메뉴 건너뛰기




Volumn 175, Issue 6, 2006, Pages 971-980

The nuclear receptor hepatocyte nuclear factor 4α acts as a morphogen to induce the formation of microvilli

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; ERM BINDING PHOSPHOPROTEIN 50; EZRIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MEMBRANE PROTEIN; MOESIN; MORPHOGEN; PHOSPHOPROTEIN; RADIXIN; RETINOID X RECEPTOR;

EID: 33845693542     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200608012     Document Type: Article
Times cited : (34)

References (52)
  • 1
    • 33744795211 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
    • Battle, M.A., G. Konopka, F. Parviz, A.L. Gaggl, C. Yang, F.M. Sladek, and S.A. Duncan. 2006. Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc. Natl. Acad. Sci. USA. 103:8419-8424.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8419-8424
    • Battle, M.A.1    Konopka, G.2    Parviz, F.3    Gaggl, A.L.4    Yang, C.5    Sladek, F.M.6    Duncan, S.A.7
  • 2
    • 0020804117 scopus 로고
    • Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells
    • Bretscher, A. 1983. Purification of an 80,000-dalton protein that is a component of the isolated microvillus cytoskeleton, and its localization in nonmuscle cells. J. Cell Biol. 97:425-432.
    • (1983) J. Cell Biol. , vol.97 , pp. 425-432
    • Bretscher, A.1
  • 3
  • 4
    • 0030697963 scopus 로고    scopus 로고
    • Specific and redundant functions of retinoid X receptor/retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells
    • Chiba, H., J. Clifford, D. Metzger, and P. Chambon. 1997a. Specific and redundant functions of retinoid X receptor/retinoic acid receptor heterodimers in differentiation, proliferation, and apoptosis of F9 embryonal carcinoma cells. J. Cell Biol. 139:735-747.
    • (1997) J. Cell Biol. , vol.139 , pp. 735-747
    • Chiba, H.1    Clifford, J.2    Metzger, D.3    Chambon, P.4
  • 5
    • 0030947316 scopus 로고    scopus 로고
    • Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells
    • Chiba, H., J. Clifford, D. Metzger, and P. Chambon. 1997b. Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. Mol. Cell. Biol. 17:3013-3020.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3013-3020
    • Chiba, H.1    Clifford, J.2    Metzger, D.3    Chambon, P.4
  • 6
    • 0034331337 scopus 로고    scopus 로고
    • F9 embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression
    • Chiba, H., D. Metzger, and P. Chambon. 2000. F9 embryonal carcinoma cells engineered for tamoxifen-dependent Cre-mediated site-directed mutagenesis and doxycycline-inducible gene expression. Exp. Cell Res. 260:334-339.
    • (2000) Exp. Cell Res. , vol.260 , pp. 334-339
    • Chiba, H.1    Metzger, D.2    Chambon, P.3
  • 7
    • 0037621983 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells
    • Chiba, H., T. Gotoh, T. Kojima, S. Satohisa, K. Kikuchi, M. Osanai, and N. Sawada. 2003. Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells. Exp. Cell Res. 286:288-297.
    • (2003) Exp. Cell Res. , vol.286 , pp. 288-297
    • Chiba, H.1    Gotoh, T.2    Kojima, T.3    Satohisa, S.4    Kikuchi, K.5    Osanai, M.6    Sawada, N.7
  • 10
    • 0034627754 scopus 로고    scopus 로고
    • F-actin bundles are derivatives of microvilli: What does this tell us about how bundles might form?
    • DeRosier, D.J., and L.G. Tilney. 2000. F-actin bundles are derivatives of microvilli: what does this tell us about how bundles might form? J. Cell Biol. 148:1-6.
    • (2000) J. Cell Biol. , vol.148 , pp. 1-6
    • DeRosier, D.J.1    Tilney, L.G.2
  • 11
    • 0033593481 scopus 로고    scopus 로고
    • Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout
    • Doi, Y., M. Itoh, S. Yonemura, H. Ishihara, T. Takano, T. Noda, and S. Tsukita. 1999. Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout. J. Biol. Chem. 274:2315-2321.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2315-2321
    • Doi, Y.1    Itoh, M.2    Yonemura, S.3    Ishihara, H.4    Takano, T.5    Noda, T.6    Tsukita, S.7
  • 13
    • 0028031296 scopus 로고
    • Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst
    • Duncan, S.A., K. Manova, W.S. Chen, P. Hoodless, D.C. Weinstein, R.F. Bachvarova, and J.E. Darnell Jr. 1994. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc. Natl. Acad. Sci. USA. 91:7598-7602.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7598-7602
    • Duncan, S.A.1    Manova, K.2    Chen, W.S.3    Hoodless, P.4    Weinstein, D.C.5    Bachvarova, R.F.6    Darnell Jr., J.E.7
  • 15
    • 2342436207 scopus 로고    scopus 로고
    • The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain
    • Finnerty, C.M., D. Chambers, J. Ingraffea, H.R. Faber, P.A. Karplus, and A. Bretscher. 2004. The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain. J. Cell Sci. 117:1547-1552.
    • (2004) J. Cell Sci. , vol.117 , pp. 1547-1552
    • Finnerty, C.M.1    Chambers, D.2    Ingraffea, J.3    Faber, H.R.4    Karplus, P.A.5    Bretscher, A.6
  • 17
    • 1642543216 scopus 로고    scopus 로고
    • Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions
    • Fujibe, M., H. Chiba, T. Kojima, T. Soma, T. Wada, T. Yamashita, and N. Sawada. 2004. Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions. Exp. Cell Res. 295:36-47.
    • (2004) Exp. Cell Res. , vol.295 , pp. 36-47
    • Fujibe, M.1    Chiba, H.2    Kojima, T.3    Soma, T.4    Wada, T.5    Yamashita, T.6    Sawada, N.7
  • 18
    • 0029121577 scopus 로고
    • Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding sites
    • Gary, R., and A. Bretscher. 1995. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding sites. Mol. Biol. Cell. 6:1061-1075.
    • (1995) Mol. Biol. Cell. , vol.6 , pp. 1061-1075
    • Gary, R.1    Bretscher, A.2
  • 20
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • Hayhurst, G.P., Y.H. Lee, G. Lambert, J.M. Ward, and F.J. Gonzalez. 2001. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21:1393-1403.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 21
    • 0019780848 scopus 로고
    • Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm
    • Hogan, B.L., A. Taylor, and E. Adamson. 1981. Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm. Nature. 291:235-237.
    • (1981) Nature , vol.291 , pp. 235-237
    • Hogan, B.L.1    Taylor, A.2    Adamson, E.3
  • 24
    • 0035242434 scopus 로고    scopus 로고
    • Retinoid X receptor α and retinoic acid receptor γ mediate expression of genes encoding tight junction proteins and barrier function in F9 cells during visceral endodermal differentiation
    • Kubota, H., H. Chiba, Y. Takakuwa, M. Osanai, H. Tobioka, G. Kohama, M. Mori, and N. Sawada. 2001. Retinoid X receptor α and retinoic acid receptor γ mediate expression of genes encoding tight junction proteins and barrier function in F9 cells during visceral endodermal differentiation. Exp. Cell Res. 263:163-172.
    • (2001) Exp. Cell Res. , vol.263 , pp. 163-172
    • Kubota, H.1    Chiba, H.2    Takakuwa, Y.3    Osanai, M.4    Tobioka, H.5    Kohama, G.6    Mori, M.7    Sawada, N.8
  • 25
    • 0023952245 scopus 로고
    • A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation
    • Lankes, W., A. Griesmacher, J. Grunwald, R. Schwartz-Albiez, and R. Keller. 1988. A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation. Biochem. J. 251:831-842.
    • (1988) Biochem. J. , vol.251 , pp. 831-842
    • Lankes, W.1    Griesmacher, A.2    Grunwald, J.3    Schwartz-Albiez, R.4    Keller, R.5
  • 27
    • 0034090310 scopus 로고    scopus 로고
    • Mammalian hepatocyte differentiation requires the transcription factor HNF-4α
    • Li, J., G. Ning, and S.A. Duncan. 2000. Mammalian hepatocyte differentiation requires the transcription factor HNF-4α. Genes Dev. 14:464-474.
    • (2000) Genes Dev. , vol.14 , pp. 464-474
    • Li, J.1    Ning, G.2    Duncan, S.A.3
  • 28
    • 27144512719 scopus 로고    scopus 로고
    • HNF4α reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma
    • Lucas, B., K. Grigo, S. Erdmann, J. Lausen, L. Klein-Hitpass, and G.U. Ryffel. 2005. HNF4α reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma. Oncogene. 24:6418-6431.
    • (2005) Oncogene , vol.24 , pp. 6418-6431
    • Lucas, B.1    Grigo, K.2    Erdmann, S.3    Lausen, J.4    Klein-Hitpass, L.5    Ryffel, G.U.6
  • 29
    • 0032940071 scopus 로고    scopus 로고
    • ERM proteins in cell adhesion and membrane dynamics
    • Mangeat, P., C. Roy, and M. Martin. 1999. ERM proteins in cell adhesion and membrane dynamics. Trends Cell Biol. 9:187-192.
    • (1999) Trends Cell Biol. , vol.9 , pp. 187-192
    • Mangeat, P.1    Roy, C.2    Martin, M.3
  • 30
    • 0032498528 scopus 로고    scopus 로고
    • Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
    • Matsui, T., M. Maeda, Y. Doi, S. Yonemura, M. Amano, K. Kaibuchi, and S. Tsukita. 1998. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J. Cell Biol. 140:647-657.
    • (1998) J. Cell Biol. , vol.140 , pp. 647-657
    • Matsui, T.1    Maeda, M.2    Doi, Y.3    Yonemura, S.4    Amano, M.5    Kaibuchi, K.6    Tsukita, S.7
  • 31
    • 0034842640 scopus 로고    scopus 로고
    • Site- and time-specific gene targeting in the mouse
    • Metzger, D., and P. Chambon. 2001. Site- and time-specific gene targeting in the mouse. Methods. 24:71-80.
    • (2001) Methods , vol.24 , pp. 71-80
    • Metzger, D.1    Chambon, P.2
  • 32
    • 11144241263 scopus 로고    scopus 로고
    • Ezrinradixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia
    • Morales, F.C., Y. Takahashi, E.L. Kreimann, and M.-M. Georgescu. 2004. Ezrinradixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia. Proc. Natl. Acad. Sci. USA. 101:17705-17710.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 17705-17710
    • Morales, F.C.1    Takahashi, Y.2    Kreimann, E.L.3    Georgescu, M.-M.4
  • 34
    • 0034724536 scopus 로고    scopus 로고
    • Structure of ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
    • Pearson, M.A., D. Reczek, A. Bretscher, and P.A. Karplus. 2000. Structure of ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell. 101:259-270.
    • (2000) Cell , vol.101 , pp. 259-270
    • Pearson, M.A.1    Reczek, D.2    Bretscher, A.3    Karplus, P.A.4
  • 35
    • 0031984186 scopus 로고    scopus 로고
    • Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli
    • Pinson, K.I., L. Dunbar, L. Samuelson, and D.L. Gumucio. 1998. Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. Dev. Dyn. 211:109-121.
    • (1998) Dev. Dyn. , vol.211 , pp. 109-121
    • Pinson, K.I.1    Dunbar, L.2    Samuelson, L.3    Gumucio, D.L.4
  • 36
    • 0032541057 scopus 로고    scopus 로고
    • The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule
    • Reczek, D., and A. Bretscher. 1998. The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule. J. Biol. Chem. 273:18452-18458.
    • (1998) J. Biol. Chem. , vol.273 , pp. 18452-18458
    • Reczek, D.1    Bretscher, A.2
  • 37
    • 0030608877 scopus 로고    scopus 로고
    • Identification of EBP50: A PDZ- containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
    • Reczek, D., M. Berryman, and A. Bretscher. 1997. Identification of EBP50: a PDZ- containing phosphoprotein that associates with members of the ezrin-radixin-moesin family. J. Cell Biol. 139:169-179.
    • (1997) J. Cell Biol. , vol.139 , pp. 169-179
    • Reczek, D.1    Berryman, M.2    Bretscher, A.3
  • 38
    • 2942622503 scopus 로고    scopus 로고
    • Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine
    • Saotome, I., M. Curto, and A.I. McClatchey. 2004. Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev. Cell. 6:855-864.
    • (2004) Dev. Cell. , vol.6 , pp. 855-864
    • Saotome, I.1    Curto, M.2    McClatchey, A.I.3
  • 39
    • 25844464135 scopus 로고    scopus 로고
    • Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4α-induced epithelial polarization
    • Satohisa, S., H. Chiba, M. Osanai, S. Ohno, T. Kojima, T. Saito, and N. Sawada. 2005. Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4α-induced epithelial polarization. Exp. Cell Res. 310:66-78.
    • (2005) Exp. Cell Res. , vol.310 , pp. 66-78
    • Satohisa, S.1    Chiba, H.2    Osanai, M.3    Ohno, S.4    Kojima, T.5    Saito, T.6    Sawada, N.7
  • 40
    • 33645736042 scopus 로고    scopus 로고
    • Cadherin Cad99C is required for normal microvilli morphology in Drosophila follicle cells
    • Schlichting, K., M. Wilsch-Brauninger, F. Demontis, and C. Dahmann. 2006. Cadherin Cad99C is required for normal microvilli morphology in Drosophila follicle cells. J. Cell Sci. 119:1184-1195.
    • (2006) J. Cell Sci. , vol.119 , pp. 1184-1195
    • Schlichting, K.1    Wilsch-Brauninger, M.2    Demontis, F.3    Dahmann, C.4
  • 41
    • 0038121958 scopus 로고    scopus 로고
    • EBP50, a β-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma
    • Shibata, T., M. Chuma, A. Kokubu, M. Sakamoto, and S. Hirohashi. 2003. EBP50, a β-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma. Hepatology. 38:178-186.
    • (2003) Hepatology , vol.38 , pp. 178-186
    • Shibata, T.1    Chuma, M.2    Kokubu, A.3    Sakamoto, M.4    Hirohashi, S.5
  • 42
    • 0002772438 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4α
    • T.P. Burris and E.R.B. McCabe, editors. Academic Press, San Diego, CA
    • Sladek, F.M., and S.D. Seidel. 2001. Hepatocyte nuclear factor 4α. In Nuclear Receptors and Genetic Disease. T.P. Burris and E.R.B. McCabe, editors. Academic Press, San Diego, CA. 309-361.
    • (2001) Nuclear Receptors and Genetic Disease , pp. 309-361
    • Sladek, F.M.1    Seidel, S.D.2
  • 43
    • 0025690311 scopus 로고
    • Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
    • Sladek, F.M., W. Zhong, E. Lai, and I.E. Darnel. 1990. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev. 4:2353-2365.
    • (1990) Genes Dev. , vol.4 , pp. 2353-2365
    • Sladek, F.M.1    Zhong, W.2    Lai, E.3    Darnel, I.E.4
  • 44
    • 0032559647 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells
    • Späth, G.F., and M.C. Weiss. 1998. Hepatocyte nuclear factor 4 provokes expression of epithelial marker genes, acting as a morphogen in dedifferentiated hepatoma cells. J. Cell Biol. 140:935-946.
    • (1998) J. Cell Biol. , vol.140 , pp. 935-946
    • Späth, G.F.1    Weiss, M.C.2
  • 45
    • 0019473285 scopus 로고
    • Mouse teratocarcinoma cells: Prospects for the study of embryogenesis and neoplasia
    • Strickland, S. 1981. Mouse teratocarcinoma cells: prospects for the study of embryogenesis and neoplasia. Cell. 24:277-278.
    • (1981) Cell , vol.24 , pp. 277-278
    • Strickland, S.1
  • 49
    • 0033521010 scopus 로고    scopus 로고
    • Cortical actin organization: Lessons from ERM (ezrin/radixin/moesin) proteins
    • Tsukita, S., and S. Yonemura. 1999. Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. J. Biol. Chem. 274:34507-34510.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34507-34510
    • Tsukita, S.1    Yonemura, S.2
  • 50
    • 0024320199 scopus 로고
    • A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: Purification and characterization
    • Tsukita, Sa., Y. Hieda, and Sh. Tsukita. 1989. A new 82-kD barbed end-capping protein (radixin) localized in the cell-to-cell adherens junction: purification and characterization. J. Cell Biol. 108:2369-2382.
    • (1989) J. Cell Biol. , vol.108 , pp. 2369-2382
    • Tsukita, Sa.1    Hieda, Y.2    Tsukita, Sh.3
  • 51
    • 0038241793 scopus 로고    scopus 로고
    • HNF4: A central regulator of hepatocyte differentiation and function
    • Watt, A.J., W.D. Garrison, and S.A. Duncan. 2003. HNF4: a central regulator of hepatocyte differentiation and function. Hepatology. 37:1249-1253.
    • (2003) Hepatology , vol.37 , pp. 1249-1253
    • Watt, A.J.1    Garrison, W.D.2    Duncan, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.