Contribution of globular death domains and unstructured linkers to MyD88·IRAK-4 heterodimer formation: An explanation for the antagonistic activity of MyD88s

Biochemical and Biophysical Research Communications

Volumn 380, Issue 1, 2009, Pages 183-187

  Mendoza Barberá, Elena ^a,b   Corral Rodríguez, María Ángeles ^a   Soares Schanoski, Alessandra ^b   Velarde, Milko ^c   Macieira, Sofia ^c   Messerschmidt, Albrecht ^c   López Collazo, Eduardo ^b   Fuentes Prior, Pablo ^a  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Death domain; IRAK; Monocytes macrophages; MyD88; Toll like receptor

Indexed keywords

GLUTAMIC ACID; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MYELOID DIFFERENTIATION FACTOR 88;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; DIMERIZATION; GLUTAMIC ACID; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

EID: 59649121759     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.01.069     Document Type: Article

References (30)

1. Visintin A., Latz E., Monks B.G., Espevik T., and Golenbock D.T. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J. Biol. Chem. 278 (2003) 48313-48320
2. Akira S., and Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4 (2004) 499-511
3. Wesche H., Henzel W.J., Shillinglaw W., Li S., and Cao Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7 (1997) 837-847
4. Janssens S., and Beyaert R. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell 11 (2003) 293-302
5. Silverman N., and Maniatis T. NF-{kappa}B signaling pathways in mammalian and insect innate immunity. Genes Dev. 15 (2001) 2321-2342
6. Park H.H., Lo Y.C., Lin S.C., Wang L., Yang J.K., and Wu H. The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu. Rev. Immunol. 25 (2007) 561-586
7. Xiao T., Towb P., Wasserman S.A., and Sprang S.R. Three-dimensional structure of a complex between the death domains of Pelle and Tube. Cell 99 (1999) 545-555
8. Horng T., and Medzhitov R. Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc. Natl. Acad. Sci. USA 98 (2001) 12654-12658
9. Sun H., Bristow B.N., Qu G., and Wasserman S.A. A heterotrimeric death domain complex in Toll signaling. Proc. Natl. Acad. Sci. USA 99 (2002) 12871-12876
10. Li S., Strelow A., Fontana E.J., and Wesche H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. USA 99 (2002) 5567-5572
11. Burns K., Janssens S., Brissoni B., Olivos N., Beyaert R., and Tschopp J. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J. Exp. Med. 197 (2003) 263-268
12. Lye E., Mirtsos C., Suzuki N., Suzuki S., and Yeh W.-C. The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J. Biol. Chem. 279 (2004) 40653-40658
13. Kawagoe T., Sato S., Jung A., Yamamoto M., Matsui K., Kato H., Uematsu S., Takeuchi O., and Akira S. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J. Exp. Med. 204 (2007) 1013-1024
14. Kim T.W., Staschke K., Bulek K., Yao J., Peters K., Oh K.-H., Vandenburg Y., Xiao H., Qian W., Hamilton T., Min B., Sen G., Gilmour R., and Li X. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J. Exp. Med. 204 (2007) 1025-1036
15. Brikos C., Wait R., Begum S., O'Neill L.A.J., and Saklatvala J. Mass spectrometric analysis of the endogenous IL-1RI signalling complex formed after IL-1 binding, identifies IL-1RAcP, MyD88 and IRAK-4 as the stable components. Mol. Cell. Proteomics 6 (2007) 1551-1559
16. Janssens S., Burns K., Vercammen E., Tschopp J., and Beyaert R. MyD88s, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression. FEBS Lett. 548 (2003) 103-107
17. Janssens S., Burns K., Tschopp J., and Beyaert R. Regulation of interleukin-1- and lipopolysaccharide-induced NF-[kappa]B activation by alternative splicing of MyD88. Curr. Biol. 12 (2002) 467-471
18. Lasker M.V., Gajjar M.M., and Nair S.K. Molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling. J. Immunol. 175 (2005) 4175-4179
19. Armstrong N., de Lencastre A., and Gouaux E. A new protein folding screen: application to the ligand binding domains of a glutamate and kainate receptor and to lysozyme and carbonic anhydrase. Protein Sci. 8 (1999) 1475-1483
20. del Fresno C., Otero K., Gómez-García L., González-León M.C., Soler-Ranger L., Fuentes-Prior P., Escoll P., Baos R., Caveda L., García F., Arnalich F., and López-Collazo E. Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4. J. Immunol. 174 (2005) 3032-3040
21. Jaunin F., Burns K., Tschopp J., Martin T.E., and Fakan S. Ultrastructural distribution of the death-domain-containing MyD88 protein in HeLa cells. Exp. Cell Res. 243 (1998) 67-75
22. Kawai T., Sato S., Ishii K.J., Coban C., Hemmi H., Yamamoto M., Terai K., Matsuda M., Inoue J., Uematsu S., Takeuchi O., and Akira S. Interferon-[alpha] induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5 (2004) 1061-1068
23. Honda K., Ohba Y., Yanai H., Negishi H., Mizutani T., Takaoka A., Taya C., and Taniguchi T. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040
24. Kagan J.C., and Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125 (2006) 943-955
25. Nishiya T., Kajita E., Horinouchi T., Nishimoto A., and Miwa S. Distinct roles of TIR and non-TIR regions in the subcellular localization and signaling properties of MyD88. FEBS Lett. 581 (2007) 3223-3229
26. Burns K., Martinon F., Esslinger C., Pahl H., Schneider P., Bodmer J.-L., Di Marco F., French L., and Tschopp J. MyD88, an adapter protein involved in interleukin-1 signaling. J. Biol. Chem. 273 (1998) 12203-12209
27. Hacker H., Redecke V., Blagoev B., Kratchmarova I., Hsu L.-C., Wang G.G., Kamps M.P., Raz E., Wagner H., Hacker G., Mann M., and Karin M. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439 (2006) 204-207
28. Jiang Z., Georgel P., Li C., Choe J., Crozat K., Rutschmann S., Du X., Bigby T., Mudd S., Sovath S., Wilson I.A., Olson A., and Beutler B. Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc. Natl. Acad. Sci. USA 103 (2006) 10961-10966
29. Park H.H., Logette E., Raunser S., Cuenin S., Walz T., Tschopp J., and Wu H. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 128 (2007) 533-546
30. Moncrieffe M.C., Grossmann J.G., and Gay N.J. Assembly of oligomeric death domain complexes during toll receptor signalling. J. Biol. Chem. 283 (2008) 33447-33454