Molecular structure and stereochemistry of silybin A, silybin B, isosilybin A, and isosilybin B, isolated from Silybum marianum (milk thistle)

Journal of Natural Products

Volumn 66, Issue 9, 2003, Pages 1171-1174

  Lee, David Y W ^a   Liu, Yanze ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVONOLIGNAN; ISOSILYBIN A; ISOSILYBIN B; SILIBININ; SILYBIN A; SILYBIN B; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CRYSTALLIZATION; DIASTEREOISOMER; GEL CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OPTICAL ROTATION; PROTON NUCLEAR MAGNETIC RESONANCE; SILYBUM MARIANUM; STEREOCHEMISTRY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CIRSIUM; SILYBUM MARIANUM;

EID: 0141566436     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np030163b     Document Type: Article

References (14)

1. Škottová, K.; Krecman, V. Physiol. Res. 1998, 47, 1-7.
2. Pelter, A.; Hänsel, R. Chem. Ber. 1975, 108, 790-802.
3. Pelter, A.; Hänsel, R. Chem. Ber. 1975, 108, 1482-1501.
4. Merlini, L.; Zanarotti, A. J. Chem. Soc., Chem. Commun. 1979, 695.
5. Merlini, L.; Zanarotti, A.; Pelter, A.; Rochefort, M. P.; Hänsel, R. J. Chem. Soc., Perkin Trans. 1 1980, 775-778.
6. Arnone, A.; Merlini, L.; Zanarotti, A. J. Chem. Soc., Chem. Commun. 1979, 696-697.
7. Tanaka, H.; Shibata, M.; Ohira, K.; Ito, K. Chem. Pharm. Bull. 1985, 33, 1419-1423.
8. Tittel, G.; Wagner, H. J. Chromatogr. 1977, 135, 499-501.
9. Tittel, G.; Wagner, H. J. Chromatogr. 1978, 153, 227-232.
10. Ding, T.; Tian, S.; Zhang, Z.; Shi, Y.; Sun, Z. Acta Pharm. Sin. 2000, 35, 778-781.
11. Lotter, H.; Wagner, H. Z. Naturforsch. 1983, 38c, 339-341.
12. Delfini, M.; Di Cocco, M. E.; Gaggelli, E.; Lepri, A.; Valensin, G. Spectrosc. Lett. 1990, 23, 1007-1025.
13. Křen, V.; Kupisch, J.; Sedmera, P.; Harada, P.; Přikrylová, V.; Jegorov, A. J. Chem. Soc., Perkin Trans. 1 1997, 2467-2477.
14. X-ray data of isosilybin A (6) have been deposited at the Cambridge Crystallographic Data Center. Copies of the data can be obtained free of charge on application to the Director, CCDC, 12 Union Rd., Cambridge CB2 1EZ, UK (fax: +44-(0)1223-336033 or e-mail: deposit@ccdc.cam.ac.uk).