Clonal expansion of different mtDNA variants without selective advantage in solid tumors

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 662, Issue 1-2, 2009, Pages 28-32

  Gekeler, Julia ^a   Zsurka, Gábor ^b,c   Kunz, Wolfram S ^b,c   Preuss, Simon F ^a   Klussmann, Jens Peter ^a   Guntinas Lichius, Orlando ^a,d   Wiesner, Rudolf J ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c Life and Brain Center   (Germany)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Clonal expansion; Mitochondrial DNA (mtDNA) mutations; Random drift; Tumor

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; AGED; ARTICLE; CANCER STAGING; CARCINOGENESIS; CLINICAL ARTICLE; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROPLASMY; HUMAN; HYPOTHESIS; MALE; MOLECULAR CLONING; MUTANT; PRIORITY JOURNAL; SOLID TUMOR; SQUAMOUS CELL CARCINOMA; WILD TYPE;

AGED; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA, MITOCHONDRIAL; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PEDIGREE; POLYMORPHISM, GENETIC;

EID: 60449093308     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2008.11.020     Document Type: Article

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