An In Vitro Screen of Bacterial Lipopolysaccharide Biosynthetic Enzymes Identifies an Inhibitor of ADP-Heptose Biosynthesis

Chemistry and Biology

Volumn 13, Issue 4, 2006, Pages 437-441

  De Leon, Gladys P ^a   Elowe, Nadine H ^a   Koteva, Kalinka P ^a   Valvano, Miguel A ^b   Wright, Gerard D ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b Siebens Drake Research Institute   (Canada)

Author keywords

CHEMBIO; MICROBIO

Indexed keywords

ADENOSINE DIPHOSPHATE SUGAR; D,D HEPTOSE 7 PHOSPHATE KINASE D,D HEPTOSE 1 PHOSPHATE ADENYLYLTRANSFERASE, E COLI; D,D HEPTOSE 7-PHOSPHATE KINASE-D,D-HEPTOSE 1-PHOSPHATE ADENYLYLTRANSFERASE, E COLI; ENZYME INHIBITOR; GLYCOSYLTRANSFERASE; HEPTOSYLTRANSFERASE; LIPOPOLYSACCHARIDE; MULTIENZYME COMPLEX; NUCLEOTIDYLTRANSFERASE; PHOSPHOTRANSFERASE; RECOMBINANT PROTEIN;

ARTICLE; BIOSYNTHESIS; CELL MEMBRANE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; KINETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION;

ADENOSINE DIPHOSPHATE SUGARS; CELL MEMBRANE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ESCHERICHIA COLI; GLYCOSYLTRANSFERASES; GRAM-NEGATIVE BACTERIA; KINETICS; LIPOPOLYSACCHARIDES; MICROBIAL SENSITIVITY TESTS; MULTIENZYME COMPLEXES; NUCLEOTIDYLTRANSFERASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 33646037670     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2006.02.010     Document Type: Article

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