Activation of natural killer cells and macrophages by porcine endothelial cells augments specific T-cell xenoresponse

American Journal of Transplantation

Volumn 2, Issue 4, 2002, Pages 314-322

  Xu, Xiao Chun ^a   Goodman, Jeremy ^a   Sasaki, Hitomi ^a   Lowell, Jeffrey ^a   Mohanakumar, T ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular immunity; Cytokines; Macrophages; Natural killer cells; Xenotransplantation

Indexed keywords

CD3 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MACROPHAGE ACTIVATION; NATURAL KILLER CELL; NONHUMAN; SWINE; T LYMPHOCYTE ACTIVATION; XENOTRANSPLANTATION;

ANIMALS; ANTIGENS, HETEROPHILE; CELL LINEAGE; ENDOTHELIUM; FLOW CYTOMETRY; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; ISOANTIGENS; KILLER CELLS, NATURAL; MACROPHAGES; SPECIES SPECIFICITY; SWINE; T-LYMPHOCYTES; TIME FACTORS;

EID: 0036556163     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2002.20405.x     Document Type: Article

References (28)

1. Parker W, Saadi S, Lin SS, Holzknecht ZE, Bustos M, Platt JL. Transplantation of discordant xenografts: a challenge revisited, Immunol Today 1996; 17: 373-378.
2. Auchincloss H, Jr, Sachs DH. Xenogeneic transplantation. Ann Rev Immunol 1998; 16: 433-470.
3. Kaufman CL, Gaines BA, Ildstad ST. Xenotransplantation. Annu Rev Immunol 1995; 13: 339-367.
4. Heckl-Ostreicher B, Wosnik A, Kirschfi NKM. Protection of porcine endothelial cells from complement-mediated cytotoxicity by the human complement regulators CD59, C1 inhibitor, and soluble complement receptor type 1. Analysis in a pig-to-human in vitro model relevant to hyperacute xenograft rejection. Transplantation 1996; 62: 1693-1696.
5. McCurry KR, Kooyman DL, Alvarado CG et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat Med 1995; 1: 423-427.
6. Fodor WL, William BL, Matis LA et al. Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection. Proc Natl Acad Sci USA 1994; 91: 11153-11157.
7. Diamond LE, McCurry KR, Martin MJ et al. Characterization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium. Transplantation 1996; 61: 1241-1249.
8. LaVecchio JA, Dunne AD, Edge AS. Enzymatic removal of alpha-galactosyl epitopes from porcine endothelial cells diminishes the cytotoxic effect of natural antibodies. Transplantation 1995; 60: 841-847.
9. Osman N, McKenzie IF, Ostenried K, Ioannou YA, Desnick RJ, Sandrin MS. Combined transgenic expression of alpha-galactosidase and alpha1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galalpha (1,3) Gal. Proc Natl Acad Sci USA 1997; 94: 14677-14682.
10. Itescu S, Kwiatkowski P, Artrip JH et al. Role of natural killer cells, macrophages, and accessory molecule interactions in the rejection of pig-to-primate xenografts beyond the hyperacute period. Hum Immunol 1998; 59: 275-286.
11. Lin Y, Vandeputte M, Waer M. Natural killer cell- and macrophage-mediated rejection of concordant xenografts in the absence of T and B cell responses. J Immunol 1997; 158: 5658-5667.
12. Bach FH, Winkler H, Ferran C, Hancock WW, Robson SC. Delayed xenograft rejection. Immunol Today 1996; 17: 379-384.
13. Sullivan JA, Oettinger HF, Sachs DH, Edge AS. Analysis of polymorphism in porcine MHC class I genes. J Immunol 1997; 159: 2318-2326.
14. Smith DM, Asbury J, Swearingen W, Hildebrand W. The structure of swine class I major histocompatibility antigens (SLA). 15th ASTP Meeting Abstracts 1996: 142.
15. Sasaki H, Xu XC, Mohanakumar T. HLA-E and HLA-G expression on porcine endothelial cells inhibit xenoreactive human NK cells through CD94/NKG2-dependent and -independent pathways. J Immunol 1999; 163: 6301-6305.
16. Orange JS, Biron CA. An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections. J Immunol 1996; 156: 1138-1142.
17. Scharton-Kersten T, Afonso LC, Wysocka M, Trinchieri G, Scott P. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental Leishmaniasis. J Immunol 1995; 154: 5320-5330.
18. Bohn E, Autenrieth IB. IL-12 is essential for resistance against Yersinia enterocolitica by triggering IFN-gamma production in NK cells and CD4+ T cells. J Immunol 1996; 156: 1458-1468.
19. Shishido S, Naziruddin B, Howard T, Mohanakumar T. Recognition of porcine MHC class I antigens by human CD8+ cytotoxic T cell clones. Transplantation 1996; 64: 340-346.
20. Carmichael A, Jin X, Sissons P, Borysiewicz L. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J Exp Med 1993; 177: 249-256.
21. Groski J, Yassai M, Zhu X, Kissella B, Keever C, Flomenberg N. Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectrotyping correlation with immune status. J Immunol 1994; 152: 5109-5119.
22. Xu XC, Naziruddin B, Sasaki H, Smith DM, Mohanakumar T. Allele-specific and peptide-dependent recognition of swine leukocyte antigen class I by human cytotoxic T-cell clones. Transplantation 1999; 68: 473-479.
23. Shishido S, Naziruddin B, Xu XC, Howard T, Mohanakumar T. Indirect recognition of porcine xenoantigens by human CD4+ T cell clones. Transplantation 1998; 65: 706-712.
24. Yamada K, Sachs DH, DerSimonian H. Human anti-porcine xenogeneic T cell response: evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J Immunol 1995; 155: 5249-5256.
25. Batten P, Yacoub MH, Rose ML. Effect of human cytokines (IFN-gamma, TNF-alpha, IL-1 beta, IL-4) on porcine endothelial cells: induction of MHC and adhesion molecules and functional significance of these changes. Immunology 1996; 87: 127-133.
26. Sultan P, Murray AG, McNiff JM et al. Pig but not human interferon-gamma initiates human cell-mediated rejection of pig tissue in vivo. PNAS 1997; 94: 8767-8772.
27. Maki T, Yasunami Y, Ikehara Y et al. Prolongation of rat islet xenograft survival in the liver of IFN-gamma-deficient mice. J Surg Res 2000; 93: 101-107.
28. Sandberg JO, Benda B, Lycke N, Korsgren O. Xenograft rejection of porcine islet-like cell clusters in normal, interferon-gamma, and interferon-gamma receptor deficient mice. Transplantation 1997; 63: 1446-1452.