Genetics of the metabolic syndrome and implications for therapy

International Congress Series

Volumn 1262, Issue C, 2004, Pages 224-229

  Hughes, Robert I ^a   Aitman, Timothy J ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b MRC CLINICAL SCIENCES CENTRE   (United Kingdom)

Author keywords

Atherogenesis; Cd36; Insulin resistance; Metabolic syndrome; Thiazolidinedione

Indexed keywords

EID: 60049091760     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.ics.2003.12.005     Document Type: Article

References (22)

1. G.M. Reaven Role of insulin resistance in human disease (Banting Lecture) Diabetes 37 1988 1595 1607
2. P.M. McKeigue J.E. Ferrie T. Pierpoint M.G. Marmot Association of early-onset coronary heart disease in South Asian men with glucose intolerance and hyperinsulinemia Circulation 87 1 1993 152 161
3. D.M. Nathan J. Meigs D.E. Singer The epidemiology of cardiovascular disease in type 2 diabetes mellitus: how sweet it is … or is it? Lancet 350 Suppl. 1 1997 SI4 SI9
4. D. Altshuler J.N. Hirschhorn M. Klannemark C.M. Lindgren M.C. Vohl J. Nemesh C.R. Lane S.F. Schaffner S. Bolk C. Brewer T. Tuomi D. Gaudet T.J. Hudson M. Daly L. Groop E.S. Lander The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes Nat. Genet. 26 2000 76 79
5. T.J. Aitman T. Gotoda A.L. Evans H. Imrie K.E. Heath P.M. Trembling H. Truman C.A. Wallace A. Rahman C. Doré J. Flint V. Kren V. Zidek T. Kurtz M. Pravenec J. Scott Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats Nat. Genet. 16 2 1997 197 201
6. T.J. Aitman A.M. Glazier C.A. Wallace L.D. Cooper P.J. Norsworthy F.N. Wahid K.M. Al-Majali P.M. Trembling C.J. Mann C.C. Shoulders D. Graf E.S. Lezin T.W. Kurtz V. Kren M. Pravenec A. Ibrahimi N.A. Abumrad L.W. Stanton J. Scott Identification of Cd36 ( Fat ) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats Nat. Genet. 21 1999 76 83
7. N.A. Abumrad M.R. El-Maghrabi E.-Z. Amri E. Lopez P.A. Grimaldi Cloning of a rat adipocyte membrane protein implicated in binding or transport of long chain fatty acids that is induced during preadipocyte differentiation J. Biol. Chem. 268 1993 17665 17668
8. G. Endemann L.W. Stanton K.S. Madden C.M. Bryant R.T. White A.A. Protter CD36 is a receptor for oxidized low density lipoprotein J. Biol. Chem. 268 16 1993 11811 11816
9. P. Tontonoz L. Nagy J. Alvarez V. Thomazy R. Evans PPARγ promotes monocote/macrophage differentiation and uptake of oxidized LDL Cell 93 1998 241 252
10. L. Nagy P. Tontonoz J. Alvarez H. Chen R. Evans Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ Cell 93 1998 229 240
11. G. Chinetti S. Lestavel V. Bocher A.T. Remaley B. Neve I.P. Torra E. Teissier A. Minnich M. Jaye N. Duverger H.B. Brewer J.-C. Fruchart V. Clavey B. Staels PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway Nat. Med. 7 2001 53 58
12. M. Febbraio N.A. Abumrad D.P. Hajjar K. Sharma W. Cheng S.F.A. Pearce R.L. Silverstein A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism J. Biol. Chem. 274 1999 19055 19062
13. T. Hajri X.X. Han A. Bonen N.A. Abumrad Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice J. Clin. Invest. 109 10 2002 1381 1389
14. M. Pravenec V. Landa V. Zidek A. Musilova V. Kren L. Kazdova T.J. Aitman A.M. Glazier A. Ibrahimi N.A. Abumrad N. Qi J.-M. Wang E.M. St. Lezin T.W. Kurtz Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats Nat. Genet. 27 2 2001 156 158
15. M. Febbraio E.A. Podrez J.D. Smith D.P. Hajjar S.L. Hazen H.F. Hoff K. Sharma R.L. Silverstein Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice J. Clin. Invest. 105 2000 1049 1056
16. B.R. Curtis S. Ali A.M. Glazier D.D. Ebert T.J. Aitman R.H. Aster Isoimmunization against CD36 (glycoprotein IV): description of four cases of neonatal isoimmune thrombocytopenia and brief review of the literature Transfusion 42 2002 1173 1179
17. K. Miyaoka T. Kuwasako K. Hirano S. Nozaki S. Yamashita Y. Matsuzawa Human CD36 deficiency is associated with insulin resistance Lancet 357 2001 686 687
18. M. Furuhashi N. Ura T. Nakata K. Shimamoto Insulin sensitivity and lipid metabolism in human CD36 deficiency Diabetes Care 26 2003 471 474
19. A.C. Li K.K. Brown M.J. Silvestre T.M. Willson W. Palinski C.K. Glass Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice J. Clin. Invest. 106 2000 523 531
20. H. Koshiyama D. Shimono N. Kuwamura J. Minamikawa Y. Nakamura Rapid communication: inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes J. Clin. Endocrinol. Metab. 86 2001 3452 3456
21. N. Qi L. Kazdova V. Zidek V. Landa V. Kren H.A. Pershadsingh E.S. Lezin N.A. Abumrad M. Pravenec T.W. Kurtz Pharmacogenetic evidence that Cd36 is a key determinant of the metabolic effects of pioglitazone J. Biol. Chem. 277 2002 48501 48507
22. O. Seda L. Kazdova D. Krenova V. Kren Rosiglitazone fails to improve hypertriglyceridemia and glucose tolerance in CD36-deficient BN. SHR4 congenic rat strain Physiol. Genomics 12 2003 73 78