4-(Pyrrolidinyl)methoxybenzoic acid derivatives as a potent, orally active VLA-4 antagonist

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 11, 2006, Pages 1515-1529

  Chiba, Jun ^a   Iimura, Shin ^a   Yoneda, Yoshiyuki ^a   Sugimoto, Yuichi ^a   Horiuchi, Takao ^a   Muro, Fumito ^a   Ochiai, Yuichi ^a   Ogasawara, Tomomi ^a   Tsubokawa, Masao ^a   Iigou, Yutaka ^a   Takayama, Gensuke ^a   Taira, Tomoe ^a   Takata, Yoshimi ^a   Yokoyama, Mika ^a   Takashi, Tohru ^a   Nakayama, Atsushi ^a   Machinaga, Nobuo ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Asthma; Human serum albumin; Integrin; VLA 4

Indexed keywords

4 (PYRROLIDINYL)METHOXYBENZOIC ACID DERIVATIVE; BENZOIC ACID DERIVATIVE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IC 50; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; ASTHMA; BENZOIC ACIDS; CELL MEMBRANE PERMEABILITY; DISEASE MODELS, ANIMAL; DOGS; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; INTEGRIN ALPHA4BETA1; KIDNEY; MALE; MICE; MICE, INBRED BALB C; MOLECULAR CONFORMATION; PYRROLIDINES; PYRROLIDINONES; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750707245     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.1515     Document Type: Article

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