Mechanism of antibacterial action of dermaseptin B2: Interplay between helix - Hinge - Helix structure and membrane curvature strain

Biochemistry

Volumn 48, Issue 2, 2009, Pages 313-327

  Galanth, Cécile ^a   Abbassi, Feten ^a   Lequin, Olivier ^b   Ayala Sanmartin, Jésus ^c   Ladram, Ali ^a   Nicolas, Pierre ^a   Amiche, Mohamed ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b Centre National de la Recherche Scientifique   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIONIC LIPIDS; ANIONIC PHOSPHOLIPIDS; ANTI-BACTERIAL ACTIVITIES; ANTI-MICROBIAL PEPTIDES; ANTIBACTERIAL ACTIONS; BI LAYERS; BILAYER SURFACES; BINARY LIPID MIXTURES; BROAD SPECTRUMS; CATIONIC CHARGES; CIRCULAR DICHROISMS; GLYCEROL BACKBONES; HEAD GROUPS; HELICAL STRUCTURES; HELIX STRUCTURES; HYDROCARBON CORES; HYDROPHOBIC CORES; HYDROPHOBIC RESIDUES; INTERFACIAL LOCATIONS; LIPID ACYL-CHAINS; LIVING CELLS; MECHANISM OF ACTIONS; MEMBRANE CURVATURES; MEMBRANE PERMEABILIZATION; MULTILAMELLAR; NMR SPECTROSCOPIES; NMR STUDIES; PHOSPHOLIPID VESICLES; POLAR HEAD GROUPS; SDS MICELLES; THRESHOLD NUMBERS; UNILAMELLAR; WATER INTERFACES;

AMINES; ASSAYS; BACTERIA; BACTERIOLOGY; BINARY MIXTURES; BIOCHEMISTRY; CIRCULAR DICHROISM SPECTROSCOPY; DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; DIFFUSERS (OPTICAL); DYES; GLYCEROL; HYDROCARBONS; HYDROPHOBICITY; LIPID BILAYERS; LIPOSOMES; MICELLES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPIDS; SUGAR (SUCROSE);

MEMBRANES;

DERMASEPTIN; DERMASEPTIN B2; DODECYL SULFATE SODIUM; GLYCEROL; GLYCINE; HYDROCARBON; MELITTIN; PHOSPHOLIPID; UNCLASSIFIED DRUG; VALINE; WATER; AMPHIBIAN PROTEIN; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; PEPTIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS MEGATERIUM; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG MECHANISM; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; HYDROPHOBICITY; LIPID BILAYER; LIPID VESICLE; MICELLE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PSEUDOMONAS AERUGINOSA; RAT; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS HAEMOLYTICUS; STRUCTURE ACTIVITY RELATION; BIOASSAY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; ISOLATION AND PURIFICATION; MEMBRANE; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; SPECTROFLUOROMETRY; SYNTHESIS;

BACTERIA (MICROORGANISMS); FUNGI; PROTOZOA;

AMINO ACID SEQUENCE; AMPHIBIAN PROTEINS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL ASSAY; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HYDROCARBONS; LIPID BILAYERS; MEMBRANES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; WATER;

EID: 59849092098     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802025a     Document Type: Article

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