Involvement of caspases and transmembrane metalloproteases in sulphur mustard-induced microvesication in adult human skin in organ culture: Directions for therapy

Toxicology

Volumn 258, Issue 1, 2009, Pages 39-46

  Mol, Marijke A E ^a   van den Berg, Roland M ^a   Benschop, Henk P ^a  

^a TNO   (Netherlands)

Author keywords

Caspase; Skin organ culture; Sulphur mustard; TACE ADAM17; Transmembrane metalloprotease; Vesication

Indexed keywords

ADAM PROTEIN; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 8; CASPASE 8 INHIBITOR; CASPASE 9; CASPASE 9 INHIBITOR; DEATH RECEPTOR; DECANOYL ARGINYLVALYLLYSYLARGINYL CHLOROMETHYLKETONE; EPIDERMAL GROWTH FACTOR RECEPTOR; FURIN; ILOMASTAT; LIGAND; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; MUSTARD GAS; N (2 (HYDROXYAMINOCARBONYL)METHYL) 4 METHYLPENTANOYL T BUTYL GLYCINE ALANINE 2 AMINOETHYL AMIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BLISTER; CELL STRUCTURE; CELL TRANSFORMATION; CONCENTRATION (PARAMETERS); DERMIS; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; EPIDERMIS; EX VIVO STUDY; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN TISSUE; MICROVESICATION; MITOCHONDRION; MODEL; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN SECRETION; SKIN;

ADULT; BLISTER; CASPASES; CELL MEMBRANE; CHEMICAL WARFARE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; KERATINOCYTES; METALLOPROTEASES; MUSTARD GAS; ORGAN CULTURE TECHNIQUES; SKIN;

EID: 60249100682     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.01.004     Document Type: Article

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