Distribution of Foxp3+ T-regulatory cells in experimental autoimmune neuritis rats

Experimental Neurology

Volumn 216, Issue 1, 2009, Pages 75-82

  Zhang, Zhiren ^a   Zhang, Zhi Yuan ^a   Fauser, Uwe ^a   Schluesener, Hermann J ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

EAN, Foxp3; Sphingosine 1 phosphate receptor, FTY720; T regulatory cells

Indexed keywords

FINGOLIMOD; SPHINGOSINE 1 PHOSPHATE RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXPERIMENTAL AUTOIMMUNE NEURITIS; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IMMUNOPATHOGENESIS; LYMPH NODE; MALE; NEURITIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REGULATORY T LYMPHOCYTE; SCIATIC NERVE; SPLEEN;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FORKHEAD TRANSCRIPTION FACTORS; IMMUNITY, CELLULAR; IMMUNOSUPPRESSIVE AGENTS; LYMPH NODES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; LYMPHOID TISSUE; MALE; NEURITIS, AUTOIMMUNE, EXPERIMENTAL; POLYRADICULONEUROPATHY; PROPYLENE GLYCOLS; RATS; RATS, INBRED LEW; SCIATIC NERVE; SPHINGOSINE; SPLEEN; T-LYMPHOCYTES, REGULATORY;

EID: 59749086849     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.11.014     Document Type: Article

References (33)

1. Akbar A.N., Vukmanovic-Stejic M., Taams L.S., and Macallan D.C. The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nat. Rev., Immunol. 7 (2007) 231-237
2. Bluestone J.A., and Abbas A.K. Natural versus adaptive regulatory T cells. Nat. Rev., Immunol. 3 (2003) 253-257
3. Chiba K., Matsuyuki H., Maeda Y., and Sugahara K. Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell. Mol. Immunol. 3 (2006) 11-19
4. Daniel C., Sartory N., Zahn N., Geisslinger G., Radeke H.H., and Stein J.M. FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells. J. Immunol. 178 (2007) 2458-2468
5. Fontenot J.D., and Rudensky A.Y. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6 (2005) 331-337
6. Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4 (2003) 330-336
7. Gavin M.A., Rasmussen J.P., Fontenot J.D., Vasta V., Manganiello V.C., Beavo J.A., and Rudensky A.Y. Foxp3-dependent programme of regulatory T-cell differentiation. Nature 445 (2007) 771-775
8. Gillen C., Jander S., and Stoll G. Sequential expression of mRNA for proinflammatory cytokines and interleukin-10 in the rat peripheral nervous system: comparison between immune-mediated demyelination and Wallerian degeneration. J. Neurosci. Res. 51 (1998) 489-496
9. Gold R., Hartung H.P., and Toyka K.V. Animal models for autoimmune demyelinating disorders of the nervous system. Mol Med Today 6 (2000) 88-91
10. Jordan M.S., Boesteanu A., Reed A.J., Petrone A.L., Holenbeck A.E., Lerman M.A., Naji A., and Caton A.J. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2 (2001) 301-306
11. Kiefer R., Funa K., Schweitzer T., Jung S., Bourde O., Toyka K.V., and Hartung H.P. Transforming growth factor-beta 1 in experimental autoimmune neuritis. Cellular localization and time course. Am. J. Pathol. 148 (1996) 211-223
12. Kim C.H. Trafficking of FoxP3+ regulatory T cells: myths and facts. Arch. Immunol. Ther. Exp. (Warsz) 55 (2007) 151-159
13. Korn T., Anderson A.C., Bettelli E., and Oukka M. The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis. J. Neuroimmunol. 191 (2007) 51-60
14. Li B., and Greene M.I. Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells-how diverse signals regulate suppression. Immunology 123 (2008) 17-19
15. O'Connor R.A., and Anderton S.M. Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease. J. Neuroimmunol. 193 (2008) 1-11
16. Rosen H., Sanna M.G., Cahalan S.M., and Gonzalez-Cabrera P.J. Tipping the gatekeeper: S1P regulation of endothelial barrier function. Trends Immunol. 28 (2007) 102-107
17. Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22 (2004) 531-562
18. Sakaguchi S., Ono M., Setoguchi R., Yagi H., Hori S., Fehervari Z., Shimizu J., Takahashi T., and Nomura T. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212 (2006) 8-27
19. Sakaguchi S., Yamaguchi T., Nomura T., and Ono M. Regulatory T cells and immune tolerance. Cell 133 (2008) 775-787
20. Sawicka E., Dubois G., Jarai G., Edwards M., Thomas M., Nicholls A., Albert R., Newson C., Brinkmann V., and Walker C. The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity. J. Immunol. 175 (2005) 7973-7980
21. Sehrawat S., and Rouse B.T. Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators. J. Immunol. 180 (2008) 7636-7647
22. Torgerson T.R. Regulatory T cells in human autoimmune diseases. Springer Semin. Immunopathol. 28 (2006) 63-76
23. Valencia X., and Lipsky P.E. CD4+CD25+FoxP3+ regulatory T cells in autoimmune diseases. Nat. Clin. Pract. Rheumatol. 3 (2007) 619-626
24. Vignali D.A., Collison L.W., and Workman C.J. How regulatory T cells work. Nat. Rev., Immunol. 8 (2008) 523-532
25. von Wenckstern H., Zimmermann K., and Kleuser B. The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. Arch. Immunol. Ther. Exp. (Warsz) 54 (2006) 239-251
26. Wei S., Kryczek I., and Zou W. Regulatory T-cell compartmentalization and trafficking. Blood 108 (2006) 426-431
27. Zettl U.K., Gold R., Hartung H.P., and Toyka K.V. Apoptotic cell death of T-lymphocytes in experimental autoimmune neuritis of the Lewis rat. Neurosci. Lett. 176 (1994) 75-79
28. Zhang Z., and Schluesener H.J. FTY720: a most promising immunosuppressant modulating immune cell functions. Mini Rev. Med. Chem. 7 (2007) 845-850
29. Zhang Z., Fauser U., and Schluesener H.J. Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis. J. Cell. Mol. Med. 11 (2007) 111-119
30. Zhang Z., Zhang Z.Y., Fauser U., and Schluesener H.J. FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves. Exp. Neurol. 210 (2008) 681-690
31. Zheng Y., and Rudensky A.Y. Foxp3 in control of the regulatory T cell lineage. Nat. Immunol. 8 (2007) 457-462
32. Zhu J., Bai X.F., Mix E., and Link H. Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin. Clin. Immunol. Immunopathol. 84 (1997) 85-94
33. Zhu J., Mix E., and Link H. Cytokine production and the pathogenesis of experimental autoimmune neuritis and Guillain-Barre syndrome. J. Neuroimmunol. 84 (1998) 40-52