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Volumn 13, Issue 2, 2000, Pages 77-85

Adenosine as a potential analgesic target in inflammatory and neuropathic pains

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE DERIVATIVE; HISTAMINE; SEROTONIN;

EID: 0034006941     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200013020-00001     Document Type: Article
Times cited : (58)

References (107)
  • 1
    • 0025773885 scopus 로고
    • Mechanisms of the analgesic actions of opiates and opioids
    • Dickenson AH. Mechanisms of the analgesic actions of opiates and opioids. Br Med Bull 1991; 47: 690-702
    • (1991) Br Med Bull , vol.47 , pp. 690-702
    • Dickenson, A.H.1
  • 3
    • 0002102540 scopus 로고
    • The spinal actions of opioids
    • Herz A, editor. Heidelberg: Springer-Verlag
    • Yaksh TL. The spinal actions of opioids. In: Herz A, editor. Handbook of experimental pharmacology. Opioids. Vol. 104/11. Heidelberg: Springer-Verlag, 1993; 53-90
    • (1993) Handbook of Experimental Pharmacology. Opioids , vol.104 , Issue.11 , pp. 53-90
    • Yaksh, T.L.1
  • 4
    • 0017713888 scopus 로고
    • Studies on the direct spinal action of narcotics in the production of analgesia in the rat
    • Yaksh TL, Rudy TA. Studies on the direct spinal action of narcotics in the production of analgesia in the rat. J Pharmacol Exp Ther 1977; 202: 411-28
    • (1977) J Pharmacol Exp Ther , vol.202 , pp. 411-428
    • Yaksh, T.L.1    Rudy, T.A.2
  • 5
    • 0028183014 scopus 로고
    • Nomenclature and classification of purinoreceptors
    • Fredholm BB, Abbracchio MP, Burnstock G, et al. Nomenclature and classification of purinoreceptors. Pharmacol Rev 1994; 46 (2): 143-56
    • (1994) Pharmacol Rev , vol.46 , Issue.2 , pp. 143-156
    • Fredholm, B.B.1    Abbracchio, M.P.2    Burnstock, G.3
  • 6
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyramidines
    • Ralevic V, Burnstock G. Receptors for purines and pyramidines. Pharmacol Rev 1998; 50: 413-92
    • (1998) Pharmacol Rev , vol.50 , pp. 413-492
    • Ralevic, V.1    Burnstock, G.2
  • 7
    • 0024116373 scopus 로고
    • 2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: An autoradiography study
    • 2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study. J Pharmacol Exp Ther 1988; 247: 757-64
    • (1988) J Pharmacol Exp Ther , vol.247 , pp. 757-764
    • Choca, J.I.1    Green, R.D.2    Proudfit, H.K.3
  • 8
    • 0023405220 scopus 로고
    • 1 receptors in the human brain: A quantitative autoradiographic study
    • 1 receptors in the human brain: a quantitative autoradiographic study. Neuroscience 1987; 22: 827-39
    • (1987) Neuroscience , vol.22 , pp. 827-839
    • Fastbom, J.1    Pazos, A.2    Probst, A.3
  • 9
    • 0020580775 scopus 로고
    • Adenosine receptors: Autoradiographic evidence for their location on axon terminals of excitatory neurones
    • Goodman RR, Kuhar MJ, Hester L, et al. Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurones. Science 1983; 220: 967-9
    • (1983) Science , vol.220 , pp. 967-969
    • Goodman, R.R.1    Kuhar, M.J.2    Hester, L.3
  • 10
    • 0020355715 scopus 로고
    • Autoradiographic localization of adenosine receptors in rat brain using [3H]cyclohexyladenosine
    • Goodman RR, Snyder SH. Autoradiographic localization of adenosine receptors in rat brain using [3H]cyclohexyladenosine. J Neurosci 1982; 2: 1230-41
    • (1982) J Neurosci , vol.2 , pp. 1230-1241
    • Goodman, R.R.1    Snyder, S.H.2
  • 11
    • 0021148155 scopus 로고
    • Characterization and localization of adenosine receptors in rat spinal cord
    • Geiger JD, LaBella FS, Nagy JI. Characterization and localization of adenosine receptors in rat spinal cord. J Neurosci 1984; 4: 2303-10
    • (1984) J Neurosci , vol.4 , pp. 2303-2310
    • Geiger, J.D.1    LaBella, F.S.2    Nagy, J.I.3
  • 12
    • 0028169223 scopus 로고
    • Cloned adenosine A3 receptors: Pharmacological properties, species differences and receptor functions
    • Linden J. Cloned adenosine A3 receptors: pharmacological properties, species differences and receptor functions. Trends Pharmacol Sci 1994; 15: 298-306
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 298-306
    • Linden, J.1
  • 13
    • 0023200840 scopus 로고
    • Functional receptors for neurotransmitters on astroglial cells
    • Murphy S, Pearce B. Functional receptors for neurotransmitters on astroglial cells. Neuroscience 1987; 22: 381-94
    • (1987) Neuroscience , vol.22 , pp. 381-394
    • Murphy, S.1    Pearce, B.2
  • 14
    • 0027241693 scopus 로고
    • Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine
    • Sweeney MI, White TD, Sawynok J. Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine. Brain Res 1993; 614: 301-7
    • (1993) Brain Res , vol.614 , pp. 301-307
    • Sweeney, M.I.1    White, T.D.2    Sawynok, J.3
  • 15
    • 0022446728 scopus 로고
    • Adenosine-containing neurones in the brain localized by immunocytochemistry
    • Braas KM, Newby AC, Wilson VS, et al. Adenosine-containing neurones in the brain localized by immunocytochemistry. J Neurosci 1986; 6: 1952-61
    • (1986) J Neurosci , vol.6 , pp. 1952-1961
    • Braas, K.M.1    Newby, A.C.2    Wilson, V.S.3
  • 16
    • 0024462440 scopus 로고
    • NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices
    • Garthwaite J, Garthwaite G, Palmer RMJ, et al. NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur J Pharmacol 1989; 172: 413-6
    • (1989) Eur J Pharmacol , vol.172 , pp. 413-416
    • Garthwaite, J.1    Garthwaite, G.2    Palmer, R.M.J.3
  • 17
    • 0027340213 scopus 로고
    • 1 receptors mediate the presynaptic inhibition of calcitonin gene related peptide release by adenosine in the rat spinal cord
    • 1 receptors mediate the presynaptic inhibition of calcitonin gene related peptide release by adenosine in the rat spinal cord. Eur J Pharm 1993; 231: 139-42
    • (1993) Eur J Pharm , vol.231 , pp. 139-142
    • Santicioli, P.1    Del Bianco, E.2    Maggi, C.A.3
  • 18
    • 0022451761 scopus 로고
    • Distribution of adenosine deaminase activity in rat brain and spinal cord
    • Geiger JD, Nagy JI. Distribution of adenosine deaminase activity in rat brain and spinal cord. J Neurosci 1986; 6: 2707-14
    • (1986) J Neurosci , vol.6 , pp. 2707-2714
    • Geiger, J.D.1    Nagy, J.I.2
  • 19
    • 0022364806 scopus 로고
    • Anatomical and cytochemical relationships of adenosine deaminase-containing primary afferent neurons in the rat
    • Nagy JI, Daddona PE. Anatomical and cytochemical relationships of adenosine deaminase-containing primary afferent neurons in the rat. Neurosci Int 1985, 15: 799-813
    • (1985) Neurosci Int , vol.15 , pp. 799-813
    • Nagy, J.I.1    Daddona, P.E.2
  • 20
    • 0021242709 scopus 로고
    • Immunohistochemical localization of adenosine deaminase in primary afferent neurons of the rat
    • Nagy JI, Buss M, LaBella LA, et al. Immunohistochemical localization of adenosine deaminase in primary afferent neurons of the rat. Neurosci Lett 1984; 48: 133-8
    • (1984) Neurosci Lett , vol.48 , pp. 133-138
    • Nagy, J.I.1    Buss, M.2    LaBella, L.A.3
  • 21
    • 0021743592 scopus 로고
    • Heterogeneous distribution of adenosine transport sites labelled by [3H]nitrobenzylthioinosine in rat brain: An autoradiographic and membrane binding study
    • Geiger JD, Nagy JI. Heterogeneous distribution of adenosine transport sites labelled by [3H]nitrobenzylthioinosine in rat brain: an autoradiographic and membrane binding study. Brain Res Bull 1984; 13: 657-66
    • (1984) Brain Res Bull , vol.13 , pp. 657-666
    • Geiger, J.D.1    Nagy, J.I.2
  • 22
    • 0022271889 scopus 로고
    • Localization of [3H]nitrobenzylthioinosine binding sites in rat spinal cord and primary afferent neurones
    • Geiger JD, Nagy JI. Localization of [3H]nitrobenzylthioinosine binding sites in rat spinal cord and primary afferent neurones. Brain Res 1985; 347: 321-7
    • (1985) Brain Res , vol.347 , pp. 321-327
    • Geiger, J.D.1    Nagy, J.I.2
  • 23
    • 0024330761 scopus 로고
    • The role of purines in nociception
    • Sawynok J, Sweeney MI. The role of purines in nociception. Neuroscience 1989; 32: 557-69
    • (1989) Neuroscience , vol.32 , pp. 557-569
    • Sawynok, J.1    Sweeney, M.I.2
  • 24
    • 0021892992 scopus 로고
    • Effects of (-)-N6-(R-phenylisopropyl)-adenosine (PIA) and caffeine on nociception and morphine-induced analgesia, tolerance and dependence in mice
    • Ahlijanian MK, Takemori AE. Effects of (-)-N6-(R-phenylisopropyl)-adenosine (PIA) and caffeine on nociception and morphine-induced analgesia, tolerance and dependence in mice. Eur J Pharmacol 1985; 112: 171-9
    • (1985) Eur J Pharmacol , vol.112 , pp. 171-179
    • Ahlijanian, M.K.1    Takemori, A.E.2
  • 25
    • 0020509319 scopus 로고
    • Antinociceptive effects in the rat of an adenosine analogue, N6-phenylisopropyladenosine
    • Holmgren M, Hedner J, Nordberg G, et al. Antinociceptive effects in the rat of an adenosine analogue, N6-phenylisopropyladenosine. J Pharm Pharmacol 1983; 35: 679-80
    • (1983) J Pharm Pharmacol , vol.35 , pp. 679-680
    • Holmgren, M.1    Hedner, J.2    Nordberg, G.3
  • 26
    • 0022868907 scopus 로고
    • Characterization of the antinociceptive effects of some adenosine analogues in the rat
    • Holmgren M, Hedner J, Mellstrand T, et al. Characterization of the antinociceptive effects of some adenosine analogues in the rat. Naunyn Schmiedebergs Arch Pharmakol 1986; 334: 290-3
    • (1986) Naunyn Schmiedebergs Arch Pharmakol , vol.334 , pp. 290-293
    • Holmgren, M.1    Hedner, J.2    Mellstrand, T.3
  • 27
    • 0016615914 scopus 로고
    • Stereospecificity in some central and circulatory effects of phenylisopropyl-adenosine (PIA)
    • Vapaatalo H, Onken D, Neuvonen PJ, et al. Stereospecificity in some central and circulatory effects of phenylisopropyl-adenosine (PIA). Arzneimittl-Forsch 1975; 25: 407-10
    • (1975) Arzneimittl-Forsch , vol.25 , pp. 407-410
    • Vapaatalo, H.1    Onken, D.2    Neuvonen, P.J.3
  • 28
    • 0024563436 scopus 로고
    • Evaluation of adenosine agonists as potential analgesics
    • Herrick-Davis K, Chippari S, Luttinger D, et al. Evaluation of adenosine agonists as potential analgesics. Eur J Pharmacol 1989; 162: 365-9
    • (1989) Eur J Pharmacol , vol.162 , pp. 365-369
    • Herrick-Davis, K.1    Chippari, S.2    Luttinger, D.3
  • 29
    • 0022908184 scopus 로고
    • Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine
    • DeLander GE, Hopkins CJ. Spinal adenosine modulates descending antinociceptive pathways stimulated by morphine. J Pharm Exp Ther 1986; 239: 88-93
    • (1986) J Pharm Exp Ther , vol.239 , pp. 88-93
    • DeLander, G.E.1    Hopkins, C.J.2
  • 30
    • 0023193999 scopus 로고
    • Spinal antinociceptive effects of adenosine compounds in mice
    • Doi T, Kuzuna S, Maki Y. Spinal antinociceptive effects of adenosine compounds in mice. Eur J Pharmacol 1987; 137: 227-31
    • (1987) Eur J Pharmacol , vol.137 , pp. 227-231
    • Doi, T.1    Kuzuna, S.2    Maki, Y.3
  • 31
    • 0025012275 scopus 로고
    • Effects of intrathecal injection of the adenosine receptor agonists R-phenylisopropyl-adenosine and N-ethylcarboxamide-adenosine on nociception and motor function in the rat
    • Karlsten R, Gordh Jr T, Hartvig P, et al. Effects of intrathecal injection of the adenosine receptor agonists R-phenylisopropyl-adenosine and N-ethylcarboxamide-adenosine on nociception and motor function in the rat. Anesth Analg 1990; 71: 60-4
    • (1990) Anesth Analg , vol.71 , pp. 60-64
    • Karlsten, R.1    Gordh T., Jr.2    Hartvig, P.3
  • 32
    • 0027177760 scopus 로고
    • Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and isobolographic analysis of the NSAID interaction
    • Malmberg AB, Yaksh TL. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and isobolographic analysis of the NSAID interaction. Anesthesiology 1993; 79: 270-81
    • (1993) Anesthesiology , vol.79 , pp. 270-281
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 33
    • 0021691378 scopus 로고
    • Antinociceptive effects in mice after intrathecal injection of 5′-N-Ethylcarboxamide adenosine
    • Post C. Antinociceptive effects in mice after intrathecal injection of 5′-N-Ethylcarboxamide adenosine. Neurosci Lett 1984; 51: 325-30
    • (1984) Neurosci Lett , vol.51 , pp. 325-330
    • Post, C.1
  • 34
    • 0022486503 scopus 로고
    • Classification of adenosine receptors mediating antinociception in the rat spinal cord
    • Sawynok J, Sweeney MI, White TD. Classification of adenosine receptors mediating antinociception in the rat spinal cord. Br J Pharmacol 1986; 88: 923-30
    • (1986) Br J Pharmacol , vol.88 , pp. 923-930
    • Sawynok, J.1    Sweeney, M.I.2    White, T.D.3
  • 35
    • 0024850743 scopus 로고
    • Role of spinal adenosine receptors in modulating the hyperesthesia produced by spinal glycine receptor antagonism
    • Sosnowski M, Yaksh TL. Role of spinal adenosine receptors in modulating the hyperesthesia produced by spinal glycine receptor antagonism. Anesth Analg 1989; 69: 587-92
    • (1989) Anesth Analg , vol.69 , pp. 587-592
    • Sosnowski, M.1    Yaksh, T.L.2
  • 36
    • 0019775336 scopus 로고
    • In vivo behavioral assessment of central nervous system purinergic receptors
    • Yarbrough GY, McGuffin-Clineschmidt JC. In vivo behavioral assessment of central nervous system purinergic receptors. Eur J Pharmacol 1981; 76: 137-44
    • (1981) Eur J Pharmacol , vol.76 , pp. 137-144
    • Yarbrough, G.Y.1    McGuffin-Clineschmidt, J.C.2
  • 37
    • 0029070186 scopus 로고
    • Electrophysiological study on spinal antinociceptive interactions between adenosine and morphine in the dorsal horn of the rat
    • Reeve AJ, Dickenson AH. Electrophysiological study on spinal antinociceptive interactions between adenosine and morphine in the dorsal horn of the rat. Neurosci Lett 1995; 194: 81-4
    • (1995) Neurosci Lett , vol.194 , pp. 81-84
    • Reeve, A.J.1    Dickenson, A.H.2
  • 38
    • 0028883696 scopus 로고
    • The roles of spinal adenosine receptors in the control of acute and more persistent nociceptive responses of dorsal horn neurones in the anaesthetized rat
    • Reeve AJ, Dickenson AH. The roles of spinal adenosine receptors in the control of acute and more persistent nociceptive responses of dorsal horn neurones in the anaesthetized rat. Br J Pharmacol 1995; 116: 2221-8
    • (1995) Br J Pharmacol , vol.116 , pp. 2221-2228
    • Reeve, A.J.1    Dickenson, A.H.2
  • 39
    • 0031941211 scopus 로고    scopus 로고
    • 1-receptor agonist, morphine, and an NMDA-receptor antagonist
    • 1-receptor agonist, morphine, and an NMDA-receptor antagonist, J Neurophys 1998; 79: 1494-507
    • (1998) J Neurophys , vol.79 , pp. 1494-1507
    • Reeve, A.J.1    Dickenson, A.H.2    Kerr, N.C.3
  • 40
    • 0013970150 scopus 로고
    • Physiological properties of unmyelinated fiber projection to the spinal cord
    • Mendell LM. Physiological properties of unmyelinated fiber projection to the spinal cord. Exp Neurol 1966; 16: 316-32
    • (1966) Exp Neurol , vol.16 , pp. 316-332
    • Mendell, L.M.1
  • 41
    • 0023605956 scopus 로고
    • Evidence for involvement of N-methyl-D-aspartate receptors in wind-up of class 2 neurones in the dorsal horn of the rat
    • Davies SN, Lodge D. Evidence for involvement of N-methyl-D-aspartate receptors in wind-up of class 2 neurones in the dorsal horn of the rat. Brain Res 1987; 424: 402-6
    • (1987) Brain Res , vol.424 , pp. 402-406
    • Davies, S.N.1    Lodge, D.2
  • 42
    • 0023189510 scopus 로고
    • Evidence, for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C-fibre stimulation
    • Dickenson AH, Sullivan AF. Evidence, for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C-fibre stimulation. Neuropharmacol 1987; 26: 1235-8
    • (1987) Neuropharmacol , vol.26 , pp. 1235-1238
    • Dickenson, A.H.1    Sullivan, A.F.2
  • 43
    • 0029996021 scopus 로고    scopus 로고
    • Potentiation of excitatory amino-acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine
    • White TD. Potentiation of excitatory amino-acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine. Eur J Pharmacol 1996; 303: 27-38
    • (1996) Eur J Pharmacol , vol.303 , pp. 27-38
    • White, T.D.1
  • 44
    • 0031837374 scopus 로고    scopus 로고
    • Intraspinal injection of adenosine agonists protect against L-NAME induced neuronal loss in the rat
    • Dora CD, Koch S, Sanchez A, et al. Intraspinal injection of adenosine agonists protect against L-NAME induced neuronal loss in the rat. J Neurotrauma 1998; 15: 473-83
    • (1998) J Neurotrauma , vol.15 , pp. 473-483
    • Dora, C.D.1    Koch, S.2    Sanchez, A.3
  • 45
    • 0030593746 scopus 로고    scopus 로고
    • Altered sensory behaviors in mice following manipulation of endogenous spinal adenosine neurotransmission
    • Keil GJH, DeLander GE. Altered sensory behaviors in mice following manipulation of endogenous spinal adenosine neurotransmission. Eur J Pharmacol 1996; 312: 7-14
    • (1996) Eur J Pharmacol , vol.312 , pp. 7-14
    • Keil, G.J.H.1    DeLander, G.E.2
  • 46
    • 0027979341 scopus 로고
    • Response of chronic neuropathic pain syndromes to ketamine: A preliminary study
    • Backonja M, Arndt G, Gombar KA, et al. Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. Pain 1994; 56: 51-7
    • (1994) Pain , vol.56 , pp. 51-57
    • Backonja, M.1    Arndt, G.2    Gombar, K.A.3
  • 47
    • 0028068262 scopus 로고
    • Enhanced responses of rat dorsal horn neurones after UV irradiation of the hindpaw; roles of the NMDA receptor
    • Chapman V, Dickenson AH. Enhanced responses of rat dorsal horn neurones after UV irradiation of the hindpaw; roles of the NMDA receptor. Neurosci Lett 1994; 176: 41-4
    • (1994) Neurosci Lett , vol.176 , pp. 41-44
    • Chapman, V.1    Dickenson, A.H.2
  • 49
    • 0028038355 scopus 로고
    • Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo
    • Eide PK, Jorum E, Stubhaug A, et al. Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo. Pain 1994; 58: 347-54
    • (1994) Pain , vol.58 , pp. 347-354
    • Eide, P.K.1    Jorum, E.2    Stubhaug, A.3
  • 50
    • 0028998508 scopus 로고
    • Noxious stimuli induce an N-methyl-D-aspartate receptor-dependent hypersensitivity of the flexion withdrawal reflex to touch: Implications for the treatment of mechanical allodynia
    • Ma Q-P, Woolf CJ. Noxious stimuli induce an N-methyl-D-aspartate receptor-dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia. Pain 1995; 61: 383-90
    • (1995) Pain , vol.61 , pp. 383-390
    • Ma, Q.-P.1    Woolf, C.J.2
  • 51
    • 0028857603 scopus 로고
    • Beneficial effects of ketamine in a chronic pain state with allodynia, possibly due to central sensitization
    • Persson J, Axelsson G, Hallin RG, et al. Beneficial effects of ketamine in a chronic pain state with allodynia, possibly due to central sensitization. Pain 1995; 60: 217-22
    • (1995) Pain , vol.60 , pp. 217-222
    • Persson, J.1    Axelsson, G.2    Hallin, R.G.3
  • 52
    • 0027979339 scopus 로고
    • Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat
    • Sherman SE, Loomis CW. Morphine insensitive allodynia is produced by intrathecal strychnine in the lightly anesthetized rat. Pain 1994; 56: 17-29
    • (1994) Pain , vol.56 , pp. 17-29
    • Sherman, S.E.1    Loomis, C.W.2
  • 53
    • 0024602581 scopus 로고
    • Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: Effects of modulatory receptor systems and excitatory amino acid antagonists
    • Yaksh TL. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 1989; 37: 111-23
    • (1989) Pain , vol.37 , pp. 111-123
    • Yaksh, T.L.1
  • 54
    • 0027272042 scopus 로고
    • Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain
    • Desmeules JA, Kayser V, Guilbaud G. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain. Pain 1993; 53: 277-85
    • (1993) Pain , vol.53 , pp. 277-285
    • Desmeules, J.A.1    Kayser, V.2    Guilbaud, G.3
  • 55
    • 0026638717 scopus 로고
    • Morphine responsiveness of chronic pain: Double-blind randomized crossover study with patient-controlled analgesia
    • Jadad AR, Carroll D, Glynn CJ, et al. Morphine responsiveness of chronic pain: double-blind randomized crossover study with patient-controlled analgesia. Lancet 1992; 339: 1367-71
    • (1992) Lancet , vol.339 , pp. 1367-1371
    • Jadad, A.R.1    Carroll, D.2    Glynn, C.J.3
  • 56
    • 0030632098 scopus 로고    scopus 로고
    • Adenosine for pain control
    • Sollevi A. Adenosine for pain control. Acta Anaesthesiol Scand 1997; Suppl. 110: 135-6
    • (1997) Acta Anaesthesiol Scand , Issue.SUPPL. 110 , pp. 135-136
    • Sollevi, A.1
  • 57
    • 0028023537 scopus 로고
    • The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers
    • Segerdahl M, Ekblom A, Sollevi A. The influence of adenosine, ketamine, and morphine on experimentally induced ischemic pain in healthy volunteers. Anesth Analg 1994; 79: 787-91
    • (1994) Anesth Analg , vol.79 , pp. 787-791
    • Segerdahl, M.1    Ekblom, A.2    Sollevi, A.3
  • 58
    • 0028953261 scopus 로고
    • Systemic adenosine attenuates touch evoked allodynia induced by mustard oil in humans
    • Segerdahl M, Ekblom A, Sjolund K-F, et al. Systemic adenosine attenuates touch evoked allodynia induced by mustard oil in humans. Neuroreport 1995; 6: 753-6
    • (1995) Neuroreport , vol.6 , pp. 753-756
    • Segerdahl, M.1    Ekblom, A.2    Sjolund, K.-F.3
  • 59
    • 0029068638 scopus 로고
    • Adenosine increases the cutaneous heat pain threshold in healthy volunteers
    • Ekblom A, Segerdahl M, Sollevi A. Adenosine increases the cutaneous heat pain threshold in healthy volunteers. Acta Anaesthesiol Scand 1995; 39: 717-22
    • (1995) Acta Anaesthesiol Scand , vol.39 , pp. 717-722
    • Ekblom, A.1    Segerdahl, M.2    Sollevi, A.3
  • 60
    • 0031795426 scopus 로고    scopus 로고
    • Intrathecal adenosine administration: A phase I clinical safety study in healthy volunteers, with additional evaluation of its influence on sensory thresholds and experimental pain
    • Rane K, Segerdahl M, Goiny M, et al. Intrathecal adenosine administration: a phase I clinical safety study in healthy volunteers, with additional evaluation of its influence on sensory thresholds and experimental pain. Anesthesiology 1998; 89: 1108-15
    • (1998) Anesthesiology , vol.89 , pp. 1108-1115
    • Rane, K.1    Segerdahl, M.2    Goiny, M.3
  • 61
    • 0030827378 scopus 로고    scopus 로고
    • A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional syndrome
    • Kingery WS. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional syndrome. Pain 1997; 73: 123-39
    • (1997) Pain , vol.73 , pp. 123-139
    • Kingery, W.S.1
  • 62
    • 0030457368 scopus 로고    scopus 로고
    • Adenosine and neuropathic pain
    • Guieu R, Peragut JC, Roussel P, et al. Adenosine and neuropathic pain. Pain 1996; 68: 271-4
    • (1996) Pain , vol.68 , pp. 271-274
    • Guieu, R.1    Peragut, J.C.2    Roussel, P.3
  • 63
    • 0024992879 scopus 로고
    • Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: Effects of chronic constriction injury, transection, and strychnine
    • Sugimoto T, Bennett GJ, Kajander KC. Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: effects of chronic constriction injury, transection, and strychnine. Pain 1990; 42: 205-13
    • (1990) Pain , vol.42 , pp. 205-213
    • Sugimoto, T.1    Bennett, G.J.2    Kajander, K.C.3
  • 64
    • 0344352468 scopus 로고    scopus 로고
    • 1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain
    • 1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain. Neurosci Lett 1998; 243: 89-92
    • (1998) Neurosci Lett , vol.243 , pp. 89-92
    • Sjolund, K.F.1    Von Heijne, M.2    Hao, J.X.3
  • 65
    • 0000707976 scopus 로고    scopus 로고
    • Adenosine receptor activation suppresses tactile hypersensitivity and potentiates spinal cord stimulation in mononeuropathic rats
    • Cui J-G, Sollevi A, Linderoth B, et al. Adenosine receptor activation suppresses tactile hypersensitivity and potentiates spinal cord stimulation in mononeuropathic rats. Neurosci Lett 1997; 223: 173-6
    • (1997) Neurosci Lett , vol.223 , pp. 173-176
    • Cui, J.-G.1    Sollevi, A.2    Linderoth, B.3
  • 66
    • 0030440984 scopus 로고    scopus 로고
    • Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists
    • Lee Y-W, Yaksh TL. Pharmacology of the spinal adenosine receptor which mediates the antiallodynic action of intrathecal adenosine agonists. J Pharmacol Exp Ther 1996; 277: 1642-8
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1642-1648
    • Lee, Y.-W.1    Yaksh, T.L.2
  • 67
    • 0029912602 scopus 로고    scopus 로고
    • Intrathecal and systemic R-phenylisopropyl-adenosine reduces scratching behaviour in a rat mononeuropathy model
    • Sjolund KF, Sollevi A, Segerdahl M, et al. Intrathecal and systemic R-phenylisopropyl-adenosine reduces scratching behaviour in a rat mononeuropathy model. Neuroreport 1996; 7: 1856-60
    • (1996) Neuroreport , vol.7 , pp. 1856-1860
    • Sjolund, K.F.1    Sollevi, A.2    Segerdahl, M.3
  • 68
    • 0026727999 scopus 로고
    • An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
    • Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992; 50: 355-63
    • (1992) Pain , vol.50 , pp. 355-363
    • Kim, S.H.1    Chung, J.M.2
  • 69
    • 0032995813 scopus 로고    scopus 로고
    • Exogenous and endogenous adenosine enhance the spinal antiallodynic effects of morphine in a rat model of neuropathic pain
    • Lavand'homme PM, Eisenach JC. Exogenous and endogenous adenosine enhance the spinal antiallodynic effects of morphine in a rat model of neuropathic pain. Pain 1999; 80: 31-6
    • (1999) Pain , vol.80 , pp. 31-36
    • Lavand'homme, P.M.1    Eisenach, J.C.2
  • 70
    • 0029125351 scopus 로고
    • Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain
    • Belfrage M, Sollevi A, Segerdahl M, et al. Systemic adenosine infusion alleviates spontaneous and stimulus evoked pain in patients with peripheral neuropathic pain. Anesth Analg 1995; 81: 713-7
    • (1995) Anesth Analg , vol.81 , pp. 713-717
    • Belfrage, M.1    Sollevi, A.2    Segerdahl, M.3
  • 71
    • 0028903356 scopus 로고
    • Systemic adenosine infusion: A new treatment modality to alleviate neuropathic pain
    • Sollevi A, Belfrage, Lundeberg T, et al. Systemic adenosine infusion: a new treatment modality to alleviate neuropathic pain. Pain 1995; 61: 155-8
    • (1995) Pain , vol.61 , pp. 155-158
    • Sollevi, A.1    Belfrage2    Lundeberg, T.3
  • 72
    • 0028987038 scopus 로고
    • 1-selective adenosine agonist abolishes allodynia elicited by vibration and touch after intrathecal injection
    • 1-selective adenosine agonist abolishes allodynia elicited by vibration and touch after intrathecal injection. Anesth Analg 1995; 80: 844-7
    • (1995) Anesth Analg , vol.80 , pp. 844-847
    • Karlsten, R.1    Gordh T., Jr.2
  • 73
    • 0013655713 scopus 로고    scopus 로고
    • Intrathecal adenosine injection elevates cutaneous pain thresholds in man
    • Seattle (WA): IASP Press
    • Sollevi A, Rane K, Segerdahl M, et al. Intrathecal adenosine injection elevates cutaneous pain thresholds in man [abstract]. In: 8th World Congress on Pain: 1996 Aug 18-22: Vancouver. Seattle (WA): IASP Press, 1996: 356
    • (1996) 8th World Congress on Pain: 1996 Aug 18-22: Vancouver , pp. 356
    • Sollevi, A.1    Rane, K.2    Segerdahl, M.3
  • 74
    • 0021814366 scopus 로고
    • Pertussis toxin reverses adenosine inhibition of neuronal glutamate release
    • Dolphin AC, Prestwich SA. Pertussis toxin reverses adenosine inhibition of neuronal glutamate release. Nature 1985; 316: 148-50
    • (1985) Nature , vol.316 , pp. 148-150
    • Dolphin, A.C.1    Prestwich, S.A.2
  • 75
    • 0026754071 scopus 로고
    • Low-level N-methyl-D-aspartate receptor activation provides a purinergic inhibitory threshold against further N-methyl-D-aspartate-mediated neurotransmission in the cortex
    • Craig CG, White TD. Low-level N-methyl-D-aspartate receptor activation provides a purinergic inhibitory threshold against further N-methyl-D-aspartate-mediated neurotransmission in the cortex. J Pharm Exp Ther 1992; 260: 1278-84
    • (1992) J Pharm Exp Ther , vol.260 , pp. 1278-1284
    • Craig, C.G.1    White, T.D.2
  • 76
    • 0027530982 scopus 로고
    • N-methyl-D-aspartate and non-N-methyl-D-aspartate-evoked adenosine release from rat cortical slices: Distinct purinergic sources and mechanisms of release
    • Craig CG, White TD. N-methyl-D-aspartate and non-N-methyl-D-aspartate-evoked adenosine release from rat cortical slices: distinct purinergic sources and mechanisms of release. J Neurochem 1993; 60: 1073-80
    • (1993) J Neurochem , vol.60 , pp. 1073-1080
    • Craig, C.G.1    White, T.D.2
  • 77
    • 0001019029 scopus 로고    scopus 로고
    • Intrathecal NMDA-induced release of spinal adenosine and amino acids
    • Conway CM, Marsala M, Somogyi GT, et al. Intrathecal NMDA-induced release of spinal adenosine and amino acids. Soc Neurosci Abstr 1997; 23: 1013
    • (1997) Soc Neurosci Abstr , vol.23 , pp. 1013
    • Conway, C.M.1    Marsala, M.2    Somogyi, G.T.3
  • 78
    • 0026583723 scopus 로고
    • Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy
    • Mao J, Price DD, Mayer DJ, et al. Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy. Brain Res 1992; 576: 254-62
    • (1992) Brain Res , vol.576 , pp. 254-262
    • Mao, J.1    Price, D.D.2    Mayer, D.J.3
  • 79
    • 0029937786 scopus 로고    scopus 로고
    • Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy
    • Qian J, Brown SD, Carlton SM. Systemic ketamine attenuates nociceptive behaviors in a rat model of peripheral neuropathy. Brain Res 1996; 715: 51-62
    • (1996) Brain Res , vol.715 , pp. 51-62
    • Qian, J.1    Brown, S.D.2    Carlton, S.M.3
  • 80
    • 0031892874 scopus 로고    scopus 로고
    • Spinal R-phenyl-isopropyl adenosine inhibits spinal dorsal horn neurons responding to noxious heat stimulation in the absence and presence of sensitization
    • Sumida T, Smith MA, Machara Y, et al. Spinal R-phenyl-isopropyl adenosine inhibits spinal dorsal horn neurons responding to noxious heat stimulation in the absence and presence of sensitization. Pain 1998; 74: 307-13
    • (1998) Pain , vol.74 , pp. 307-313
    • Sumida, T.1    Smith, M.A.2    Machara, Y.3
  • 82
    • 0031593803 scopus 로고    scopus 로고
    • 1 receptor-mediated excitation of nociceptive afferents innervating the normal and arthritic knee joint
    • 1 receptor-mediated excitation of nociceptive afferents innervating the normal and arthritic knee joint. Br J Pharm 1998; 125: 1267-71
    • (1998) Br J Pharm , vol.125 , pp. 1267-1271
    • Dowd, E.1    McQueen, D.S.2    Chessell, I.P.3
  • 83
    • 0030610258 scopus 로고    scopus 로고
    • Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine
    • Sawynok J, Zarrindast MR, Reid AR, et al. Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine. Eur J Pharmacol 1997; 333: 1-7
    • (1997) Eur J Pharmacol , vol.333 , pp. 1-7
    • Sawynok, J.1    Zarrindast, M.R.2    Reid, A.R.3
  • 84
    • 0032540196 scopus 로고    scopus 로고
    • Adenosine receptor activation and nociception
    • Sawynok J. Adenosine receptor activation and nociception. Eur J Pharmacol 1998; 347: 1-11
    • (1998) Eur J Pharmacol , vol.347 , pp. 1-11
    • Sawynok, J.1
  • 85
    • 0020043446 scopus 로고
    • Morphine analgesia in the tail-flick and formalin pain tests is mediated by different neural systems
    • Abbott FV, Melzack R, Samuel C. Morphine analgesia in the tail-flick and formalin pain tests is mediated by different neural systems. Exp Neurol 1982; 75: 644-51
    • (1982) Exp Neurol , vol.75 , pp. 644-651
    • Abbott, F.V.1    Melzack, R.2    Samuel, C.3
  • 86
    • 0017643233 scopus 로고
    • The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
    • Dubuisson D, Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 1977; 4: 161-74
    • (1977) Pain , vol.4 , pp. 161-174
    • Dubuisson, D.1    Dennis, S.G.2
  • 87
    • 0023924046 scopus 로고
    • A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
    • Hargreaves K, Dubner R, Brown F, et al. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88
    • (1988) Pain , vol.32 , pp. 77-88
    • Hargreaves, K.1    Dubner, R.2    Brown, F.3
  • 88
    • 0026674117 scopus 로고
    • The formalin test: An evaluation of the method
    • Tjolsen A, Berge O-G, Hunskaar S, et al. The formalin test: an evaluation of the method. Pain 1992; 51: 5-17
    • (1992) Pain , vol.51 , pp. 5-17
    • Tjolsen, A.1    Berge, O.-G.2    Hunskaar, S.3
  • 89
    • 0025805581 scopus 로고
    • Standardization of the rat paw formalin test for the evaluation of analgesics
    • Wheeler-Aceto H, Cowan A. Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacol 1991; 104: 35-44
    • (1991) Psychopharmacol , vol.104 , pp. 35-44
    • Wheeler-Aceto, H.1    Cowan, A.2
  • 90
    • 0029116480 scopus 로고
    • Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat
    • Doak GJ, Sawynok J. Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat. Bur J Pharmacol 1995; 281: 311-8
    • (1995) Bur J Pharmacol , vol.281 , pp. 311-318
    • Doak, G.J.1    Sawynok, J.2
  • 91
    • 0026691557 scopus 로고
    • Local antinociceptive and hyperalgesic effects in the formalin test after peripheral administration of adenosine analogues in mice
    • Karlsten R, Gordh T, Post C. Local antinociceptive and hyperalgesic effects in the formalin test after peripheral administration of adenosine analogues in mice. Pharmacol Toxicol 1992; 70: 434-8
    • (1992) Pharmacol Toxicol , vol.70 , pp. 434-438
    • Karlsten, R.1    Gordh, T.2    Post, C.3
  • 92
    • 0000563758 scopus 로고
    • The capillary dilator substances in dry powders of spinal roots: A possible role of adenosine triphosphate in chemical transmission from nerve endings
    • Holton FA, Holton P. The capillary dilator substances in dry powders of spinal roots: a possible role of adenosine triphosphate in chemical transmission from nerve endings. J Physiol 1954; 126: 124-40
    • (1954) J Physiol , vol.126 , pp. 124-140
    • Holton, F.A.1    Holton, P.2
  • 93
    • 0011731358 scopus 로고
    • The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves
    • Holton P. The liberation of adenosine triphosphate on antidromic stimulation of sensory nerves. J Physiol 1959; 145: 494-504
    • (1959) J Physiol , vol.145 , pp. 494-504
    • Holton, P.1
  • 94
    • 0033028529 scopus 로고    scopus 로고
    • Analgesic effect of adenosine on ischaemic pain in human volunteers
    • Rae CP, Mansfield MD, Dryden C, et al. Analgesic effect of adenosine on ischaemic pain in human volunteers. Br J Anaesth 1999; 82: 427-8
    • (1999) Br J Anaesth , vol.82 , pp. 427-428
    • Rae, C.P.1    Mansfield, M.D.2    Dryden, C.3
  • 95
    • 18544404962 scopus 로고    scopus 로고
    • Adenosine reduces secondary hyperalgesia in two human models of cutaneous inflammatory pain
    • Sjolund KF, Segerdahl M, Sollevi A. Adenosine reduces secondary hyperalgesia in two human models of cutaneous inflammatory pain. Anesth Analg 1999; 88: 605-10
    • (1999) Anesth Analg , vol.88 , pp. 605-610
    • Sjolund, K.F.1    Segerdahl, M.2    Sollevi, A.3
  • 96
    • 0017682312 scopus 로고
    • Observations on the allogenic actions of adenosine compounds on the human blister base preparation
    • Bleehen T, Keele CA. Observations on the allogenic actions of adenosine compounds on the human blister base preparation. Pain 1977; 3: 367-77
    • (1977) Pain , vol.3 , pp. 367-377
    • Bleehen, T.1    Keele, C.A.2
  • 97
    • 0028891913 scopus 로고
    • Antinociception by adenosine analogs and an adenosine kinase inhibitor: Dependence on formalin concentration
    • Poon A, Sawynok J. Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration. Eur J Pharmacol 1995; 286: 177-84
    • (1995) Eur J Pharmacol , vol.286 , pp. 177-184
    • Poon, A.1    Sawynok, J.2
  • 98
    • 0031884745 scopus 로고    scopus 로고
    • Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test
    • Sawynok J, Reid A, Poon A. Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test. Pain 1998; 74: 75-81
    • (1998) Pain , vol.74 , pp. 75-81
    • Sawynok, J.1    Reid, A.2    Poon, A.3
  • 99
    • 0026739165 scopus 로고
    • Spinally-mediated antinociception is induced in mice by an adenosine kinase-, but not by an adenosine deaminase-, inhibitor
    • Keil 2nd GJ, DeLander GE. Spinally-mediated antinociception is induced in mice by an adenosine kinase-, but not by an adenosine deaminase-, inhibitor. Life Sci 1992; 51: 171-6
    • (1992) Life Sci , vol.51 , pp. 171-176
    • Keil G.J. II1    DeLander, G.E.2
  • 100
    • 0028034410 scopus 로고
    • Adenosine kinase and adenosine deaminase inhibition modulate spinal adenosine- and opioid agonist-induced antinociception in mice
    • Keil 2nd GJ, DeLander GE. Adenosine kinase and adenosine deaminase inhibition modulate spinal adenosine- and opioid agonist-induced antinociception in mice. Eur J Pharmacol 1994; 271: 37-46
    • (1994) Eur J Pharmacol , vol.271 , pp. 37-46
    • Keil G.J. II1    DeLander, G.E.2
  • 101
    • 0031914926 scopus 로고    scopus 로고
    • Antinociception by adenosine analogues and inhibition of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat
    • Poon A, Sawynok J. Antinociception by adenosine analogues and inhibition of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat. Pain 1998; 74: 235-45
    • (1998) Pain , vol.74 , pp. 235-245
    • Poon, A.1    Sawynok, J.2
  • 102
    • 0002376293 scopus 로고
    • Adenosine production and metabolism
    • Stone TW, editor. London: Academic Press
    • Meghji P. Adenosine production and metabolism. In: Stone TW, editor. Adenosine in the nervous system. London: Academic Press, 1991: 25-42
    • (1991) Adenosine in the Nervous System , pp. 25-42
    • Meghji, P.1
  • 104
    • 0023162442 scopus 로고
    • 2 adenosine receptors in spinal mechanisms of antinociception
    • 2 adenosine receptors in spinal mechanisms of antinociception. Eur J Pharm 1987; 139: 215-23
    • (1987) Eur J Pharm , vol.139 , pp. 215-223
    • DeLander, G.E.1    Hopkins, C.J.2
  • 105
    • 0013635859 scopus 로고    scopus 로고
    • Ketamine and adenosine infusion prevent thermal changes in the secondary hyperalgesic area after mustard oil skin application
    • Seattle (WA): IASP Press
    • Segerdahl M, Forsberg C, Sollevi A. Ketamine and adenosine infusion prevent thermal changes in the secondary hyperalgesic area after mustard oil skin application [abstract]. In: 8th World Congress on Pain: 1996 Aug 18-22: Vancouver. Seattle (WA): IASP Press, 1996: 35
    • (1996) 8th World Congress on Pain: 1996 Aug 18-22: Vancouver , pp. 35
    • Segerdahl, M.1    Forsberg, C.2    Sollevi, A.3
  • 106
    • 0026684018 scopus 로고
    • Adenosine infusion during isoflurane-nitrous oxide anaesthesia: Indications of perioperative analgesic effect
    • Sollevi A. Adenosine infusion during isoflurane-nitrous oxide anaesthesia: indications of perioperative analgesic effect. Acta Anaesthesiol Scand 1992, 36: 595-9
    • (1992) Acta Anaesthesiol Scand , vol.36 , pp. 595-599
    • Sollevi, A.1
  • 107
    • 0029766808 scopus 로고    scopus 로고
    • Analgesic effects of adenosine during exercise-provoked myocardial ischaemia
    • Sylven C, Eriksson B, Jensen J, et al. Analgesic effects of adenosine during exercise-provoked myocardial ischaemia. Neuroreport 1996; 7: 1521-5
    • (1996) Neuroreport , vol.7 , pp. 1521-1525
    • Sylven, C.1    Eriksson, B.2    Jensen, J.3


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