Acne: Etiopathogenesis;Acne: Etiopatogenia

Anais Brasileiros de Dermatologia

Volumn 75, Issue 1, 2000, Pages 7-15

  Hassun, Karime Marques ^a,b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

Acne vulgaris; Sebaceous glandes; Sebum

Indexed keywords

ANDROGEN; ANDROSTANOLONE; COMPLEMENT COMPONENT C3; CYTOKINE; EPIDERMAL GROWTH FACTOR; ESTROGEN; IMMUNOGLOBULIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 8; SEX HORMONE BINDING GLOBULIN; STEROID 5ALPHA REDUCTASE; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA;

ACNE; ANDROGEN BLOOD LEVEL; ANDROGEN SYNTHESIS; BACTERIAL COLONIZATION; CHRONIC INFLAMMATION; COMEDO; KERATINIZATION; LIPOGENESIS; MALASSEZIA FURFUR; PROPIONIBACTERIACEAE; REVIEW; SEBACEOUS GLAND; SEBUM SECRETION; STAPHYLOCOCCUS AUREUS;

EID: 0034102183     PISSN: 03650596     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. Cunliffe WJ, Simpson NB. Disorders of the sebaceous glands. In: Champion RH, Burton JL, Burns DA, Breathnach SM, eds, Rook, Wilkinson, Ebling: Textbook of dermatology. Oxford: Blackwell Science, 1998:1940-82
2. Burton JL, Cunliffe WJ, Stafford L et al. The prevalence of acne vulgaris in adolescence. Br J Dermatol 1971;85:119-26.
3. Lucky AW, Biro FM, Huster FA et al. Arch Dermatol 1991;172:210-6.
4. Cunliffe WJ, Gould DJ. Prevalence of facial acne vulgaris in late adolescence and in adults. Br Med J 1979;1:1109-10.
5. Goulden V, Clark SM, Cunlifffe WJ. Post-adolescent acne: a review of clinical features. Br J Dermatol 1997;136:66-70.
6. Kranning KK, Odland GF. Prevalence, morbidity and cost of dermatological diseases. J Invest Dermatol 1979,73:395-513.
7. Thiboutot DM. Acne: an overview of clinical research findings. Dermatologic clinics 1997;15:97-109.
8. Walton S, Wyatt E, Cunlifffe WJ. Genetic control of sebum excretion and acne. A twin study. Br J Dermatol 1998;18:393-6.
9. Lim LS, James VHT. Plasma androgens in acne vulgaris. Br J Dermatol 1974;91:135-43.
10. Walton S, Cunlifffe WJ, Keczkes K et al. Clinical, ultrasound and hormonal markers of androgenicity in acne vulgaris. Br J Dermatol 1995;133:249-53.
11. Peserico A, Angeloni G, Bertoli P et al. Prevalence of polycistic ovaries in women with acne. Arch Dermatol Res 1989;281:502-3.
12. Downing DT, Strauss JS, Pochi PE. Variability in the chemical composition of human skin surface lipids. J Invest Dermatol 1969;53:322-7.
13. Cotteril JA, Cunlifffe WJ, Williamson B et al. Further investigations on the pathogenesis of acne. Br Med J 1972;ii:400-6.
14. Kellum RL, Strangfeld KE. Acne vulgaris: studies in pathogenesis. Fatty acids of human surface tryglicerids of pacients with and without acne. J Invest Dermatol 1972;58:315-8.
15. Holmes RL, Williams M, Cunlifffe WJ. Pilo-sebaceous duct obstruction and acne. Br J Dermatol 1972;87:327-32.
16. Plewig G, Fulton JE. Kligman AM. Cellular dynamics of comedo formation in acne vulgaris. Arch Dermatol Forsch 1971;242:12-29.
17. Knaggs HE, Holland DB, Morris C et al. Quantification of cellular proliferation in acne using the monoclonal antibody Ki-67. J Soc Invest Dermatol 1994;102:89-92.
18. Hughes BR, Morris C, Cunlifffe WJ, Leigh IM. Keratin expression in the pilosebaceous epithelia in truncal skin of acne pacients. Br J Dermatol 1996;134:247-56
19. Knaggs HE, Hughes BR, Morris C et al. Immunohistochemical study of desmososmes in acne vulgaris. Br J Dermatol 1994;130:731-7.
20. Aldana OL, Holland DB, Cunlifffe WJ. The theory of comedone cycling. J Invest Dermatol 1997;108:384(abstract 77).
21. Gonzales-Serva A. Excretion of sebum is channeled by a keratimous envelope from sebaceous duct origin: the sebolemmal sheath. J Invest Dermatol 1997;108:376.
22. Stewart ME, Wertz PW, Crahek MO. Relationship between sebum secretion rates and the concentration of linoleate in sebum and epidermal lipids. Clin Res 1985;33:684-8.
23. Motoyoshi K. Enhanced comedo formation in rabbit ear skin by squalen and olcic acid peroxides. Br J Dermatol 1983; 109:191-8.
24. Guy R, Green MR, Kealy T. Modelling acne in vitro. J Invest Dermatol 1996;106:176-82.
25. Guy R, Kealy T. Modelling the infundibulum in acne. Dermatol 1998;196:32-7.
26. Thiboutot DM, Knaggs H, Gilliland K, Hagari S. Activity of type 1 5a-redutase is greater in the follicular infrainfundibullum compared with epidermis. Br J Dermatol 1997;136:166-71.
27. Ingham E, Eady A, Goodwin CE et al. Pro-inflammatory levels of interleukin la-like bioactivity are present in the majority of open comedones in acne vulgaris. J Invest Dermatol 1992;98:895-901.
28. Marples RR. The microflora of the face and acne lesions. J Invest Dermatol 1974:62:326-31.
29. Leyden JL, Mcginley KJ, Mills OH et al. Propionebacterium levels in patients with and without acne vulgaris. J Invest Dermatol 1975;65:382-4.
30. Cove JH, Holland KT, Cunliffe WJ. An analysis of sebum excretion rate, bacterial population and the production rate of free fatty acids on human skin. Br J Dermatol 1980;103:383-6.
31. Allaker RP, Greenman J, Osborne RH. The production of inflammatory compounds by Propionibacterium acnes and other skin organisms. Br J Dermatol 1987;117:175-83.
32. Webster GF, Tsai C-C, Leyden JJ. Neutrophil lysosomal release in response to Propionibacterium acnes. J Invest Dermatol 1979;72:209 (abstract).
33. Webster GF, Leyden JJ, Nilsson UR. Complement activation in acne vulgaris consuption of complement by comedones. Infect Immun 1979;26:183-6.
34. Gribbon EM, Cunliffe WJ, Holland KT. Interaction of Propionibacterium acnes with skin lipids in vitro. J Gen Microbiol 1993;139:1745-51.
35. Vowels BR, Yang S, Leyden JJ. Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect Immun 1995;63:3158-65.
36. Ingham E, Walters CE, Eady A, Cove JH, Kearney JN, Cunliffe WJ. Inflammation in acne vulgaris: failure of skin micro-organisms to modulate keratinocyte interleukin 1a production in vitro. Dermatol 1998;196:86-8.
37. Burkhart CC, Lehmann PF. Abscense of circulating immune complexes in acne vulgaris. Br J Dermatol 1982;106:120-2.
38. Norris JF, Cunliffe WJ. A histological and immunocytochemical study of early acne lesions. Br J Dermatol 1988;118:651-9.
39. Leyden JJ. New understandings of the pathogenesis of acne. J Am Acad Dermatol 1995;32:S15-25.
40. Dahl MGC, McGibbon DH. Complement in inflammatory acne vulgaris. Br Med J 1976;2:1383 (letter).
41. Kersey P, Sussman M, Dahl MGC. Delayed skin test reactivity to Propionibacterium acnes correlates with severity of inflammation in acne vulgaris. Br J Dermatol 1980;103:651-5.
42. Webster GF. Inflammatory acne represents hypersensitivity to Propionibacterium acnes. Dermatol 1998;196:80-1.
43. Zoubolis ChC, Xia L, Akamatsu H et al. The human sebocyte culture model provides new insights into development and management of seborrhoea and acne. Dermatol 1998;196:21-31.
44. Guy R, Kealey T. The organ-mantained human sebaceous gland. Dermatol 1998;196:16-20.
45. Strauss JS. Sebaceous gland, acne and related disorders - an epilogue. Dermatol 1998;196:182-4.