Effects of trichostatin A, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells

International Journal of Molecular Medicine

Volumn 22, Issue 5, 2008, Pages 605-611

  Park, Hyeyoung ^a   Lee, Young Jun ^a   Kim, Tae Hyung ^a   Lee, Jaewon ^a   Yoon, Sungpil ^b   Choi, Wahn Soo ^c   Myung, Chang Seon ^d   Kim, Hyung Sik ^a  

^a Pusan National University   (South Korea)

^b National Cancer Center   (South Korea)

^c Konkuk University   (South Korea)

^d Chungnam National University   (South Korea)

Author keywords

Apoptosis; Cell cycle arrest; Histone deacetylase inhibitor; MCF10A ras cells; Trichostatin A

Indexed keywords

CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; HISTONE H3; HISTONE H4; PROTEIN BAX; PROTEIN P53; RETINOBLASTOMA PROTEIN; TRICHOSTATIN A; BAX PROTEIN, HUMAN; CELL CYCLE PROTEIN; ENZYME INHIBITOR; HISTONE DEACETYLASE; HYDROXAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TP53 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; DOWN REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ONCOGENE H RAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING; BIOSYNTHESIS; BREAST TUMOR; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; FEMALE; MAMMARY GLAND; METABOLISM; METHODOLOGY; ONCOGENE RAS; PATHOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 3; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; G1 PHASE; GENE EXPRESSION REGULATION; GENES, RAS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; MAMMARY GLANDS, HUMAN; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; TUMOR SUPPRESSOR PROTEIN P53;

EID: 59149095489     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm_00000062     Document Type: Article

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