Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity-role of individual hydroxyl groups

Free Radical Biology and Medicine

Volumn 46, Issue 6, 2009, Pages 745-758

  Gažák, Radek ^a   Sedmera, Petr ^a   Vrbacký, Marek ^b   Vostálová, Jitka ^c   Drahota, Zdeněk ^b   Marhol, Petr ^a   Walterová, Daniela ^c   Křen, Vladimír ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Antiradical mechanism; Dehydrosilybin; Dimer formation; Free radicals; Laccase (Trametes pubescens); Reactive oxygen species; Silybin; Silymarin

Indexed keywords

2,3 DEHYDROSILYBIN; DIMER; HYDROXYL GROUP; LIGNAN DERIVATIVE; NATURAL PRODUCT; RADICAL; SILIBININ; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG MECHANISM; LIPID PEROXIDATION; METHYLATION; MOLECULAR INTERACTION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

TRAMETES PUBESCENS;

DIMERIZATION; FREE RADICAL SCAVENGERS; HYDROXYL RADICAL; LIPID PEROXIDATION; MILK THISTLE; MODELS, MOLECULAR; OXIDATION-REDUCTION; OXIDATIVE STRESS; SILYMARIN;

EID: 60449093727     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.11.016     Document Type: Article

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