The state of the art of chemical biology

ChemBioChem

Volumn 10, Issue 1, 2009, Pages 16-29

  Altmann, Karl Heinz ^h   Buchner, Johannes ^h   Kessler, Horst ^h   Diederich, François ^a   Kräutler, Bernhard ^h   Lippard, Stephen J ^b   Liskamp, Rob ^h   Müller, Klaus ^h   Nolan, Elizabeth M ^c   Samorì, Bruno ^d   Schneider, Gisbert ^e   Schreiber, Stuart L ^h   Schwalbe, Harald ^e   Toniolo, Claudio ^f   van Boeckel, Constant A A ^h   Waldmann, Herbert ^g   Walsh, Christopher T ^c  

^a ETH ZURICH   (Switzerland)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF BOLOGNA   (Italy)

^e GOETHE UNIVERSITY   (Germany)

^f UNIVERSITY OF PADOVA   (Italy)

^g MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^h Max Planck Institute of Molecular Physiology ^*

Author keywords

[No Author keywords available]

Indexed keywords

ABBYSOMICIN C; BIOMATERIAL; CYANOCOBALAMIN; FONDAPARINUX; IDRAPARINUX; MYCANGIMYCIN; NATURAL PRODUCT; ORGANIC COMPOUND; PENTASACCHARIDE; PEPTIDE; PLATENSIMYCIN; PROTEIN; RECOMBINANT HUMAN INSULIN; SALINOSPORAMIDE A; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT;

ACTINOBACTERIA; ANALYTIC METHOD; BIOLOGICAL MODEL; BIOLOGY; BIOMEDICINE; CATALYST; CELL MEMBRANE TRANSPORT; CHEMICAL BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; CLINICAL TRIAL; DEVELOPMENTAL BIOLOGY; DRUG DESIGN; GEL ELECTROPHORESIS; GENE CLUSTER; GENE SEQUENCE; GENETIC ENGINEERING; HEALTH CARE ORGANIZATION; HUMAN; HYDROGEN BOND; MACROMOLECULE; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULE; NANOTECHNOLOGY; NOTE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RIBOSWITCH; SCIENTIST; SPECTROSCOPY; STREPTOMYCETACEAE; SUPRAMOLECULAR CHEMISTRY; X RAY DIFFRACTION; ARTICLE; BIOSYNTHESIS; CONFORMATION; DRUG DEVELOPMENT; GENETICS; METABOLISM; RESEARCH;

BIOLOGICAL PRODUCTS; BIOLOGY; CHEMISTRY; DRUG DISCOVERY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RESEARCH;

EID: 59649093964     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800758     Document Type: Note

References (34)

1. H. Kessler, Angew. Chem. 1982, 94, 509-520; Angew. Chem. Int. Ed. Engl. 1982, 21, 512-523.
2. L. M. Salonen, C. Bucher, D. W. Banner, W. Haap, J.-L. Mary, J. Benz, O. Kuster, P. Seiler, W. B. Schweizer, F. Diederich, Angew. Chem. 2008, 120, in press; Angew. Chem. Int. Ed. 2008, 47, in press.
3. K. C. Nicolaou, T. Montagnon, Molecules that Changed the World, Wiley-VCH, Weinheim, 2008.
4. a) A. Nahvi, N. Sudarsan, M. S. Ebert, X. Zou, K. L. Brown, R. R. Breaker, Chem. Biol. 2002, 9, 1043-1049;
5. b) W. C. Winkler, R. R. Breaker, Ann. Rev. Microbiol. 2005, 59, 487-517;
6. c) S. Gallo, M. Oberhuber, R. K. O. Sigel, B. Kräutler, ChemBioChem 2008, 9, 1408-1414.
7. N. Sudarsan, M. C. Hammond, K. F. Block, R. Welz, J. E. Barrick, A. Roth, R. R. Breaker, Science 2006, 314, 300-304.
8. M. T. Croft, A. D. Lawrence, E. Raux-Deery, M. J. Warren, A. G. Smith, Nature 2005, 438, 90-93.
9. K. P. Locher, A. T. Lee, D. C. Rees, Science 2002, 296, 1091-1098.
10. a) D. Padovani, T. Labunska, B. A. Palfey, D. P. Ballou, R. Banerjee, Nature Chem. Biol. 2008, 4, 194-196; b) S. N. Fedosov, N. U. Fedosova, B. Kräutler, E. Nexo, T. E. Petersen, Biochemistry 2007, 46, 6446-6458.
11. a) R. F. Gesteland, T. R. Cech, J. F. Atkins, The RNA World, 2nd ed., Cold Spring Harbor Laboratory Press, New York, 1999; b) R. F. Gesteland, T. R. Cech, J. F. Atkins, The RNA World, 3rd ed., 2006.
12. a) A. Eschenmoser, Angew. Chem. 1988, 100, 5-40; Angew. Chem. Int. Ed. 1988, 27, 5-39;
13. b) S. Gschösser, K. Gruber, C. Kratky, C. Eichmüller, B. Kräutler, Angew. Chem. 2005, 117, 2324-2328; Angew. Chem. Int. Ed. 2005, 44, 2284-2288.
14. Physical Biology (Ed.: A. H. Zewail), Imperial College Press, London, 2008.
15. H. C. Kolb, M. G. Finn, K. B. Sharpless, Angew. Chem. 2001, 113, 2056-2075; Angew. Chem. Int. Ed. 2001, 40, 2004-2021.
16. P. E. Dawson, T. W. Muir, I. Clark-Lewis, S. B. H. Kent, Science 1994, 266, 776-779.
17. M. Petitou, C. A. A. van Boeckel, Angew. Chem. 2004, 116, 3180-3196; Angew. Chem. Int. Ed. 2004, 43, 3118-3133.
18. M. de Kort, B. Gianotten, J. A. J. Wisse, E. S. Bos, M. H. M. Eppink, E. Mattaar, G. M. T. Vogel, W. H. A. Dokter, M. Honing, S. Vonsovic, M.-J. Smit, J. C. H. M. Wijkmans, C. A. A. van Boeckel, ChemMedChem 2008, 3, 1189-1193.
19. N. C. R. van Straten, N. C. R. van Straten, G. G. Schoonus-Gerritsma, R. G. van Someren, J. Draaijer, A. E. P. Adang, C. M. Timmers, R. G. J. M. Hanssen, C. A. A. van Boeckel, ChemBioChem 2002, 3, 1023-1026.
20. M. A. Fischbach, C. T. Walsh, Chem. Rev. 2006, 106, 3468-3496.
21. K. J. Weissman, R. Müller, ChemBioChem 2006, 9, 828-848.
22. S. Jenni, M. Leibundgut, D. Boehringer, C. Frick, B. Mikolásek, N. Ban, Scicence 2007, 316, 254-261.
23. A. Tanovic, S. A. Samel, L.-O. Essen, M. A. Marahiel, Science 2008, 321, 659-663.
24. A. Koglin, F. Löhr, F. Bernhard, V. V. Rogov, D. P. Freuh, E. R. Streiter, M. R. Mofid, P. Guntert, G. Wagner, C. T. Walsh, M. A. Marahiel, V. Dötsch, Nature 2008, 454, 907-912.
25. K. S. Lam, Curr. Opin. Microbiol. 2006, 9, 245-251.
26. B. Bister, D. Bischoff, M. Ströbele, J. Riedlinger, A. Reicke, F. Wolter, A. T. Bull, H. Zähner, H.-P. Fiedler, R. D. Süssmuth, Angew. Chemie. Int. Ed. 2004, 43, 2574-2576.
27. J. J. Scott, D.-C. Oh, M. C. Yuceer, K. D. Klepzig, J. Clardy, C. R. Currie, Science 2008, 322, 63.
28. J. Wang, S. M. Soisson, K. Young, W. Shoop, S. Kodali, A. Galgoci, R. Painter, G. Parthasarathy, Y. S. Tang, R. Cummings, S. Ha, K. Dorso, M. Motyl, H. Jayasuriya, J. Ondeyka, K. Herath, C. Zhang, L. Hernandez, J. Allocco, À. Basilio, J. R. Tormo, O. Genilloud, F. Vicente, F. Pelaez, L. Colwell, S. H. Lee, B. Michael, T. Felcetto, C. Gill, L. L. Silver, J. D. Hermes, K. Bartizal, J. Barrett, D. Schmatz, J. W. Becker, D. Cully, S. B. Singh, Nature, 2006, 441, 358-361.
29. H. Waldmann, P. Jannings in Chemical Biology: A Practical Course, Wiley-VCH, Weinheim, 2004.
30. Nature Chem. Biol. 2005, 1, 3.
31. S. L. Schreiber, Nature Chem. Biol. 2005, 1, 64-66.
32. K. L. Morrison, G. A. Weiss, Nature Chem. Biol. 2006, 2, 3-6.
33. a) J. Drews, Nat. iotechnol. 1996, 14, 1516-1518; b) J. Drews, Nat. Rev. Drug Discovery 2006, 5, 975.
34. "Small-molecule probe" is a term familiar to many academic scientists. It is related to (although not the same as) "proof-ofconcept compound", a term familiar to many pharmaceutical industry scientists. Small-molecule probes are in general not as advanced as proof-of-concepts compounds (the former are generally used in cells, whereas the latter are used in animals), but they are on a path that can yield the latter.