DY-9760e inhibits endothelin-1-induced cardiomyocyte hypertrophy through inhibition of CaMKII and ERK activities

Cardiovascular Therapeutics

Volumn 27, Issue 1, 2009, Pages 17-27

  Lu, Ying Mei ^a   Shioda, Norifumi ^a   Han, Feng ^a   Kamata, Akifumi ^a   Shirasaki, Yasufumi ^b   Qin, Zheng Hong ^c   Fukunaga, Kohji ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

CaMKII; Cardiac hypertrophy; DY 9760e; Endothelin 1; ERK; Intracellular calcium

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CALCIMYCIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN INHIBITOR; DY 9760E; ENDOTHELIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; UNCLASSIFIED DRUG; UO 126;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSFECTION; HEART CELL CULTURE; HEART HYPERTROPHY; IMMUNOBLOTTING; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS;

ANIMALS; ANIMALS, NEWBORN; ATRIAL NATRIURETIC FACTOR; BENZYLAMINES; BUTADIENES; CALCIMYCIN; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CARDIOMEGALY; CELL PROLIFERATION; CELL SIZE; CELLS, CULTURED; DNA REPLICATION; ENDOTHELIN-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INDAZOLES; IONOPHORES; MYOCYTES, CARDIAC; NATRIURETIC PEPTIDE, BRAIN; NITRILES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; RNA, MESSENGER; SULFONAMIDES; TIME FACTORS; TRANSFECTION;

EID: 60349090388     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/j.1755-5922.2008.00068.x     Document Type: Article

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