Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents

Clinical Science

Volumn 116, Issue 4, 2009, Pages 317-326

  Tjønna, Arnt E ^a   Stølen, Tomas O ^a   Bye, Anja ^a   Volden, Marte ^b   Slördahl, Stig A ^a   Ødegård, Rönnaug ^b   Skogvoll, Eirik ^b,c   Wisløff, Ulrik ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Adolescent; Aerobic interval training; Blood pressure; Cardiovascular risk factor; Endothelial function; Obesity

Indexed keywords

ADIPONECTIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; NITRIC OXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN;

ADOLESCENT; AEROBIC CAPACITY; AEROBIC EXERCISE; AEROBIC INTERVAL TRAINING; ARTICLE; BLOOD VESSEL FUNCTION; BODY FAT; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIET THERAPY; EXERCISE INTENSITY; FEMALE; GLYCEMIC CONTROL; HEART RATE; HORMONE BLOOD LEVEL; HUMAN; INSULIN SENSITIVITY; INTERMETHOD COMPARISON; LEG STRENGTH; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; NORWAY; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PSYCHOLOGICAL WELL BEING; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; STRENGTH; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; TREATMENT OUTCOME; WEIGHT REDUCTION; ANTHROPOMETRY; BLOOD; BLOOD PRESSURE; BODY COMPOSITION; CARDIOVASCULAR DISEASE; DIET; FEEDING BEHAVIOR; GLUCOSE BLOOD LEVEL; KINESIOTHERAPY; METABOLISM; METHODOLOGY; MULTIMODALITY CANCER THERAPY; PATHOPHYSIOLOGY; PATIENT COMPLIANCE; RISK FACTOR;

ADOLESCENT; ANTHROPOMETRY; BLOOD GLUCOSE; BLOOD PRESSURE; BODY COMPOSITION; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; COMBINED MODALITY THERAPY; DIET; EXERCISE THERAPY; FEMALE; FOOD HABITS; HUMANS; MALE; OBESITY; OVERWEIGHT; OXYGEN CONSUMPTION; PATIENT COMPLIANCE; RISK FACTORS;

EID: 60549091718     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20080249     Document Type: Article

References (41)

1. Kopelman, P. G. (2000) Obesity as a medical problem. Nature 404, 635-643
2. Gielen, S. and Hambrecht, R. (2004) The childhood obesity epidemic: impact on endothelial function. Circulation 109, 1911-1913
3. National Centers for Health Statistics (2004) Prevalence of overweight and obesity among adults: United States, 1999-2002, Centers for Disease Control and Prevention, Atlanta, GA
4. Tounian, P., Aggoun, Y., Dubern, B. et al. (2001) Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 358, 1400-1404
5. Woo, K. S., Chook, P., Yu, C. W. et al. (2004) Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening. Int. J. Obes. Relat. Metab. Disord. 28, 852-857
6. Halcox, J. P., Schenke, W. H., Zalos, G. et al. (2002) Prognostic value of coronary vascular endothelial dysfunction. Circulation 106, 653-658
7. Ross, R. (1999) Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340, 115-126
8. Freedman, D. S., Dietz, W. H., Srinivasan, S. R. and Berenson, G. S. (1999) The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 103, 1175-1182
9. Must, A., Jacques, P. F., Dallal, G. E., Bajema, C. J. and Dietz, W. H. (1992) Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N. Engl. J. Med. 327, 1350-1355
10. Ribeiro, M. M., Silva, A. G., Santos, N. S. et al. (2005) Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation 111, 1915-1923
11. Woo, K. S., Chook, P., Yu, C.W. et al. (2004) Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation 109, 1981-1986
12. Tjønna, A. E., Lee, S. J., Rognmo, O. et al. (2008) Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation 118, 346-354
13. Steinberger, J. and Daniels, S. R. (2003) Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation 107, 1448-1453
14. Rognmo, O., Hetland, E., Helgerud, J., Hoff, J. and Slordahl, S. A. (2004) High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur. J. Cardiovasc. Prev. Rehabil. 11, 216-222
15. Bergh, U., Sjodin, B., Forsberg, A. and Svedenhag, J. (1991) The relationship between body mass and oxygen uptake during running in humans. Med. Sci Sports Exercise 23, 205-211
16. Corretti, M. C., Anderson, T. J., Benjamin, E. J. et al. (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J. Am. Coll. Cardiol. 39, 257-265
17. Schjerve, I. E., Tyldum, G. A., Tjønna, A. E. et al. (2008) Both aerobic endurance and strength training programmes improve cardiovascular health in obese adults. Clin. Sci. 115, 283-293
18. Pyke, K. E. and Tschakovsky, M. E. (2005) The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J. Physiol. 568, 357-369
19. Wallace, T. M., Levy, J. C. and Matthews, D. R. (2004) Use and abuse of HOMA modeling. Diabetes Care 27, 1487-1495
20. Overby, N. C., Flaaten, V., Veierod, M. B. et al. (2007) Children and adolescents with type 1 diabetes eat a more atherosclerosis-prone diet than healthy control subjects. Diabetologia 50, 307-316
21. Wisløff, U., Stoylen, A., Loennechen, J. P. et al. (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115, 3086-3094
22. Machin, D., Campbell, M., Fayers, P. and Pinol, A. (1997) Sample Size Tables for Clinical Studies, Blackwell Science, Oxford
23. Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S. and Atwood, J. E. (2002) Exercise capacity and mortality among men referred for exercise testing. N. Engl. J. Med. 346, 793-801
24. 2max more than moderate training. Med. Sci. Sports Exercise 39, 665-671
25. Slordahl, S. A., Wang, E., Hoff, J., Kemi, O. J., Amundsen, B. H. and Helgerud, J. (2005) Effective training for patients with intermittent claudication. Scand. Cardiovasc. J. 39, 244-249
26. Blair, S. N. and Brodney, S. (1999) Effects of physical inactivity and obesity on morbidity and mortality: current evidence and research issues. Med. Sci. Sports Exercise 31, S646-S662
27. Gaesser, G. A. (1999) Thinness and weight loss: beneficial or detrimental to longevity? Med. Sci. Sports Exercise 31, 1118-1128
28. Janssen, I., Katzmarzyk, P. T. and Ross, R. (2004) Waist circumference and not body mass index explains obesity-related health risk. Am. J. Clin. Nutr. 79, 379-384
29. Wei, M., Gaskill, S. P., Haffner, S. M. and Stern, M. P. (1997) Waist circumference as the best predictor of noninsulin dependent diabetes mellitus (NIDDM) compared with body mass index, waist/hip ratio and other anthropometric measurements in Mexican Americans: a 7-year prospective study. Obes. Res. 5, 16-23
30. Watts, K., Beye, P., Siafarikas, A. et al. (2004) Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents. J. Am. Coll. Cardiol. 43, 1823-1827
31. Gutin, B., Barbeau, P., Owens, S. et al. (2002) Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents. Am. J. Clin. Nutr. 75, 818-826
32. Gutin, B., Yin, Z., Humphries, M. C. and Barbeau, P. (2005) Relations of moderate and vigorous physical activity to fitness and fatness in adolescents. Am. J. Clin. Nutr. 81, 746-750
33. Tremblay, A., Simoneau, J. A. and Bouchard, C. (1994) Impact of exercise intensity on body fatness and skeletal muscle metabolism. Metab. Clin. Exp. 43, 814-818
34. 2 consumption. Metab. Clin. Exp. 40, 836-841
35. Medbo, J. I. and Jebens, E. (2002) Leg gas exchange, release of glycerol, and uptake of fats after two minutes bicycling to exhaustion. Scand. J. Clin. Lab. Invest. 62, 211-221
36. Davignon, J. and Ganz, P. (2004) Role of endothelial dysfunction in atherosclerosis. Circulation 109, III27-III32
37. Oberbach, A., Tonjes, A., Kloting, N. et al. (2006) Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur. J. Endocrinol. 154, 577-585
38. Nicholls, S. J., Lundman, P., Harmer, J. A. et al. (2006) Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. J. Am. Coll. Cardiol. 48, 715-720
39. Host, H. H., Hansen, P. A., Nolte, L. A., Chen, M. M. and Holloszy, J. O. (1998) Rapid reversal of adaptive increases in muscle GLUT-4 and glucose transport capacity after training cessation. J. Appl. Physiol. 84, 798-802
40. Cotton, B., Smith, A., Hansen, I., Davis, C., Doyle, A. and Walsh, A. (2006) Physician-directed primary care intervention to reduce risk factors for type 2 diabetes in high-risk youth. Am. J. Med. Sci. 332, 108-111
41. Savoye, M., Shaw, M., Dziura, J. et al. (2007) Effects of a weight management program on body composition and metabolic parameters in overweight children: a randomized controlled trial. JAMA, J. Am. Med. Assoc. 297, 2697-2704