The organization and evolution of the Dipteran and Hymenopteran Down syndrome cell adhesion molecule (Dscam) genes

RNA

Volumn 10, Issue 10, 2004, Pages 1499-1506

  Graveley, Brenton R ^a   Kaur, Amardeep ^b   Gunning, Dorian ^c   Lawrence Zipursky, S ^c   Rowen, Lee ^b   Clemens, James C ^c  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b Institute for System Biology   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alternative splicing; Down syndrome cell adhesion molecule (Dscam); Drosophila; Exon duplication

Indexed keywords

AXON GUIDANCE RECEPTOR; CELL RECEPTOR; FIBRONECTIN; FIBRONECTIN TYPE 3; IMMUNOGLOBULIN; ISOPROTEIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANOPHELES GAMBIAE; ARTICLE; CYTOPLASMIC DOMAIN; DELETION MUTANT; DNA RECOMBINATION; DOWN SYNDROME CELL ADHESION MOLECULE GENE; DROSOPHILA MELANOGASTER; DROSOPHILA PSEUDOOBSCURA; DROSOPHILA VIRILIS; EVOLUTION; EVOLUTIONARY HOMOLOGY; EXON; EXON DUPLICATION; EXPRESSED SEQUENCE TAG; FLY; GENE; GENE EXPRESSION; GENETIC ORGANIZATION; GENETIC VARIABILITY; HONEYBEE; HYMENOPTERA; IMMUNOGLOBULIN DOMAIN; NERVE FIBER; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM FUNCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SPECIES DIFFERENCE; TRANSMEMBRANE DOMAIN;

ANIMALS; ANOPHELES; BEES; DIPTERA; DNA; DROSOPHILA; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EVOLUTION, MOLECULAR; EXONS; GENES, INSECT; HYMENOPTERA; INSECT PROTEINS; PROTEINS; RECOMBINATION, GENETIC;

ANOPHELES GAMBIAE; APIS; APIS MELLIFERA; DIPTERA; DROSOPHILA MELANOGASTER; DROSOPHILA PSEUDOOBSCURA; DROSOPHILA VIRILIS; HEXAPODA; HYMENOPTERA; INSECTA; MELANOGASTER;

EID: 4644353346     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1261/rna.7105504     Document Type: Article

References (15)

1. Barlow, G.M., Micales, B., Chen, X.N., Lyons, G.E., and Korenberg, J.R. 2002. Mammalian DSCAMs: Roles in the development of the spinal cord, cortex, and cerebellum? Biochem. Biophys. Res. Commun. 293: 881-891.
2. Celotto, A.M. and Graveley, B.R. 2001. Alternative splicing of the Drosophila Dscam pre-mRNA is both temporally and spatially regulated. Genetics 159: 599-608.
3. Ewing, B. and Green, P. 1998. Base-calling of automated sequencer traces using phred. II. Error probabilities. Genome Res. 8: 186-194.
4. Holt, R.A., Subramanian, G.M., Halpern, A., Sutton, G.G., Charlab, R., Nusskern, D.R., Wincker, P., Clark, A.G., Ribeiro, J.M., Wides, R., et al. 2002. The genome sequence of the malaria mosquito Anopheles gambiae. Science 298: 129-149.
5. Hummel, T., Vasconcelos, M.L., Clemens, J.C., Fishilevich, Y., Vosshall, L.B., and Zipursky, S.L. 2003. Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron 37: 221-231.
6. Kondrashov, F.A. and Koonin, E.V. 2001. Origin of alternative splicing by tandem exon duplication. Hum. Mol. Genet. 10: 2661-2669.
7. Letunic, I., Copley, R.R., and Bork, P. 2002. Common exon duplication in animals and its role in alternative splicing. Hum. Mol. Genet. 11: 1561-1567.
8. Neves, G., Zucker, J., Daly, M., and Chess, A. 2004. Stochastic yet biased expression of multiple Dscam splice variants by individual cells. Nat. Genet. 36: 240-246.
9. Schmucker, D., Clemens, J.C., Shu, H., Worby, C.A., Xiao, J., Muda, M., Dixon, J.E., and Zipursky, S.L. 2000. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101: 671-684.
10. Schwartz, S., Zhang, Z., Frazer, K.A., Smit, A., Riemer, C., Bouck, J., Gibbs, R., Hardison, R., and Miller, W. 2000. PipMaker - A web server for aligning two genomic DNA sequences. Genome Res. 10: 577-586.
11. Vassalli, A., Rothman, A., Feinstein, P., Zapotocky, M., and Mombaerts, P. 2002. Minigenes impart odorant receptor-specific axon guidance in the olfactory bulb. Neuron 35: 681-696.
12. Wang, J., Zugates, C.T., Liang, I.H., Lee, C.H., and Lee, T. 2002. Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons. Neuron 33: 559-571.
13. Wojtowicz, W.M., Flanagan, J.J., Millard, S.S., Zipursky, S.L., and Clemens, J.C. 2004. Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell 118: 619-633.
14. Yamakawa, K., Huot, Y.K., Haendelt, M.A., Hubert, R., Chen, X.N., Lyons, G.E., and Korenberg, J.R. 1998. DSCAM: A novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum. Mol. Genet. 7: 227-237.
15. Zhan, X.-L., Clemens, J.C., Neves, G., Hattori, D., Flanagan, J.J., Hummel, T., Vasconcelos, M.L., Chess, A., and Zipursky, S.L. 2004. Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom body neurons. Neuron 43: 673-686.