Editorial: A closer look at mucosal inflammation in irritable bowel syndrome: Sex- and gender-related disparities - Quantity, quality, or both?

American Journal of Gastroenterology

Volumn 104, Issue 2, 2009, Pages 401-403

  Alonso, Carmen ^a   Santos, Javier ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; THYMIC STROMAL LYMPHOPOIETIN; TRANSFORMING GROWTH FACTOR BETA; TRYPTASE; TUMOR NECROSIS FACTOR ALPHA;

CELL SPECIFICITY; COLON BIOPSY; COLON MUCOSA; CYTOKINE RELEASE; DIARRHEA; ENDOSCOPIC BIOPSY; GASTROINTESTINAL SYMPTOM; HISTOPATHOLOGY; HUMAN; IMMUNE SYSTEM; INFLAMMATION; IRRITABLE COLON; LYMPHOCYTIC INFILTRATION; MAST CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; SOCIOECONOMICS; T LYMPHOCYTE; FEMALE; HEALTH DISPARITY; IMMUNOLOGY; INTESTINE MUCOSA; MALE; NOTE; PATHOLOGY; RISK FACTOR;

FEMALE; HEALTH STATUS DISPARITIES; HUMANS; INTESTINAL MUCOSA; IRRITABLE BOWEL SYNDROME; MALE; RISK FACTORS; SEX FACTORS;

EID: 59749106499     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2008.105     Document Type: Review

References (38)

1. Cremonini F, Talley NJ. Irritable bowel syndrome: epidemiology, natural history, health care seeking and emerging risk factors. Gastroenterol Clin N Am 2005;34:189-204.
2. Maxion-Bergemann S, Thielecke F, Abel F et al. Costs of irritable bowel syndrome in the UK and US. Pharmacoeconomics 2006;24:21-37.
3. Wood JD. Neuropathophysiology of functional gastrointestinal disorders. World J Gastroenterol 2007;13:113-32.
4. Wizemann TM, Pardue ML (eds). Exploring the Biological Contributions to Human Health - Does Sex Matter? Institute of Medicine, Committee on Understanding the Biology of Sex and Gender Differences. Board on Health Sciences Policy. National Academies Press: Washington, DC, 2001, 288p.
5. Saito YA, Talley NJ. Genetics of irritable bowel syndrome. Am J Gastroenterol 2008;103:2100-4.
6. Naliboff BD, Berman S, Chang L et al. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology 2003;124:1738-47.
7. Chang L, Mayer EA, Labus JS et al. Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome. Am J Physiol Regul Integr Comp Physiol 2006;291:R277-84.
8. Greenspan JD, Craft RM, LeResche L et al. Studying sex and gender differences in pain and analgesia: a consensus report. Pain 2007;132 :S26-45.
9. Tillisch K, Mayer EA, Labus JS et al. Sex specific alterations in autonomic function among patients with irritable bowel syndrome. Gut 2005;54 :1396-401.
10. Kajantie E, Phillips DIW. The effects of sex and hormonal status on the physiological response to acute psychosocial stress. Psychoneuroendocrinology 2006;31:151-78.
11. Houghton LA, Lea R, Jackson N et al. The menstrual cycle affects rectal sensitivity in patients with irritable bowel syndrome but not healthy volunteers. Gut 2002;50:471-4.
12. Ouyang A, Wrzos HF. Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women? Am J Gastroenterol 2006;101:S602-9.
13. Chang L, Toner BB, Fukudo S et al. Gender, age, society, culture, and the patient's perspective in the functional gastrointestinal disorders. Gastroenterology 2006;130:1435-46.
14. Talley NJ, Spiller R. Irritable bowel syndrome: a little understood organic bowel disease? Lancet 2002;360:555-64.
15. Medzhitov R. Origin and physiological roles of inflammation. Nature 2008;454:428-35.
16. Gwee KA, Leong YL, Graham C et al. The role of psychological and biological factors in postinfective gut dysfunction. Gut 1999;44:400-6.
17. Spence MJ, Moss-Morris R. The cognitive behavioural model of irritable bowel syndrome: a prospective investigation of gastroenteritis patients. Gut 2007;56:1066-71.
18. Cremon C, Gargano L, Morselli-Labate AM et al. Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. Am J Gastroenterol 2009;104:392-400 (this issue).
19. Kirsch R, Riddell RH. Histopathological alterations in irritable bowel syndrome. Mod Pathol 2006;19:1638-45.
20. Barbara G, Stanghellini V, De Giorgio R et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004;126:693-702.
21. Guilarte M, Santos J, de Torres I e t al. Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 2007;56:203-9.
22. Spiller RC, Jenkins D, Thornley JP et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000;47:804-11.
23. Chadwick VS, Chen W, Shu D et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002;122:1778-83.
24. Weston AP, Biddle WL, Bhatia PS et al. Terminal ileal mucosal mast cells in irritable bowel syndrome. Dig Dis Sci 1993;38:1590-5.
25. Wang LH, Fang XC, Pan GZ. Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis. Gut 2004;53:1096-101.
26. Forshammar J, Isaksson S, Strid H et al. A pilot study of colonic B cell pattern in irritable bowel syndrome. Scand J Gastroenterol 2008;29:1-6.
27. O'Mahony L, McCarthy J, Kelly P et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005;128:541-51.
28. Liebregts T, Adam B, Bredack C et al. Immune activation in patients with irritable bowel syndrome. Gastroenterology 2007;132:913-20.
29. Rimoldi M, Chieppa M, Salucci V. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol 2005;6:507-14.
30. Aerssens J, Camilleri M, Talloen W et al. Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2008;6:194-205.
31. Ramos L, Martínez M, Alonso C et al. Long-term mast cell stabilization downregulates mucosal microinflammation in the jejunum of diarrhea-prone irritable bowel syndrome (IBS). Gastroenterology 2007;132(Suppl 29):A325.
32. Santos J, Benjamin M, Yang PC et al. Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells. Am J Physiol Gastrointest Liver Physiol 2000;278:G847-54.
33. Federman DD. The biology of human sex differences. N Engl J Med 2006;354:1507-14.
34. Bird MD, Karavitis J, Kovacs EJ. Sex differences and estrogen modulation of the cellular immune response after injury. Cell Immunol 2008;252 :57-67.
35. Alonso C, Guilarte M, Vicario M et al. Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation. Gastroenterology 2008;135:163-72.
36. Soderholm JD, Perdue MH. Stress and gastrointestinal tract. II. Stress and intestinal barrier function. Am J Physiol Gastrointest Liver Physiol 2001;280:G7-13.
37. Cenac N, Andrews CN, Holzhausen M et al. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 2007;117:636-47.
38. Barbara G, Wang B, Stanghellini V e t al. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 2007;132:26-37.