Human leukocyte transmigration across galα(1,3)gal-negative porcine endothelium is regulated by human CD18 and CD99

Transplantation

Volumn 87, Issue 4, 2009, Pages 491-499

  Schneider, Mårten K J ^a   Ghielmetti, Maddalena ^a   Rhyner, Daniel M ^a,b   Antsiferova, Maria A ^a,c   Seebach, Jörg D ^a,d  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

^d University Hospital and Medical Faculty ^*  (Switzerland)

Author keywords

Adhesion; Endothelial Cells; Monocytes; Transmigration; Xenotransplantation

Indexed keywords

ALPHA 1,3 GALACTOSYLTRANSFERASE; CD18 ANTIGEN; CD99 ANTIGEN; CD99 PROTEIN, HUMAN; CELL ADHESION MOLECULE; DISACCHARIDE; GALACTOSYL (1 3)GALACTOSE; GALACTOSYL-(1-3)GALACTOSE; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL MEMBRANE PERMEABILITY; CELL SUBPOPULATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOREGULATION; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MONOCYTE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SWINE; T LYMPHOCYTE; XENOTRANSPLANTATION; ANIMAL; CELL ADHESION; CELL MOTION; DRUG EFFECT; GRAFT REJECTION; HOMEOSTASIS; LEUKOCYTE; PHYSIOLOGY; VASCULAR ENDOTHELIUM; XENOGRAFT;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD18; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; DISACCHARIDES; ENDOTHELIUM, VASCULAR; GRAFT REJECTION; HOMEOSTASIS; HUMANS; LEUKOCYTES; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 60449090544     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318195fb8d     Document Type: Article

References (52)

1. Lai L, Kolber-Simonds D, Park KW, et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 2002; 295: 1089.
2. Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299: 411.
3. Galili U. The alpha-gal epitope (Gal alpha 1-3Gal beta 1-4GlcNAc-R) in xenotransplantation. Biochimie 2001; 83: 557.
4. Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11: 29.
5. YamadaK, YazawaK, ShimizuA, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11: 32.
6. Rieben R, Seebach JD. Xenograft rejection: IgG(1), complement and NK cells team up to activate and destroy the endothelium. Trends Immunol 2005; 26: 2.
7. Yang YG, Sykes M. Xenotransplantation: current status and a perspective on the future. Nat Rev Immunol 2007; 7: 519.
8. Schneider MK, Seebach JD. Current cellular innate immune hurdles in pig-to-primate xenotransplantation. Curr Opin Organ Transplant 2008; 13: 171.
9. Loetscher P, Seitz M, Clark-Lewis I, et al. Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release. J Immunol 1996; 156: 322.
10. Ehrnfelt C, Serrander L, Holgersson J. Porcine endothelium activated by anti-alpha-GAL antibody binding mediates increased human neutrophil adhesion under flow. Transplantation 2003; 76: 1112.
11. Gilli UO, Schneider MKJ, Loetscher P, et al. Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2. Transplantation 2005; 79: 1324.
12. Fox A, Harrison LC. Innate immunity and graft rejection. Immunol Rev 2000; 173: 141.
13. Simon AR, Warrens AN, Yazzie NP, et al. Cross-species interaction of porcine and human integrins with their respective ligands: implications for xenogeneic tolerance induction. Transplantation 1998; 66: 385.
14. Robinson LA,Tu L, Steeber DA,et al. The roleof adhesion molecules in human leukocyte attachment to porcine vascular endothelium: implications for xenotransplantation. J Immunol 1998; 161: 6931.
15. Schneider MK, Forte P, Seebach JD. Adhesive interactions between human NK cells and porcine endothelial cells. Scand J Immunol 2001; 54: 70.
16. Hauzenberger E, Hauzenberger D, Hultenby K, et al. Porcine endothelium supports transendothelial migration of human leukocyte sub-populations: anti-porcine vascular cell adhesion molecule antibodies as species-specific blockers of transendothelial monocyte and natural killer cell migration. Transplantation 2000; 69: 1837.
17. Schneider MK, Strasser M, Gilli UO, et al. Rolling adhesion of human NK cells to porcine endothelial cells mainly relies on CD49d-CD106 interactions. Transplantation 2002; 73: 789.
18. Hauzenberger E, Klominek J, Holgersson J. Anti-Gal IgG potentiates natural killer cell migration across porcine endothelium via endothelial cell activation and increased natural killer cell motility triggered by CD16 cross-linking. Eur J Immunol 2004; 34: 1154.
19. Cardozo LA, Rouw DB, Ambrose LR, et al. The neutrophil: the unnoticed threat in xenotransplantation? Transplantation 2004; 78: 1721.
20. Peterson MD, Jin R, Hyduk S, et al. Monocyte Adhesion to xenoge-neic endothelium during laminar flow is dependent on {alpha}-gal-mediated monocyte activation. J Immunol 2005; 174: 8072.
21. Jin R, Greenwald A, Peterson MD, et al. Human monocytes recognize porcine endothelium via the interaction of galectin 3 and alpha-GAL. J Immunol 2006; 177: 1289.
22. Ehrnfelt C, Kumagai-Braesch M, Uzunel M, et al. Adult porcine islets produce MCP-1 and recruit human monocytes in vitro. Xenotransplantation 2004; 11: 184.
23. Goodman DJ, Von Albertini M, Willson A, et al. Direct activation of porcine endothelial cells by human natural killer cells. Transplantation 1996; 61: 763.
24. Millan MT, Geczy C, Stuhlmeier KM, et al. Human monocytes activate porcine endothelial cells, resulting in increased E-selectin, interleukin-8, monocyte chemotactic protein-1, and plasminogen activator inhibitor-type-1 expression. Transplantation 1997; 63: 421.
25. Sheikh S, Parhar R, Kwaasi A, et al. Alpha-gal-independent dual recognition and activation of xenogeneic endothelial cells and human naive natural killer cells. Transplantation 2000; 70: 917.
26. Peterson MD, Vlasova E, Ciano-Oliveira C, et al. Monocyte-induced endothelial calcium signaling mediates early xenogeneic endothelial activation. Am J Transplant 2005; 5: 237.
27. Xu XC, Goodman J,Sasaki H, et al. Activation of natural killer cells and macrophages by porcine endothelial cells augments specific T-cell xenoresponse. Am J Transplant 2002; 2: 314.
28. Saethre M, Schneider MK, Lambris JD, et al. Cytokine secretion depends on Galalpha(1,3)Gal expression in a pig-to-human whole blood model. J Immunol 2008; 180: 6346.
29. Kwiatkowski P, Artrip JH, Ankersmit J, et al. Importance of CD49d-VCAM interactions in human monocyte adhesion to porcine endothelium. Xenotransplantation 1998; 5: 67.
30. Kwiatkowski P, Artrip JH, Edwards NM, et al. High-level porcine endothelial cell expression of alpha(1,2)-fucosyltransferase reduces human monocyte adhesion and activation. Transplantation 1999; 67: 219.
31. Schenkel AR, Mamdouh Z, Muller WA. Locomotion of monocytes on endothelium is a critical step during extravasation. Nat Immunol 2004; 5: 393.
32. Berman ME, Xie Y, Muller WA. Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta2integrin activation. J Immunol 1996; 156: 1515.
33. Muller WA, Weigl SA, Deng X, et al. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 1993; 178: 449.
34. NasuK, Whyte A,Green SJ,et al. Alpha-galactosyl-mediated activation of porcine endothelial cells: studies on CD31 and VE-cadherin in adhesion and signaling. Transplantation 1999; 68: 861.
35. Schenkel AR, Mamdouh Z, Chen X, et al. CD99 plays a major role in the migration of monocytes through endothelial junctions. Nat Immunol 2002; 3: 143.
36. Lou O, Alcaide P, Luscinskas FW, et al. CD99 is a key mediator of the transendothelial migration of neutrophils. J Immunol 2007; 178: 1136.
37. Weber C, Fraemohs L, Dejana E. The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol 2007; 7: 467.
38. Piali L, Hammel P, Uherek C, et al. CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium. J Cell Biol 1995; 130: 451.
39. Thompson RD, Wakelin MW, Larbi KY, et al. Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta3 integrin blockade on leukocyte transmigration in vivo. J Immunol 2000; 165: 426.
40. Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 1996; 272: 50.
41. Inverardi L, Clissi B, Stolzer AL, et al. Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues. Transplantation 1997; 63: 1318.
42. Goodman DJ, Millan MT, FerranC,et al. Mechanismsofdelayed xenograft rejection. In: Cooper DKC, Kemp E, Paul WE, et al., eds. Xenotransplantation. Berlin, Germany, Springer 1997, p 77.
43. Kwiatkowski P, Artrip JH, Wang SF, et al. Human monocytes bind to two distinct carbohydrate capping structures on porcine endothelium. Transplant Proc 2000; 32: 927.
44. Sheikh S, Parhar R, al Mohanna F. Rapid static adhesion of human naive neutrophil to naive xenoendothelium under physiologic flow is independent of Galalpha1,3-gal structures. J Leukoc Biol 2002; 71: 932.
45. Baumann BC, Schneider MK, Lilienfeld BG, et al. Endothelial cells derived from pigs lacking Gala(1,3)Gal: no reduction of human leukocyte adhesion and NK cytotoxicity. Transplantation 2005; 79: 1067.
46. He Z, Ehrnfelt C, Kumagai-Braesch M, et al. Aberrant expression of alpha-Gal on primary human endothelium does not confer susceptibility to NK cell cytotoxicity or increased NK cell adhesion. Eur J Immunol 2004; 34: 1185.
47. Kolber-Simonds D, Lai L, Watt SR, et al. Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibro-blasts bearing loss of heterozygosity mutations. Proc Natl Acad Sci USA 2004; 101: 7335.
48. Seebach JD, YamadaK,McMorrow I,et al. Xenogeneic human anti-pig cytotoxicity mediated by activated natural killer cells. Xenotransplantation 1996; 3: 188.
49. Baumann BC, Stussi G, Huggel K, et al. Reactivity of human natural antibodies to endothelial cells from Galalpha(1,3)Gal-deficient pigs. Transplantation 2007; 83: 193.
50. Woodfin A, Voisin MB, Nourshargh S. PECAM-1: a multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol 2007; 27: 2514.
51. Ostermann G, Weber KS, Zernecke A, et al. JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol 2002; 3: 151.
52. Bradfield PF, Scheiermann C, Nourshargh S, et al. JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood 2007; 110: 2545.