-
1
-
-
0026770377
-
Integrins: Versatility, modulation and signalling in cell adhesion
-
Hynes RO: Integrins: versatility, modulation and signalling in cell adhesion. Cell (1992) 69:11-25.
-
(1992)
Cell
, vol.69
, pp. 11-25
-
-
Hynes, R.O.1
-
2
-
-
0033233464
-
4 integrin: an alternative pathway for neutrophil recruitment?
-
4 integrin: an alternative pathway for neutrophil recruitment? Immunol Today (1999) 20:545-550.
-
(1999)
Immunol Today
, vol.20
, pp. 545-550
-
-
Johnson, B.1
Kubes, P.2
-
3
-
-
0025161990
-
VCAM-1 on activated endothelium interact with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
-
Elices ME, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME, Lobb RR: VCAM-1 on activated endothelium interact with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell (1990) 59:577-584.
-
(1990)
Cell
, vol.59
, pp. 577-584
-
-
Elices, M.E.1
Osborn, L.2
Takada, Y.3
Crouse, C.4
Luhowskyj, S.5
Hemler, M.E.6
Lobb, R.R.7
-
4
-
-
0024418764
-
Identfication and characterization of the T-lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin
-
Wayner EA, Garcia-Pardo A, Humphries MJ, McDonald JA, Carter WG: Identfication and characterization of the T-lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J Cell Biol (1989) 109:321-1330.
-
(1989)
J Cell Biol
, vol.109
, pp. 321-1330
-
-
Wayner, E.A.1
Garcia-Pardo, A.2
Humphries, M.J.3
McDonald, J.A.4
Carter, W.G.5
-
5
-
-
0031802697
-
Osteopontin is a ligand for the α4β1 integrin
-
Bayless KJ, Meininger GA, Scholtz JM, Davis GE, Osteopontin is a ligand for the α4β1 integrin. J Cell Sci (1998) 111:1165-1174.
-
(1998)
J Cell Sci
, vol.111
, pp. 1165-1174
-
-
Bayless, K.J.1
Meininger, G.A.2
Scholtz, J.M.3
Davis, G.E.4
-
6
-
-
0030887708
-
Propolypetide of von Willebrand factor is a novel ligand for VLA4 integrin
-
Isobe T, Hisaoka T, Shimizu A, Okuno M, Aimoto S, Takada Y, Saito Y, Takagi J: Propolypetide of von Willebrand factor is a novel ligand for VLA4 integrin. J Biol Chem (1997) 272:8447-8453.
-
(1997)
J Biol Chem
, vol.272
, pp. 8447-8453
-
-
Isobe, T.1
Hisaoka, T.2
Shimizu, A.3
Okuno, M.4
Aimoto, S.5
Takada, Y.6
Saito, Y.7
Takagi, J.8
-
7
-
-
0029046132
-
The crystal structure of an N-terminal two domain fragment of VCAM-1: A cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1 α4β1 integrin interaction
-
Wang J- H, Pepinsky RB, Stehle T, Uu, J-H, Karpaus M, Browning B, Osborn L: The crystal structure of an N-terminal two domain fragment of VCAM-1: A cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1 α4β1 integrin interaction. Proc Natl Acad Sci USA (1995) 92:5714-5718.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5714-5718
-
-
Wang, J.H.1
Pepinsky, R.B.2
Stehle, T.3
Uu, J.-H.4
Karpaus, M.5
Browning, B.6
Osborn, L.7
-
8
-
-
0025777183
-
The minimal essential sequence for a major cell type specific adhesion site (CS-1) within the alternately spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine
-
Komoriya A, Green LJ, Mervic M, Yamada SS, Yamada KM, Humphries MJ: The minimal essential sequence for a major cell type specific adhesion site (CS-1) within the alternately spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J Cell Biol (1991) 266:15075-15079.
-
(1991)
J Cell Biol
, vol.266
, pp. 15075-15079
-
-
Komoriya, A.1
Green, L.J.2
Mervic, M.3
Yamada, S.S.4
Yamada, K.M.5
Humphries, M.J.6
-
9
-
-
0028924936
-
Crystal structure of an integrin binding fragment of VCAM-1
-
Jones EY, Harlos K, Bottomley MJ, Robinson RC, Driscoll PC, Edwards RM, Dudgeon TJ, Stuart DI: Crystal structure of an integrin binding fragment of VCAM-1. Nature (1995) 373:539-544.
-
(1995)
Nature
, vol.373
, pp. 539-544
-
-
Jones, E.Y.1
Harlos, K.2
Bottomley, M.J.3
Robinson, R.C.4
Driscoll, P.C.5
Edwards, R.M.6
Dudgeon, T.J.7
Stuart, D.I.8
-
10
-
-
0029315817
-
Do integrins use a MIDAS touch to grab an Asp?
-
Bergelson JM, Hemler ME: Do integrins use a MIDAS touch to grab an Asp? Curr Biol (1995) 5:615-617.
-
(1995)
Curr Biol
, vol.5
, pp. 615-617
-
-
Bergelson, J.M.1
Hemler, M.E.2
-
11
-
-
0031013031
-
Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain
-
Springer TA: Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain. Proc Natl Acad Sci USA (1997) 94:65-72.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 65-72
-
-
Springer, T.A.1
-
12
-
-
33747470180
-
The role of the integrin α4β1 in inflammation and the development of novel anti-inflammatory and antirheumatic agents
-
Elices MJ: The role of the integrin α4β1 in inflammation and the development of novel anti-inflammatory and antirheumatic agents. Rheumatoid Arthritis (1997) 1:642-646;
-
(1997)
Rheumatoid Arthritis
, vol.1
, pp. 642-646
-
-
Elices, M.J.1
-
13
-
-
0030477285
-
VCAM-1/α4-integrin adhesion pathway: Therapeutic target for allergic inflammatory disorders
-
Foster CA: VCAM-1/α4-integrin adhesion pathway: therapeutic target for allergic inflammatory disorders. J Allergy Clin Immunol (1996) 98:S270-S277;
-
(1996)
J Allergy Clin Immunol
, vol.98
-
-
Foster, C.A.1
-
14
-
-
0001769481
-
Blockade of the VLA-4 integrin as a therapy for airway inflammation in respiratory disease
-
Elices MJ: Blockade of the VLA-4 integrin as a therapy for airway inflammation in respiratory disease. Curr Opin Anti-inflamm Immunomod Invest Drugs (1999) 1:14-20;
-
(1999)
Curr Opin Anti-inflamm Immunomod Invest Drugs
, vol.1
, pp. 14-20
-
-
Elices, M.J.1
-
15
-
-
33748365731
-
Role of the integrin α4β1 in inflammatory disorders
-
Mousa SA (Ed), Springer-Verlag and RG Landes Co
-
Elices MJ: Role of the integrin α4β1 in inflammatory disorders. In: Cell Adhesion Molecules and Matrix Proteins: Role in Health and Diseases. Mousa SA (Ed), Springer-Verlag and RG Landes Co (1998) 134-147.
-
(1998)
Cell Adhesion Molecules and Matrix Proteins: Role in Health and Diseases
, pp. 134-147
-
-
Elices, M.J.1
-
16
-
-
0006610028
-
Targeting VLA-4 integrin function: Potential Therapeutic Implications
-
Mousa SA (Ed), Springer-Verlag and RG Landes Co
-
Bochner BS: Targeting VLA-4 integrin function: Potential Therapeutic Implications. In: Cell Adhesion Molecules and Matrix Proteins: Role in Health and Diseases. Mousa SA (Ed), Springer-Verlag and RG Landes Co (1998) 113-131.
-
(1998)
Cell Adhesion Molecules and Matrix Proteins: Role in Health and Diseases
, pp. 113-131
-
-
Bochner, B.S.1
-
17
-
-
0033988511
-
Drugs in development for the treatment of multiple sclerosis: antigen non-specific therapies - An update
-
Donoghue S, Greenlees C: Drugs in development for the treatment of multiple sclerosis: antigen non-specific therapies - an update. Exp Opin Invest Drugs (2000) 9:167-171.
-
(2000)
Exp Opin Invest Drugs
, vol.9
, pp. 167-171
-
-
Donoghue, S.1
Greenlees, C.2
-
18
-
-
0032943512
-
Peptide and peptidomimetic inhibitors of VLA-4
-
Zimmerman CN: Peptide and peptidomimetic inhibitors of VLA-4. Exp Opin Ther Pat (1999) 9:129-133;
-
(1999)
Exp Opin Ther Pat
, vol.9
, pp. 129-133
-
-
Zimmerman, C.N.1
-
19
-
-
0032797233
-
Small molecule antagonists of α4 integrins: Novel drugs for asthma
-
Lobb RR, Adams SP: Small molecule antagonists of α4 integrins: novel drugs for asthma. Exp Opin Invest Drugs (1999) 8:935-945;
-
(1999)
Exp Opin Invest Drugs
, vol.8
, pp. 935-945
-
-
Lobb, R.R.1
Adams, S.P.2
-
21
-
-
0032135083
-
Very late antigen-4 (VLA-4) antagonists as anti-inflammatory agents
-
Lin K-C, Castro AC: Very late antigen-4 (VLA-4) antagonists as anti-inflammatory agents. Curr Opin Chem Biol (1998) 2:453-457.
-
(1998)
Curr Opin Chem Biol
, vol.2
, pp. 453-457
-
-
Lin, K.-C.1
Castro, A.C.2
-
22
-
-
0033545639
-
Selective tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses
-
Lin K-C, Ateeq HS, Hsiung SH, Chong LT, Zimmerman CN, Castro A, Lee, W-C, Hammond CE, Kalkunte K, Chen L-L, Pepinsky RB, Leone DR, Sprague AG, Abraham WM, Gill A, Lobb RR, Adams SP: Selective tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J Med Chem (1999) 42:920-934.
-
(1999)
J Med Chem
, vol.42
, pp. 920-934
-
-
Lin, K.-C.1
Ateeq, H.S.2
Hsiung, S.H.3
Chong, L.T.4
Zimmerman, C.N.5
Castro, A.6
Lee, W.-C.7
Hammond, C.E.8
Kalkunte, K.9
Chen, L.-L.10
Pepinsky, R.B.11
Leone, D.R.12
Sprague, A.G.13
Abraham, W.M.14
Gill, A.15
Lobb, R.R.16
Adams, S.P.17
-
23
-
-
0000678946
-
Multiple activation states of integrin α4β1 detected through their different affinities for a small molecule ligand
-
Chen LL, Whitty A, Lobb RR, Adams SP, Pepinsky RB: Multiple activation states of integrin α4β1 detected through their different affinities for a small molecule ligand. J Biol Chem (1999) 274:13167-13175.
-
(1999)
J Biol Chem
, vol.274
, pp. 13167-13175
-
-
Chen, L.L.1
Whitty, A.2
Lobb, R.R.3
Adams, S.P.4
Pepinsky, R.B.5
-
24
-
-
0028177035
-
α4 Integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep
-
Abraham WM, Sielczak MW, Ashfaq A, Cortes A, Lauredo IT, Kim J, Pepinsky B, Benjamin CD, Leone DR, Lobb RR, Weller PF: α4 Integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep. J Clin Invest (1994) 93:776.
-
(1994)
J Clin Invest
, vol.93
, pp. 776
-
-
Abraham, W.M.1
Sielczak, M.W.2
Ashfaq, A.3
Cortes, A.4
Lauredo, I.T.5
Kim, J.6
Pepinsky, B.7
Benjamin, C.D.8
Leone, D.R.9
Lobb, R.R.10
Weller, P.F.11
-
26
-
-
0000101323
-
Identification of ligand binding sites on integrin α4β1 through chemical cross-linking
-
Chen LL, Lobb RR, Cuervo JH, Lin K-C, Adams SP, Pepinsky RB: Identification of ligand binding sites on integrin α4β1 through chemical cross-linking. Biochemistry (1998) 37:8743-8753.
-
(1998)
Biochemistry
, vol.37
, pp. 8743-8753
-
-
Chen, L.L.1
Lobb, R.R.2
Cuervo, J.H.3
Lin, K.-C.4
Adams, S.P.5
Pepinsky, R.B.6
-
27
-
-
33748368150
-
RSC-SCI - Tenth Medicinal Chemistry Symposium, Cambridge, UK
-
September 5-8
-
Cliffe IA, Bebbington D, Gillespie RJ, Knutsen LJS: RSC-SCI - Tenth Medicinal Chemistry Symposium, Cambridge, UK. IDdb Meeting Report (1999) September 5-8.
-
(1999)
IDdb Meeting Report
-
-
Cliffe, I.A.1
Bebbington, D.2
Gillespie, R.J.3
Ljs, K.4
-
28
-
-
0032497423
-
Novel inhibitors of α4β1 integrin receptor interactions through library synthesis and screening
-
Souers AJ, Vigilio AA, Schürer SS, Ellman JA, Kogan TP, West HE, Ankener W, Vanderslice P: Novel inhibitors of α4β1 integrin receptor interactions through library synthesis and screening. Bioorg Med Chem Lett (1998) 8:2297-2302.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 2297-2302
-
-
Souers, A.J.1
Vigilio, A.A.2
Schürer, S.S.3
Ellman, J.A.4
Kogan, T.P.5
West, H.E.6
Ankener, W.7
Vanderslice, P.8
-
29
-
-
0034192513
-
Discovery and evaluation of potent cysteine based α4β1 integrin antagonists
-
Archibald SC, Head JC, Linsley J, Porter JR, Robinson MK, Shock A, Warrellow GJ: Discovery and evaluation of potent cysteine based α4β1 integrin antagonists. Bioorg Med Chem Lett (2000) 10:993-995;
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 993-995
-
-
Archibald, S.C.1
Head, J.C.2
Linsley, J.3
Porter, J.R.4
Robinson, M.K.5
Shock, A.6
Warrellow, G.J.7
-
30
-
-
17144433994
-
Discovery and evaluation of potent tyrosine based α4β1 integrin antagonists
-
Archibald SC, Head JC, Gozzard N, Howat DW, Parton AH, Porter JR, Robinson MK, Shock A, Warrellow GJ, Abraham WM: Discovery and evaluation of potent tyrosine based α4β1 integrin antagonists. Bioorg Med Chem Lett (2000) 10:997-999.
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 997-999
-
-
Archibald, S.C.1
Head, J.C.2
Gozzard, N.3
Howat, D.W.4
Parton, A.H.5
Porter, J.R.6
Robinson, M.K.7
Shock, A.8
Warrellow, G.J.9
Abraham, W.M.10
-
31
-
-
0032821974
-
N-Acylphenylalanines as antagonists of VLA4/VCAM-1
-
N-Acylphenylalanines as antagonists of VLA4/VCAM-1. Exp Opin Ther Pat (1999) 9:1443-1446.
-
(1999)
Exp Opin Ther Pat
, vol.9
, pp. 1443-1446
-
-
-
32
-
-
33748377217
-
Discovery of TR-9109: A novel small molecule inhibitor of α4β1 integrin mediated cell adhesion
-
New Orleans MEDI 58
-
Treegarden BR, Rishton GM, Tamagishi M, Jayakumar H, Lobl TJ, Cadarelli P, Gorcsan F, Castro M, Evans BR, Riley DT, Tanis SP, Thomas JF, Harrison AW, Alexander DL, McGrath JP: Discovery of TR-9109: A novel small molecule inhibitor of α4β1 integrin mediated cell adhesion. ACS (1999) 218 New Orleans MEDI 58.
-
(1999)
ACS
, vol.218
-
-
Treegarden, B.R.1
Rishton, G.M.2
Tamagishi, M.3
Jayakumar, H.4
Lobl, T.J.5
Cadarelli, P.6
Gorcsan, F.7
Castro, M.8
Evans, B.R.9
Riley, D.T.10
Tanis, S.P.11
Thomas, J.F.12
Harrison, A.W.13
Alexander, D.L.14
McGrath, J.P.15
-
33
-
-
33748344369
-
American Chemical Society 218th National meeting: Medicinal Chemistry poster highlights
-
August 22-26.
-
Agathangelou P: American Chemical Society 218th National meeting: Medicinal Chemistry poster highlights. IDdb Meeting Report (1999) 216 August 22-26.
-
(1999)
IDdb Meeting Report
, vol.216
-
-
Agathangelou, P.1
-
34
-
-
33748350800
-
Discovery of TR-14035: An orally dual active α4β7/α4β1 integrin antagonist
-
New Orleans MEDI 59
-
Sircar I, Gudmundsson KS, Martin R, Nomura S, Jayakumar H, Nowlin DM, Cardarelli PM, Mah JR, Castro MA, Cao Y, Griffith RC, Lazarides E: Discovery of TR-14035: An orally dual active α4β7/α4β1 integrin antagonist. ACS (1999) 218 New Orleans MEDI 59
-
(1999)
ACS
, vol.218
-
-
Sircar, I.1
Gudmundsson, K.S.2
Martin, R.3
Nomura, S.4
Jayakumar, H.5
Nowlin, D.M.6
Cardarelli, P.M.7
Mah, J.R.8
Cao, M.A.9
Cao, Y.10
Griffith, R.C.11
Lazarides, E.12
-
35
-
-
33748349954
-
SAR of TR-14035: An orally active dual α4β7/α4β1 integrin antagonist
-
New Orleans MEDI 60
-
Martin R, Sircar I, Liang JT, Nomura S, Morningstar MM, Gudmundsson, Nowlin DM, Cardarelli PM, Mah JR, Connell SA, Castro MA, Cao Y, Griffith RC, Lazarides E: SAR of TR-14035: An orally active dual α4β7/α4β1 integrin antagonist. ACS (1999) 218 New Orleans MEDI 60.
-
(1999)
ACS
, vol.218
-
-
Martin, R.1
Sircar, I.2
Liang, J.T.3
Nomura, S.4
Morningstar, M.M.5
Gudmundsson6
Nowlin, D.M.7
Cardarelli, P.M.8
Mah, J.R.9
Connell, S.A.10
Cao, M.A.11
Cao, Y.12
Griffith, R.C.13
Lazarides, E.14
-
36
-
-
33748365524
-
Parallel synthesis optimisation of TR-14035. a dual active α4β7/α4β1 integrin antagonist: Generation of α4β1 selective antagonists
-
New Orleans MEDI 61
-
Furth PS, Chiang SL, Sircar I, Griffith RC, Nowlin D, Gorscan Mah J, Lazarides E: Parallel synthesis optimisation of TR-14035. A dual active α4β7/α4β1 integrin antagonist: generation of α4β1 selective antagonists. ACS (1999) 218 New Orleans MEDI 61.
-
(1999)
ACS
, vol.218
-
-
Furth, P.S.1
Chiang, S.L.2
Sircar, I.3
Griffith, R.C.4
Nowlin, D.5
Gorscan, M.J.6
Lazarides, E.7
-
37
-
-
33748370860
-
American Chemical Society 218th National meeting: Medicinal Chemistry poster highlights
-
August 22-26
-
Hutton I: American Chemical Society 218th National meeting: Medicinal Chemistry poster highlights. IDdb Meeting Report (1999) 218 August 22-26.
-
(1999)
IDdb Meeting Report
, vol.218
-
-
Hutton, I.1
-
38
-
-
0032493398
-
Novel modified tripeptide inhibitors of α4β7 mediated lymphoid cell adhesion to MAdCAM-1
-
Shroff, HN, Schwender CF, Baxter AD, Brookfield F, Payne LJ, Cochran NA, Gallant DL, Briskin MJ: Novel modified tripeptide inhibitors of α4β7 mediated lymphoid cell adhesion to MAdCAM-1. Bioorg Med Chem Lett (1998) 8:1601-1606.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 1601-1606
-
-
Shroff, H.N.1
Schwender, C.F.2
Baxter, A.D.3
Brookfield, F.4
Payne, L.J.5
Cochran, N.A.6
Gallant, D.L.7
Briskin, M.J.8
-
39
-
-
0028073216
-
Distinct but overlapping epitopes are involved in α4β7 mediated adhesion to VCAM-1, MAdCAM-1, fibronectin and lymphocyte aggregation
-
Andrew DP, Berlin C, Honda S, Yoshino T, Hamann A, Holzmann B, Kilshaw PJ, Butcher EC: Distinct but overlapping epitopes are involved in α4β7 mediated adhesion to VCAM-1, MAdCAM-1, fibronectin and lymphocyte aggregation. J Immunol (1994) 153:3847-3861;
-
(1994)
J Immunol
, vol.153
, pp. 3847-3861
-
-
Andrew, D.P.1
Berlin, C.2
Honda, S.3
Yoshino, T.4
Hamann, A.5
Holzmann, B.6
Kilshaw, P.J.7
Butcher, E.C.8
-
40
-
-
0027207679
-
MAdCAM-1 has homology to immunoglobulin and mucin like adhesion receptors and to IgA1
-
Briskin MJ, McEvoy LM, Butcher EC: MAdCAM-1 has homology to immunoglobulin and mucin like adhesion receptors and to IgA1. Nature (1993) 363:461-464;
-
(1993)
Nature
, vol.363
, pp. 461-464
-
-
Briskin, M.J.1
McEvoy, L.M.2
Butcher, E.C.3
-
41
-
-
0030584707
-
Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the α4β7 integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences
-
Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ: Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the α4β7 integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences. J Immunol (1996) 156:2851-2857.
-
(1996)
J Immunol
, vol.156
, pp. 2851-2857
-
-
Shyjan, A.M.1
Bertagnolli, M.2
Kenney, C.J.3
Briskin, M.J.4
-
42
-
-
0024968166
-
Identification of a murine Peyers patch-specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA4 α
-
Holzmann B, McIntyre BW Weissmann IL: Identification of a murine Peyers patch-specific lymphocyte homing receptor as an integrin molecule with an α chain homologous to human VLA4 α. Cell (1989) 56:37-46.
-
(1989)
Cell
, vol.56
, pp. 37-46
-
-
Holzmann, B.1
McIntyre, B.W.2
Weissmann, I.L.3
-
43
-
-
0033583322
-
The integrin α9β1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through intraction with vascular cell adhesion molecule-1
-
Taooka Y, Chen J, Yednock T, Sheppard D: The integrin α9β1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through intraction with vascular cell adhesion molecule-1. J Cell Biol (1999) 145:413-419.
-
(1999)
J Cell Biol
, vol.145
, pp. 413-419
-
-
Taooka, Y.1
Chen, J.2
Yednock, T.3
Sheppard, D.4
-
45
-
-
33748363384
-
-
WO-09622966
-
BIOGEN INC (Adams SP, Lin K-C, Lee W-C, Castro AC, Zimmerman CN, Hammond CE, Liao Y-S, Cuervo JH, Singh J): Cell adhesion inhibitors. WO-09622966 (1996).
-
(1996)
Cell Adhesion Inhibitors
-
-
Adams, S.P.1
Lin, K.-C.2
Lee, W.-C.3
Castro, A.C.4
Zimmerman, C.N.5
Hammond, C.E.6
Liao, Y.-S.7
Cuervo, J.H.8
Singh, J.9
-
46
-
-
33748359409
-
-
WO-09923063
-
RHÔNE-POULENC RORER LTD (Astles PC, Clark DE, Collis AJ, Cox PJ, Eastwood PJ, Harris NV, Lai JYQ, Morley AD, Porter B): Substituted anilides. WO-09923063 (1999).
-
(1999)
Substituted Anilides
-
-
Astles, P.C.1
Clark, D.E.2
Collis, A.J.3
Cox, P.J.4
Eastwood, P.J.5
Harris, N.V.6
Lai, J.Y.Q.7
Morley, A.D.8
Porter, B.9
-
55
-
-
33748376150
-
-
WO-09952898
-
TEXAS BIOTECHNOLOGY CORP (Kassir JM, Biediger RJ, Grabbe VO, Lin S, Market RV, Raju BG, Scott IL, Kogan TP): N,N-disubstituted amides that inhibit the binding of integrins to their receptors. WO-09952898 (1999).
-
(1999)
N,N-disubstituted Amides That Inhibit the Binding of Integrins to Their Receptors
-
-
Kassir, J.M.1
Biediger, R.J.2
Grabbe, V.O.3
Lin, S.4
Market, R.V.5
Raju, B.G.6
Scott, I.L.7
Kogan, T.P.8
-
56
-
-
33748359568
-
-
EP-00903353
-
HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (Wehner I, Stilz HU, Schmidt W, Seiffge D): Imidazolidine derivates, their preparation and use, and pharmaceutical compositions containing them. EP-00903353 (1999)
-
(1999)
Imidazolidine Derivates, Their Preparation and Use, and Pharmaceutical Compositions Containing Them
-
-
Wehner, I.1
Stilz, H.U.2
Schmidt, W.3
Seiffge, D.4
-
57
-
-
33748353495
-
-
EP-00905139
-
HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (Wehner I, Stilz HU, Schmidt W, Seiffge D): 5 Ring heterocyles, process for preparation, use as inhibitors of leukocyte adhesion and pharmaceutical preparations comprising them. EP-00905139 (1999).
-
(1999)
5 Ring Heterocyles, Process for Preparation, Use As Inhibitors of Leukocyte Adhesion and Pharmaceutical Preparations Comprising Them
-
-
Wehner, I.1
Stilz, H.U.2
Schmidt, W.3
Seiffge, D.4
-
58
-
-
33748359568
-
-
EP-00918059
-
HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (Wehner V, Stilz HU, Schmidt W, Seiffge D): Substituted imidazoline derivatives, their preparation, their use, and pharmaceutical compositions containing them. EP-00918059 (1999).
-
(1999)
Substituted Imidazoline Derivatives, Their Preparation, Their Use, and Pharmaceutical Compositions Containing Them
-
-
Wehner, V.1
Stilz, H.U.2
Schmidt, W.3
Seiffge, D.4
-
60
-
-
33748374098
-
-
WO-00002903
-
CYTEL CORP (Arrhenius TS, Elices MJ, Gaeta FCA, He Y-B, Huyghe BG, Chen PG): CS-1 peptidomimetics, compositions and method of using the same. WO-00002903 (2000).
-
(2000)
CS-1 Peptidomimetics, Compositions and Method of Using the Same
-
-
Arrhenius, T.S.1
Elices, M.J.2
Fca, G.3
He, Y.-B.4
Huyghe, B.G.5
Chen, P.G.6
-
61
-
-
33748359410
-
Sulfonamides as cell adhesion inhibitors
-
MERCK & CO INC (Durette PL, Hagmann WK, MacCoss M, Mills SG, Mumford RA): Sulfonamides as cell adhesion inhibitors. WO-09853818 (1998).
-
(985)
WO
, vol.3818
, pp. 1998
-
-
Durette, P.L.1
Hagmann, W.K.2
MacCoss, M.3
Mills, S.G.4
Mumford, R.A.5
-
63
-
-
33748344577
-
-
WO-09853814
-
MERCK & CO INC (Durette PL, Hagmann WK, MacCoss M, Mills SG, Mumford RA, van Riper GM, Schmidt JA, Kevin NJ): Heterocyclic amide compounds as cell adhesion inhibitors. WO-09853814 (1998).
-
(1998)
Heterocyclic Amide Compounds As Cell Adhesion Inhibitors
-
-
Durette, P.L.1
Hagmann, W.K.2
MacCoss, M.3
Mills, S.G.4
Mumford, R.A.5
Van Riper, G.M.6
Schmidt, J.A.7
Kevin, N.J.8
-
67
-
-
33748354123
-
-
WO-09926921
-
MERCK & CO INC (Durette PL, Hagmann WK, Kopka IE, Macoss M, Mills SG, Mumford RA, Magriotis PA): Substituted beta-alanine derivatives as cell adhesion inhibitors. WO-09926921 (1999).
-
(1999)
Substituted Beta-alanine Derivatives As Cell Adhesion Inhibitors
-
-
Durette, P.L.1
Hagmann, W.K.2
Kopka, I.E.3
Macoss, M.4
Mills, S.G.5
Mumford, R.A.6
Magriotis, P.A.7
-
70
-
-
33748339443
-
-
WO-09906390
-
ATHENA NEUROSCIENCES INC, AMERICAN HOME PRODUCTS CORP (Thorsett ED, Semko CM, Sarantakis D, Pleiss MA, Kreft A, Konradi AW, Grant FS, Dressen DB, Ashwell S et al): Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4. WO-09906390 (1999);
-
(1999)
Carbamyloxy Compounds Which Inhibit Leukocyte Adhesion Mediated by VLA-4
-
-
Thorsett, E.D.1
Semko, C.M.2
Sarantakis, D.3
Pleiss, M.A.4
Kreft, A.5
Konradi, A.W.6
Grant, F.S.7
Dressen, D.B.8
Ashwell, S.9
-
71
-
-
33748339443
-
-
WO-09906431
-
ATHENA NEUROSCIENCES INC, AMERICAN HOME PRODUCTS CORP (Thorsett ED, Semko CM, Sarantakis D, Pleiss MA, Kreft A, Konradi AW, Grant FS, Dressen DB et al): Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4.WO-09906431 (1999);
-
(1999)
Substituted Phenylalanine Type Compounds Which Inhibit Leukocyte Adhesion Mediated by VLA-4
-
-
Thorsett, E.D.1
Semko, C.M.2
Sarantakis, D.3
Pleiss, M.A.4
Kreft, A.5
Konradi, A.W.6
Grant, F.S.7
Dressen, D.B.8
-
72
-
-
33748367754
-
-
WO-09906432
-
ATHENA NEUROSCIENCES INC, AMERICAN HOME PRODUCTS CORP (Thorsett ED, Semko CM, Pleiss MA, Lombardo LJ, Grant FS, Dressen DB, Dappen MS): Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4. WO-09906432 (1999);
-
(1999)
Dipeptide and Related Compounds Which Inhibit Leukocyte Adhesion Mediated by VLA-4
-
-
Thorsett, E.D.1
Semko, C.M.2
Pleiss, M.A.3
Lombardo, L.J.4
Grant, F.S.5
Dressen, D.B.6
Dappen, M.S.7
-
73
-
-
33748359783
-
-
WO-09906433
-
ATHENA NEUROSCIENCES INC, AMERICAN HOME PRODUCTS CORP (Dappen MS, Dressen DB, Grant FS, Pleiss MA, Robinson CY, Sarantakis D, Thorsett ED): Compounds which inhibit leukocyte adhesion mediated by VLA-4. WO-09906433 (1999);
-
(1999)
Compounds Which Inhibit Leukocyte Adhesion Mediated by VLA-4
-
-
Dappen, M.S.1
Dressen, D.B.2
Grant, F.S.3
Pleiss, M.A.4
Robinson, C.Y.5
Sarantakis, D.6
Thorsett, E.D.7
-
74
-
-
33748343275
-
-
WO-09906434
-
ATHENA NEUROSCIENCES INC, AMERICAN HOME PRODUCTS CORP (Ashwell S, Grant FS, Konradi AW, Kreft A, Lombardo LJ, Pleiss MA, Sarantakis D, Semko CM, Thorsett ED): 4-Aminophenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4. WO-09906434 (1999);
-
(1999)
4-Aminophenylalanine Type Compounds Which Inhibit Leukocyte Adhesion Mediated by VLA-4
-
-
Ashwell, S.1
Grant, F.S.2
Konradi, A.W.3
Kreft, A.4
Lombardo, L.J.5
Pleiss, M.A.6
Sarantakis, D.7
Semko, C.M.8
Thorsett, E.D.9
-
75
-
-
33748343275
-
-
WO-09906435
-
ATHENA NEUROSCIENCES INC, AMERICAN HOME PRODUCTS CORP (Ashwell S, Grant FS, Konradi AW, Krett A, Lombardo LJ, Pleiss MA, Sarantakis D, Semko CM, Thorsett ED): Dipeptide compounds which inhibit leukocyte adhesion mediated by VLA-4. WO-09906435 (1999);
-
(1999)
Dipeptide Compounds Which Inhibit Leukocyte Adhesion Mediated by VLA-4
-
-
Ashwell, S.1
Grant, F.S.2
Konradi, A.W.3
Krett, A.4
Lombardo, L.J.5
Pleiss, M.A.6
Sarantakis, D.7
Semko, C.M.8
Thorsett, E.D.9
-
76
-
-
33748339443
-
-
WO-09906436
-
ATHENA NEUROSCIENCES INC, AMERICAN HOME PRODUCTS CORP (Thorsett ED, Semko CM, Pleiss MA, Lombardo LJ, Konradi AW, Grant FS, Dressen DB, Dappen MS): Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4. WO-09906436 (1999);
-
(1999)
Benzyl Compounds Which Inhibit Leukocyte Adhesion Mediated by VLA-4
-
-
Thorsett, E.D.1
Semko, C.M.2
Pleiss, M.A.3
Lombardo, L.J.4
Konradi, A.W.5
Grant, F.S.6
Dressen, D.B.7
Dappen, M.S.8
-
77
-
-
33748367754
-
-
WO-09906437
-
ATHENA NEUROSCIENCES INC, AMERICAN HOME PRODUCTS CORP (Thorsett ED, Semko CM, Pleiss MA, Kreft A, Konradi AW, Grant FS, Baudy RB, Sarantakis D): Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by VLA-4. WO-09906437 (1999).
-
(1999)
Sulfonylated Dipeptide Compounds Which Inhibit Leukocyte Adhesion Mediated by VLA-4
-
-
Thorsett, E.D.1
Semko, C.M.2
Pleiss, M.A.3
Kreft, A.4
Konradi, A.W.5
Grant, F.S.6
Baudy, R.B.7
Sarantakis, D.8
-
84
-
-
33748348043
-
-
WO-09967230
-
PHARMACIA & UPJOHN CO (Blinn JR, Chrusciel RA, Fisher JF, Tanis SP, Thomas EW, Lobl TJ, Teegarden BR): Inhibitors of α4β1 mediated cell adhesion. WO-09967230 (1999).
-
(1999)
Inhibitors of α4β1 Mediated Cell Adhesion
-
-
Blinn, J.R.1
Chrusciel, R.A.2
Fisher, J.F.3
Tanis, S.P.4
Thomas, E.W.5
Lobl, T.J.6
Teegarden, B.R.7
-
85
-
-
4844230444
-
-
WO-09910313
-
HOFFMANN-LA ROCHE AG (Chen L, Guthrie RW, Huang T-N, Hull KG, Sidduri A, Tilley JW): N-aroylphenylalanine derivatives. WO-09910313 (1999).
-
(1999)
N-aroylphenylalanine Derivatives
-
-
Chen, L.1
Guthrie, R.W.2
Huang, T.-N.3
Hull, K.G.4
Sidduri, A.5
Tilley, J.W.6
-
86
-
-
33748368584
-
-
WO-09858902
-
TANABE SEIKAYU CO LTD; PHARMACIA & UPJOHN CO (Lobl TJ, Rishton G, Teegarden B, Polinsky A, Yamagishi M, Tanis SP, Fisher JF, Thomas EW, Chrusciel RA): Inhibitors of α4β1 mediated cell adhesion. WO-09858902 (1998).
-
(1998)
Inhibitors of α4β1 Mediated Cell Adhesion
-
-
Lobl, T.J.1
Rishton, G.2
Teegarden, B.3
Polinsky, A.4
Yamagishi, M.5
Tanis, S.P.6
Fisher, J.F.7
Thomas, E.W.8
Chrusciel, R.A.9
-
90
-
-
4844230444
-
-
WO-09910312
-
F HOFFMANN-LA ROCHE AG (Chen L, Guthrie RW, Huang T-N, Hull KG, Sidduri A, Tilley JW): N-alkanoylphenylalanine derivatives. WO-09910312 (1999).
-
(1999)
N-alkanoylphenylalanine Derivatives
-
-
Chen, L.1
Guthrie, R.W.2
Huang, T.-N.3
Hull, K.G.4
Sidduri, A.5
Tilley, J.W.6
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