CD38 cross-linking enhances TLR-induced B cell proliferation but decreases IgM plasma cell differentiation

European Journal of Immunology

Volumn 37, Issue 2, 2007, Pages 358-367

  Manjarrez Orduño, Nataly ^a   Moreno García, Miguel E ^a,c   Fink, Katja ^b,d   Santos Argumendo, Leopoldo ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Novartis Institute for Tropical Diseases   (Singapore)

Author keywords

B cells; Cell differentiation; Cell surface molecules; Toll like receptors

Indexed keywords

ANTIBODY; CD38 ANTIGEN; IMMUNOGLOBULIN M; LIGAND; LIPOPOLYSACCHARIDE; PROTEIN BCL 6; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR PAX5; CCND2 PROTEIN, MOUSE; CYCLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL SURFACE; CONTROLLED STUDY; CROSS LINKING; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FOLLICULAR DENDRITIC CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; CYTOLOGY; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD38; B-LYMPHOCYTES; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CYCLINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNOGLOBULIN M; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; PLASMA CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 33947716710     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636453     Document Type: Article

References (30)

1. Santos-Argumedo, L., Teixeira, C., Preece, G., Kirkham, P. A. and Parkhouse, R. M., A B lymphocyte surface molecule mediating activation and protection from apoptosis via calcium channels. J. Immunol. 1993. 151: 3119-3130.
2. + splenic B cells and peritoneal B-1 cells in response to IL-5 and CD38 ligation. Int. Immunol. 1999. 11: 915-923.
3. Moreno-Garcia, M. E., Lopez-Bojorques, L. N., Zentella, A., Humphries, L. A., Rawlings, D. J. and Santos-Argumedo, L., CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kiriase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade. J. Immunol. 2005. 174: 2687-2695.
4. Cockayne, D. A., Muchamuel, T., Grimaldi, J. C., Muller-Stefffier, H., Randall, T. D., Lund, F. E., Murray, R. et al., Mice deficient for the ecto-nicotinamide adenine dinucleotide glycohydrolase CD38 exhibit altered humoral immune responses. Blood 1998. 92: 1324-1333.
5. Deaglio, S., Vaisitti, T., Bergui, L., Bonello, L., Horenstein, A. L., Tamagnone, L., Boumsell, L. and Malavasi, F., CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival. Blood 2005. 105: 3042-3050.
6. Deaglio, S., Capobianco, A., Bergui, L., Durig, J., Morabito, F., Duhrsen, U. and Malavasi, F., CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. Blood 2003. 102: 2146-2155.
7. Bernasconi, N. L., Onai, N. and Lanzavecchia, A., A role for Toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 2003. 101: 4500-4504.
8. Andersson, J., Sjoberg, O. and Moller, G., Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides. Eur. J. Immunol. 1972. 2: 349-353.
9. Peng, S. L., Signaling in B cells via Toll-like receptors. Curr. Opin. Immunol. 2005. 17: 230-236.
10. Coutinho, A., Forni, L., Melchers, F. and Watanabe, T., Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide. Eur. J. Immunol. 1977. 7: 325-328.
11. Santos-Argumedo, L., Lund, F. E., Heath, A. W., Solvason, N., Wu, W. W., Grimaldi, J. C., Parkhouse, R. M. and Howard, M., CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regular of CD38 induced signal transduction. Int. Immunol. 1995. 7: 163-170.
12. Kikuchi, Y., Yasue, T., Miyake, K., Kimoto, M. and Takatsu, K., CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: Synergistic effects with interleukin 5. Proc. Natl. Acad. Sci. USA 1995. 92: 11814-11818.
13. Chan, V. W., Mecklenbrauker, I., Su, I., Texido, G., Leitges, M., Carsetti, R., Lowell, C. A. et al., The molecular mechanism of B cell activation by Toll-like receptor protein RP-105. J. Exp. Med. 1998. 188: 93-101.
14. Hebeis, B., Vigorito, E., Kovesdi, D. and Turner, M., Vav proteins are required for B-lymphocyte responses to LPS. Blood 2005. 106: 635-640.
15. Kumagai, M., Coustan-Smith, E., Murray, D. J., Silvennoinen, O., Murti, K. G., Evans, W. E., Malavasi, F. and Campana, D., Ligation of CD38 suppresses human B lymphopoiesis. J. Exp. Med. 1995. 181: 1101-1110.
16. + T cells during lymphophenia-driven proliferation. J. Immunol. 2005. 174: 1178-1187.
17. Oliver, A. M., Grimaldi, J. C., Howard, M. C. and Kearney, J. F., independently ligating CD38 and Fc gammaRIIB relays a dominant negative signal to B cells. Hybridoma 1999. 18: 113-119.
18. Howard, M., Grimaldi, J. C., Bazan, J. F., Lund, F. E., Santos-Argumedo, L., Parkhouse, R. M., Walseth, T. F. and Lee, H. C., Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 1993. 262: 1056-1059.
19. Wykes, M. N., Beattie, L., Macpherson, G. G. and Hart, D. N., Dendritic cells and fofficular dendritic cells express a novel ligand for CD38 which influences their maturation and antibody responses. Immunology 2004. 113: 318-327.
20. Lund, F. E., Yu, N., Kim, K. M., Reth, M. and Howard, M. C., Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression. J. Immunol. 1996. 157: 1455-1467.
21. Mizoguchi, C., Uehara, S., Akira, S. and Takatsu, K., IL-5 induces IgG1 isotype switch recombination in mouse CD38-activated sIgD-positive B lymphocytes. J. Immunol. 1999. 162: 2812-2819.
22. Lin, K. L, Angelin-Duclos, C., Kuo, T. C. and Calame, K., Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells. Mol. Cell. Biol. 2002. 22: 4771-4780.
23. Partida-Sanchez, S., Goodrich, S., Kusser, K., Oppenheimer, N., Randall, T. D. and Lund, F. E., Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: Impact on the development of humoral immunity. Immunity 2004. 20: 279-291.
24. Shaffer, A. L., Lin, K. L, Kuo, T. C., Yu, X., Hurt, E. M., Rosenwald, A., Giltriane, J. M. et al., Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 2002. 17: 51-62.
25. Kearney, J. F., Cooper, M. D. and Lawton, A. R., B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by anti-mouse immunoglobulin antibodies. J. Immunol. 1976. 116: 1664-1668.
26. Ridderstad, A. and Tarlinton, D. M., Kinetics of establishing the memory B cell population as revealed by CD38 expression. J. Immunol. 1998. 160: 4688-4695.
27. Chayen, A. and Parkhouse, R. M., Preparation and properties of a cytotoxic monoclonal rat anti-mouse Thy-1 antibody. J. Immunol. Methods 1982. 49: 17-23.
28. Junt, T., Fink, K., Forster, R., Senn, B., Lipp, M., Muramatsu, M., Zinkernagel, R. M. et al., CXCR5-dependent seeding of follicular niches by B and Th cells augments antiviral B cell responses. J. Immunol. 2005. 175: 7109-7116.
29. Gett, A. V. and Hodgkin, P. D., A cellular calculus for signal integration by T cells. Nat. Immunol. 2000. 1: 239-244.
30. Steinke, J. W., Hodsdon, W., Parenti, S., Ostraat, R., Lutz, R., Borish, L. and Hagman, J., Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells. Mol. Immunol. 2004. 41: 1145-1153.