Pyridone 6, a pan-janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression

Biological and Pharmaceutical Bulletin

Volumn 32, Issue 1, 2009, Pages 45-50

  Kwak, Han Bok ^a   Kim, Hun Soo ^a   Lee, Myeung Su ^a   Kim, Kwang Jin ^a   Choi, Eun Yong ^a   Choi, Min Kyu ^a   Kim, Jeong Joong ^a   Cho, Hae Joong ^a   Kim, Jeong Woo ^a   Bae, Ji Myung ^a   Kim, Yun Kyung ^a   Park, Byoung Hyun ^a   Ha, Hyunil ^a   Chun, Churl Hong ^a   Oh, Jaemin ^a  

^a Wonkwang University   (South Korea)

Author keywords

Differentiation; Osteoclast; Pyridone 6

Indexed keywords

ACTIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE INHIBITOR; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; PYRIDINE 6 (2 TERT BUTYL 9 FLUORO 3,6 DIHYDRO 7H BENZ[H]IMIDAZ[4,5 F ]ISOQUINOLINE 7 ONE); PYRIDONE 6; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; COCULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; EX VIVO STUDY; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; ORGAN CULTURE; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BENZIMIDAZOLES; BONE MARROW CELLS; BONE RESORPTION; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; MACROPHAGES; MICE; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PROTO-ONCOGENE PROTEINS C-FOS; PYRIDONES; RANK LIGAND; SIGNAL TRANSDUCTION;

EID: 59949098140     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.32.45     Document Type: Article

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