Evolution of key cell signaling and adhesion protein families predates animal origins

Science

Volumn 301, Issue 5631, 2003, Pages 361-363

  King, Nicole ^a   Hittinger, Christopher T ^a   Carroll, Sean B ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; CELLS; ENZYMES;

KINASE INHIBITORS;

PROTEINS;

ADHESION PROTEIN; C TYPE LECTIN; CADHERIN; CELL ADHESION MOLECULE; LECTIN; PHOSPHOPROTEIN; PROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; TYROSINE PHOSPHOPROTEIN; UNCLASSIFIED DRUG;

EVOLUTION; PROTEIN; SIGNALING;

ANIMAL; ARTICLE; CELL COMMUNICATION; CELL PROLIFERATION; CHOANOFLAGELLATE; EVOLUTION; FLAGELLATE; METAZOON; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTOZOON; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; EVOLUTION; EVOLUTION, MOLECULAR; EXPRESSED SEQUENCE TAGS; FUNGAL PROTEINS; LECTINS, C-TYPE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PHOSPHOTYROSINE; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PROTEOME; PROTOZOA; PROTOZOAN PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

ANIMALIA; CHOANOFLAGELLIDA; MASTIGOPHORA (FLAGELLATES); METAZOA; PROTOZOA;

EID: 0037962406     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083853     Document Type: Article

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27. We thank P. Bertics, A. Guadarrama, B. Leadbeater, and T. Hunter for advice and technical assistance; L. Olds for assistance with graphics; J. Holt for computing support; and B. Hersh and C. Malone for critical reading of the manuscript. N.K. is supported by an NIH postdoctoral fellowship (GM-20734) and C.T.H. is an HHMI predoctoral fellow. This work was supported by the HHMI (S.B.C.).