A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 3, 2009, Pages 1232-1243

  Muro, Fumihito ^a   Iimura, Shin ^a   Yoneda, Yoshiyuki ^a   Chiba, Jun ^a   Watanabe, Toshiyuki ^a   Setoguchi, Masaki ^a   Takayama, Gensuke ^a   Yokoyama, Mika ^a   Takashi, Tohru ^a   Nakayama, Atsushi ^a   Machinaga, Nobuo ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Integrin; Pharmacophore; trans 4 Substituted cyclohexanecarboxylic acid; VLA 4

Indexed keywords

4 [[2 (2 METHYLPHENYLAMINO) 6 BENZOXAZOLYLACETYL]FLUOROPYRROLIDINYLMETHOXY]CYCLOHEXANECARBOXYLIC ACID; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MALE; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; BENZOXAZOLES; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANECARBOXYLIC ACIDS; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; MALE; MOLECULAR CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 58949088440     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.12.026     Document Type: Article

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