Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production

Molecular Immunology

Volumn 46, Issue 7, 2009, Pages 1278-1288

  Tsukamoto, Yumiko ^a   Nagai, Yoshinori ^a   Kariyone, Ai ^a   Shibata, Takuma ^a   Kaisho, Tsuneyasu ^b   Akira, Shizuo ^c   Miyake, Kensuke ^a   Takatsu, Kiyoshi ^a  

^a THE UNIVERSITY OF TOKYO   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

8 Mercaptoguanosine (8 SGuo); AID; Blimp 1; CD38; Class switch recombination (CSR); Interleukin 4 (IL 4); Toll like receptor 7 (TLR7)

Indexed keywords

8 MERCAPTOGUANOSINE; B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; BRUTON TYROSINE KINASE; CD38 ANTIGEN; IMMUNOGLOBULIN G1; INTERLEUKIN 4; INTERLEUKIN 5; LOXORIBINE; LYMPHOCYTE ANTIGEN RECEPTOR; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 7;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENETIC RECOMBINATION; IMMUNOGLOBULIN PRODUCTION; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPLEEN CELL;

ANIMALS; ANTIBODIES; ANTIGENS, CD38; B-LYMPHOCYTES; CELLS, CULTURED; CYTIDINE DEAMINASE; DRUG SYNERGISM; GUANOSINE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, ANTIGEN, B-CELL; RECOMBINATION, GENETIC; TOLL-LIKE RECEPTOR 7; TRANSCRIPTION FACTORS;

MUS;

EID: 60449095987     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.11.022     Document Type: Article

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