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Volumn 44, Issue 4, 2008, Pages 535-548

Mucoadhesion studies in the gastrointestinal tract to increase oral drug bioavailability;Estudos de mucoadesão no trato gastrointestinal para o aumento da biodisponibilidade oral de fármacos

Author keywords

Drugs absortion; Drugs oral bioavailability; Gastrointestinal tract mucoadhesion study; Mucoadhesion in vitro and in vivo studies

Indexed keywords

COLON; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG RELEASE; GAMMA SCINTIGRAPHY; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TRACT; HUMAN; INTESTINE MOTILITY; MUCOADHESION; NONHUMAN; REVIEW;

EID: 59649114054     PISSN: 15169332     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1516-93322008000400002     Document Type: Review
Times cited : (8)

References (83)
  • 1
    • 0030606882 scopus 로고    scopus 로고
    • Gastro-intestinal transit of a multiple-unit formulation (metoprolol CR/ZOK) and a non-disintegrating tablet with the emphasis on colon
    • ABRAHAMSSON, B.; ALPSTEN, M.; JONSSON, U.E.; LUNDBERG, P.J.; SANDBERG, A.; SUNDGREN, M.; SVENHEDEN, A.; TOLLI, J. Gastro-intestinal transit of a multiple-unit formulation (metoprolol CR/ZOK) and a non-disintegrating tablet with the emphasis on colon. Int. J. Pharm., v.140, n.2, p.229-235, 1996.
    • (1996) Int. J. Pharm , vol.140 , Issue.2 , pp. 229-235
    • ABRAHAMSSON, B.1    ALPSTEN, M.2    JONSSON, U.E.3    LUNDBERG, P.J.4    SANDBERG, A.5    SUNDGREN, M.6    SVENHEDEN, A.7    TOLLI, J.8
  • 3
    • 0028083314 scopus 로고
    • Preparation, characterization and mucoadhesive interactions of poly(methacrylic acid) copolymers with rat mucosa
    • ACHAR, L.; PEPPAS, N.A. Preparation, characterization and mucoadhesive interactions of poly(methacrylic acid) copolymers with rat mucosa. J. Control. Release, v.31, p.271-276, 1994.
    • (1994) J. Control. Release , vol.31 , pp. 271-276
    • ACHAR, L.1    PEPPAS, N.A.2
  • 4
  • 5
    • 0030902837 scopus 로고    scopus 로고
    • Mucoadhesive drug delivery systems
    • AHUJA, A.; KHAR, R.K.; ALI, J. Mucoadhesive drug delivery systems. Drug Dev. Ind. Pharm., v.23, n.5, p.489-515, 1997.
    • (1997) Drug Dev. Ind. Pharm , vol.23 , Issue.5 , pp. 489-515
    • AHUJA, A.1    KHAR, R.K.2    ALI, J.3
  • 6
    • 0031890348 scopus 로고    scopus 로고
    • Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites
    • AKIYAMA, Y.; NAGAHARA, N.; NARA, E.; KITANO, M.; SUSUMU, I.; YAMAMOTO, I.; AZUMA, J.; OGAWA, Y. Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites. J. Pharm. Pharmacol., v.50, p.159-166, 1998.
    • (1998) J. Pharm. Pharmacol , vol.50 , pp. 159-166
    • AKIYAMA, Y.1    NAGAHARA, N.2    NARA, E.3    KITANO, M.4    SUSUMU, I.5    YAMAMOTO, I.6    AZUMA, J.7    OGAWA, Y.8
  • 7
    • 0035026232 scopus 로고    scopus 로고
    • The adherent gastrointestinal mucus gel layer: Thickness and physical state in vivo
    • ATUMA, C.; STRUGALA, V.; ALLEN, A.; HOLM, L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am. J. Physiol. Gastrointest. Liver Physiol., v.280, p.922-929, 2001.
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol , vol.280 , pp. 922-929
    • ATUMA, C.1    STRUGALA, V.2    ALLEN, A.3    HOLM, L.4
  • 8
    • 23444440934 scopus 로고    scopus 로고
    • Advances in colonic drug delivery
    • BASIT, A.W. Advances in colonic drug delivery. Drugs, v.65, n.14, p.1991-2007, 2005.
    • (2005) Drugs , vol.65 , Issue.14 , pp. 1991-2007
    • BASIT, A.W.1
  • 9
    • 16844379775 scopus 로고    scopus 로고
    • Bioadhesive dosage forms for esophageal drug delivery
    • BATCHELOR, H. Bioadhesive dosage forms for esophageal drug delivery. Pharm. Res., v.22, n.2, p.175-181, 2005.
    • (2005) Pharm. Res , vol.22 , Issue.2 , pp. 175-181
    • BATCHELOR, H.1
  • 10
    • 0037093735 scopus 로고    scopus 로고
    • An in vitro mucosal model for prediction of the bioadhesion of alginate solutions to the oesophagus
    • BATCHELOR, H.K.; BANNING, D.; DETTMAR, P.W.; HAMPSON, F.C.; JOLLIFFE, I.G.; CRAIG, D.Q.M. An in vitro mucosal model for prediction of the bioadhesion of alginate solutions to the oesophagus. Int. J. Pharm., v.238, p.123-132, 2002.
    • (2002) Int. J. Pharm , vol.238 , pp. 123-132
    • BATCHELOR, H.K.1    BANNING, D.2    DETTMAR, P.W.3    HAMPSON, F.C.4    JOLLIFFE, I.G.5    CRAIG, D.Q.M.6
  • 12
    • 0033955625 scopus 로고    scopus 로고
    • Synthesis and characterisation of mucoadhesive thiolated polymers
    • BERNKOP-SCHNURCH, A.; STEININGER, S. Synthesis and characterisation of mucoadhesive thiolated polymers. Int. J. Pharm., v.194, p.239-247, 2000.
    • (2000) Int. J. Pharm , vol.194 , pp. 239-247
    • BERNKOP-SCHNURCH, A.1    STEININGER, S.2
  • 13
    • 0033020555 scopus 로고    scopus 로고
    • Polymers with thiol groups: A new generation of mucoadhesive polymers?
    • BERNKOP SCHNURCH, A.; SCHWARZ, V.; STEININGER, S. Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm. Res., v.16, n.6, p.876-881, 1999.
    • (1999) Pharm. Res , vol.16 , Issue.6 , pp. 876-881
    • BERNKOP SCHNURCH, A.1    SCHWARZ, V.2    STEININGER, S.3
  • 14
    • 0021963276 scopus 로고
    • Bioadhesive polymers as platforms for oral controlled drug delivery II: Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers
    • CH'NG, H.S.; PARK, H.; KELLY, P.; ROBINSON, J.R. Bioadhesive polymers as platforms for oral controlled drug delivery II: Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J. Pharm. Sci., v.74, n.4, p.399-405, 1985.
    • (1985) J. Pharm. Sci , vol.74 , Issue.4 , pp. 399-405
    • CH'NG, H.S.1    PARK, H.2    KELLY, P.3    ROBINSON, J.R.4
  • 15
    • 0032944748 scopus 로고    scopus 로고
    • In vitro and in vivo adhesion testing of mucoadhesive drug delivery systems
    • CHARY, R.B.R.; VANI, G.; RAO, Y.M. In vitro and in vivo adhesion testing of mucoadhesive drug delivery systems. Drug Dev. Ind. Pharm., v.25, n.5, p.685-690, 1999.
    • (1999) Drug Dev. Ind. Pharm , vol.25 , Issue.5 , pp. 685-690
    • CHARY, R.B.R.1    VANI, G.2    RAO, Y.M.3
  • 16
    • 33750811176 scopus 로고    scopus 로고
    • Ex-vivo evaluation of alginate microparticles for Polymyxin B oral administration
    • COPPI, G.; SALA, N.; BONDI, M.; SERGI, S.; IANNUCCELLI, V. Ex-vivo evaluation of alginate microparticles for Polymyxin B oral administration. J. Drug Target., v.14, n.9, p.599-606, 2006.
    • (2006) J. Drug Target , vol.14 , Issue.9 , pp. 599-606
    • COPPI, G.1    SALA, N.2    BONDI, M.3    SERGI, S.4    IANNUCCELLI, V.5
  • 17
    • 0025734920 scopus 로고
    • Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects
    • COUPE, A.J.; DAVIS, S.S.; WILDING, I.R. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm. Res., v.8, n.3, p.360-364, 1991.
    • (1991) Pharm. Res , vol.8 , Issue.3 , pp. 360-364
    • COUPE, A.J.1    DAVIS, S.S.2    WILDING, I.R.3
  • 18
    • 13544252601 scopus 로고    scopus 로고
    • Formulation strategies for absorption windows
    • DAVIS, S.S. Formulation strategies for absorption windows Drug Discov. Today, v.10, n.4, p.249-257, 2005.
    • (2005) Drug Discov. Today , vol.10 , Issue.4 , pp. 249-257
    • DAVIS, S.S.1
  • 19
    • 0028837299 scopus 로고
    • Mucoadhesion of poly(2-hydroxyethyl methacrylate) is improved when linear poly(ethylene oxide) chains are added to the polymer network
    • DE ASCENTIIS, A.; DEGRAZIA, J.L.; BOWMAN, C.N.; COLOMBO, P.; PEPPAS, N.A. Mucoadhesion of poly(2-hydroxyethyl methacrylate) is improved when linear poly(ethylene oxide) chains are added to the polymer network. J. Control. Release, v.33, n.1, p.197-201, 1995.
    • (1995) J. Control. Release , vol.33 , Issue.1 , pp. 197-201
    • DE ASCENTIIS, A.1    DEGRAZIA, J.L.2    BOWMAN, C.N.3    COLOMBO, P.4    PEPPAS, N.A.5
  • 20
    • 0025042445 scopus 로고
    • The influence of density on the gastrointestinal transit of pellets
    • DEVEREUX, J.E.; NEWTON, J.M.; SHORT, M.B. The influence of density on the gastrointestinal transit of pellets. J. Pharm. Pharmacol., v.42, p.500-1, 1990.
    • (1990) J. Pharm. Pharmacol , vol.42 , pp. 500-501
    • DEVEREUX, J.E.1    NEWTON, J.M.2    SHORT, M.B.3
  • 21
    • 0032842524 scopus 로고    scopus 로고
    • Comparative mucoretention of sucralfate suspensions in an everted rat esophagus model
    • DOBROZSI, D.J.; SMITH, R.L.; SAKR, A.A. Comparative mucoretention of sucralfate suspensions in an everted rat esophagus model. Int. J. Pharm., v.189, p.81-89, 1999.
    • (1999) Int. J. Pharm , vol.189 , pp. 81-89
    • DOBROZSI, D.J.1    SMITH, R.L.2    SAKR, A.A.3
  • 22
    • 11144319352 scopus 로고    scopus 로고
    • Pharmaceutical applications of mucoadhesion for the non-oral routes
    • EDSMAN, K.; HÄGERSTRÖM, H. Pharmaceutical applications of mucoadhesion for the non-oral routes. J. Pharm. Pharmacol., v.57, p.3-22, 2005.
    • (2005) J. Pharm. Pharmacol , vol.57 , pp. 3-22
    • EDSMAN, K.1    HÄGERSTRÖM, H.2
  • 23
    • 0031563889 scopus 로고    scopus 로고
    • Physiology of the colorectal barrier
    • EDWARDS, C. Physiology of the colorectal barrier. Adv. Drug Deliv. Rev., v.28, n.2, p.173-190, 1997.
    • (1997) Adv. Drug Deliv. Rev , vol.28 , Issue.2 , pp. 173-190
    • EDWARDS, C.1
  • 24
    • 0026608368 scopus 로고
    • Biopharmaceutical comparison of oral multiple-unit and single-unit sustained-release dosage forms
    • FOLLONIER, N.; DOELKER, E. Biopharmaceutical comparison of oral multiple-unit and single-unit sustained-release dosage forms. S.T.P. Pharma Sci., v.2, p.141-158, 1992.
    • (1992) S.T.P. Pharma Sci , vol.2 , pp. 141-158
    • FOLLONIER, N.1    DOELKER, E.2
  • 25
    • 32644440948 scopus 로고    scopus 로고
    • Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats
    • GOTO, T.; MORISHITA, M.; KAVIMANDAN, N.J.; TAKAYAMA, K.; PEPPAS, N.A. Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats. J. Pharm. Sci., v.95, n.2, p.462-469, 2006.
    • (2006) J. Pharm. Sci , vol.95 , Issue.2 , pp. 462-469
    • GOTO, T.1    MORISHITA, M.2    KAVIMANDAN, N.J.3    TAKAYAMA, K.4    PEPPAS, N.A.5
  • 26
    • 26644434123 scopus 로고    scopus 로고
    • Comparison of the mucoadhesive properties of various polymers
    • GRABOVAC, V.; GUGGI, D.; BERNKOP-SCHNURCH, A. Comparison of the mucoadhesive properties of various polymers. Adv. Drug Deliv. Rev., v.57, p.1713-1723, 2005.
    • (2005) Adv. Drug Deliv. Rev , vol.57 , pp. 1713-1723
    • GRABOVAC, V.1    GUGGI, D.2    BERNKOP-SCHNURCH, A.3
  • 27
    • 59649090006 scopus 로고    scopus 로고
    • HAEBERLIN, B.; FRIEND, D.R. Anatomy and Physiology of the gastrointestinal tract: Implications for colonic drug delivery. In: Friend, D.R. eds. Oral colon-specific drug delivery. Boca Raton: CCR Press, 1992. cap.1, p.2-43.
    • HAEBERLIN, B.; FRIEND, D.R. Anatomy and Physiology of the gastrointestinal tract: Implications for colonic drug delivery. In: Friend, D.R. eds. Oral colon-specific drug delivery. Boca Raton: CCR Press, 1992. cap.1, p.2-43.
  • 28
    • 59649101600 scopus 로고    scopus 로고
    • HARDY, J.G. Colonic transit and drug delivery. In: Hardy, J.G., Davis, S.S., Wilson, C.G. eds. Drug delivery to the gastrointestinal tract. New York: Ellis Horwood, 1989. cap.6, p.75-81.
    • HARDY, J.G. Colonic transit and drug delivery. In: Hardy, J.G., Davis, S.S., Wilson, C.G. eds. Drug delivery to the gastrointestinal tract. New York: Ellis Horwood, 1989. cap.6, p.75-81.
  • 29
    • 0025320595 scopus 로고
    • GI transit of potential bioadhesive formulations in man: A scintigraphic study
    • HARRIS, D.; FELL, J.T.; SHARMA, H.L.; TAYLOR, D.C. GI transit of potential bioadhesive formulations in man: A scintigraphic study. J. Control. Release, v.12, p.45-53, 1990.
    • (1990) J. Control. Release , vol.12 , pp. 45-53
    • HARRIS, D.1    FELL, J.T.2    SHARMA, H.L.3    TAYLOR, D.C.4
  • 30
    • 33646802666 scopus 로고    scopus 로고
    • Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer
    • HAUPT, S.; ZIONI, T.; GATI, I.; KLEINSTERN, J.; RUBINSTEIN, A. Luminal delivery and dosing considerations of local celecoxib administration to colorectal cancer. Eur. J. Pharm. Sci., v.28, n.3, p.204-211, 2006.
    • (2006) Eur. J. Pharm. Sci , vol.28 , Issue.3 , pp. 204-211
    • HAUPT, S.1    ZIONI, T.2    GATI, I.3    KLEINSTERN, J.4    RUBINSTEIN, A.5
  • 31
    • 0030573069 scopus 로고    scopus 로고
    • Bioadhesion of hydrated chitosans: An in vitro and in vivo study
    • HENRIKSEN, I.; GREEN, K.L.; SMART, J.D.; SMISTAD, G.; KARLSEN, J. Bioadhesion of hydrated chitosans: An in vitro and in vivo study. Int. J. Pharm., v.145, n.1-2, p.231-240, 1996.
    • (1996) Int. J. Pharm , vol.145 , Issue.1-2 , pp. 231-240
    • HENRIKSEN, I.1    GREEN, K.L.2    SMART, J.D.3    SMISTAD, G.4    KARLSEN, J.5
  • 32
    • 0030003078 scopus 로고    scopus 로고
    • Formulation and comparative evaluation of bioadhesive containing diclofenac sodium and commercial enteric coated tablets in-vitro and in dogs
    • HOSNY, E.A. Formulation and comparative evaluation of bioadhesive containing diclofenac sodium and commercial enteric coated tablets in-vitro and in dogs. Int. J. Pharm., v.133, n.1-2, p.149-153, 1996.
    • (1996) Int. J. Pharm , vol.133 , Issue.1-2 , pp. 149-153
    • HOSNY, E.A.1
  • 33
    • 0034892282 scopus 로고    scopus 로고
    • In vitro assessment of the mucoadhesion of cholestyramine to porcine and human gastric mucosa
    • JACKSON, S.J.; PERKINS, A.C. In vitro assessment of the mucoadhesion of cholestyramine to porcine and human gastric mucosa. Eur. J. Pharm. Biopharm., v.52, p.121-127, 2001.
    • (2001) Eur. J. Pharm. Biopharm , vol.52 , pp. 121-127
    • JACKSON, S.J.1    PERKINS, A.C.2
  • 34
    • 0031782537 scopus 로고    scopus 로고
    • Azocrosslinked poly(acrylic acid) for colonic delivery and adhesion specificity: In vitro degradation and preliminary ex vivo bioadhesion studies
    • KAKOULIDES, E.P.; SMART, J.D.; TSIBOUKLIS, J. Azocrosslinked poly(acrylic acid) for colonic delivery and adhesion specificity: in vitro degradation and preliminary ex vivo bioadhesion studies. J. Control. Release, v.54, n.1, p.95-109, 1998.
    • (1998) J. Control. Release , vol.54 , Issue.1 , pp. 95-109
    • KAKOULIDES, E.P.1    SMART, J.D.2    TSIBOUKLIS, J.3
  • 35
    • 17644385834 scopus 로고    scopus 로고
    • In vitro and ex vivo intestinal tissue models to measure mucoadhesion of Poly(methacrylate) and N-Trimethylated chitosan polymers
    • KEELY, S.; RULLAY, A.; WILSON, C.; CARMICHAEL, A.; CARRINGTON, S.; CORFIELD, A.; HADDLETON, D.M.; BRAYDEN, D.J. In vitro and ex vivo intestinal tissue models to measure mucoadhesion of Poly(methacrylate) and N-Trimethylated chitosan polymers. Pharm. Res., v.22, n.1, p.38-49, 2005.
    • (2005) Pharm. Res , vol.22 , Issue.1 , pp. 38-49
    • KEELY, S.1    RULLAY, A.2    WILSON, C.3    CARMICHAEL, A.4    CARRINGTON, S.5    CORFIELD, A.6    HADDLETON, D.M.7    BRAYDEN, D.J.8
  • 36
    • 84868880023 scopus 로고    scopus 로고
    • KENDALL, R.A.; BASIT, A.W. The role of polymers in solid oral dosage forms. In: UCHEGBU, I.F., SCHÄTZLEIN, A.G. Eds. Polymers in drug delivery. Boca Raton: Taylor and Francis, 2006. cap.6, p.35-48.
    • KENDALL, R.A.; BASIT, A.W. The role of polymers in solid oral dosage forms. In: UCHEGBU, I.F., SCHÄTZLEIN, A.G. Eds. Polymers in drug delivery. Boca Raton: Taylor and Francis, 2006. cap.6, p.35-48.
  • 37
    • 0023119830 scopus 로고
    • The effect of polycarbophil on the gastric emptying of pellets
    • KHOSLA, R.; DAVIS, S.S. The effect of polycarbophil on the gastric emptying of pellets. J. Pharm. Pharmacol., v.39, p.47-49, 1987.
    • (1987) J. Pharm. Pharmacol , vol.39 , pp. 47-49
    • KHOSLA, R.1    DAVIS, S.S.2
  • 38
    • 33750926464 scopus 로고    scopus 로고
    • In vivo evaluation of a nasal insulin delivery system based on thiolated chitosan
    • KRAULAND, A.H.; LEITNER, V.M.; GRABOVAC, V.; BERNKOP SCHNURCH, A. In vivo evaluation of a nasal insulin delivery system based on thiolated chitosan. J. Pharm. Sci., v.95, n.11, p.2463-2472, 2006.
    • (2006) J. Pharm. Sci , vol.95 , Issue.11 , pp. 2463-2472
    • KRAULAND, A.H.1    LEITNER, V.M.2    GRABOVAC, V.3    BERNKOP SCHNURCH, A.4
  • 39
    • 0033813758 scopus 로고    scopus 로고
    • Bioadhesive-based dosage forms: The next generation
    • LEE, J.W.; PARK, J.H.; ROBINSON, J.R. Bioadhesive-based dosage forms: The next generation. J. Pharm. Sci., v.89, p.850-866, 2000.
    • (2000) J. Pharm. Sci , vol.89 , pp. 850-866
    • LEE, J.W.1    PARK, J.H.2    ROBINSON, J.R.3
  • 40
    • 0030037291 scopus 로고    scopus 로고
    • From sticky stuff to sweet receptors - achievements, limits and novel approaches to bioadhesion
    • LEHR, C.-M. From sticky stuff to sweet receptors - achievements, limits and novel approaches to bioadhesion. Eur. J. Drug Metab. Pharmacokinet., v.21, n.2, p.139-148, 1996.
    • (1996) Eur. J. Drug Metab. Pharmacokinet , vol.21 , Issue.2 , pp. 139-148
    • LEHR, C.-M.1
  • 41
    • 0026800237 scopus 로고
    • in vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
    • LEHR, C.-M.; BOUWSTRA, J.A.; SCHACHT, E.H.; JUNGINGER, H.E. in vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm., v.78, p.43-48, 1992.
    • (1992) Int. J. Pharm , vol.78 , pp. 43-48
    • LEHR, C.-M.1    BOUWSTRA, J.A.2    SCHACHT, E.H.3    JUNGINGER, H.E.4
  • 42
    • 0025301733 scopus 로고
    • Intestinal transit of bioadhesive microspheres in an in situ loop in the rat - A comparative study with copolymers and blends based on poly(acrylic acid)
    • LEHR, C.-M.; BOUWSTRA, J.A.; TUKKER, J.J.; JUNGINGER, H.E. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat - A comparative study with copolymers and blends based on poly(acrylic acid). J. Control. Release, v.13, p.51-62, 1990.
    • (1990) J. Control. Release , vol.13 , pp. 51-62
    • LEHR, C.-M.1    BOUWSTRA, J.A.2    TUKKER, J.J.3    JUNGINGER, H.E.4
  • 43
    • 0025846959 scopus 로고
    • An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop
    • LEHR, C.-M.; POELMA, F.G.J.; JUNGINGER, H.E.; TUKKER, J.J. An estimate of turnover time of intestinal mucus gel layer in the rat in situ loop. Int. J. Pharm., v.70, p.235-240, 1991.
    • (1991) Int. J. Pharm , vol.70 , pp. 235-240
    • LEHR, C.-M.1    POELMA, F.G.J.2    JUNGINGER, H.E.3    TUKKER, J.J.4
  • 44
    • 0021916758 scopus 로고
    • Bioadhesive polymers as platforms for oral controlled drug delivery III: Oral delivery of chlorothiazide using a bioadhesive polymer
    • LONGER, M.A.; CH'NG, H.S.; ROBINSON, J.R. Bioadhesive polymers as platforms for oral controlled drug delivery III: oral delivery of chlorothiazide using a bioadhesive polymer. J. Pharm. Sci., v.74, n.4, p.406-411, 1985.
    • (1985) J. Pharm. Sci , vol.74 , Issue.4 , pp. 406-411
    • LONGER, M.A.1    CH'NG, H.S.2    ROBINSON, J.R.3
  • 45
    • 0030737814 scopus 로고    scopus 로고
    • Histochemistry of the surface mucous gel layer of the human colon
    • MATSUO, K.; OTA, H.; AKAMATSU, T.; SUGIYAMA, A.; KATSUYAMA, T. Histochemistry of the surface mucous gel layer of the human colon. Gut, v.40, n.6, p.782-789, 1997.
    • (1997) Gut , vol.40 , Issue.6 , pp. 782-789
    • MATSUO, K.1    OTA, H.2    AKAMATSU, T.3    SUGIYAMA, A.4    KATSUYAMA, T.5
  • 46
    • 0035902688 scopus 로고    scopus 로고
    • The in-vitro porcine adhesion model is not predictive of the esophageal transit of risedronate tablets in humans
    • MCCARGAR, L.; CRAIL, D.; DANSEREAU, R.; MYERS, W.; LANE, M. The in-vitro porcine adhesion model is not predictive of the esophageal transit of risedronate tablets in humans. Int. J. Pharm., v.222, p.191-197, 2001.
    • (2001) Int. J. Pharm , vol.222 , pp. 191-197
    • MCCARGAR, L.1    CRAIL, D.2    DANSEREAU, R.3    MYERS, W.4    LANE, M.5
  • 47
    • 13544260088 scopus 로고
    • Pill-induced esophageal strictures: Clinical features and risk factors for development
    • MCCORD, G.S.; CLOUSE, R.E. Pill-induced esophageal strictures: clinical features and risk factors for development. Am. J. Med., v.88, p.512-518, 1990.
    • (1990) Am. J. Med , vol.88 , pp. 512-518
    • MCCORD, G.S.1    CLOUSE, R.E.2
  • 48
    • 0029087733 scopus 로고
    • An in vitro assessment of mucus/ mucoadhesive interactions
    • MORTAZAVI, S.A. An in vitro assessment of mucus/ mucoadhesive interactions. Int. J. Pharm., v.124, n.2, p.173-182, 1995.
    • (1995) Int. J. Pharm , vol.124 , Issue.2 , pp. 173-182
    • MORTAZAVI, S.A.1
  • 49
    • 0027233057 scopus 로고
    • An investigation into the role of water movement and mucus gel dehydation in mucoadhesion
    • MORTAZAVI, S.A.; SMART, J.D. An investigation into the role of water movement and mucus gel dehydation in mucoadhesion. J. Control. Release, v.25, p.197-203, 1993.
    • (1993) J. Control. Release , vol.25 , pp. 197-203
    • MORTAZAVI, S.A.1    SMART, J.D.2
  • 50
    • 0032531311 scopus 로고    scopus 로고
    • Use of sodium salt of Carbopol 934P in oral peptide delivery
    • NAKANISHI, T.; KAIHO, F.; HAYASHI, M. Use of sodium salt of Carbopol 934P in oral peptide delivery. Int. J. Pharm., v.171, n.2, p.177-183, 1998.
    • (1998) Int. J. Pharm , vol.171 , Issue.2 , pp. 177-183
    • NAKANISHI, T.1    KAIHO, F.2    HAYASHI, M.3
  • 51
    • 0021344079 scopus 로고
    • Bioadhesive polymers as platforms for oral-controlled drug delivery: Method to study bioadhesion
    • PARK, K.; ROBINSON, J.R. Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion. Int. J. Pharm., v.19, p.107-127, 1984.
    • (1984) Int. J. Pharm , vol.19 , pp. 107-127
    • PARK, K.1    ROBINSON, J.R.2
  • 52
    • 0030208529 scopus 로고    scopus 로고
    • Hydrogels as mucoadhesive and bioadhesive materials: A review
    • PEPPAS, N.A.; SALLIN, J.J. Hydrogels as mucoadhesive and bioadhesive materials: A review. Biomaterials, v.17, p.1553-1561, 1996.
    • (1996) Biomaterials , vol.17 , pp. 1553-1561
    • PEPPAS, N.A.1    SALLIN, J.J.2
  • 53
    • 0242525615 scopus 로고    scopus 로고
    • Oxprenolol-loaded bioadhesive microspheres: Preparation and in vitro/ in vivo characterization
    • PREDA, M.; LEUCUTA, S.E. Oxprenolol-loaded bioadhesive microspheres: preparation and in vitro/ in vivo characterization. J. Microencapsul., v.20, n.6, p.777-789, 2003.
    • (2003) J. Microencapsul , vol.20 , Issue.6 , pp. 777-789
    • PREDA, M.1    LEUCUTA, S.E.2
  • 54
    • 0030572680 scopus 로고    scopus 로고
    • Aminophylline bioadhesive tablets attempted by wet granulation
    • PRUDAT-CHRISTIAENS, C.; ARNAUD, P.; ALLAIN, P.; CHAUMEIL, J.C. Aminophylline bioadhesive tablets attempted by wet granulation. Int. J. Pharm., v.141, n.1-2, p.109-116, 1996.
    • (1996) Int. J. Pharm , vol.141 , Issue.1-2 , pp. 109-116
    • PRUDAT-CHRISTIAENS, C.1    ARNAUD, P.2    ALLAIN, P.3    CHAUMEIL, J.C.4
  • 56
    • 8444240005 scopus 로고    scopus 로고
    • Oesophageal bioadhesion of sodium alginate suspensions: Particle swelling and mucosal retention
    • RICHARDSON, J.C.; DETTMAR, P.W.; HAMPSON, F.C.; MELIA, C.D. Oesophageal bioadhesion of sodium alginate suspensions: particle swelling and mucosal retention. Eur. J. Pharm. Sci., v.23, p.49-56, 2004.
    • (2004) Eur. J. Pharm. Sci , vol.23 , pp. 49-56
    • RICHARDSON, J.C.1    DETTMAR, P.W.2    HAMPSON, F.C.3    MELIA, C.D.4
  • 57
    • 0026539979 scopus 로고
    • In vitro bioadhesion of carbohydrate containing N-(2-hydroxypropyl)methacrylamide copolymers to the GI tract of guinea pigs
    • RÍHOVÁ, B.; RATHI, R.C.; KOPECKOVÁ, P.; KOPECÉK, J. In vitro bioadhesion of carbohydrate containing N-(2-hydroxypropyl)methacrylamide copolymers to the GI tract of guinea pigs. Int. J. Pharm., v.87, p.105-116, 1992.
    • (1992) Int. J. Pharm , vol.87 , pp. 105-116
    • RÍHOVÁ, B.1    RATHI, R.C.2    KOPECKOVÁ, P.3    KOPECÉK, J.4
  • 58
    • 0029953050 scopus 로고    scopus 로고
    • Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery
    • ROUGE, N.; BURI, P.; DOELKER, E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int. J. Pharm., v.136, p.117-139, 1996.
    • (1996) Int. J. Pharm , vol.136 , pp. 117-139
    • ROUGE, N.1    BURI, P.2    DOELKER, E.3
  • 59
    • 0028366107 scopus 로고
    • Mucus gel thickness and turnover in the gastrointestinal tract of the rat: Response to cholinergic stimulus and implication for mucoadhesion
    • RUBINSTEIN, A.; TIROSH, B. Mucus gel thickness and turnover in the gastrointestinal tract of the rat: response to cholinergic stimulus and implication for mucoadhesion. Pharm. Res., v.11, n.6, p.794-799, 1994.
    • (1994) Pharm. Res , vol.11 , Issue.6 , pp. 794-799
    • RUBINSTEIN, A.1    TIROSH, B.2
  • 60
    • 0037413391 scopus 로고    scopus 로고
    • In vivo evaluation of matrix granules containing microcrystalline chitosan as a gel-forming excipient
    • SÄKKINEN, M.; LINNA, A.; OJALA, S.; JÜRJENSON, H.; VESKI, P.; MARVOLA, M. In vivo evaluation of matrix granules containing microcrystalline chitosan as a gel-forming excipient. Int. J. Pharm., v.250, p.227-237, 2003.
    • (2003) Int. J. Pharm , vol.250 , pp. 227-237
    • SÄKKINEN, M.1    LINNA, A.2    OJALA, S.3    JÜRJENSON, H.4    VESKI, P.5    MARVOLA, M.6
  • 64
    • 0034862390 scopus 로고    scopus 로고
    • Bioadhesive characteristics of chitosan microspheres to the mucosa of rat small intestine
    • SHIMODA, J.; ONISHI, H.; MACHIDA, Y. Bioadhesive characteristics of chitosan microspheres to the mucosa of rat small intestine. Drug Dev. Ind. Pharm., v.27, n.6, p.567-576, 2001.
    • (2001) Drug Dev. Ind. Pharm , vol.27 , Issue.6 , pp. 567-576
    • SHIMODA, J.1    ONISHI, H.2    MACHIDA, Y.3
  • 65
    • 26644454810 scopus 로고    scopus 로고
    • The basics and underlying mechanisms of mucoadhesion
    • SMART, J.D. The basics and underlying mechanisms of mucoadhesion. Adv. Drug Deliv. Rev., v.57, p.1556-1568, 2005.
    • (2005) Adv. Drug Deliv. Rev , vol.57 , pp. 1556-1568
    • SMART, J.D.1
  • 66
    • 0024395207 scopus 로고
    • Pharmaceutical factors influencing the rate of gastrointestinal transit in an animal model
    • SMART, J.D.; KELLAWAY, I.W. Pharmaceutical factors influencing the rate of gastrointestinal transit in an animal model. Int. J. Pharm., v.53, p.79-83, 1989.
    • (1989) Int. J. Pharm , vol.53 , pp. 79-83
    • SMART, J.D.1    KELLAWAY, I.W.2
  • 67
    • 0021236615 scopus 로고
    • An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery
    • SMART, J.D.; KELLAWAY, I.W.; WORTHINGTON, H.E.C. An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol., v.36, p.295-299, 1984.
    • (1984) J. Pharm. Pharmacol , vol.36 , pp. 295-299
    • SMART, J.D.1    KELLAWAY, I.W.2    WORTHINGTON, H.E.C.3
  • 68
    • 26644447977 scopus 로고    scopus 로고
    • Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems
    • TAKEUCHI, H.; THONGBORISUTE, J.; MATSUI, Y.; SUGIHARA, H.; YAMAMOTO, H.; KAWASHIMA, Y. Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems. Adv. Drug Deliv. Rev., v.57, p.1583-1594, 2005.
    • (2005) Adv. Drug Deliv. Rev , vol.57 , pp. 1583-1594
    • TAKEUCHI, H.1    THONGBORISUTE, J.2    MATSUI, Y.3    SUGIHARA, H.4    YAMAMOTO, H.5    KAWASHIMA, Y.6
  • 69
    • 9644262439 scopus 로고    scopus 로고
    • Gastroretentive delivery systems: A mini review
    • TALUKDER, R.; FASSIHI, R. Gastroretentive delivery systems: A mini review. Drug Dev. Ind. Pharm., v.30, n.10, p.1019-1028, 2004.
    • (2004) Drug Dev. Ind. Pharm , vol.30 , Issue.10 , pp. 1019-1028
    • TALUKDER, R.1    FASSIHI, R.2
  • 70
    • 0031390438 scopus 로고    scopus 로고
    • A comparison of different in vitro methods for measuring mucoadhesive performance
    • TAMBURIC, S.; CRAIG, D.Q.M. A comparison of different in vitro methods for measuring mucoadhesive performance. Eur. J. Pharm. Biopharm., v.44, p.159-167, 1997.
    • (1997) Eur. J. Pharm. Biopharm , vol.44 , pp. 159-167
    • TAMBURIC, S.1    CRAIG, D.Q.M.2
  • 71
    • 0029100666 scopus 로고
    • Factors affecting in vitro gastric mucoadhesion. I. Test Conditions and instrumental parameters
    • TOBYN, M.J.; JOHNSON, J.R.; DETTMAR, P.W. Factors affecting in vitro gastric mucoadhesion. I. Test Conditions and instrumental parameters. Eur. J. Pharm. Biopharm., v.41, n.4, p.235-241, 1995.
    • (1995) Eur. J. Pharm. Biopharm , vol.41 , Issue.4 , pp. 235-241
    • TOBYN, M.J.1    JOHNSON, J.R.2    DETTMAR, P.W.3
  • 72
    • 0029886451 scopus 로고    scopus 로고
    • Factors affecting in vitro gastric mucoadhesion. II. Physical properties of polymers
    • TOBYN, M.J.; JOHNSON, J.R.; DETTMAR, P.W. Factors affecting in vitro gastric mucoadhesion. II. Physical properties of polymers. Eur. J. Pharm. Biopharm., v.42, n.1, p.56-61, 1996.
    • (1996) Eur. J. Pharm. Biopharm , vol.42 , Issue.1 , pp. 56-61
    • TOBYN, M.J.1    JOHNSON, J.R.2    DETTMAR, P.W.3
  • 73
    • 0033034920 scopus 로고    scopus 로고
    • Gastrointestinal transit of pellets in rats: Effect of size and density
    • TULEU, C.; ANDRIEUX, C.; BOY, P.; CHAUMEIL, J.C. Gastrointestinal transit of pellets in rats: effect of size and density. Int. J. Pharm., v.180, n.1, p.123-131, 1999.
    • (1999) Int. J. Pharm , vol.180 , Issue.1 , pp. 123-131
    • TULEU, C.1    ANDRIEUX, C.2    BOY, P.3    CHAUMEIL, J.C.4
  • 74
    • 0036791174 scopus 로고    scopus 로고
    • Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose-coated hydroxypropylmethylcellulose capsules
    • TULEU, C.; BASIT, A.W.; WADDINGTON, W.A.; ELL, P.J.; NEWTON, J. Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose-coated hydroxypropylmethylcellulose capsules. Aliment. Pharmacol. Ther., v.16, p.1771-1779, 2002.
    • (2002) Aliment. Pharmacol. Ther , vol.16 , pp. 1771-1779
    • TULEU, C.1    BASIT, A.W.2    WADDINGTON, W.A.3    ELL, P.J.4    NEWTON, J.5
  • 75
    • 26644434124 scopus 로고    scopus 로고
    • Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives
    • UGWOKE, M.I.; AGU, R.U.; VERBEKE, N.; KINGET, R. Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives. Adv. Drug Deliv. Rev., v.57, p.1640-1665, 2005.
    • (2005) Adv. Drug Deliv. Rev , vol.57 , pp. 1640-1665
    • UGWOKE, M.I.1    AGU, R.U.2    VERBEKE, N.3    KINGET, R.4
  • 76
    • 0037436923 scopus 로고    scopus 로고
    • Bioadhesive microspheres as a controlled drug delivery system
    • VASIR, J.K.; TAMBWEKAR, K.; GARG, S. Bioadhesive microspheres as a controlled drug delivery system. Int. J. Pharm., v.255, p.13-32, 2003.
    • (2003) Int. J. Pharm , vol.255 , pp. 13-32
    • VASIR, J.K.1    TAMBWEKAR, K.2    GARG, S.3
  • 77
    • 0030931837 scopus 로고    scopus 로고
    • Colonic drug delivery
    • WATTS, P.J.; ILLUM, L. Colonic drug delivery. Drug Dev. Ind. Pharm., v.23, n.9, p.893-913, 1997.
    • (1997) Drug Dev. Ind. Pharm , vol.23 , Issue.9 , pp. 893-913
    • WATTS, P.J.1    ILLUM, L.2
  • 78
    • 0028829981 scopus 로고
    • Scintigraphic evaluation of colonic delivery systems
    • WILDING, I.R. Scintigraphic evaluation of colonic delivery systems. S.T.P. Pharma Sci., v.5, n.1, p.13-18, 1995.
    • (1995) S.T.P. Pharma Sci , vol.5 , Issue.1 , pp. 13-18
    • WILDING, I.R.1
  • 79
    • 0034510598 scopus 로고    scopus 로고
    • Site-specific drug delivery in the gastrointestinal tract
    • WILDING, I.R. Site-specific drug delivery in the gastrointestinal tract. Crit. Rev. Ther. Drug Carrier Syst., v.17, n.6, p.557-620, 2000.
    • (2000) Crit. Rev. Ther. Drug Carrier Syst , vol.17 , Issue.6 , pp. 557-620
    • WILDING, I.R.1
  • 80
    • 0035293050 scopus 로고    scopus 로고
    • The role of gamma-scintigraphy in oral drug delivery
    • WILDING, I.R.; COUPE, A.J.; DAVIS, S.S. The role of gamma-scintigraphy in oral drug delivery. Adv. Drug Deliv. Rev., v.46, p.103-124, 2001.
    • (2001) Adv. Drug Deliv. Rev , vol.46 , pp. 103-124
    • WILDING, I.R.1    COUPE, A.J.2    DAVIS, S.S.3
  • 81
    • 33645037223 scopus 로고    scopus 로고
    • Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone
    • WITTAYA-AREEKUL, S.; KRUENATE, J.; PRAHSARN, C. Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone. Int. J. Pharm., v.312, p.113-118, 2006.
    • (2006) Int. J. Pharm , vol.312 , pp. 113-118
    • WITTAYA-AREEKUL, S.1    KRUENATE, J.2    PRAHSARN, C.3
  • 82
    • 0035068551 scopus 로고    scopus 로고
    • Bioadhesion: New possibilities for drug administration?
    • WOODLEY, J. Bioadhesion: new possibilities for drug administration? Clin. Pharmacokinet., v.40, n.2, p.77-84, 2001.
    • (2001) Clin. Pharmacokinet , vol.40 , Issue.2 , pp. 77-84
    • WOODLEY, J.1
  • 83
    • 0037139415 scopus 로고    scopus 로고
    • Colon-specific drug delivery: New approaches and in vitro/in vivo evaluation
    • YANG, L.; CHU, J.S.; FIX, J.A. Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation. Int. J. Pharm., v.235, p.1-15, 2002.
    • (2002) Int. J. Pharm , vol.235 , pp. 1-15
    • YANG, L.1    CHU, J.S.2    FIX, J.A.3


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