Gating of information flow within the limbic system and the pathophysiology of schizophrenia

Brain Research Reviews

Volumn 31, Issue 2-3, 2000, Pages 330-341

  Grace, Anthony A ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Amygdala; Dopamine; Glutamate; Hippocampus; Nucleus accumbens; Prefrontal cortex; Schizophrenia

Indexed keywords

DOPAMINE; GLUTAMIC ACID;

AMYGDALOID NUCLEUS; BRAIN DEVELOPMENT; CONFERENCE PAPER; DOPAMINERGIC SYSTEM; ENTORHINAL CORTEX; HIPPOCAMPUS; HUMAN; LIMBIC SYSTEM; NERVE CELL PLASTICITY; NONHUMAN; NUCLEUS ACCUMBENS; ONTOGENY; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA;

ANIMALS; HUMANS; LIMBIC SYSTEM; PREFRONTAL CORTEX; SCHIZOPHRENIA;

EID: 0034054792     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(99)00049-1     Document Type: Conference Paper

References (128)

1. Adler M. Changes in sensitivity to amphetamine in rats with chronic brain lesions. J. Pharmacol. Exp. Ther. 134:1961;214-224.
2. Andreasen N.C., Rezai K., Alliger R., Swayze V.W. 2nd, Flaum M., Kirchner P., Cohen G., O'Leary D.S. Hypofrontality in neuroleptic-naive patients and in patients with chronic schizophrenia. Assessment with xenon 133 single-photon emission computed tomography and the Tower of London. Arch. Gen. Psychiatry. 49(12):1992;943-958.
3. Angrist B., Rotrosen J., Gershon S. Differential effects of amphetamine and neuroleptics on negative vs. positive symptoms in schizophrenia. Psychopharmacology. 72:1980;17-19.
4. Angrist B., Santhananthan G., Wilk S., Gershon S. Amphetamine psychosis: behavioral and biochemical aspects. J. Psychiatr. Res. 11:1974;13-23.
5. Angrist B., Shopin B., Gershon S. Comparative psychotomimetic effects of stereoisomers of amphetamine. Nature. 234:1971;152-153.
6. Arnold S.E., Hyman B.T., Van Hoesen G.W., Damasio A.R. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Arch. Gen. Psychiatry. 48:1991;625-632.
7. Beckstead R.M. An autoradiographic examination of corticostriatal and subcortical projections of the mediodorsal-projection (prefrontal) cortex in the rat. J. Comp. Neurol. 184:1979;43-62.
8. Beckstead R.M., Domesick V.B., Nauta W.J. Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res. 175:1979;191-217.
9. Berman K.F., Zec R.F., Weinberger D.R. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort. Arch. Gen. Psychiatry. 43:1986;126-135.
10. Bertolino A., Knable M.B., Saunders R.C., Callicott J.H., Kolachana B., Mattay V.S., Bachevalier J., Frank J.A., Egan M., Weinberger D.R. The relationship between dorsolateral prefrontal acetylaspartate measures and striatal dopamine activity in schizophrenia. Biol. Psychiatry. 45:1999;660-667.
11. Beuger M., van Kammen D.P., Kelley M.E., Yao J. Dopamine turnover in schizophrenia before and after haloperidol withdrawal CSF, plasma, and urine studies. Neuropsychopharmacology. 15:1996;75-86.
12. Blaha C.D., Yang C.R., Floresco S.B., Barr A.M., Phillips A.G. Stimulation of the ventral subiculum of the hippocampus evokes glutamatereceptor-mediated changes in dopamine efflux in the rat nucleus accumbens. Eur. J. Neurosci. 9(5):1997;902-911.
13. Boeijinga P.H., Pennartz C.M.A., Lopes da Silva F.H. Paired-pulse facilitation in the nucleus accumbens following stimulation of subicular inputs in the rat. Neuroscience. 35:1990;301-311.
14. Boeijinga P.H., Mulder A.B., Pennartz C.M.A., Manshanden I., Lopes da Silva F.H. Responses of the nucleus accumbens following fornix/fimbria stimulation in the rat. Identification and long-term potentiation of mono- and polysynaptic pathways. Neuroscience. 53:1993;1049-1058.
15. Bogerts B., Meertz E., Schönfeldt-Bausch R. Basal ganglia and limbic system pathology in schizophrenia. Arch. Gen. Psychiatry. 42:1985;784-791.
16. Breier A., Adler C.M., Weisenfeld N.et al. Effects of NMDA antagonism on striatal dopamine release in healthy subjects: application of a novel PET approach. Synapse. 29:1998;142-147.
17. Breier A., Su T.P., Saunders R.et al. Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method. Proc. Natl. Acad. Sci. USA. 94:1997;2569-2574.
18. Bruno J.P., Snyder A.M., Stricker E.M. Effect of dopamine-depleting brain lesions on suckling and weaning in rats. Behav. Neurosci. 98:1984;156-161.
19. Bunney B.S., Grace A.A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sci. 23:1978;1715-1728.
20. Buchsbaum M.S., Cappelletti J., Ball R., Hazlett E., King A.C., Johnson J., Wu J., DeLisi L.E. Positron emission tomographic image measurement in schizophrenia and affective disorders. Annals Neurol. 15(Suppl.):1984;S157-165.
21. Carlsson M., Carlsson A. Interactions between glutamatergic and monoaminergic systems within the basal ganglia - implications for schizophrenia and Parkinson's disease. Trends Neurosci. 13:1990;272-276.
22. Carlsson A., Lindqvist M. Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacol. Toxicol. 20:1963;140-144.
23. Cattabeni F., Di Luca M. Developmental models of brain dysfunctions induced by targeted cellular ablations with methylazoxymethanol. Physiol. Rev. 77:1997;199-215.
24. L.J. Chapman, J.P. Chapman, G.A. Miller, A theory on verbal behavior in schizophrenia, in: B. Maher (Ed.), Prog. Experimental Personality Research, Vol. I., Academic Press, New York, 1964, pp. 49-77.
25. Christie M.J., Summers R.J., Stephenson J.A., Cook D.J., Beart P.M. Excitatory amino acid projections to the nucleus accumbens septi in the rat: a retrograde transport study utilizing D[3H]aspartate and [3H]GABA. Neuroscience. 22:1987;425-439.
26. Church W.H., Justice J.B., Neill D.B. Detecting behaviorally relevant changes in extracellular dopamine with microdialysis. Brain Res. 412:1987;397-399.
27. Conrad A.J., Abebe T., Austin R., Forsythe S., Scheibel A.B. Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. Arch. Gen. Psychiatry. 48:1991;413-417.
28. Cornwall J., Phillipson O.T. Afferent projections to the dorsal thalamus of the rat as shown by retrograde lectin transport. II. The midline nuclei. Brain Res. Bull. 21:1998;147-161.
29. Creese I., Burt D.R., Snyder S.H. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science. 192:1976;596-598.
30. DeFrance J.F., Sikes R.W., Chronister R.B. Dopamine action in the nucleus accumbens. J. Neurophysiol. 54:1985;1568-1577.
31. de Silva W.P., Hemsley D.R. The influence of context on language perception in schizophrenia. Brit. J. Soc. Clin. Psychol. 16:1977;337-345.
32. Deutch A.Y., Lee M.C., Iadarola M.J. Regionally specific effects of atypical antipsychotic drugs on striatal fos expression: the nucleus accumbens shell as a locus of antipsychotic action. Molec. Cell. Neurosci. 3:1992;332-341.
33. O. Devinsky, D. Luciano, The contribution of the cingulate cortex to human behavior, in: B.A. Vogt, M. Gabriel (Eds.), Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook, Birkauser, Boston, 1993.
34. Emmi A., Rajabi H., Stewart J. Behavioral and neurochemical recovery from partial 6-hydroxydopamine lesions of the substantia nigra is blocked by daily treatment with glutamate receptor antagonists MK-801 and CPP. J. Neurosci. 16:1996;5216-5224.
35. Everitt B.J., Cador M., Robbins T.W. Interactions between the amygdala and ventral striatum in stimulus-reward associations: studies using a second-order schedule of sexual reinforcement. Neuroscience. 30:1989;63-75.
36. Fabre M., Rolls E.T., Ashton J.P., Williams G. Activity of neurons in the ventral tegmental region of the behaving monkey. Behav. Brain Res. 9:1983;213-235.
37. Fey E.T. The performance of young schizophrenics and young normals on the Wisconsin Card Sorting Test. J. Consulting Psychol. 15:1951;311-319.
38. Floresco S.B., Yang C.R., Phillips A.G., Blaha C.D. Basolateral amygdala stimulation evokes glutamate receptor-dependent dopamine efflux in the nucleus accumbens of the anaesthetized rat. Eur. J. Neurosci. 10(4):1998;1241-1251.
39. Friston K.J. The dorsolateral prefrontal cortex, schizophrenia and PET. J. Neural Trans. 37:1992;79-93.
40. Fuller T.A., Russchen F.T., Price J.L. Sources of presumptive glutamergic/aspartergic afferents to the rat ventral striatopallidal region. J. Comp. Neurol. 258:1987;317-338.
41. Ghajarnia M., Moore H., Grace A.A. Enhanced behavioral effects of phencyclidine (PCP) in rats with developmental abnormalities of the temporal lobe. Soc. Neurosci. Abstr. 24:1998;2177.
42. Garris P.A., Wightman R.M. Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study. J. Neurosci. 14:1994;442-450.
43. Glowinski J., Chéramy A., Romo R., Barbeito L. Presynaptic regulation of dopaminergic transmission in the striatum. Cell. Molec. Neurobiol. 8:1998;7-17.
44. Goldberg T.E., Weinberger D.R., Berman K.F., Pliskin N.H., Podd M.H. Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test. Arch. Gen. Psychiatry. 44:1987;1008-1014.
45. P.S. Goldman-Rakic, The prefrontal contribution to working memory and conscious experience, in: O. Creuzfeld, J. Eccles (Eds.), The Brain and Conscious Experience, Pontifical Academy Press, Rome, 1998.
46. Grace A.A. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia. Neuroscience. 41:1991;1-24.
47. Grace A.A. The depolarization block hypothesis of neuroleptic action: Implications for the etiology and treatment of schizophrenia. J. Neural Transm. 36(suppl.):1992;91-131.
48. Grace A.A. Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia. J. Neural Transm. 91:1993;111-134.
49. Grace A.A., Bunney B.S. Induction of depolarization block in nigral dopamine neurons by repeated administration of haloperidol: Analysis using in vivo intracellular recording. J. Pharmacol. Exp. Therapeut. 238:1986;1092-1100.
50. Grace A.A., Bunney B.S., Moore H., Todd C.L. Dopamine cell depolarization block as a model for the therapeutic actions of antipsychotic drugs. Trends Neurosci. 20:1997;31-37.
51. A.A. Grace, H. Moore, Regulation of information flow in the nucleus accumbens: A model for the pathophysiology of schizophrenia, in: M.F. Lenzenweger, R.H. Dworkin (Eds.), Origins and Development of Schizophrenia: Advances in Experimental Psychopathology, American Psychological Association Press, Washington, DC, 1998, pp. 123-157.
52. Groenewegen H.J. Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography. Neuroscience. 24:1998;379-431.
53. Gur R.C., Gur R.E. Hypofrontality in schizophrenia: RIP. Lancet. 345(8962):1995;1383-1384.
54. Heimer L., Zahm D.S., Churchill L., Kalivas P.W., Wohltmann C. Specificity in the projection patterns of accumbal core and shell in the rat. Neuroscience. 41:1991;89-125.
55. Honey C.R., Miljovic Z., MacDonald J.F. Ketamine and phencyclidine cause a voltage-dependent block of responses to L-aspartic acid. Neurosci. Lett. 61:1985;135-139.
56. Ingvar D.H., Franzen G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta. Psychiatr. Scand. 50:1974;425-462.
57. Iversen S.D. The effect of surgical lesions to frontal cortex and substantia nigra on amphetamine responses in rats. Brain Res. 31:1971;295-311.
58. Jarrard L.E. What does the hippocampus really do? Behav. Brain Res. 71:1995;1-10.
59. Jenkins R.B., Groh R.H. Mental symptoms in parkinsonian patients treated with L-DOPA. Lancet. 2(7665):1970;177-179.
60. Johnstone E.C., Crow T.J., Frith C.D., Carney M.W.P., Price J.S. Mechanism of the antipsychotic effect in the treatment of acute schizophrenia. Lancet. 1(8069):1978;848-851.
61. Kalivas P.W. Interactions between dopamine and excitatory amino acids in behavioral sensitization to psychostimulants. Drug Alcohol Depend. 37:1995;95-100.
62. Kelley A.E., Domesick V.B. The distribution of the projection from the hippocampal formation to the nucleus accumbens in the rat: an anterograde- and retrograde-horseradish peroxidase study. Neuroscience. 7:1982;2321-2335.
63. Kirkpatrick B., Buchanan R.W. The neural basis of the deficit syndrome of schizophrenia. J. Nerv. Mental Disease. 178:1990;545-555.
64. Kovelman J.A., Scheibel A.B. A neurohistological correlate of schizophrenia. Biol. Psychiatry. 19:1984;1601-1917.
65. Laruelle M., D'Souza C.D., Baldwin R.M.et al. Imaging D2 receptor occupancy by endogenous dopamine in humans. Neuropsychopharmacology. 17:1997;162-174.
66. Laruelle M., Iyer R.N., al-Tikriti M.S.et al. Microdialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates. Synapse. 25:1997;1-14.
67. Lavin A., Grace A.A. The modulation of dorsal thalamic cell activity by the ventral pallidum: Its role in the regulation of thalamocortical activity by the basal ganglia. Synapse. 18:1994;104-127.
68. Lavin A., Grace A.A. Effects of afferent stimulation and DA application on prefrontal cortical cells recorded intracellularly in vivo: comparisons between intact rats and rats with pharmacologically-induced disruption of cortical development. Soc. Neurosci. Abstr. 23:1997;2080.
69. Lavin A., Grace A.A. Dopamine modulates the responsivity of mediodorsal thalamic cells recorded in vitro. J. of Neurosci. 18:1998;10566-10578.
70. Ledoux J.E., Muller J. Emotional memory and psychopathology. Phil. Trans. Royal Soc. London - Series B: Biological Sciences. 352:1997;1719-1726.
71. Leung L.S., Yim C.Y.C. Rhythmic delta-frequency activities in the nucleus accumbens of anesthetized freely moving rats. Can. J. Physiol. Pharmacol. 71:1993;311-320.
72. Liddle P.F., Friston K.J., Frith C.D., Frachowiak R.S.J. Cerebral blood flow and mental processes in schizophrenia. J. Royal Soc. Med. 85:1992;224-227.
73. Liddle P.F., Friston K.J., Frith C.D., Hirsch S.R., Jones T., Frachowiak R.S.J. Patterns of cerebral blood flow in schizophrenia. Brit. J. Psychiatry. 160:1992;179-186.
74. Lipska B.K., Jaskiw G.E., Weinberger D.R. Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal hippocampal damage: A potential animal model of schizophrenia. Neuropsychopharmacology. 9:1993;67-75.
75. Lipska B.K., Swerdlow N.R., Geyer M.A., Jaskiw G.E., Braff D.L., Weinberger D.R. Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology. 122:1995;35-43.
76. Luby E.D., Gottlieb J.S., Cohen B.D., Rosenbaum G., Domino E.F. Model psychoses and schizophrenia. Am. J. Psychiatry. 119:1962;61-67.
77. McDonald A.J. Topographical organization of amygdaloid projections to the caudatoputamen, nucleus accumbens, and related striatal-like areas of the rat brain. Neuroscience. 44:1991;15-33.
78. Merchant K.M., Dorsa D.M. Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics. Proc. Natl. Acad. Sci. USA. 90(8):1993;3447-3451.
79. Mogenson G.J., Yang C.R., Yim C.Y. Influence of dopamine on limbic inputs to the nucleus accumbens. Ann. N.Y. Acad. Sci. 537:1988;86-100.
80. Moghaddam B., Gruen R.J. Do endogenous excitatory amino acids influence striatal dopamine release? Brain Res. 544:1991;329-330.
81. Moore H., Grace A.A. Interactions between amygdala and prefrontal cortical afferents to the nucleus accumbens and their modulation by dopamine receptor activation. Soc. Neurosci. Abstr. 22:1996;1088.
82. Moore H., Grace A.A. Anatomical changes in limbic structures produced by methylazoxymethanol acetate (MAM) during brain development are associated with changes in physiological interactions among afferents to the nucleus accumbens. Soc. Neurosci. Abstr. 23:1997;2378.
83. Nasrallah H.A., Fowler R.C., Judd L.L. Schizophrenia-like illness following head injury. Psychosomatics. 22:1981;359-361.
84. O'Donnell P., Grace A.A. Physiological and morphological properties of accumbens core and shell neurons recorded in vitro. Synapse. 13:1993;135-160.
85. O'Donnell P., Grace A.A. Dopaminergic modulation of dye coupling between neurons in the core and shell regions of the nucleus accumbens. J. Neurosci. 13:1993;3456-3471.
86. O'Donnell P., Grace A.A. Tonic D2-mediated attenuation of cortical excitation in nucleus accumbens neurons recorded in vitro. Brain Res. 634:1994;105-112.
87. O'Donnell P., Grace A.A. Synaptic interactions among excitatory afferents to nucleus accumbens neurons: Hippocampal gating of prefrontal cortical input. J. Neurosci. 15:1995;3622-3639.
88. O'Donnell P., Grace A.A. Differential effects of subchronic clozapine and haloperidol on dye coupling between neurons in the rat striatal complex. Neuroscience. 66:1995;763-767.
89. O'Donnell P., Grace A.A. Dopaminergic reduction of excitability in nucleus accumbens neurons recorded in vitro. Neuropsychopharmacology. 15:1996;87-97.
90. O'Donnell P., Grace A.A. Hippocampal gating of cortical throughput in the nucleus accumbens: Modulation by dopamine. Biol. Psychiatry. 39:1996;632.
91. O'Donnell P., Grace A.A. Cortical modulation of striatal gap junction permeability is mediated via nitric oxide. Neuroscience. 76:1997;1-5.
92. O'Donnell P., Grace A.A. Dysfunctions in multiple interrelated systems as the neurobiological bases of schizophrenic symptom clusters. Schizophr. Bull. 24:1998;267-283.
93. O'Donnell P., Grace A.A. Phencyclidine interferes with the hippocampal gating of nucleus accumbens neuronal activity in vivo. Neuroscience. 87:1998;823-830.
94. Onn S.-P., Grace A.A. Dye coupling between rat striatal neurons recorded in vivo: Compartmental organization and modulation by dopamine. J. Neurophysiol. 71:1994;1917-1934.
95. Onn S.-P., Grace A.A. Repeated treatment with haloperidol and clozapine exerts differential effects on dye coupling between neurons in subregions of striatum and nucleus accumbens. J. Neurosci. 15:1995;7024-7036.
96. Onn S.-P., Grace A.A. Withdrawal following repeated amphetamine treatment increases dye coupling between neurons and activates output pathways in rat limbic cortical/striatal regions. Soc. Neurosci. Abstr. 21:1995;1905.
97. Onn S.-P., Grace A.A. Amphetamine differentially modulates gap junctional permeability in limbic- vs motor-related striatal subregions: Its correspondence with membrane excitability. Soc. Neurosci. Abstr. 23:1997;1280.
98. Pennartz C.M.A., Dollerman-van der Weel M.J., Kitai S.T., Lopes da Silva F.H. Presynaptic dopamine D1 receptors attenuate excitatory and inhibitory limbic inputs to the shell region of the rat nucleus accumbens. J. Neurophysiol. 67:1992;1325-1334.
99. Post R.M., Fink E., Carpenter W.T., Goodwin F.K. Cerebrospinal fluid amine metabolites in acute schizophrenia. Arch. Gen. Psychiatry. 32:1975;1063-1069.
100. Reivich M., Kuhl D., Wolf A., Greenberg J., Phelps M., Ido T., Casella V., Fowler J., Hoffman E., Alavi A., Som P., Sokoloff L. The (18F) fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circulation Res. 44:1979;127-137.
101. G.P. Reynolds, The amygdala and the neurochemistry of schizophrenia, in: J.P. Aggleton (Ed.), The Amygdala: Neurobiological Aspects of Emotion, Memory and Mental Dysfunction, Wiley-Liss, New York, 1992.
102. Richfield E.K., Penney J.B., Young A.B. Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system. Neuroscience. 30:1989;767-777.
103. Robertson G.S., Fibiger H.C. Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine. Neuroscience. 46:1992;315-328.
104. Schultz W., Romo R. Dopamine neurons of the monkey midbrain: contingencies of responses to stimuli eliciting immediate behavioral reactions. J. Neurophysiol. 63:1990;607-624.
105. Sedvall G., Farde L., Persson A., Wiesel F.A. Imaging of neurotransmitter receptors in the living human brain. Arch. Gen. Psychiatry. 43:1986;995-1005.
106. Seeman P. Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse. 1:1987;133-152.
107. Segal M., Bloom F.E. The action of norepinephrine in the rat hippocampus. III. Hippocampal cellular responses to locus coeruleus stimulation in the awake rat. Brain Res. 107:1976;499-511.
108. Sesack S.R., Deutch A.Y., Roth R.H., Bunney B.S. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J. Comp. Neurol. 290:1989;213-242.
109. Sesack S.R., Pickel V.M. In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other. Brain Res. 527:1990;266-279.
110. Shapiro R.M. Regional neuropathology in schizophrenia: Where are we? Where are we going? Schizophr. Res. 10:1993;187-239.
111. Sharp T., Zetterstrom T., Ungerstedt U. An in vivo study of dopamine release and metabolism in rat brain regions using intracerebral dialysis. J. Neurochem. 47:1986;113-122.
112. Sharp T., Zetterstrom T., Ljungberg T., Ungerstedt U. A direct comparison of amphetamine-induced behaviours and regional brain dopamine release in the rat using intracerebral dialysis. Brain Res. 401:1987;322-330.
113. Snyder S.H. Catecholamines in the brain as mediators of amphetamine psychosis. Arch. Gen. Psychiatry. 27:1972;169-179.
114. Spitzer M. The psychopathology, neuropsychology, and neurobiology of associative and working memory in schizophrenia. Eur. Arch. Psychiatry Clin. Neurosci. 243:1993;57-70.
115. Suddath R.L., Christison G.W., Torrey E.F., Casanova M.F., Weinberger D.R. Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Eng. J. Med. 322:1990;789-794.
116. Tamminga C.A., Thaker G.K., Buchanan R., Kirkpatrick B., Alphs L.D., Chase T.N., Carpenter W.T. Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch. Gen. Psychiatry. 49:1992;522-530.
117. Uchimura N., Higashi H., Nishi S. Hyperpolarizing and depolarizing actions of dopamine via D-1 and D-2 receptors on nucleus accumbens neurons. Brain Res. 375:1986;368-372.
118. Uylings H.B.M., van Eden C.G. Qualitative and quantitative comparison of the prefrontal cortex in rat and in primates, including humans. Prog. Brain Res. 85:1990;31-62.
119. van Kammen D.P., Bok van Kammen W., Mann L.S., Seppala T., Linnoila M. Dopamine metabolism in the cerebrospinal fluid of drug-free schizophrenic patients with and without cortical atrophy. Arch. Gen. Psychiatry. 43:1986;978-983.
120. J.M. Van Rossum, The significance of dopamine-receptor blockade for the actions of neuroleptic drugs, in: H. Brill, J.O. Cole, P. Deniker, H. Hippius, P.B. Bradley, (Eds.), Proc. of the 5th Collegium Internationale Neuropsychopharmacologicum, 1967, pp. 321-329.
121. Verma A., Moghaddam B. Regulation of striatal dopamine release by metabotropic glutamate receptors. Synapse. 28:1998;220-226.
122. Voorn P., Jorritsma-Byham B., Van Dijk C., Buijs R.M. The dopaminergic innervation of the ventral striatum in the rat: a light and electron microscopical study with antibodies against dopamine. J. Comp. Neurol. 251:1986;84-99.
123. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry. 44:1987;660-669.
124. Weinberger D.R., Lipska B.K. Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground. Schizophr. Res. 16:1995;87-110.
125. Wolf M.E., Dahlin S.L., Hu X.-T., Xue C.-J., White K. Effects of lesions of prefrontal cortex, amygdala, or fornix on behavioral sensitization to amphetamine: comparison with N-methyl-D-aspartate antagonists. Neuroscience. 69:1995;417-439.
126. Yim C.Y., Mogenson G.J. Mesolimbic dopamine projection modulates amygdala-evoked EPSP in nucleus accumbens neurons: an in vivo study. Brain Res. 369:1986;347-352.
127. Yim C.Y., Mogenson G.J. Neuromodulatory action of dopamine in the nucleus accumbens: an in vivo intracellular study. Neuroscience. 26:1988;403-415.
128. Young W.S., Alheid G.F., Heimer L. The ventral pallidal projection to the mediodorsal thalamus: a study with fluorescent retrograde tracers and immunohistofluorescence. J. Neurosci. 4:1984;1626-1638.