Digital image analysis of the effect of topically applied linoleic acid on acne microcomedones

Clinical and Experimental Dermatology

Volumn 23, Issue 2, 1998, Pages 56-58

  Letawe, C ^a   Boone, M ^b   Pierard G E ^a,c  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b BRUGMANN UNIVERSITY HOSPITAL   (Belgium)

^c CHU SART TILMAN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ESSENTIAL FATTY ACID; LINOLEIC ACID; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; COMEDO; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIAGNOSTIC ACCURACY; DOUBLE BLIND PROCEDURE; ESSENTIAL FATTY ACID DEFICIENCY; HUMAN; HYPOTHESIS; IMAGE ANALYSIS; PATHOGENESIS; PATHOGENICITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; TOPICAL DRUG ADMINISTRATION;

ACNE VULGARIS; ADOLESCENT; ADULT; CHILD; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LINOLEIC ACID; MALE;

EID: 0031830949     PISSN: 03076938     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2230.1998.00315.x     Document Type: Article

References (25)

1. Kanaar R. Follicular-keratogenic properties of fatty acids in the external ear canal of the rabbit. Dermatologica 1971; 142: 14-22.
2. Mills OH, Porte M, Kligman AM. Enhancement of comedogenic substances in ultraviolet radiation. Br J Drrmatol 1978; 98: 145-50.
3. Saint-Léger D, Bague A, Lefebvre E et al. A possible role for squalene in the pathogenesis of acne. In vitro study of squalene oxidation. Br J Dermatol 1986; 114: 535-42.
4. Morello AM, Downing DT, Strauss JS. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol 1976; 66: 319-23.
5. Wertz PW, Miethke MC, Long SA et al. The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol 1985; 84: 410-2.
6. Stewart ME, Grahak MO, Cambier LS. Dilutional effect of increased sebaceous gland activity on the proportion of linoleic acid in sebaceous wax esters and in epidermal acylceramides. J Invest Dermatol 1986; 87: 733-6.
7. Perisho K, Wertz PW, Madison KC et al. Patty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. J Invest Dermatol 1988; 90: 350-3.
8. Downing DT, Stewart ME, Wertz PW, Strauss JS. Essential fatty acids and acne. J Am Acad Dermatol 1986; 14: 221-5.
9. Piérard GE, Nikkels-Tassoudji N, Goffin V et al. Acne improvement in young women using a low-dose triphasic oral contraceptive containing gestodene and ethinylestradiol (Tri-Minulet). Interim evaluation of an open, non-controlled clinical study combined with objective biometrological methods. Gynecol Endocrinol 1996; 10 (Suppl. 5): 61-6.
10. Marks R, Dawber RPR. Skin surface biopsy. An improved technique for the examination of the horny layer. Br J Dermatol 1971; 84: 117-23.
11. Holmes RL, Williams M, Cunliffe WJ. Pilosebaceous duct obstruction and acne. Br J Dermatol 1972; 87: 327-32.
12. Cunliffe WJ, Percra WDH, Thackray P et al. Pilosebaceous duct physiology. Br J Dermatol 1976; 95: 153-6.
13. Mills OH, Kligman AM. A human model for assaying comedolytic substances. Br J Dermatol 1982; 107: 543-8.
14. Mills OH, Kligman AM. A human model for assessing comedogenic substances. Arch Dermatol 1982; 118: 903-5.
15. Mills OH, Kligman AM. The follicular biopsy. Dermatologica 1983; 167: 57-63.
16. Piérard-Franchimont C, Piérard GE. Assessment of aging and actinic damage by cyanoacrylate skin surface strippings. Am J Dermatopathol 1987; 9: 500-509.
17. Groh DG, Mills OH, Kligman AM. Quantitative assessment of cyanoacrylate follicular biopsies by image analysis. J Soc Cosmet Chem 1992; 43: 101-12.
18. Pagnoni A, Kligman AM, El Gammal S, Stoudemayer T. Determination of density of follicles on various regions of the face by cyanoacrylate biopsy: correlation with sebum output. Br J Dermatol 1994; 131: 862-5.
19. Piérard GE, Piérard-Franchimont C, Goffin V. Digital image analysis of microcomedones. Dermatology 1995; 190: 99-103.
20. Kligman AM, Kwong T. An improved rabbit ear model for assessing comedogenic substances. Br J Dermatol 1979; 100: 699-702.
21. Morris WE, Kwan SC. Use of the rabbit ear model in evaluating the comedogenic potential of cosmetic ingredients. J Soc Cosmet Chem 1983; 34: 215-25.
22. American Academy of Dermatology. Invitational symposium on comedogenicity. J Am Acad Dermatol 1989; 20: 272-7.
23. Nelson FP, Rumsfield J. Cosmetics: content and function. Int J Dermatol 1988; 27: 665-72.
24. Katoulis AC, Kakepis EM, Kintziou H et al. Comedogenicity of cosmetics: a review. J Eur Acad Dermatol Vener 1996; 7: 115-9.
25. Ghyczy M, Nissen HP, Biltz, H The treatment of acne vulgaris by phosphatidylcholine from soybeans, with a high content of linoleic acid. Int Cosmet Conf Proc, Paris 1995; 151-61.