Etiopathogenic features of acne vulgaris;Fatores etiopatogênicos da acne vulgar

Anais Brasileiros de Dermatologia

Volumn 83, Issue 5, 2008, Pages 451-459

  Costa, Adilson ^a,b,c   Alchorne, Maurício Motta De Avelar ^a   Goldschmidt, Maria Cristina Bezzan ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b PONTIFÍCIA UNIVERSIDADE CATÓLICA DE CAMPINAS   (Brazil)

^c Rua Cayowáa 710 ^*  (Brazil)

Author keywords

Acne vulgaris; Propionibacterium acnes; Sebum

Indexed keywords

ANDROSTANOLONE; ANDROSTENEDIONE; AROMATASE; ESTRADIOL; ESTRONE; PRASTERONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TOLL LIKE RECEPTOR;

ACNE VULGARIS; BACTERIAL COLONIZATION; HORMONAL REGULATION; HORMONE METABOLISM; KERATINIZATION; PATHOGENESIS; REVIEW; SEBUM SECRETION; SKIN DISEASE;

EID: 58949090063     PISSN: 03650596     EISSN: 18064841     Source Type: Journal    
DOI: 10.1590/S0365-05962008000500010     Document Type: Review

References (82)

1. Winston MH, Shalita AR. Acne vulgaris. Pathogenesis and treatment. Pediat Clin North Am. 1991;38:889-903.
2. Steiner D. Acne na mulher. Rev Bras Med. 2002;59:135-9.
3. Steiner D, Bedin V, Melo JSJ. Acne vulgar. Rev Bras Med. 2003;60:489-95.
4. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002;138:1584-90.
5. Stathakis V, Kilkenny M, Marks R. Descriptive epidemiology of acne vulgaris in the community. Australas J Dermatol. 1997;38:115-23.
6. Namazi MR. Further insight into the pathomechanism of acne by considering the 5-alpha-reductase inhibitory effect of linoleic acid. Int J Dermatol. 2004;43:701-2.
7. Burton JL. Dietary fatty acids and inflammatory skin disease. Lancet. 1989;1:27-31.
8. Dreno B, Poli F. Epidemiology of acne. Dermatology. 2003;206:7-10.
9. Sobral Filho JF, Nunes Maia HGS, Fonseca ESVB, Damião RS. Aspectos epidemiológicos da acne vulgar em universitários de João Pessoa - PB. An Bras Dermatol. 1993;68:225-8.
10. Sobral Filho JF, Silva CNA, Rodrigues JC, Rodrigues JLTD, Aboui-Azouz M. Avaliação da herdabilidade e concordância da acne vulgar em gêmeos. An Bras Dermatol. 1997;72:417-20.
11. Rustin MHA. Dermatology. Postgrad Med J. 1990;66:894-905.
12. Molina MTC. Patogenia del acné. Rev Chil Dermatol. 1996;12:163-6.
13. Hassun KM. Acne: etiopatogenia. An Bras Dermatol. 2000;75:7-15.
14. Talarico Filho S, Hassun KM. Acne. Rev Bras Med. 2001;58:17-21.
15. Sampaio SAP, Rivitti EA. Foliculoses. In: Sampaio SAP, Rivitti EA. Dermatologia. São Paulo: Artes Médicas; 2001. p. 291-300.
16. Uribe LFU, Cabezas AM, Molina MTC. Glândulas sebáceas y acne. Dermatología. 1986;2:22-4.
17. Stewart ME, Steele WA, Downing DT. Changes in the relative amounts of endogenous and exogenous fatty acids in sebaceous lipids during early adolescence. J Invest Dermatol. 1989;92:371-8.
18. Stewart ME, Downing DT. Measurement of sebum secretion rates in young children. J Invest Dermatol. 1985;84:59-61.
19. Powell EW, Beveridge GW. Sebum excretion and sebum composition in adolescent men with and without acne vulgaris. Br J Dermatol. 1970;82:243-9.
20. Green SC, Stewart ME, Downing DT. Variation in sebum fatty acid composition among adult humans. J Invest Dermatol. 1984;83:114-7.
21. Nordstrom NK, Noble WC. Application of computer taxonomic techniques to the study of cutaneous Propionibacteria and skin-surface lipid. Arch Dermatol. 1985;278:107-13.
22. Cotterill JA, Cunliffe WJ, Williamson B, Bulusu L. Age and sex variation in skin surface lipid composition and sebum excretion rate. Br J Dermatol. 1972;87:333-40.
23. Yamamoto A, Serizawa S, Ito M, Sato Y. Effect of aging on sabaceous gland activity and on the fatty acid composition of wax esters. J Invest Dermatol. 1987;89:507-12.
24. Cotterill JA, Cunliffe WJ, Williamson B. Variation in skin surface lipid composition and sebum excretion rate with time. Acta Derm Venereol. 1973;53:271-4.
25. Ikaraocha CI, Taylor GOL, Anetor JI, Onuegbu JA. Pattern of skin surface lipids in some south-western Nigerians with acne vulgaris. West Afr J Med. 2004;23:65-8.
26. Horrobin DF. Essential fatty acids in clinical dermatology. J Am Acad Dermatol. 1989;20:1045-53.
27. Morello AM, Downing DT, Strauss JS. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol. 1976;66:319-23.
28. Downing DT, Stewart ME, Wertz PW, Strauss JS. Essential fatty acids and acne. J Am Acad Dermatol. 1986;14:221-5.
29. Downing DT, Stewart ME, Wetz PW, Colton SW, Abraham W, Strauss JS. Skin lipids: an update. J Invest Dermatol. 1987;88(Suppl 3):S2-6.
30. Summerly R, Yardley HJ, Raymond M, Tabiowo A, Ilderton E. The lipid compositon of sebaceous glands as a reflection of gland size. Br J Dermatol. 1976;94:45-53.
31. Montpoint A, Guillot B, Truchetet F, Grosshans E, Guilhou JJ. Acides gras essentiels en dermatologie. Ann Dermatol Venereol. 1992;119:233-9.
32. Cordain L. Implications for the role of diet in acne. Semin Cutan Med Surg. 2005;24:84-91
33. Honeyman J. Comedogénesis. Rev Chil Dermatol. 2001;17:69-79.
34. Plewig G, Fulton JE, Kligman AM. Cellular dynamics of comedo formation in acne vulgaris. Arch Dermatol Forsch. 1971;242:12-29.
35. Rosenfield RL, Kentsis A, Deplewski D, Ciletti N. Rat prepucial sebocyte differential involves peroxisome proliferator-actived receptors. J Invest Dermatol. 1999;112:226-32.
36. Cunliffe WJ, Holland DB, Clark SM, Stables GI. Comedogenesis: some aetiological, clinical and therapeutic strategies. Dermatology. 2003;206:11-6.
37. Wertz PW, Miethke MC, Long SA, Strauss JS, Downing DT. The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol. 1985;84:410-2.
38. Perisho K, Wertz PW, Madison KC, Stewart ME, Downing DT. Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. J Invest Dermatol. 1988;90:350-3.
39. Letawe C, Boone M, Piérard GE. Digital image analysis of the effect of topically applied linoleic acido on acne microcomedones. Clin Exp Dermatol. 1998;23:56-8.
40. Motoyoshi K. Enhanced comedo formation in rabbit ear skin by squalene and oleic acid peroxides. Br J Dermatol. 1983;109:191-8.
41. Woo-Sam PC. A quantitative study of membrane coating granules in follicles undergoing experimental comedo formation. Br J Dermatol. 1978;99:387-94.
42. Choi EH, Ahn SK, Lee SH. The changes of stratum corneum interstices and calcium distribution of follicular epithelium of experimentally induced comedo (EIC) by oleic acid. Exp Dermatol. 1997;6:29-35.
43. Katsuta Y, Iida T, Inomata S, Denda M. Unsaturated fatty acids induce calcium influx into keratinocytes and cause abnormal differentiation of epidermis. J Invest Dermatol. 2005;124:1008-13.
44. Maeda T. An electron microscopic study of experimentally-induced comedo and effects of vitamin A acid oncomedo formation. J Dermatol. 1991;18:397-407.
45. Edmondson SR, Thumiger SP, Werther GA, Wraight CJ. Epidermal homeostasis: the hole of the growth hormone and insulin-like growth factor systems. Endocr Rev. 2003;24:737-64.
46. Azulay DA, Azulay RD. Acne e doenças afins. In: Azulay DA, Azulay RD. Dermatologia. 3 ed. Rio de Janeiro: Guanabara Koogan; 2004. p. 326-9.
47. Whiteside JA, Voss JG. Incidence and lipolytic activity of Propionibacterium acnes (Corynebacterium acnes group I) and P. granulosum (C. acnes group II) in acne and in normal skin. J Invest Dermatol. 1973;60:94-8.
48. Bojar RA, Holland KT. Acne and propionibacterium acnes. Clin Dermatol. 2004;22:375-9.
49. McGinley KJ, Webster GF, Ruggieri MR, Leyden JJ. Regional variations in density of cutaneous Propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. J Clin Microbiol. 1980;12:672-5.
50. Basta M, Wilburg J, Heczko PB. In vitro effects of skin lipid extracts on skin bacteria in relation to age and acne changes. J Invest Dermatol. 1980;74:437-9.
51. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21:335-76.
52. McInturff JE, Kim J. The Role of Toll-Like Receptors in the Pathophysiology of Acne. Sem Cutan Med Surg. 2005;24:73-8.
53. Heymann WR. Toll-like receptors in acne vulgaris. J Am Acad Dermatol. 2006;55:691-2.
54. Kellum RE. Acne vulgaris. Studies in pathogenesis: relative irritancy of free fatty acids from C2 to C16. Arch Dermatol. 1968;97:722-6.
55. Stillman MA, Maibach HI, Shalita AR. Relative irritancy of free fatty acids of different chain length. Contact Dermatitis. 1975;1:65-9.
56. Abad-Machado A, Fundora Guerra V, Diaz Almeida JG, Molinet DuarteI, René Manrique J. Acne vulgar e imunidad celular. Rev Cubana Med. 1996;35:1-3.
57. Tucker SB, Rogers III RS, Winkelmann RK, Privett OS, Jordon RE. Inflammation in acne vulgaris: leukocyte attraction and cytotoxicity by comedonal material. J Invest Dermatol. 1980;74:21-5.
58. Akamatsu H, Komura J, Miyachi Y, Asada Y, Niwa Y. Supressive effects of linoleic acido n neutrophil oxygen metabolism and phagocytosis. J Invest Dermatol. 1990;95:271-4.
59. Akamatsu H, Horio T. The possible role of reactive oxy gen species generated by neutrophils in mediating acne inflammation. Dermatology. 1998;196:82-5.
60. Akamatsu H, Niwa Y, Matsunaga K. Effect of palmitic acido n neutrophil functions in vitro. Int J Dermatol. 2001;40:640-3.
61. Graham GM, Farrar MD, Cruse-Sawyer JE, Holland KT, Ingham E. Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL. Br J Dermatol. 2004;150:421-8.
62. Filgueira AL, Filgueira MVFSL. Avaliação do zinco sérico em portadores de acne. An Bras Dermatol. 1984;59:267-70.
63. Horrobin DF, Cunnane SC. Zinc, essential fatty acids, and prostaglandins. Arch Dermatol. 1979;115:641-2.
64. Vignale RA, Lasalvia E, Espasandin J. Antiproteasas seric as en la acne vulgaris. Arch Argent Dermatol. 1982;32:17-23.
65. Thiboutot D, Knaggs H, Gilliland K, Lin G. Activity of 5-alpha-reductase and 17-beta-hydroxysteroid dehydrogenase in the infrainfundibulum of subjects with and with out acne vulgaris. Dermatology. 1998;196:38-42.
66. Thiboutot DM. Regulation of human sebaceous glands. J Invest Dermatol. 2004;123:1-12.
67. Yarak S, Bagatin E, Hassun KM, Parada MOAB, Talarico Filho S. Hiperandrogenismo e pele: síndrome do ovário policístico e resistência periférica à insulina. An Bras Dermatol. 2005;80:395-410.
68. Zouboulis CC, Böhm M. Neuroendocrine regulation of sebocytes - a pathogenic link between stress and acne. Exp Dermatol. 2004;13:31-5.
69. Rosenfield RL, Deplewski D, Kentsis A, Ciletti N. Mechanisms of androgen induction of sebocyte differentiation. Dermatology. 1998;196:43-6.
70. Stewart ME, Grahek MO, Cambier LS, Wertz PW, Downing DT. Dilutional effect of incresead sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides. J Invest Dermatol. 1986;87:733-6.
71. Burkhart CG. 5 alpha-reductase and finasteride in pattern alopecia and acne. J Drugs Dermatol. 2004;3:363-4.
72. Cappel M, Mauger D, Thiboutot D. Correlation between serum levels of insuli-like growth factor 1, dihydroepiandrosterone sulfate, and dihydrotestosterone and acne lesions counts in adult women. Arch Dermatol. 2005;141:333-8.
73. Stewart ME, Downing DT, Cook JS. Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. Arch Dermatol. 1992;128:1345-8.
74. Poch PE, Strauss JS, Downing DT. Skin surface lipid composition, acne, pubertal development, and urinary excretion of testosterone and 17-ketosteroids in children. J Invest Dermatol. 1977;69:485-9.
75. Adebamowo CA, Spiegelman D, Danby FW, Franzier AL, Willet WC, Holmes MD. High scholl dietary dairy intake and teenage acne. J Am Acad Dermatol. 2005;52:207-14.
76. Adebamowo CA, Spiegelman D, Berkey CS, Danby FW, Rockett HH, Colditz GA, et al. Milk consumption and acne in adolescent girls. Dermatol Online J. 2006;12:1.
77. Danby FW. Acne and milk, the diet myth, and beyond. J Am Acad Dermatol. 2005;52:360-2
78. Burral B. The relationship of diet and acne. Dermatol Online J. 2006;12:25
79. Sociedade Brasileira de Dermatologia. Perfil nosológico das consultas dermatológicas no Brasil. An Bras Dermatol. 2006;81:549-58.
80. PuBMed [database on the Internet]. Beteshda (MD): U.S. National Library of Medicine. C1993 - [updated 2008 Ouct; cited 2008 Ouct 7]. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=searc&DB=pubmed
81. Cunliffe WJ, Simpson NB. Disorders of the sebaceous glands. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Rook/ Wilkinson/ Ebling Textbook of Dermatology. 6th ed. Oxford: Blackwell Science; 1998. p.1940.
82. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002;138:1584-90.