TGF-β-induced SOCS3 expression augments TNF-α-induced osteoclast formation

Biochemical and Biophysical Research Communications

Volumn 309, Issue 4, 2003, Pages 762-767

  Lovibond, Alison C ^a   Haque, S Jaharul ^b   Chambers, Timothy J ^a   Fox, Simon W ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Lineage commitment; Osteoclast; SOCS3; TGF ; TNF

Indexed keywords

STAT PROTEIN; SUPPRESSOR FACTOR; SUPPRESSOR OF CYTOKINE STIMULATION 3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; HUMAN; HUMAN CELL; INFLAMMATION; NUCLEIC ACID PROBE; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETROVIRUS INFECTION; UPREGULATION;

EID: 0141564944     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.08.068     Document Type: Article

References (29)

1. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S.-I., Tomoyasu A., Yano K., Goto M., Murakami A., Tsuda E., Morinaga T., Higashio K., Udagawa N., Takahashi N., Suda T. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and identical to TRANCE-RANKL. Proc. Natl. Acad. Sci. USA. 95:1998;3597-3602.
2. Chambers T.J. Regulation of the differentiation and function of osteoclasts. J. Pathol. 192:2000;4-13.
3. Kobayashi K., Takahashi N., Jimi E., Udagawa N., Takami M., Kotake S., Nakagawa N., Kinosaki M., Yamaguchi K., Shima N., Yasuda H., Morinaga T., Higashio K., Martin T.J., Suda T. Tumor necrosis factor α stimulates osteoclastic differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J. Exp. Med. 191:2000;275-285.
4. Roggia C., Gao Y., Cenci S., Weitzmann M.N., Toraldo G., Isaia G., Pacifici R. Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo. Proc. Natl. Acad. Sci. USA. 98:2001;13960-13965.
5. 1 and IFN-γ direct macrophage activation by TNF-α to osteoclastic or cytocidal phenotype J. Immunol. 165:2000;4957-4963.
6. 1 in osteoclast differentiation and survival J. Cell Sci. 113:2000;2445-2453.
7. Kaneda T., Nojima T., Nakagawa M., Ogasawara A., Kaneko H., Sato T., Mano H., Kumegawa M., Hakeda Y. Endogenous production of TGF-beta is essential for osteoclastogenesis induced by a combination of receptor activator of NF-kappa B ligand and macrophage-colony-stimulating factor. J. Immunol. 165:2000;4254-4263.
8. Thyberg J. Differentiated properties and proliferation of arterial smooth muscle cells in culture. Int. Rev. Cytol. 169:1996;183-265.
9. Schindler C., Darnell J.E. Transcriptional responses to polypeptide ligands: the Jak-Stat pathway. Ann. Rev. Biochem. 64:1995;621-651.
10. Starr R., Willson T.A., Viney E.M., Murray L.J., Rayner J.R., Jenkins B.J., Gonda T.J., Alexander W.S., Metcalf D., Nicola N.A., Hilton D.J. A family of cytokine-inducible inhibitors of signalling. Nature. 387:1997;917-921.
11. Naka T., Fujimoto M., Kishimoto T. Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. TIBS. 24:1999;394-398.
12. Naka T., Narazaki M., Hirata M., Matsumoto T., Minamoto S., Aono a., Nishimoto N., Kajita T., Taga T., Yoshizaki K., Akira S., Kishimoto T. Structure and function of a new STAT-induced STAT inhibitor. Nature. 387:1997;924-929.
13. Hilton D.J., Richardson R.T., Alexander W.S., Viney E.M., Willson T.A., Spriggs N.S., Starr R., Nicholson S.E., Metcalf D., Nicola N.A. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl. Acad. Sci. USA. 95:1998;114-119.
14. Song M.M., Shuai K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273:1998;35056-35062.
15. Crespo A., Filla M.B., Murphy W.J. Low responsiveness to IFN-gamma, after pretreatment of mouse macrophages with lipopolysaccarides, develops via diverse regulatory pathways. Eur. J. Immunol. 32:2002;710-719.
16. Ito S., Ansari P., Sakatsume M., Dickensheets H., Vazquez N., Donnelly R.P., Larner A.C., Finbloom D.S. Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma-induced genes by suppressing tyrosine phosphorylation of STAT1. Blood. 93:1999;1456-1463.
17. Fox S.W., Haque S.J., Lovibond A.C., Chambers T.J. The Possible role of TGF-beta-induced suppressors of cytokine signaling expression in osteoclast/macrophage lineage commitment in vitro. J. Immunol. 170:2003;3679-3687.
18. Kinsella T.M., Nolan G.P. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther. 7:1996;1405-1413.
19. Chambers T.J., McSheehy P.M., Thomson B.M., Fuller K. The effect of calcium-regulating hormones and prostaglandins on bone resorption by osteoclasts disaggregated from neonatal rabbit bones. Endocrinology. 116:1985;234-239.
20. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium-thiocynate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
21. Morgenstern J.P., Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18:1990;3587-3596.
22. Haque S.J., Harbor P.C., Williams B.R. Identification of critical residues required for suppressor of cytokine signaling-specific regulation of interleukin-4 signaling. J. Biol Chem. 275:2000;26500-26506.
23. Takayanagi H., Kim S., Matsuo K., Suzuki H., Suzuki T., Sato K., Yokochi T., Oda H., Nakamura K., Ida N., Wagner E.F., Taniguchi T. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature. 416:2002;744-749.
24. Owens J.M., Gallagher A.C., Chambers T.J. IL-10 modulates formation of osteoclasts in murine hemopoietic cultures. J. Immunol. 157:1996;936-940.
25. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., Schreiber R.D. How cells respond to interferons. Ann. Rev. Biochem. 67:1998;227-264.
26. Fickenscher H., Hor S., Kupers H., Knappe A., Wittmann S., Sticht H. The interleukin-10 family of cytokines. Trends Immunol. 23:2002;89-96.
27. Niemand C., Nimmesgern A., Haan S., Fischer P., Schaper F., Rossaint R., Heinrich P.C., Muller-Newen G. Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3. J. Immunol. 170:2003;3263-3272.
28. Dokter W.H., Koopmans S.B., Vellenga E. Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-IL6 and NF-kappa B) which are involved in IL-6 regulation. Leukemia. 10:1996;1308-1316.
29. Zhang Y., Feng X.H., Derynck R. Smad 3 and Smad4 cooperate with c-jun/c-fos to mediate TGF-β induced transcription. Nature. 394:1998;909-913.