Aspergillus flavus genomics as a tool for studying the mechanism of aflatoxin formation

Food Additives and Contaminants - Part A

Volumn 25, Issue 9, 2008, Pages 1152-1157

  Yu, Jiujiang ^a   Payne, Gary A ^b   Nierman, William C ^c,d   Machida, Masayuki ^e   Bennett, Joan W ^f   Campbell, Bruce C ^g   Robens, Jane F ^h   Bhatnagar, Deepak ^a   Dean, Ralph A ^b   Cleveland, Thomas E ^a  

^a SOUTHERN REGIONAL RESEARCH CENTER   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c J CRAIG VENTER INSTITUTE   (United States)

^d GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^e NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^f RUTGERS UNIVERSITY   (United States)

^g WESTERN REGIONAL RESEARCH CENTER   (United States)

^h AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

Aflatoxins; Aspergillus; Expressed Sequence tags; Gene profiling; Genomics; Microarrays; Mycotoxins; Toxigenic fungi

Indexed keywords

AFLATOXIN;

ARTICLE; ASPERGILLUS FLAVUS; BIOSYNTHESIS; CONTROLLED STUDY; FUNGAL CONTAMINATION; FUNGAL GENOME; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC DATABASE; GENETIC TRANSCRIPTION; GENOMICS; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SEQUENCE ANALYSIS;

ANIMALIA; ASPERGILLUS; ASPERGILLUS FLAVUS; ASPERGILLUS ORYZAE; FUNGI;

AFLATOXINS; ASPERGILLUS FLAVUS; ASPERGILLUS ORYZAE; GENE EXPRESSION PROFILING; GENES, FUNGAL; GENOME, FUNGAL; GENOMICS; MULTIGENE FAMILY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS;

EID: 60349098226     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/02652030802213375     Document Type: Article

References (57)

1. Abnet CC. 2007. Carcinogenic food contaminants. Cancer Invest. 25:189-196.
2. Bennett JW, Lee LS, Vinnett CH. 1971. The correlation of aflatoxin and norsolorinic acid production. J Am Chem Soc. 48:368-370.
3. Bennett JW, Chang PK, Bhatnagar D. 1997. One gene to whole pathway: the role of norsolorinic acid in aflatoxin research. Adv Appl Microbiol. 45:1-15.
4. Bennett JW, Klich M. 2003. Mycotoxins. Clin Microbiol Rev. 16:497-516.
5. Bhatnagar D, Ehrlich KC, Cleveland TE. 1992. Oxidation- reduction reactions in biosynthesis of secondary metabolites. In: Bhatnagar D, Lillehoj EB, Arora DK, editors. Mycotoxins in Ecological Systems. New York: Marcel Dekker. p. 255-285.
6. Bok J-W, Keller NP. 2004. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell. 3:527-535.
7. Butchko RA, Adams TH, Keller NP. 1999. Aspergillus nidulans mutants defective in stc gene cluster regulation. Genetics. 153:715-720.
8. Calvo AM, Wilson RA, Bok JW, Keller NP. 2002. Relationship between secondary metabolism and fungal development. Microbiol Mol Biol Rev. 66:447-459.
9. Cary JW, Klich MA, Beltz SB. 2005. Characterization of aflatoxin-producing fungi outside of Aspergillus section Flavi. Mycologia. 97:425-432.
10. Chang PK. 2003. The Aspergillus parasiticus protein AFLJ interacts with the aflatoxin pathway-specific regulator AFLR. Mol Genet Genomics. 268:711-719.
11. Chang PK, Skory CD, Linz JE. 1992. Cloning of a gene associated with aflatoxin B1 biosynthesis in Aspergillus parasiticus. Curr Genet. 21:231-233.
12. Chang PK, Cary JW, Bhatnagar D, Cleveland TE, Bennett JW, Linz JE, Woloshuk CP, Payne GA. 1993. Cloning of the Aspergillus parasiticus apa. Appl Environ Microbiol. 59:3273-3279.
13. Chang PK, Cary JW, Yu J, Bhatnagar D, Cleveland TE. 1995a. The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1 biosynthesis. Mol Gen Genet. 248:270-277.
14. Chang PK, Ehrlich KC, Yu J, Bhatnagar D, Cleveland TE. 1995b. Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis. Appl Environ Microbiol. 61:2372-2377.
15. Chang PK, Yu J, Yu JH. 2004. aflT, a MFS transporter- encoding gene located in the aflatoxin gene cluster, does not have a significant role in aflatoxin secretion. Fungal Genet Biol. 41:911-920.
16. Cleveland TE, Bhatnagar D. 1990. Evidence for de novo synthesis of an aflatoxin pathway methyltransferase near the cessation of active growth and the onset of aflatoxin biosynthesis in Aspergillus parasiticus mycelia. Can J Microbiol. 36:1-5.
17. Cleveland TE, Yu J, Bhatnagar D, Chen Z-Y, Brown R, Chang P-K, Cary JW. 2005. Progress in elucidating the molecular basis of the host plant-Aspergillus flavus interaction: A basis for devising strategies to reduce aflatoxin contamination in crops. In: Abbas HK, editor. Aflatoxin and Food Safety. Boca Raton, FL: CRC Pressp. 167-193.
18. Denning DW, Follansbee SE, Scolaro M, Norris S, Edelstein H, Stevens DA. 1991. Pulmonary aspergillosis in the acquired immunodeficiency syndrome. N Engl J Med. 324:654-662.
19. Ehrlich KC, Montalbano BG, Cary JW. 1999. Binding of the C6-zinc cluster protein, AFLR, to the promoters of aflatoxin pathway biosynthesis genes in Aspergillus parasiticus. Gene. 230:249-257.
20. Ehrlich KC, Yu J, Cotty PJ. 2005. Aflatoxin biosynthesis gene clusters and flanking regions. J Appl Microbiol. 99:518-527.
21. Galagan JE, Calvo SE, Cuomo C, Ma LJ, Wortman JR, Batzoglou S, et al. 2005. Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature. 438:1105-1115.
22. Groopman JD, Johnson D, Kensler TW. 2005. Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk. Cancer Biomark. 1:5-14.
23. Keller NP, Watanabe CM, Kelkar HS, Adams TH, Townsend CA. 2000. Requirement of monooxygenase- mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulans. Appl Environ Microbiol. 66:359-362.
24. Kim JH, Campbell BC, Yu J, Mahoney N, Chan KL, Molyneux RJ, Bhatnagar D, Cleveland TE. 2005. Examination of fungal stress response genes using Saccharomyces cerevisiae as a model system: targeting genes affecting aflatoxin biosynthesis by Aspergillus flavus Link. Appl Microbiol Biotechnol. 67:807-815.
25. Kim JH, Campbell BC, Molyneux R, Mahoney N, Chan KL, Yu J, Wilkinson JR, Cary J, Bhatnagar D, Cleveland TE. 2006. Gene targets for fungal and mycotoxin control. Mycotoxin Res. 22:3-8.
26. Kusumoto K, Yabe K, Nogata Y, Ohta H. 1998. Transcript of a homolog of aflR, a regulatory gene for aflatoxin synthesis in Aspergillus parasiticus, was not detected in Aspergillus oryzae strains. FEMS Microbiol Lett. 169:303-307.
27. Lancaster MD, Jenkins FP, Philip JM. 1961. Toxicity associated with certain samples of ground nuts. Nature. 192:1095-1096.
28. Lewis L, Onsongo M, Njapau H, Schurz-Rogers H, Luber G, Kieszak S, Nyamongo J, Backer L, Dahiye AM, Misore A, et al. 2005. Aflatoxin contamination of commercial maize products during an outbreak of acute aflatoxicosis in eastern and central Kenya. Environ Health Perspect. 113:1763-1767.
29. Machida M, Asai K, Sano M, Tanaka T, Kumagai T, Terai G, et al. 2005. Genome sequencing and analysis of Aspergillus oryzae. Nature. 438:1157-1161.
30. Mahoney N, Molyneux RJ, Campbell BC. 2000. Regulation of aflatoxin production by naphthoquinones of walnut (Juglans regia). J Agric Food Chem. 48:4418-4421.
31. Mahoney N, Molyneux RJ. 2004. Phytochemical inhibition of aflatoxigenicity in Aspergillus flavus by constituents of walnut (Juglans regia). J Agric Food Chem. 52:1882-1889.
32. Meyers DM, Obrian G, Du WL, Bhatnagar D, Payne GA. 1998. Characterization of aflJ, a gene required for conversion of pathway intermediates to aflatoxin. Appl Environ Microbiol. 64:3713-3717.
33. Minto RE, Townsend CA. 1997. Enzymology and molecular biology of aflatoxin biosynthesis. Chem Rev. 97:2537-2555.
34. Nierman WC, Pain A, Anderson MJ, Wortman JR, Kim HS, Arroyo J, et al. 2005. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature. 438:1151-1156.
35. O'Brian GR, Fakhoury AM, Payne GA. 2003. Identification of genes differentially expressed during aflatoxin biosynthesis in Aspergillus flavus and Aspergillus parasiticus. Fungal Genet Biol. 39:118-127.
36. Payne GA, Brown MP. 1998. Genetics and physiology of aflatoxin biosynthesis. Annu Rev Phytopathol. 36:329-362.
37. Payne GA, Nystrom GJ, Bhatnagar D, Cleveland TE, Woloshuk CP. 1993. Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus. Appl Environ Microbiol. 59:156-162.
38. Price MS, Conners SB, Tachdjian S, Kelly RM, Payne GA. 2005. Aflatoxin conducive and non-conducive growth conditions reveal new gene associations with aflatoxin production. Fungal Genet Biol. 42:506-518.
39. Price MS, Yu J, Nierman WC, Kim HS, Pritchard B, Jacobus CA, Bhatnagar D, Cleveland TE, Payne GA. 2006. The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster. FEMS Microbiol Lett. 255:275-279.
40. Richard JL, Payne GA. 2003. Mycotoxins: Risks in Plant, Animal and Human Systems. Council for Agricultural Science and Technology (CAST): Ames, IA.
41. Robens JF. 2001. The costs of mycotoxin management to the USA: Management of aflatoxins in the United States. APSnet Feature Available: http://www.apsnet.org/online/feature/mycotoxin/top.html:2-8. Accessed: 12 May 2007.
42. Robens JF, Cardwell K. 2005. The cost of mycotoxin management in the United States. In: Abbas HK, editor. Aflatoxin and Food Safety. Boca Raton, FL: CRC Press. p. 1-12.
43. Skory CD, Chang PK, Cary J, Linz JE. 1992. Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis. Appl Environ Microbiol. 58:3527-3537.
44. St Leger RJ, Screen SE, Shams-Pirzadeh B. 2000. Lack of host specialization in Aspergillus flavus. Appl Environ Microbiol. 66:320-324.
45. Varga J, Rigo K, Toth B, Teren J, Kozakiewicz Z. 2003. Evolutionary relationships among Aspergillus species producing economically important mycotoxins. Food Technol Biotechnol. 41:29-36.
46. Watson AJ, Fuller LJ, Jeenes DJ, Archer DB. 1999. Homologs of aflatoxin biosynthesis genes and sequence of aflR in Aspergillus oryzae and Aspergillus sojae. Appl Environ Microbiol. 65:307-310.
47. Wild CP, Turner PC. 2002. The toxicology of aflatoxins as a basis for public health decisions. Mutagenesis. 17:471-481.
48. Wilkinson JR, Yu J, Bland JM, Nierman WC, Bhatnagar D, Cleveland TE. 2007. Amino acid supplementation reveals differential regulation of aflatoxin biosynthesis in Aspergillus flavus NRRL 3357 and Aspergillus parasiticus SRRC 143. Appl Microbiol Biotechnol. 74:1308-1319.
49. Williams JH, Phillips TD, Jolly PE, Stiles JK, Jolly CM, Aggarwal D. 2004. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr. 80:1106-1122.
50. Yabe K, Nakajima H. 2004. Enzyme reactions and genes in aflatoxin biosynthesis. Appl Microbiol Biotechnol. 64:745-755.
51. Yu J, Chang PK, Cary JW, Wright M, Bhatnagar D, Cleveland TE, Payne GA, Linz JE. 1995. Comparative mapping of aflatoxin pathway gene clusters in Aspergillus parasiticus and Aspergillus flavus. Appl Environ Microbiol. 61:2365-2371.
52. Yu J. 2004. Genetics and biochemistry of mycotoxin synthesis. In: Arora DK, editor. Fungal Biotechnology in Agricultural, Food, and Environmental Applications. New York: Marcel Dekker. p. 343-361.
53. Yu J, Bhatnagar D, Cleveland TE. 2004a. Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus. FEBS Lett. 564:126-130.
54. Yu J, Chang PK, Ehrlich KC, Cary JW, Bhatnagar D, Cleveland TE, Payne GA, Linz JE, Woloshuk CP, Bennett JW. 2004b. Clustered pathway genes in aflatoxin biosynthesis. Appl Environ Microbiol. 70:1253-1262.
55. Yu J, Whitelaw CA, Nierman WC, Bhatnagar D, Cleveland TE. 2004c. Aspergillus flavus expressed sequence tags for identification of genes with putative roles in aflatoxin contamination of crops. FEMS Microbiol Lett. 237:333-340.
56. Yu J, Cleveland TE, Nierman WC, Bennett JW. 2005. Aspergillus flavus genomics: gateway to human and animal health, food safety, and crop resistance to diseases. Rev Iberoam Micol. 22:194-202.
57. Yu J, Cleveland TE, Wilkinson JR, Campbell BC, Kim JH, Kim HS, Bhatnagar D, Payne GA, Nierman WC. 2006. Aspergillus flavus expressed sequence tags and microarray as tools in understanding aflatoxin biosynthesis. Mycotoxin Res. 22:16-21.