Cytoprotective effect of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl] ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) against ischemia/reperfusion-induced injury in rat heart involves inhibition of fodrin breakdown and protein tyrosine nitration

Journal of Pharmacological Sciences

Volumn 98, Issue 2, 2005, Pages 142-150

  Hashimoto, Masami ^a   Takada, Yoko ^a   Takeuchi, Yusuke ^a   Kasahara, Jiro ^a   Hisa, Hiroaki ^a   Shirasaki, Yasufumi ^b   Fukunaga, Kohji ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Calmodulin antagonist; Calpain; Cardiomyocyte; Caspase 3; Coronary occlusion

Indexed keywords

3 [2 [4 (3 CHLORO 2 METHYLPHENYL) 1 PIPERAZINYL]ETHYL] 5,6 DIMETHOXY 1 (4 IMIDAZOLYLMETHYL) 1H INDAZOLE; CALMODULIN INHIBITOR; CALPAIN; CASPASE 3; DY 9760E; EVANS BLUE; FODRIN; SODIUM CHLORIDE; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NITRATION; NONHUMAN; PROTEIN DEGRADATION; RAT; REPERFUSION INJURY;

EID: 21744454642     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0040551     Document Type: Article

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