Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients

Journal of Immunology

Volumn 179, Issue 6, 2007, Pages 4272-4282

  Winter, Dorian ^a,b   Moser, Julia ^b   Kriehuber, Ernst ^a,b   Wiesner, Christoph ^b   Knobler, Robert ^b   Trautinger, Franz ^b   Bombosi, Paula ^c   Stingl, Georg ^b   Petzelbauer, Peter ^b   Rot, Antal ^c   Maurer, Dieter ^a,b  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b Universitatsklinik fur Dermatologie   (Austria)

^c Novartis Institutes for Biomedical Research   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; MITOGEN ACTIVATED PROTEIN KINASE; CHEMOKINE RECEPTOR; CXC CHEMOKINE RECEPTOR 3; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; L SELECTIN; LIGAND; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CELL POPULATION; CHEMOTAXIS; CLINICAL ARTICLE; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE G0 PHASE; CELL MEMBRANE; CELL MOTION; CELL STRAIN K 562; DRUG ANTAGONISM; ENDOSOME; ENDOTHELIUM CELL; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYSOSOME; METABOLISM; PATHOLOGY; PHYSIOLOGY; SKIN TUMOR;

CD8-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; CELL MOVEMENT; CELLS, CULTURED; DOWN-REGULATION; E-SELECTIN; ENDOSOMES; ENDOTHELIAL CELLS; G0 PHASE; HUMANS; IMMUNOLOGIC MEMORY; K562 CELLS; L-SELECTIN; LIGANDS; LYMPHOMA, T-CELL, CUTANEOUS; LYSOSOMES; RECEPTORS, CHEMOKINE; SKIN NEOPLASMS; TUMOR CELLS, CULTURED; VASCULAR CELL ADHESION MOLECULE-1;

EID: 35748929086     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.6.4272     Document Type: Article

References (32)

1. - immunophenotype in patients with benign and malignant lymphoproliferative dermatoses. J. Am. Acad. Dermatol. 35: 404-410.
2. - T cell frequency and polymerase chain reactionbased clonality assay correlate with stage in cutaneous T cell lymphomas. J. Invest. Dermatol. 114: 107-111.
3. - subset in the identification of circulating Sézary cells. Br. J. Dermatol. 144: 125-135.
4. Matutes, E., D. Robinson, M. O'Brien, B. F. Haynes, H. Zola, and D. Catovsky. 1983. Candidate counterparts of Sézary cells and adult T-cell lymphoma-leukemia cells in normal peripheral blood: an ultrastructural study with the immunogold method and monoclonal antibodies. Leuk. Res. 7: 787-801.
5. Siegel, R. S., T. Pandolfino, J. Guitart, S. Rosen, and T. M. Kuzel. 2000. Primary cutaneous T-cell lymphoma: review and current concepts. J. Clin. Oncol. 18: 2908-2925.
6. Winter, D., E. Fiebiger, P. Meraner, H. Auer, C. Brna, R. Strohal, F. Trautinger, R. Knobler, G. F. Fischer, G. Stingl, and D. Maurer. 2003. Definition of TCR epitopes for CTL-mediated attack of cutaneous T cell lymphoma. J. Immunol. 171: 2714-2724.
7. Eichmüller, S., D. Usener, R. Dummer, A. Stein, D. Thiel, and D. Schadendorf. 2001. Serological detection of cutaneous T-cell lymphoma-associated antigens. Proc. Natl. Acad. Sci. USA 98: 629-634.
8. Eichmüller, S., D. Usener, D. Thiel, and D. Schadendorf. 2003. Tumor-specific antigens in cutaneous T-cell lymphoma: expression and sero-reactivity. Int. J. Cancer 104: 482-487.
9. Häffner, A. C., A. Tassis, K. Zepter, M. Storz, O. Tureci, G. Burg, and F. O. Nestle. 2002. Expression of cancer/testis antigens in cutaneous T cell lymphomas. Int. J. Cancer 97: 668-670.
10. + T cells in cutaneous T-cell lymphoma: expression of cytotoxic proteins, Fas ligand, and killing inhibitory receptors and their relationship with clinical behavior. J. Clin. Oncol. 19: 4322-4329.
11. Hoppe, R. T., L. J. Medeiros, R. A. Warnke, and G. S. Wood. 1995. CD8-positive tumor-infiltrating lymphocytes influence the long-term survival of patients with mycosis fungoides. J. Am. Acad. Dermatol. 32: 448-453.
12. Willemze, R., E. S. Jaffe, G. Burg, L. Cerroni, E. Berti, S. H. Swerdlow, E. Ralfkiaer, S. Chimenti, J. L. Diaz-Perez, L. M. Duncan, et al. 2005. WHOEORTC classification for cutaneous lymphomas. Blood 105: 3768-3785.
13. Kriehuber, E., W. Bauer, A. S. Charbonnier, D. Winter, S. Amatschek, D. Tamandl, N. Schweifer, G. Stingl, and D. Maurer. 2005. The balance between NF-κB and JNK/AP-1 activity controls dendritic cell life and death. Blood 106: 175-183.
14. Blomberg, K., C. Granberg, I. Hemmila, and T. Lovgren. 1986. Europium-labelled target cells in an assay of natural killer cell activity. I. A novel nonradioactive method based on time-resolved fluorescence. J. Immunol. Methods 86: 225-229.
15. Lasagni, L., M. Francalanci, F. Annunziato, E. Lazzeri, S. Giannini, L. Cosmi, C. Sagrinati, B. Mazzinghi, C. Orlando, E. Maggi, et al. 2003. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J. Exp. Med. 197: 1537-1549.
16. Charbonnier, A. S., N. Kohrgruber, E. Kriehuber, G. Stingl, A. Rot, and D. Maurer. 1999. Macrophage inflammatory protein 3a is involved in the constitutive trafficking of epidermal Langerhans cells. J. Exp. Med. 190: 1755-1768.
17. Lechleitner, S., R. Kunstfeld, C. Messeritsch-Fanta, K. Wolff, and P. Petzelbauer. 1999. Peripheral lymph node addressins are expressed on skin endothelial cells. J. Invest. Dermatol. 113: 410-414.
18. Lechleitner, S., J. Gille, D. R. Johnson, and P. Petzelbauer. 1998. Interferon enhances tumor necrosis factor-induced vascular cell adhesion molecule 1 (CD106) expression in human endothelial cells by an interferon-related factor 1-dependent pathway. J. Exp. Med. 187: 2023-2030.
19. Mohan, K., E. Cordeiro, M. Vaci, C. McMaster, and T. B. Issekutz. 2005. CXCR3 is required for migration to dermal inflammation by normal and in vivo activated T cells: differential requirements by CD4 and CD8 memory subsets. Eur. J. Immunol. 35: 1702-1711.
20. + effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. J. Immunol. 176: 4235-4243.
21. + T cells. J. Exp. Med. 186: 1407-1418.
22. Ehlert, J. E., C. A. Addison, M. D. Burdick, S. L. Kunkel, and R. M. Strieter. 2004. Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping. J. Immunol. 173: 6234-6240.
23. Sauty, A., R. A. Colvin, L. Wagner, S. Rochat, F. Spertini, and A. D. Luster. 2001. CXCR3 internalization following T cell-endothelial cell contact: preferential role of IFN-inducible T cell α chemoattractant (CXCL11). J. Immunol. 167: 7084-7093.
24. + T cells. J. Immunol. 168: 2225-2232.
25. + T cells from memory to memory/effector phenotype. J. Immunol. 168: 5538-5550.
26. Neel, N. F., E. Schutyser, J. Sai, G. H. Fan, and A. Richmond. 2005. Chemokine receptor internalization and intracellular trafficking. Cytokine Growth Factor Rev. 16: 637-658.
27. Hess, C., T. K. Means, P. Autissier, T. Woodberry, M. Altfeld, M. M. Addo, N. Frahm, C. Brander, B. D. Walker, and A. D. Luster. 2004. IL-8 responsiveness defines a subset of CD8 T cells poised to kill. Blood 104: 3463-3471.
28. Axelrod, P. I., B. Lorber, and E. C. Vonderheid. 1992. Infections complicating mycosis fungoides and Sézary syndrome. J. Am. Med. Assoc. 267: 1354-1358.
29. + effector T cells. J. Leukocyte Biol. 71: 669-676.
30. Kohrgruber, N., M. Gröger, P. Meraner, E. Kriehuber, P. Petzelbauer, S. Brandt, G. Stingl, A. Rot, and D. Maurer. 2004. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J. Immunol. 173: 6592-6602.
31. Ludwig, A., F. Schiemann, R. Mentlein, B. Lindner, and E. Brandt. 2002. Dipeptidyl peptidase IV (CD26) on T cells cleaves the CXC chemokine CXCL11 (I-TAC) and abolishes the stimulating but not the desensitizing potential of the chemokine. J. Leukocyte Biol. 72: 183-191.
32. + T cells is associated with survival in melanoma patients with stage III disease. Cancer Res. 64: 7697-7701.