Structural determinants of lolitrems for inhibition of BK large conductance Ca2+-activated K+ channels

European Journal of Pharmacology

Volumn 605, Issue 1-3, 2009, Pages 36-45

  Imlach, Wendy L ^a,c   Finch, Sarah C ^b   Dunlop, James ^a   Dalziel, Julie E ^a  

^a AGRESEARCH GRASSLANDS   (New Zealand)

^b RUAKURA RESEARCH CENTRE   (New Zealand)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

BK channel; Fungal toxin; Indole diterpene; Large conductance calcium activated potassium channel; Lolitrem; Patch clamp

Indexed keywords

31 EPILOLITREM B; INDOLE DERIVATIVE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LOLITREM B; LOLITREM E; LOLITREM F; LOLITREM M; LOLITRIOL; MYCOTOXIN; TERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERENNIAL RYEGRASS; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TREMOR;

CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHIBITORY CONCENTRATION 50; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MYCOTOXINS; NEUROTOXINS; POTASSIUM CHANNEL BLOCKERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60349088076     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.12.031     Document Type: Article

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