Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: A pilot study

Circulation

Volumn 118, Issue 4, 2008, Pages 346-354

  Tjønna, Arnt Erik ^a   Lee, Sang Jun ^d   Rognmo, Øivind ^a   Stølen, Tomas O ^a   Bye, Anja ^a   Haram, Per Magnus ^a   Loennechen, Jan Pål ^a,d   Al Share, Qusai Y ^b   Skogvoll, Eirik ^b,d   Slørdahl, Stig A ^a,c   Kemi, Ole J ^e   Najjar, Sonia M ^c   Wisløff, Ulrik ^a,d  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c MEDICAL COLLEGE OF OHIO   (United States)

^d TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Endothelium; Exercise; Metabolic syndrome X; Obesity; Oxygen

Indexed keywords

ACETYLSALICYLIC ACID; ADIPONECTIN; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C PEPTIDE; CALCIUM ANTAGONIST; GLUCOSE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LOW DENSITY LIPOPROTEIN; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; AEROBIC CAPACITY; AEROBIC INTERVAL TRAINING; ARTICLE; BLOOD VESSEL FUNCTION; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTINUOUS MODERATE EXERCISE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENDURANCE; EXCITATION CONTRACTION COUPLING; EXERCISE INTENSITY; GLUCOSE BLOOD LEVEL; HEART RATE; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTERMETHOD COMPARISON; KINESIOTHERAPY; LIPOGENESIS; MEAN ARTERIAL PRESSURE; METABOLIC SYNDROME X; MICROALBUMINURIA; MUSCLE DEVELOPMENT; MUSCLE LEVEL; OXYGEN CONSUMPTION; PILOT STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; RUNNING; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SYSTOLIC BLOOD PRESSURE; TREADMILL EXERCISE; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR ENDOTHELIUM; WAIST CIRCUMFERENCE; WALKING; WEIGHT REDUCTION; BODY WEIGHT; CARDIOVASCULAR DISEASE; FEMALE; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; STANDARD;

ADULT; BODY WEIGHT; CARDIOVASCULAR DISEASES; EXERCISE THERAPY; FEMALE; HEART RATE; HUMANS; MALE; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; OXYGEN CONSUMPTION; PILOT PROJECTS;

EID: 49149086637     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.772822     Document Type: Article

References (32)

1. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109:433-438.
2. James PT, Rigby N, Leach R. The obesity epidemic, metabolic syndrome and future prevention strategies. Eur J Cardiovasc Prev Rehabil. 2004; 11:3-8.
3. Lakka HM, Laaksonen DE, Lakka TA, Niskanen LK, Kumpusalo E, Tuomilehto J, Salonen JT. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA. 2002;288: 2709-2716.
4. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KR, Quyyumi AA. Prognostic value of coronary vascular endothelial dysfunction. Circulation. 2002;106:653-658.
5. Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801.
6. WHO. Report of a WHO Consultation: Definition of the Metabolic Syndrome, Diagnosis, and Classification of Diabetes Mellitus and Its Complications, I: Diagnosis and Classification of Diabetes Mellitus. Geneva, Switzerland: World Health Organization, Department of Noncommunicable Disease Surveillance; 1999.
7. Andersen LF, Solvoll K, Johansson LR, Salminen I, Aro A, Drevon CA. Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. Am J Epidemiol. 1999;150:75-87.
8. Rognmo O, Hetland E, Helgerud J, Hoff J, Slordahl SA. High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur J Cardiovasc Prev Rehabil. 2004;11:216-222.
9. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. JAm Coll Cardiol. 2002;39:257-265.
10. Schjerve IE, Tyldum GA, Tjonna AE, Stolen TO, Loennechen JP, Hansen HE, Haram PM, Heinrich G, Bye A, Najjar SM, Smith GL, Slordahl SA, Kemi OJ, Wisloff U. Both aerobic endurance and strength training programs improve cardiovascular health in obese adults. Clin Sci (Lond). March 13, 2008. DOI: 10.1042/CS20070332. Available at: http://www.clinsci.org. Accessed March 13, 2008.
11. Pyke KE, Tschakovsky ME. The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol. 2005;568:357-369.
12. 2+ ATPase function is increased by aerobic interval training. Eur J Cardiovasc Prev Rehabil. 2008;15:145-148.
13. Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, Tjonna AE, Helgerud J, Slordahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen O, Skjaerpe T. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115: 3086-3094.
14. Machin D, Campbell M, Fayers P, Pinol A. Sample Size Tables for Clinical Studies. Oxford, UK: Blackwell Science; 1997.
15. Vickers AJ, Altman DG. Statistics notes: analysing controlled trials with baseline and follow up measurements. BMJ. 2001;323:1123-1124.
16. Wisloff U, Najjar SM, Ellingsen O, Haram PM, Swoap S, Al-Share Q, Fernstrom M, Rezaei K, Lee SJ, Koch LG, Britton SL. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science. 2005;307:418-420.
17. Caro JF, Sinha MK, Raju SM, Ittoop O, Pories WJ, Flickinger EG, Meelheim D, Dohm GL. Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. J Clin Invest. 1987;79:1330-1337.
18. Nolan JJ, Freidenberg G, Henry R, Reichart D, Olefsky JM. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab. 1994;78:471-477.
19. Blair SN, Brodney S. Effects of physical inactivity and obesity on morbidity and mortality: current evidence and research issues. Med Sci Sports Exerc. 1999;31:646-662.
20. Vatten LJ, Nilsen TI, Romundstad PR, Droyvold WB, Holmen J. Adiposity and physical activity as predictors of cardiovascular mortality. Eur J Cardiovasc Prev Rehabil. 2006;13:909-915.
21. 2max more than moderate training. Med Sci Sports Exerc. 2007;39:665-671.
22. Slordahl SA, Wang E, Hoff J, Kemi OJ, Amundsen BH, Helgerud J. Effective training for patients with intermittent claudication. Scand Cardiovasc J. 2005;39:244-249.
23. Steinberger J, Daniels SR. Obesity, insulin resistance, diabetes, and cardiovascular risk in children: an American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism). Circulation. 2003;107:1448-1453.
24. Kopelman PG, Grace C. New thoughts on managing obesity. Gut. 2004; 53:1044-1053.
25. Kopelman PG. Clinical treatment of obesity: are drugs and surgery the answer? Proc Nutr Soc. 2005;64:65-71.
26. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288: 373-376.
27. Hambrecht R, Adams V, Erbs S, Linke A, Krankel N, Shu Y, Baither Y, Gielen S, Thiele H, Gummert JF, Mohr FW, Schuler G. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 2003;107:3152-3158.
28. Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation. 2004;109(suppl):III-27-III-32.
29. Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903-1913.
30. Koval JA, Maezono K, Patti ME, Pendergrass M, DeFronzo RA, Mandarino LJ. Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle. Med Sci Sports Exerc. 1999;31: 998-1004.
31. Bonen A, Dohm GL, van Loon LJ. Lipid metabolism, exercise and insulin action. Essays Biochem. 2006;42:47-59.
32. Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol. 2007;102: 1439-1447.