Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women

Archives of Dermatology

Volumn 141, Issue 3, 2005, Pages 333-338

  Cappel, Mark ^a   Mauger, David ^b   Thiboutot, Diane ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; PRASTERONE SULFATE; SOMATOMEDIN C;

ACNE; ADULT; ANALYTIC METHOD; ANAMNESIS; ANDROGEN BLOOD LEVEL; ARTICLE; CALCULATION; CLINICAL ARTICLE; COHORT ANALYSIS; COMEDO; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; EXAMINATION; FEMALE; HEALTH CENTER; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; INFLAMMATION; MALE; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; SAMPLING; SERUM; SEX DIFFERENCE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ACNE VULGARIS; ADULT; AGE FACTORS; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; DEHYDROEPIANDROSTERONE SULFATE; DIHYDROTESTOSTERONE; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PROBABILITY; PROGNOSIS; RISK ASSESSMENT; SAMPLING STUDIES; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 14944384311     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archderm.141.3.333     Document Type: Article

References (24)

1. Rosenfield RL, Deplewski D. Role of androgens in the developmental biology of the pilosebaceous unit. Am J Med. 1995;98:80S-88S.
2. Cara JF, Rosenfield R, Furlanetto R. A longitudinal study of the relationship of plasma somatomedin-C concentration to the pubertal growth spurt. Am J Dis Child. 1987;141:562-564.
3. Aizawa H, Niimura M. Elevated serum insulin-like growth factor-1 (IGF-1) levels in women with postadolescent acne. J Dermatol. 1995;22:249-252.
4. Stewart ME, Downing DT, Cook JS, Hansen JR, Strauss JS. Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. Arch Dermatol. 1992;128:1345-1348.
5. De Pergola G, Cospite M, Giagulli V, et al. Insulin-like growth factor-1 (IFG-1) and dehydroepiandrosterone sulphate in obese women. Int J Obes Relat Metab Disord. 1993;17:481-483.
6. Guercio G, Rivarola M, Chaler E, Maceiras M, Belgorosky A. Relationship between the growth hormone/insulin-like growth factor-1 axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal girls. J Clin Endocrinol Metab. 2003;88:1389-1393.
7. Schmidt J, Lindmaier A, Spona J. Endocrine parameters in acne vulgaris. Endocrinol Exp. 1990;24:457-464.
8. Lucky AW, Biro FM, Huster GA, Leach AD, Morrison JA, Ratterman J. Acne vulgaris in premenarchal girls. Arch Dermatol. 1994;130:308-314.
9. Lucky AW, Biro FM, Simbartl LA, Morrison JA, Sorg NW. Predictors of severity of acne vulgaris in young adolescent girls: results of a five-year longitudinal study J Pediatr. 1997;130:30-39.
10. Thiboutot D, Gilliland K, Light J, Lookingbill D. Androgen metabolism in sebaceous glands from subjects with and without acne. Arch Dermatol. 1999;135:1041-1045.
11. Nichols Institute Diagnostics. IGF-1 by Extraction: Radioisotopic Assay Manual. San Juan Capistrano, Calif: Nichols Institute Diagnostics; 1995.
12. Hossenlopp P, Seurin D, Segovia B, Portolan G, Binoux M. Heterogeneity of insulin-like growth factor binding proteins between structure and affinity. Eur J Biochem. 1987;170:133-142.
13. Rudman S, Philpott M, Thomas G, Kealey T. The role of IGF-1 in human skin and its appendages: morphogen or mitogen? J Invest Dermatol. 1997;109:770-777.
14. Oakes S, Haynes K, Waters M, Herington A, Werther G. Demonstration and localization of growth hormone receptor in human skin and skin fibroblasts. J Clin Endocrinol Metab. 1992;75:1368-1373.
15. Deplewski D, Rosenfield RL. Growth hormone and insulin-like growth factors have different effects on sebaceous cell growth and differentiation. Endocrinology. 1999;140:4089-4094.
16. Burton J, Libman L, Cunliffe WJ, Wilkinson R, Hall R, Shuster S. Sebum excretion in acromegaly. Br Med J. 1972;1:406-408.
17. Goolamali S, Burton J, Shuster S. Sebum excretion in hypopituitarism. Br J Dermatol. 1973;89:21-24.
18. Aizawa H, Nakada Y, Niimura M. Androgen status in adolescent women with acne vulgaris. J Dermatol. 1995;22:530-532.
19. Giudice L. Growth factor action on ovarian function in polycystic ovary syndrome. Endocrinol Metab Clin North Am. 1999;28:325-333.
20. Genazzani A, Stomati M, Strucchi C, Puccetti S, Luisi S, Genazzani A. Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women. Fertil Steril. 2001;76:241-248.
21. Azziz R, Deal CL, Potter HD, Gargosky SE, Rosenfeld RG. Regulation of extragonadal insulin-like growth factor-binding protein-3 by testosterone in oophorectomized women. J Clin Endocrinol Metab. 1994;79:1747-1751.
22. Pham-Huu-Trung M, Villette J, Bogyo A, Duclos J, Fiet J, Binoux M. Effects of insulin-like growth factor 1 (IGF-1) on enzymatic activity in human adrenocortical cells: interactions with ACTH. J Steroid Biochem Mol Biol. 1991;39:903-909.
23. Thiboutot D, Jabara S, McAllister J, et al. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol. 2003;120:905-914.
24. Horton R, Pasupuletti V, Antonipillai I. Androgen induction of steroid 5α-reductase may be mediated via insulin-like growth factor 1. Endocrinology. 1993;133:447-451.