The biology of human sex differences

New England Journal of Medicine

Volumn 354, Issue 14, 2006, Pages 1507-1514

  Federman, Daniel D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTROGEN; SEX HORMONE;

BIOSYNTHESIS; FERTILITY; GENETIC DIFFERENCE; HORMONE ACTION; HORMONE BINDING; HORMONE STRUCTURE; HORMONE TRANSPORT; HUMAN; PRIORITY JOURNAL; REPRODUCTION; REVIEW; SEX DIFFERENCE; SOCIOECONOMICS; X CHROMOSOME; Y CHROMOSOME;

CHROMOSOMES, HUMAN, X; CHROMOSOMES, HUMAN, Y; FEMALE; FERTILITY; GENE SILENCING; GENOMIC IMPRINTING; GONADAL STEROID HORMONES; HUMANS; MALE; PREJUDICE; SEX CHARACTERISTICS; SOCIOECONOMIC FACTORS;

EID: 33645533945     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMra052529     Document Type: Review

References (31)

1. Wizemann TM, Pardue M, eds. Exploring the biological contributions to human health: does sex matter? Washington, D.C.: National Academies Press, 2001.
2. Bulun SE, Adashi EY. The physiology and pathology of the female reproductive axis. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, eds. Williams textbook of endocrinology. 10th ed. Philadelphia: W.B. Saunders, 2003:587-664.
3. Morita Y, Tilly JL. Oocyte apoptosis: like sand through an hourglass. Dev Biol 1999;213:1-17.
4. Bianchi DW. Fetomaternal cell trafficking: a new cause of disease? Am J Med Genet 2000;91:22-8.
5. Griffin JE, Wilson JD. Disorders of the testes and the male reproductive tract. In: Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, eds. Williams textbook of endocrinology. 10th ed. Philadelphia: W.B. Saunders, 2003:709-69.
6. Simpson ER, Mahendroo MS, Means GD, et al. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 1994;15:342-55.
7. Bulun SE. Aromatase deficiency in women and men: would you have predicted the phenotypes? J Clin Endocrinol Metab 1996;81:867-71.
8. Fortunati N. Sex hormone-binding globulin: not only a transport protein. What news is around the corner? J Endocrinol Invest 1999;22:223-34.
9. Sebastian S, Bulun SE. A highly complex organization of the regulatory region of the human CYP19 (aromatase) gene revealed by the Human Genome Project. J Clin Endocrinol Metab 2001;86: 4600-2.
10. Labrie F, Luu-The V, Lin SX, Simard J, Labrie C. Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral lutracrine tissues. Trends Endocrinol Metab 2000;11:421-7.
11. Smith EP, Boyd J, Frank GR, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994;331:1056-61. [Erratum, N Engl J Med 1995;332:131.]
12. Grumbach MM, Auchus RJ. Estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab 1999;84:4677-94.
13. Heinlein CA, Chang C. Androgen receptor (AR) coregulators: an overview. Endocr Rev 2002;23:175-200.
14. Couse JF, Hewitt SC, Bunch DO, et al. Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 1999;286:2328-31.
15. Wilson JD, Griffin JE, Russell DW. Steroid 5 alpha-reductase 2 deficiency. Endocr Rev 1993;14:577-93.
16. Takimoto GS, Graham JD, Jackson TA, et al. Tamoxifen resistant breast cancer: coregulators determine the direction of transcription by antagonist-occupied steroid receptors. J Steroid Biochem Mol Biol 1999;69:45-50.
17. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999;340:1801-11.
18. Eriksen EF, Colvard DS, Berg NJ, et al. Evidence of estrogen receptors in normal human osteoblast-like cells. Science 1988;241:84-6.
19. Vermeulen A. Andropause. Maturitas 2000;34:5-15.
20. Willard HF. The sex chromosomes and X chromosome inactivation. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill, 2001:1191-211.
21. Brown CJ. Equality of the sexes: mammalian dosage compensation. Semin Reprod Med 2001;19:125-32.
22. Wutz A, Jaenisch R. A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell 2000;5:695-705.
23. Carrel L, Willard HF. X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 2005;434:400-4.
24. Ross MT, Grafham DV, Coffey AJ, et al. The DNA sequence of the human X chromosome. Nature 2005;434:325-37.
25. Page DC. 2003 Curt Stern Award address: on low expectation exceeded; or, the genomic salvation of the Y chromosome. Am J Hum Genet 2004;74:399-402.
26. Koopman P. The genetics and biology of vertebrate sex determination. Cell 2001;105:843-7.
27. Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 2003;423:825-37.
28. Tilghman SM. The sins of the fathers and mothers: genomic imprinting in mammalian development. Cell 1999;96:185-93.
29. Knoll JH, Nicholls RD, Magenis RE, Graham JM Jr, Lalande M, Latt SA. Angelman and Prader-Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion. Am J Med Genet 1989;32:285-90.
30. Kantor B, Makedonski K, Green-Finberg Y, Shemer R, Razin A. Control elements within the PWS/AS imprinting box and their function in the imprinting process. Hum Mol Genet 2004;13:751-62.
31. Cann RL, Stoneking M, Wilson AC. Mitochondrial DNA and human evolution. Nature 1987;325:31-6.