 2002. Biallelic inactivation of the thyroid hormone receptor beta1 gene in early stage breast cancer. Cancer Res. 62, 1939-1943.
25. Kanaya T., Kyo S., Maida Y., Yatabe N., Tanaka M., Nakamura M., Inoue M. 2003. Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers. Oncogene. 22, 2352-2360.
26. Braga E., Senchenko V., Bazov I., Loginov V., Ermilova V., Kazubskaya T., Garkavtseva R., Mazurenko N., Kisseljov F., Liu J., Kisselev L., Lerman M., Klein G., Zabarovsky E. 2002. Critical tumor-suppressor gene regions on chromosome 3p regions in major human epithelial malignancies: allelotyping and quantitative real time PCR. Int. J. Cancer. 100, 534-541.
27. Senchenko V., Liu J., Loginov V., Bazov I., Angeloni D., Seryogin Y., Ermilova V., Kazubskaya T., Garkavtseva R., Zabarovska V., Kashuba V., Kisselev L.L., Minna J.D., Lerman M.I., Klein G., Braga E., Zabarovsky E.R. 2004. Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas. Oncogene. In press.