The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response

Nucleic Acids Research

Volumn 37, Issue 2, 2009, Pages 322-335

  Koeppel, Max ^a   Van Heeringen, Simon J ^a   Smeenk, Leonie ^a   Navis, Anna C ^a   Janssen Megens, Eva M ^a   Lohrum, Marion ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DACTINOMYCIN; DOXORUBICIN; INTERFERON REGULATORY FACTOR 2 BINDING PROTEIN 2; PROTEIN BAX; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE TARGETING; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSACTIVATION; UPREGULATION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BINDING SITES; CARRIER PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DACTINOMYCIN; DOXORUBICIN; HUMANS; NUCLEAR PROTEINS; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 59649098966     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn940     Document Type: Article

References (46)

1. Lozano,G. and Zambetti,G.P. (2005) What have animal models taught us about the p53 pathway? J. Pathol., 205, 206-220.
2. Vogelstein,B., Lane,D. and Levine,A.J. (2000) Surfing the p53 network. Nature, 408, 307-310.
3. Moll,U.M., Wolff,S., Speidel,D. and Deppert,W. (2005) Transcription-independent pro-apoptotic functions of p53. Curr. Opin. Cell Biol., 17, 631-636.
4. Laptenko,O. and Prives,C. (2006) Transcriptional regulation by p53: One protein, many possibilities. Cell Death Differ., 13, 951-961.
5. Vousden,K.H. (2006) Outcomes of p53 activation - spoilt for choice. J. Cell Sci., 119, 5015-5020.
6. Vousden,K.H. and Lu,X. (2002) Live or let die: The cell's response to p53. Nature Rev., 2, 594-604.
7. Coutts,A.S. and La Thangue,N.B. (2005) The p53 response: Emerging levels of co-factor complexity. Biochem. Biophys. Res. Commun., 331 778-785.
8. Tanaka,T., Ohkubo,S., Tatsuno,I. and Prives,C. (2007) hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Cell, 130, 638-650.
9. Qian,H., Wang,T., Naumovski,L., Lopez,C.D. and Brachmann,R.K. (2002) Groups of p53 target genes involved in specific p53 downstream effects cluster into different classes of DNA binding sites. Oncogene, 21, 7901-7911.
10. Samuels-Lev,Y., O'Connor,D.J., Bergamaschi,D., Trigiante,G., Hsieh,J.K., Zhong,S., Campargue,I., Naumovski,L., Crook,T. and Lu,X. (2001) ASPP proteins speci.cally stimulate the apoptotic function of p53. Mol. Cell, 8, 781-794.
11. Ryan,K.M., Ernst,M.K., Rice,N.R. and Vousden,K.H. (2000) Role of NF-kappaB in p53-mediated programmed cell death. Nature, 404 892-897.
12. Okamura,S., Arakawa,H., Tanaka,T., Nakanishi,H., Ng,C.C., Taya,Y., Monden,M. and Nakamura,Y. (2001) p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Mol. Cell, 8, 85-94.
13. Takekawa,M., Adachi,M., Nakahata,A., Nakayama,I., Itoh,F., Tsukuda,H., Taya,Y. and Imai,K. (2000) p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation. EMBO J., 19, 6517-6526.
14. Gu,W. and Roeder,R.G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell, 90 595-606.
15. Liu,L., Scolnick,D.M., Trievel,R.C., Zhang,H.B., Marmorstein,R., Halazonetis,T.D. and Berger,S.L. (1999) p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol. Cell. Biol., 19, 1202-1209.
16. Sykes,S.M., Mellert,H.S., Holbert,M.A., Li,K., Marmorstein,R., Lane,W.S. and McMahon,S.B. (2006) Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell, 24, 841-851.
17. Herold,S., Wanzel,M., Beuger,V., Frohme,C., Beul,D., Hillukkala,T., Syvaoja,J., Saluz,H.P., Haenel,F. and Eilers,M. (2002) Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol. Cell, 10, 509-521.
18. Das,S., Raj,L., Zhao,B., Kimura,Y., Bernstein,A., Aaronson,S.A. and Lee,S.W. (2007) Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell, 130, 624-637.
19. Wu,W.S., Heinrichs,S., Xu,D., Garrison,S.P., Zambetti,G.P., Adams,J.M. and Look,A.T. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell, 123, 641-653.
20. Nguyen,H., Hiscott,J. and Pitha,P.M. (1997) The growing family of interferon regulatory factors. Cytokine Growth Factor Rev., 8 293-312.
21. Tanaka,N. (2000) [Functional role of IRF-family transcription factors]. Tanpakushitsu Kakusan Koso, 45, 1551-1559.
22. Taniguchi,T., Ogasawara,K., Takaoka,A. and Tanaka,N. (2001) IRF family of transcription factors as regulators of host defense. Annu. Rev. Immunol., 19, 623-655.
23. Vaughan,P.S., Aziz,F., van Wijnen,A.J., Wu,S., Harada,H., Taniguchi,T., Soprano,K.J., Stein,J.L. and Stein,G.S. (1995) Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2. Nature, 377, 362-365.
24. Vaughan,P.S., van der Meijden,C.M., Aziz,F., Harada,H., Taniguchi,T., van Wijnen,A.J., Stein,J.L. and Stein,G.S. (1998) Cell cycle regulation of histone H4 gene transcription requires the oncogenic factor IRF-2. J. Biol. Chem., 273, 194-199.
25. Masumi,A., Wang,I.M., Lefebvre,B., Yang,X.J., Nakatani,Y. and Ozato,K. (1999) The histone acetylase PCAF is a phorbol-esterinducible coactivator of the IRF family that confers enhanced interferon responsiveness. Mol. Cell. Biol., 19, 1810-1820.
26. Harada,H., Kitagawa,M., Tanaka,N., Yamamoto,H., Harada,K., Ishihara,M. and Taniguchi,T. (1993) Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science, 259, 971-974.
27. Lowney,J.K., Boucher,L.D., Swanson,P.E. and Doherty,G.M. (1999) Interferon regulatory factor-1 and -2 expression in human melanoma specimens. Ann. Surg. Oncol., 6, 604-608.
28. Connett,J.M., Badri,L., Giordano,T.J., Connett,W.C. and Doherty,G.M. (2005) Interferon regulatory factor 1 (IRF-1) and IRF-2 expression in breast cancer tissue microarrays. J. Interferon Cytokine Res., 25, 587-594.
29. Wang,Y., Liu,D.P., Chen,P.P., Koeffler,H.P., Tong,X.J. and Xie,D. (2007) Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers. Cancers Res., 67 2535-2543.
30. Tanaka,N., Ishihara,M., Lamphier,M.S., Nozawa,H., Matsuyama,T., Mak,T.W., Aizawa,S., Tokino,T., Oren,M. and Taniguchi,T. (1996) Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature, 382, 816-818.
31. Coccia,E.M., Del Russo,N., Stellacci,E., Orsatti,R., Benedetti,E., Marziali,G., Hiscott,J. and Battistini,A. (1999) Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2. Oncogene, 18, 2129-2137.
32. Dornan,D., Eckert,M., Wallace,M., Shimizu,H., Ramsay,E., Hupp,T.R. and Ball,K.L. (2004) Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53. Mol. Cell. Biol., 24, 10083-10098.
33. Rubinstein,Y.R., Driggers,P.H., Ogryzko,V.V., Thornton,A.M., Ozato,K. and Pontzer,C.H. (2000) An IFN regulatory factor-2 DNA-binding domain dominant negative mutant exhibits altered cell growth and gene expression. Oncogene, 19, 1411-1418.
34. Childs,K.S. and Goodbourn,S. (2003) Identification of novel co-repressor molecules for interferon regulatory factor-2. Nucleic Acids Res., 31, 3016-3026.
35. Smeenk,L., van Heeringen,S.J., Koeppel,M., van Driel,M.A., Bartels,S.J., Akkers,R.C., Denissov,S., Stunnenberg,H.G. and Lohrum,M. (2008) Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res., 36, 3639-3654.
36. Denissov,S., van Driel,M., Voit,R., Hekkelman,M., Hulsen,T., Hernandez,N., Grummt,I., Wehrens,R. and Stunnenberg,H. (2007) Identification of novel functional TBP-binding sites and general factor repertoires. EMBO J., 26, 944-954.
37. el-Deiry,W.S., Kern,S.E., Pietenpol,J.A., Kinzler,K.W. and Vogelstein,B. (1992) Definition of a consensus binding site for p53. Nat. Genet. 1, 45-49.
38. Hoh,J., Jin,S., Parrado,T., Edington,J., Levine,A.J. and Ott,J. (2002) The p53MH algorithm and its application in detecting p53-responsive genes. Proc. Natl Acad. Sci. USA, 99, 8467-8472.
39. Kimura,M. (2008) IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. FEBS Lett., 582 2833-2837.
40. Horn,H.F. and Vousden,K.H. (2007) Coping with stress: Multiple ways to activate p53. Oncogene, 26, 1306-1316.
41. Tu,Y., Wu,W., Wu,T., Cao,Z., Wilkins,R., Toh,B.H., Cooper,M.E. and Chai,Z. (2007) Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. J. Biol. Chem., 282, 11722-11731.
42. Harada,H., Taniguchi,T. and Tanaka,N. (1998) The role of interferon regulatory factors in the interferon system and cell growth control. Biochimie., 80, 641-650.
43. Xie,R.L., van Wijnen,A.J., van der Meijden,C.M., Stein,J.L. and Stein,G.S. (2002) Forced expression of the interferon regulatory factor 2 oncoprotein causes polyploidy and cell death in FDC-P1 myeloid hematopoietic progenitor cells. Cancer Res., 62, 2510-2515.
44. Shikama,N., Lee,C.W., France,S., Delavaine,L., Lyon,J., Krstic-Demonacos,M. and La Thangue,N.B. (1999) A novel cofactor for p300 that regulates the p53 response. Mol. Cell, 4, 365-376.
45. Huang,W., Horvath,E. and Eklund,E.A. (2007) PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells. J. Biol. Chem., 282, 6629-6643.
46. Tschan,M.P., Reddy,V.A., Ress,A., Arvidsson,G., Fey,M.F. and Torbett,B.E. (2008) PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity. Oncogene, 27, 3489-3493.