Towards Gram-negative antivirulence drugs: New inhibitors of HldE kinase

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1276-1289

  Desroy, Nicolas ^a   Moreau, François ^a   Briet, Sophia ^a   Fralliec, Géraldine Le ^a   Floquet, Stephanie ^a   Durant, Lionel ^a   Vongsouthi, Vanida ^a   Gerusz, Vincent ^a   Denis, Alexis ^a   Escaich, Sonia ^a  

^a MUTABILIS SA   (France)

Author keywords

Antibacterial; Antivirulence drugs; Escherichia coli; Gram negative; HldE; Lipopolysaccharide; Membrane permeability; RfaE

Indexed keywords

HEPTOSE; HLDE KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; CARBOHYDRATE SYNTHESIS; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; GRAM NEGATIVE BACTERIUM; HIGH THROUGHPUT SCREENING; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; HEPTOSES; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NUCLEOTIDYLTRANSFERASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 58949101426     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.021     Document Type: Article

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