House dust endotoxin and allergic sensitization in children

American Journal of Respiratory and Critical Care Medicine

Volumn 166, Issue 7, 2002, Pages 939-944

  Gehring, Ulrike ^a,b,c   Bischof, Wolfgang ^a,b,c   Fahlbusch, Bärbel ^a,b,c   Wichmann, Heinz Erich ^a,b,c   Heinrich, Joachim ^a,b,c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Atopy; Endotoxin; House dust; School children

Indexed keywords

ENDOTOXIN; HOUSE DUST ALLERGEN;

AGE; ALLERGY; ARTICLE; ASTHMA; ATOPY; CHILD; CONTROLLED STUDY; DEMOGRAPHY; DOMESTIC ANIMAL; FEMALE; GERMANY; HAY FEVER; HOUSE DUST; HUMAN; LIMULUS LYSATE TEST; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PARENT COUNSELING; PREVALENCE; PRIORITY JOURNAL; SENSITIZATION; SEX DIFFERENCE; TOXIN ANALYSIS;

AIR POLLUTION, INDOOR; ALLERGENS; ANIMALS; ANTIBODY SPECIFICITY; CATS; CHILD; CHILD WELFARE; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DOGS; DUST; ENDOTOXINS; ENVIRONMENTAL EXPOSURE; FEMALE; FLOORS AND FLOORCOVERINGS; GERMANY; HUMANS; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOGLOBULIN E; LOGISTIC MODELS; MALE; PREVALENCE; RISK FACTORS;

EID: 0036800204     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200203-256OC     Document Type: Article

References (35)

1. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299:1259-1260.
2. Martinez FD, Holt PG. Role of microbial burden in aetiology of allergy and asthma. Lancet 1999;354(Suppl. 2):SII12-SII15.
3. von Mutius E. Pro: the increase in asthma can be ascribed to cleanliness. Am J Respir Crit Care Med 2001;164:1106-1107.
4. Platts-Mills TAE, Woodfolk JA, Sporik R. Con: the increase in asthma cannot be ascribed to cleanliness. Am J Respir Crit Care Med 2001;164:1107-1108.
5. Bischof W, Koch A, Gehring U, Fahlbusch B, Heinrich J, Wichmann HE. Predictors of high endotoxin concentrations in German homes. Proc Healthy Buildings 2000;1:251-256.
6. Douwes J, Pearce N, Heederik D. Does environmental endotoxin exposure prevent asthma? Thorax 2002;57:86-90.
7. Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, Pauwels R, Sergysels R. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996;154:1641-1646.
8. Michel O, Duchateau J, Sergysels R. Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects. J Appl Physiol 1989;66:1059-1064.
9. Gereda JE, Leung DYM, Thatayatikom A, Streib JE, Price MR, Klinnert MD, Liu AH. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. Lancet 2000;355:1680-1683.
10. Rizzo MC, Naspitz CK, Fernández-Caldas E, Locky RF, Mimica ISD. Endotoxin exposure and symptoms in asthmatic children. Pediatr Allergy Immunol 1997;8:121-126.
11. Douwes J, Zuidhof A, Doekes G, van Der ZEE, Wouters I, Marike BH, Brunekreef B. (1 → 3)-β-D-glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med 2000;162:1348-1354.
12. Park JH, Gold DR, Spiegelman DL, Burge HA, Milton DK. House dust endotoxin and wheeze in the first year of life. Am J Respir Crit Care Med 2001;163:322-328.
13. von Mutius E, Braun-Fahrlander C, Schierl R, Riedler J, Ehlermann S, Maisch S, Waser M, Nowak D. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000;30:1230-1234.
14. Heinrich J, Gehring U, Douwes J, Koch A, Fahlbusch B, Bischof W, Wichmann HE. Pets and vermin are associated with high endotoxin levels in house dust. Clin Exp Allergy 2001;31:1839-1845.
15. Riedler J, Braun-Fahrländer C, Eder W, Schreuer M, Waser M, Maisch S, Carr D, Schierl R, Nowak D, von Mutius E. and the ALEX Study Team. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001;358:1129-1133.
16. Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exp Allergy 2000;30:194-200.
17. Braun-Fahrlander C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, Vuille JC, Wuthrich B. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss study on childhood allergy and respiratory symptoms with respect to air pollution. Clin Exp Allergy 1999;29:28-34.
18. Ernst P, Cormier Y. Relative scarcity of asthma and atopy among rural adolescents raised on a farm. Am J Respir Crit Care Med 2000;161:1563-1566.
19. Downs SH, Marks GB, Mitakakis TZ, Leuppi JD, Car NG, Peat JK. Having lived on a farm and protection against allergic diseases in Australia. Clin Exp Allergy 2001;31:570-575.
20. Leynaert B, Neukirch C, Jarvis D, Chinn S, Burney P, Neukirch F. Does living on a farm during childhood protect against asthma, allergic rhinitis, and atopy in adulthood? Am J Respir Crit Care Med 2001;164:1829-1834.
21. Von Ehrenstein OS, von Mutius E, Illi S, Baumann L, Bohm O, von Kries R. Reduced risk of hay fever and asthma among children of farmers. Clin Exp Allergy 2000;30:187-193.
22. Kilpelainen M, Terho EO, Helenius H, Koskenvuo M. Farm environment in childhood prevents the development of allergies. Clin Exp Allergy 2000;30:201-208.
23. Hesselmar B, Aberg N, Aberg B, Eriksson B, Bjorksten B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999;29:611-617.
24. Roost HP, Kunzli N, Schindler C, Jarvis D, Chinn S, Perruchoud AP, Ackermann-Liebrich U, Burney P, Wuthrich B. Role of current and childhood exposure to cat and atopic sensitization. European Community Respiratory Health Survey. J Allergy Clin Immunol 1999;104:941-947.
25. Braback L, Kjellman NI, Sandin A, Bjorksten B. Atopy among school children in northern and southern Sweden in relation to pet ownership and early life events. Pediatr Allergy Immunol 2001;12:4-10.
26. Nafstad P, Magnus P, Gaarder PI, Jaakkola JJ. Exposure to pets and atopy-related diseases in the first 4 years of life. Allergy 2001;56:307-312.
27. Svanes C, Jarvis D, Chinn S, Burney P. Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999;103:415-420.
28. Heinrich J, Hoelscher B, Frye C, Meyer I, Wjst M, Wichmann H-E. Trends in prevalence of atopic diseases and allergic sensitisation in children in eastern Germany. Eur Respir J 2002;19:1040-1046.
29. Fahlbusch B, Heinrich J, Gross I, Jager L, Richter K, Wichmann HE. Allergens in house-dust samples in Germany: results of an East-West German comparison. Allergy 1999;54:1215-1222.
30. Hastie T, Tibshirani R. Generalized additive models. London: Chapman and Hall; 1990.
31. Hosmer DW, Lemeshow S. Applied logistic regression. New York: Wiley; 1989.
32. Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 2001;357:752-756.
33. Tulic MK, Wale JL, Holt PG, Sly PD. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol 2000;22:604-612.
34. Park J-H, Spiegelmann DL, Burge HA, Gold DR, Chew GL, Milton DK. Longitudinal study of dust and airborne endotoxin in the home. Environ Health Perspect 2000;108:1023-1028.
35. Tariq SM, Matthews SM, Hakim EA, Stevens M, Arshad SH, Hide DW. The prevalence of and risk factors for atopy in early childhood: a whole population birth cohort study. J Allergy Clin Immunol 1998;101:587-593.