Porcine buccal mucosa as an in vitro model: Relative contribution of epithelium and connective tissue as permeability barriers

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 471-483

  Kulkarni, Upendra ^a   Mahalingam, Ravichandran ^a,c   Pather, S Indiran ^b   Li, Xiaoling ^a   Jasti, Bhaskara ^a  

^a UNIVERSITY OF THE PACIFIC   (United States)

^b California Northstate College of Pharmacy   (United States)

^c Formurex Inc   (United States)

Author keywords

Absorption; Bilayer; Buccal; In vitro models; Mucosal drug delivery

Indexed keywords

BUPIVACAINE; BUSPIRONE; CAFFEINE; PHENAZONE;

ANIMAL TISSUE; ARTICLE; BILAYER MEMBRANE; CHEEK MUCOSA; CONNECTIVE TISSUE; DRUG PENETRATION; EPITHELIUM; HYDROPHILICITY; IN VITRO STUDY; LIPOPHILICITY; MEMBRANE MODEL; MODEL; NONHUMAN; SWINE; THICKNESS; ANIMAL; BIOLOGICAL MODEL; BUCCAL DRUG ADMINISTRATION; CELL MEMBRANE PERMEABILITY; CONNECTIVE TISSUE CELL; CYTOLOGY; DIFFUSION; DIFFUSION CHAMBER; EPITHELIUM CELL; KINETICS; LIPID BILAYER; METABOLISM; METHODOLOGY; MOUTH MUCOSA; PHARMACEUTICS;

ADMINISTRATION, BUCCAL; ANIMALS; ANTIPYRINE; BUPIVACAINE; BUSPIRONE; CAFFEINE; CELL MEMBRANE PERMEABILITY; CONNECTIVE TISSUE CELLS; DIFFUSION; DIFFUSION CHAMBERS, CULTURE; EPITHELIAL CELLS; KINETICS; LIPID BILAYERS; MODELS, BIOLOGICAL; MOUTH MUCOSA; SWINE; TECHNOLOGY, PHARMACEUTICAL;

EID: 59849098596     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21436     Document Type: Article

References (44)

1. Squier CA, Cox P, Wertz PW. 1991. Lipid content and water permeability of skin and oral mucosa. J Invest Dermatol 96:123-126.
2. Squier CA, Wertz PW. 1996. Structure and function of the oral mucosa and implications for drug delivery. ed. New York: Marcel Dekker Inc. p. 440.
3. Harris D, Robinson JR. 1992. Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci 81:1-10.
4. Wertz PW, Squier CA. 1991. Cellular and molecular basis of barrier function in oral epithelium. Crit Rev Ther Drug Carrier Syst 8:237-269.
5. de Vries ME, Bodde HE, Verhoef JC, Junginger HE. 1991. Developments in buccal drug delivery. Crit Rev Ther Drug Carrier Syst 8:271-303.
6. Lesch CA, Squier CA, Cruchley A, Williams DM, Speight P. 1989. The permeability of human oral mucosa and skin to water. J Dent Res 68:1345-1349.
7. Squier CA, Hall BK. 1985. The permeability of skin and oral mucosa to water and horseradish peroxidase as related to the thickness of the permeability barrier. J Invest Dermatol 84:176-179.
8. Squier CA, Hopps RM. 1976. A study of the permeability barrier in epidermis and oral epithelium using horseradish peroxidase as a tracer in vitro. Br J Dermatol 95:123-129.
9. Squier CA, Hall BK. 1985. In-vitro permeability of porcine oral mucosa after epithelial separation, stripping and hydration. Arch Oral Biol 30:485-491.
10. Xiang J, Fang X, Li X. 2002. Transbuccal delivery of 2′,3′- dideoxycytidine: In vitro permeation study and histological investigation. Int J Pharm 231:57-66.
11. Shojaei AH, Khan M, Lim G, Khosravan R. 1999. Transbuccal permeation of a nucleoside analog, dideoxycytidine: Effects of menthol as a permeation enhancer. Int J Pharm 192:139-146.
12. Takács-Novák K, Avdeel A. 1996. Interlaboratory study of log P determination by shake-flask and potentiometric methods. J Pharm Biomed Anal 14:1405-1413.
13. Bergstrom CA, Luthman K, Artursson P. 2004. Accuracy of calculated pH-dependent aqueous drug solubility. Eur J Pharm Sci 22:387-398.
14. Berggren S, Hoogstraate J, Fagerholm U, Lennernas H. 2004. Characterization of jejunal absorption and apical efflux of ropivacaine, lidocaine and bupivacaine in the rat using in situ and in vitro absorption models. Eur J Pharm Sci 21:553-560.
15. Higaki K, Asai M, Suyama T, Nakayama K, Ogawara K, Kimura T. 2002. Estimation of intradermal disposition kinetics of drugs: II. Factors determining penetration of drugs from viable skin to muscular layer. Int J Pharm 239:129-141.
16. Akomeah F, Nazir T, Martin GP, Brown MB. 2004. Effect of heat on the percutaneous absorption and skin retention of three model penetrants. Eur J Pharm Sci 21:337-345.
17. Nicolazzo JA, Reed BL, Finnin BC. 2004. Modification of buccal drug delivery following pretreatment with skin penetration enhancers. J Pharm Sci 93:2054-2063.
18. De Boer AG, De Leede LG, Breimer DD. 1984. Drug absorption by sublingual and rectal routes. Br J Anaesth 56:69-82.
19. Tucker IG. 1988. A method to study the kinetics of oral mucosal drug absorption from solutions. J Pharm Pharmacol 40:679-683.
20. De Vries ME, Verhoef JC, Ponec M, Ine W, Craane HM, Junginger HE. 1991. Localization of the permeability barrier inside porcine buccal mucosa: A combined in vitro study of drug permeability, electrical resistance and tissue morphology. Int J Pharm 76:25-35.
21. Hoogstraate AJ, Cullander C, Nagelkerke JF, Spies F, Verhoef J, Schrijvers GJ, Junginger HE, Boddé HE. 1996. A novel in-situ model for continuous observation of transient drug concentration gradients across buccal epithelium at the microscopical level. J Control Release 39:71-78.
22. Reid CO, Hardcastle J, Smith CJ. 1986. A comparison of some of the permeability characteristics of intact and tape-stripped hamster cheek pouches in vitro. J Dent Res 65:673-676.
23. Tavakoli-Saberi MR, Audus KL. 1989. Cultured buccal epithelium: An in vitro model derived from the hamster pouch for studying drug transport and metabolism. Pharm Res 6:160-166.
24. De Vries ME, Bodde HE, Junginger HE. 1990. Procced Intern Symp Controlled Release Bioact Material, pp 295-296.
25. Artusi M, Santi P, Colombo P, Junginger HE. 2003. Buccal delivery of thiocolchicoside: In vitro and in vivo permeation studies. Int J Pharm 250:203-213.
26. Langoth N, Kalbe J, Bernkop-Schnurch A. 2005. Development of a mucoadhesive and permeation enhancing buccal delivery system for PACAP (pituitary adenylate cyclase-activating polypeptide). Int J Pharm 296:103-111.
27. Hoogstraate AJ, Senel S, Cullander C, Verhoef J, Junginger HE, Bodde HE. 1996. Effects of bile salts on transport rates and routes of FITC-labelled compounds across porcine buccal epithelium in vitro. J Control Release 40:211-221.
28. Hoogstraate AJ, Wertz PW, Squier CA, Geest BG, Abraham W, Garrison MD, Verhoef JC, Junginger HE, Boddé HE. 1997. Effects of the penetration enhancer glycodeoxycholate on the lipid integrity in porcine buccal epithelium in vitro. Eur J Pharm Sci 5:189-198.
29. Junginger HE, Hoogstraate JA, Verhoef JC. 1999. Recent advances in buccal drug delivery and absorption - In vitro and in vivo studies. J Control Release 62:149-159.
30. Mashru RC, Sutariya VB, Sankalia MG, Sankalia JM. 2005. Effect of pH on in vitro permeation of ondansetron hydrochloride across porcine buccal mucosa. Pharm Dev Technol 10:241-247.
31. Senel S, Hoogstraate AJ, Spies F, Verhoef JC, Bos-van GA, Junginger HE, Boddé HE. 1994. Enhancement of in vitro permeability of porcine buccal mucosa by bile salts: Kinetic and histological studies. J Control Release 32:45-56.
32. Hoogstraate AJ, Cullander C, Nagelkerke JF, Senel S, Verhoef JC, Junginger HE, Bodde HE. 1994. Diffusion rates and transport pathways of fluorescein isothiocyanate (FITC)-labeled model compounds through buccal epithelium. Pharm Res 11:83-89.
33. Senel S, Duchene D, Hincal AA, Capan Y, Ponchel G. 1998. In vitro studies on enhancing effect of sodium glycocholate on transbuccal permeation of morphine hydrochloride. J Control Release 51:107-113.
34. Mashru R, Sutariya V, Sankalia M, Sankalia J. 2005. Transbuccal delivery of lamotrigine across porcine buccal mucosa: In vitro determination of routes of buccal transport. J Pharm Pharm Sci 8:54-62.
35. Senel S, Hoogstraate AJ, Spies F, Verhoef JC, Junginger HE, Bodde HE. 1993. Visualization of enhancing effects of bile salts on buccal penetration. Eur J Morphol 31:35-41.
36. Senel S, Capan Y, Sargon MF, Kinci G, Olpan D, Güven O, Boddé HE, Hincal AA. 1997. Enhancement of transbuccal permeation of morphine sulfate by sodium glycodeoxycholate in vitro. J Control Release 45:153-162.
37. Diaz Del Consuelo I, Pizzolato GP, Falson F, Guy RH, Jacques Y. 2005. Evaluation of pig esophageal mucosa as a permeability barrier model for buccal tissue. J Pharm Sci 94:2777-2788.
38. Nielsen HM, Rassing MR. 2002. Nicotine permeability across the buccal TR146 cell culture model and porcine buccal mucosa in vitro: Effect of pH and concentration. Eur J Pharm Sci 16:151-157.
39. Ceschel GC, Maffei P, Sforzini A, Lombardi Borgia S, Yasin A, Ronchi C. 2002. In vitro permeation through porcine buccal mucosa of caffeic acid phenetyl ester (CAPE) from a topical mucoadhesive gel containing propolis. Fitoterapia 73:S44-S52.
40. Ceschel GC, Maffei P, Moretti MD, Demontis S, Peana AT. 2000. In vitro permeation through porcine buccal mucosa of Salvia desoleana Atzei & Picci essential oil from topical formulations. Int J Pharm 195:171-177.
41. Veuillez F, Rieg FF, Guy RH, Deshusses J, Buri P. 2002. Permeation of a myristoylated dipeptide across the buccal mucosa: Topological distribution and evaluation of tissue integrity. Int J Pharm 231:1-9.
42. Birudaraj R, Berner B, Shen S, Li X. 2005. Buccal permeation of buspirone: Mechanistic studies on transport pathways. J Pharm Sci 94:70-78.
43. Nicolazzo JA, Reed BL, Finnin BC. 2004. Assessment of the effects of sodium dodecyl sulfate on the buccal permeability of caffeine and estradiol. J Pharm Sci 93:431-440.
44. Nicolazzo JA, Reed BL, Finnin BC. 2003. The effect of various in vitro conditions on the permeability characteristics of the buccal mucosa. J Pharm Sci 92:2399-2410.