Influence of zinc deficiency on the mRNA expression of zinc transporters in adult rats

Journal of Trace Elements in Medicine and Biology

Volumn 17, Issue 2, 2003, Pages 97-106

  Pfaffl, Michael W ^a   Windisch, Wilhelm ^b  

^a Institute of Physiology   (Germany)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

Author keywords

DCT1; Metallothionein; Rat; Real time RT PCR; Relative expression; Zinc deficiency; Zinc transporter; ZnT1; ZnT2; ZnT3; ZnT4

Indexed keywords

CARRIER PROTEIN; MESSENGER RNA; METALLOTHIONEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; UNCLASSIFIED DRUG; ZINC TRANSPORTER 1; ZINC TRANSPORTER 2; ZINC TRANSPORTER 3; ZINC TRANSPORTER 4;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON; CONTROLLED STUDY; DISEASE MODEL; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; JEJUNUM; KIDNEY; LIVER; MUSCLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ASSAY; RAT; REPRODUCIBILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETON; UPREGULATION; ZINC BLOOD LEVEL; ZINC DEFICIENCY; ZINC METABOLISM;

ANIMALIA;

EID: 0141788579     PISSN: 0946672X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0946-672X(03)80005-6     Document Type: Article

References (57)

1. Silva JJR, and Williams RJP (Eds) (1991) The biological Chemistry of the elements: The inorganic chemistry of life. Clarendon Press, Oxford
2. Oestreicher P, and Cousins RJ (1989) Zinc uptake by basolateral membrane vesicles from rat small intestine. J Nutr. 119: 639-646
3. Reyes JG (1996) Zinc transport in mammalian cells. Am J Physiol 270: C401-410
4. Cousins RJ (1996) Zinc. In: Filer LJ, Ziegler EE (Eds) Present knowledge in nutrition, 7th ed. Internat. Life Sci. Inst. Nutr. Foundation, Washington DC, pp. 263-306
5. Failla ML, and Cousins RJ (1978) Zinc accumulation and metabolism in primary cultures of adult rat liver cells. Regulation by glucocorticoids, Biochim Biophys Acta. 543: 293-304
6. Failla ML, and Cousins RJ (1978) Zinc uptake by isolated rat liver parenchymal cells. Biochim Biophys Acta. 538: 435-444
7. Mas A, and Sarkar B (1991) Binding, uptake and efflux of 65Zn by isolated human trophoblast cells. Biochim Biophys Acta. 1092: 35-38
8. Ackland ML, Danks DM, and McArdle HJ (1988) Studies on the mechanism of zinc uptake by human fibroblasts. J Cell Physiol. 135: 521-526
9. Raffaniello RD, Lee SY, Teichberg S, and Wapnir RA (1992) Distinct mechanisms of zinc uptake at the apical and basolateral membranes of caco-2 cells. J Cell Physiol. 152: 356-361
10. Bobilya DJ, Briske-Anderson M, and Reeves PG (1992) Zinc transport into endothelial cells is a facilitated process. J Cell Physiol. 151: 1-7
11. Menard MP, and Cousins RJ (1983) Effect of citrate, glutathione and picolinate on zinc transport by brush border membrane vesicles from rat intestine. J Nutr. 113: 1653-1656
12. Tacnet F, Watkins DW, and Ripoche P (1990) Studies of zinc transport into brush-border membrane vesicles isolated from pig small intestine. Biochim Biophys Acta. 1024: 323-330
13. Brady FO (1982) The physiological function of Metallothionein. Trends Biochem. Sci. 7: 143-145
14. Vallee BL (1995) The function of metallothionein. Neurochem Int. 27:; 23-33
15. Vallee BL, and Auld DS (1995) Zinc metallochemistry in biochemistry. EXS. 73: 259-277
16. Kirchgessner M (1993) Underwood Memorial Lecture: Homeostasis and Homeorhesis in Trace Element Metabolism, In: Anke M, Meissner D, Mills CF (Eds) Trace Elements in Man and Animals TEMA 8. Verlag Media Touristik, Gersdorf, pp. 4-21
17. Windisch W, and Kirchgessner M (1995) Anpassung des Zinkstoffwechsels und des Zn-Austauschs im Ganzkörper 65Zn-markierter Ratten an eine variierende Zinkaufnahme. J. Anim. Physiol. a. Anim, Nutr. 74: 101-112
18. Windisch W, and Kirchgessner M (1995): Zinkverteilung und Zinkaustausch im Gewebe 65Zn-markierter Ratten. J. Anim. Physiol. a. Anim. Nutr. 74: 113-122
19. Bertholf RL (1988) Zinc. In: Seiler HG, Sigel H (Eds) Handbook of Toxicity of inorganic compounds. Marcel Dekker Inc., New York, pp. 788-800
20. Palmiter RD, and Findley SD (1995) Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc. EMBO J. 14: 639-649
21. Palmiter RD, Cole TB, and Findley SD (1996) ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J. 15: 1784-1791
22. Palmiter RD, Cole TB, Quaife CJ, and Findley SD (1996) ZnT3, a putative transporter of zinc into synaptic vesicles. Proc Natl Acad Sci USA 93: 14934-14939
23. Huang L, and Gitschier J (1997) A novel gene involved in zinc transport is deficient in the lethal milk mouse. Nat Genet. 17: 292-297
24. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, and Hediger MA (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388 (6641): 482-488
25. McMahon RJ, and Cousins RJ (1998) Mammalian zinc transporters. J Nutr. 128 (4): 667-670
26. Sato M, Mehra RK, and Bremner I (1984) Measurement of plasma metallothionein-1 in the assessment of the zinc status of zinc-deficient and stressed rats. J Nutr. 114 (9): 1683-1689
27. Bremner I (1987) Nutritional and physiological significance of metallothionein. Experientia Suppl 52: 81-107
28. Liuzzi JP, Blanchard RK, and Cousins RJ (2001) Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats. J Nutr 131: 46-52
29. Clifford KS, and MacDonald MJ (2000) Survey of mRNAs encoding zinc transporters and other metal complexing proteins in pancreatic islets of rats from birth to adulthood: similar patterns in the Sprague-Dawley and Wistar BB strains. Diabetes Res Clin Pract. 49 (2-3): 77-85
30. Windisch W (2003) Development of zinc deficiency in 65Zn labeled, fully grown rats as a model to adult individuals. Trace Elem. Med. Biol. 17 (2): 91-96
31. Windisch W (2001) Homeostatic reactions of quantitative Zn metabolism on deficiency and subsequent repletion with Zn in 65Zn labelled adult rats. Trace Elements and Electrolytes 18: 133-128
32. Windisch W, and Kirchgessner M (1999) Tissue Zn distribution and Zn exchange in adult rats at Zn deficiency induced by dietary phytate additions. J. Anim. Physiol. a. Anim. Nutr. 82: 116-124
33. Windisch W, and Kirchgessner M (1999) Zn absorption and excretion in adult rats at Zn deficiency induced by dietary phytate additions. J. Anim. Physiol. a. Anim. Nutr. 82: 106-115
34. Bustin SA (2000) Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol. 25: 169-193
35. ABI Prism 7700 Sequence detection System User Bulletin #2 (2001) Relative quantification of gene expression. http://docs.appliedbiosystems.com/pebiodocs/O430385g.pdf
36. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29: 2002-2007
37. Deutsches Krebsforschungs Zentrum (DKFZ), URL: http://genome,dkfz-heidelberg.de/biounit/
38. European Molecular Biology Library (EMBL), URL: http://www.ebi.ac.uk/
39. GenBank, URL: http://www.ncbi.nlm.nih.gov/Entrez/index.html
40. Pfaffl MW (2001) Development and validation of an externally standardised quantitative Insulin like growth factor-1 (IGF-1) RT-PCR using LightCycler SYBR° Green I technology. In: Meuer S, Wittwer C, Nakagawara K (Eds) Rapid Cycle Real-time PCR, Methods and Applications. Springer Press, Heidelberg, pp. 281-292
41. Higuchi R, Fockler C, Dollinger G, and Watson R (1993) Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology 11: 1026-1030
42. Rasmussen R (2001) Quantification on the LightCycler. In: Meuer S, Wittwer C, Nakagawara K (Eds) Rapid Cycle Real-time PCR, Methods and Applications. Springer Press, Heidelberg, pp. 21-34
43. 6ibson UE, Heid CA, and Williams PM (1996) A novel method for real time quantitative RT-PCR. Genome Res 6: 1095-1001
44. Marten NW, Burke EJ, Hayden JM, and Straus DS (1994) Effect of amino acid Limitation on the expression of 19 genes in rat hepatoma cells. FASEB J. 8: 538-544
45. Foss DL, Baarsch MJ, and Murtaugh MP (1998) Regulation of hypoxanthine phosphoribosyltransferase, glyceraldehyde-3-phosphate dehydrogenase and beta-actin mRNA expression in porcine immune cells and tissues. Anim Biotechnol 9: 67-78
46. Thellin O, Zorzi W, Lakaye B, De Borman B, Coumans B, Hennen G, Grisar T, Igout A, and Heinen E (1999) Housekeeping genes as internal standards: use and limits. J Biotechnol 75: 291-295
47. Pfaffl MW, Bruckmaier R, and Windisch W (2002) Metabolic effects of zinc deficiency on the somatotropic axis in non-growing rats as a new animal model to adult individuals.J Anim Sci 80 (1): 351
48. Okegbile EO, Odunuga O, and Oyewo A (1998) Effect of dietary zinc deficiency on alkaline phosphatase and nucleic acids in rats. Afr J Med Med Sci. 27: 189-192
49. West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, and Richards RI (1990) Human metallothionein genes: structure of the functional locus at 16q13. Genomics. 8 (3): 513-518
50. Andrews GK (2000) Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol. 59 (1): 95-104
51. Allan AK, Hawksworth GM, Woodhouse LR, Sutherland B, King JC, and Beattie JH (2000) Lymphocyte metallothionein mRNA responds to marginal zinc intake in human volunteers. Br J Nutr. 84 (5): 747-756
52. Heuchel R, Radtke F, Georgiev O, Stark G, Aguet M, and Schaffner W (1994) The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 13 (12): 2870-2875
53. Hempe JM, and Cousins RJ (1992) Cysteine-rich intestinal protein and intestinal metallothionein: an inverse relationship as a conceptual model for zinc absorption in rats. Nutr. 122: 89-95
54. Hara H, Konishi A, and Kasai T (2000) Contribution of the cecum and colon to zinc absorption in rats. J Nutr. 130: 83-89
55. McMahon RJ, and Cousins RJ (1998) Regulation of the zinc transporter ZnT-1 by dietary zinc. Proc Natl Acad Sci 95 (9): 4841-4846
56. Krebs NF (2000) Overview of zinc absorption and excretion in the human gastrointestinal tract. J Nutr. 130: 1374-1377
57. Rolfs A, and Hediger MA (1999) Metal ion transporters in mammals: structure, function and pathological implications, J Physiol. 518: 1-12