Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: Implications for the activity of factor B

Journal of Molecular Biology

Volumn 294, Issue 2, 1999, Pages 587-599

  Hinshelwood, Justin ^b   Spencer, Daniel I R ^a   Edwards, Yvonne J K ^b   Perkins, Stephen J ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

Complement C3; Factor B; Homology modelling; SELDIAMS; vWF A domain

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; BOVINE SERUM ALBUMIN; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; PROTEINASE; SERINE PROTEINASE; VON WILLEBRAND FACTOR;

ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CRYSTAL STRUCTURE; LASER; MASS SPECTROMETRY; MODEL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY;

BOVINAE;

EID: 0033607744     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3223     Document Type: Article

References (53)

1. Anderson C. M. Glycoprotein structure of components C2 and factor B of the human complement system. D Phil thesis. 1986;University of Oxford.
2. Baldwin E. T., Sarver R. W., Bryant G. L. Jr, Curry K. A., Fairbanks M. B., Finzel B. C., Garlick R. L., Heinrikson R. L., Horton N. C., Kelley L.-L. C., Mildner A. M., Moon J. B., Mott J. E., Mutchler V. T., Tomich C.-S. C. et al. Cation binding to the integrin CD11b I domain and activation model assessment. Structure. 6:1998;923-935.
3. Beavis R. C., Chait B. T. Matrix-assisted laser desorption ionization mass-spectrometry of proteins. Methods Enzymol. 270:1996;519-551.
4. Bienkowska J., Cruz M., Atiemo A., Liddington R. The von Willebrand A3 domain does not contain a metal ion-dependent adhesion site motif. J. Biol. Chem. 272:1997;25162-25167.
5. Campbell R. D., Bentley D. R. The structure and genetics of the C2 and factor B genes. Immunol. Rev. 87:1985;19-37.
6. Celikel R., Varughese K. I., Madhusan, Yoshioka A., Ware J., Ruggeri Z. M. Crystal structure of the von Willebrand factor A1 domain in complex with the function-blocking NMC-4 Fab. Nature Struct. Biol. 5:1998;189-194.
7. Cooney K. A., Ginsburg D. Comparative analysis of type 2b von Willebrand disease mutations: implications for the mechanism of von Willebrand factor binding to platelets. Blood. 87:1996;2322-2328.
8. DiScipio R. G. The binding of human complement proteins C5, factor B, β1H and properdin to complement fragment C3b on zymosan. Biochem. J. 199:1981;485-496.
9. Dodds A. W. Small-scale preparation of complement components C3 and C4. Methods Enzymol. 223:1993;46-61.
10. Edwards Y. J. K., Perkins S. J. The protein fold of the von Willebrand Factor type A domain is predicted to be similar to the open twisted β-sheet flanked by α-helices found in human ras-p21. FEBS Letters. 358:1995;283-286.
11. Edwards Y. J. K., Perkins S. J. Assessment of protein fold predictions from sequence information: the predicted α/β doubly wound fold of the von Willebrand Factor Type A domain is similar to its crystal structure. J. Mol. Biol. 260:1996;277-285.
12. Emsley J., King S. L., Bergelson J. M., Liddington R. C. Crystal structure of the I domain from integrin α2β1. J. Biol. Chem. 272:1997;28512-28517.
13. Emsley J., Cruz M., Handin R., Liddington R. Crystal structure of the von Willebrand factor A1 domain and implications for the binding of platelet glycoprotein Ib. J. Biol. Chem. 273:1998;10396-10401.
14. Hinshelwood J., Williams S. C., Sim R. B., Perkins S. J. Structural and functional studies of the isolated vWF-A and SP domains of complement factor B. Mol. Immunol. 33:1996;80.
15. Hourcade D. E., Wagner L. M., Oglesby T. J. Analysis of the short consensus repeats of human complement factor B by site-directed mutagenesis. J. Biol. Chem. 270:1995;19716-19722.
16. Hourcade D. E., Mitchell L. M., Oglesby T. J. Mutations of the type A domain of complement factor B that promote high-affinity C3b-binding. J. Immunol. 162:1999;2906-2911.
17. Huizinga E. G., van der Plas R. M., Kroon J., Sixma J. J., Gros P. Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding. Structure. 5:1997;1147-1156.
18. Hutchens T. W., Yip T.-T. New desorption strategies for the mass spectrometric analysis of macromolecules. Rapid Commun. Mass Spectrom. 7:1993;576-580.
19. Jenkins P. V., Pasi K. J., Perkins S. J. Molecular modelling of ligand and mutation sites of the Type A domains of human von Willebrand factor and their relevance to von Willebrand's disease. Blood. 91:1998;2032-2044.
20. Kabsch W., Sander C. Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features. Biopolymers. 22:1983;2577-2637.
21. Knott H. M., Berndt M. C., Kralicek A. V., O'Donoghue S. I., King G. F. Determination of the solution structure of a platelet-adhesion peptide of von Willebrand factor. Biochemistry. 31:1992;11152-11158.
22. Krone J. R., Nelson R. W., Dogruel D., Williams P., Granzow R. BIA/MS: Interfacing biomolecular interaction analysis with mass spectrometry. Anal. Biochem. 244:1997;124-132.
23. Kuwata H., Yip T.-T., Yip C. L., Tomita M., Hutchens T. W. Bactericidal domain of lactoferrin: detection, quantitation and characterization of lactoferricin in serum by SELDI affinity mass spectrometry. Biochem. Biophys. Res. Commun. 245:1998;764-773.
24. Lambris J. D., Müller-Eberhard H. J. Isolation and characterization of a 33,000-dalton fragment of complement factor B with catalytic and C3b binding activity. J. Biol. Chem. 259:1984;12685-12690.
25. Laskowski R. A., Macarthur M. W., Moss D. S., Thornton J. M. PROCHECK - a program to check the stereochemical quality of protein structures. J. Appl. Crystallog. 26:1993;283-291.
26. Law S. K., Reid K. B. M. Complement. 1995;IRL Press, Oxford.
27. Lee B., Richards F. M. An interpretation of protein structures: estimation of static accessibility. J. Mol. Biol. 55:1971;379-400.
28. Lee J. O., Rieu P., Arnaout M. A., Liddington R. Crystal structure of the A domain from the α subunit of integrin CR3 (CD11b/CD18). Cell. 80:1995a;631-638.
29. Lee J. O., Bankston L. A., Arnaout M. A., Liddington R. C. Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure. 3:1995b;1333-1340.
30. Leung S. M., Zeyda T., Thatcher B. A new and rapid method for phenotype screening using SELDI Proteinchip (TM) arrays demonstrated on serum from knockout and wild type mice. Mol. Biol. Cell. 9:1998;2040.
31. Liddington R., Bankston L. The integrin I domain: crystals, metals and related artefacts. Structure. 6:1998;937-938.
32. Matsushita T., Sadler J. E. Identification of amino acid residues essential for von Willebrand factor binding to platelet glycoprotein Ib. J. Biol. Chem. 270:1995;13406-13414.
33. Perkins S. J. Protein volumes and hydration effects: the calculation of partial specific volumes, neutron scattering matchpoints and 280 nm absorption coefficients for proteins and glycoproteins from amino acid sequences. Eur. J. Biochem. 157:1986;169-180.
34. Perkins S. J., Smith K. F., Williams S. C., Haris P. I., Chapman D., Sim R. B. The secondary structure of the von Willebrand domain in factor B of human complement by Fourier transform infrared spectroscopy: its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged secondary structure predictions. J. Mol. Biol. 238:1994;104-119.
35. Perkins S. J., Hinshelwood J., Edwards Y. J. K., Jenkins P. V. Structural and functional modelling of vWF-A domains in complement and coagulation. Biochem. Soc. Trans. In the press:1999.
36. Pryzdial E. L., Isenman D. E. Alternative complement pathway activation fragment Ba binds to C3b. Evidence that formation of the factor B-C3b complex involves two discrete points of contact. J. Biol. Chem. 262:1987;1519-1525.
37. 2O) and factor B in solution. J. Biol. Chem. 263:1988;1733-1738.
38. Qu A., Leahy D. J. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, αLβ2) integrin. Proc. Natl Acad. Sci. USA. 92:1995;10277-10281.
39. Qu A., Leahy D. J. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure. 4:1996;931-942.
40. Šali A., Blundell T. L. Definition of general topological equivalence in protein structures: a procedure involving comparison of properties and relationships through simulated annealing and dynamic programming. J. Mol. Biol. 212:1990;403-428.
41. Sanchez-Corral P., Anton L. C., Alcolea J. M., Marques G., Sanchez A., Vivanco F. Proteolytic activity of the different fragments of factor B on the third component of complement C3 - involvement of the N-terminal domain of Bb in magnesium binding. Mol. Immunol. 27:1990;891-900.
42. Sim E., Sim R. B. Enzymic assay of C3b receptor on intact cells and solubilized cells. Biochem. J. 210:1983;567-576.
43. Sinha D., Bakhshi M., Kunapuli S., Vora R., Gabriel J. L., Kirby E. P., Budzynski A. Z. Asp514 within the A1 domain of bovine von Willebrand factor is required for interaction with platelet glycoprotein IB. Biochem. Biophys. Res. Commun. 203:1994;881-888.
44. Smith D. B., Johnson K. S. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase. Gene. 67:1988;31-40.
45. th July. Brit. J. Cancer. 80:1999;52.
46. Taniguchi-Sidle A., Isenman D. E. Interactions of human complement component C3 with factor B and with complement receptors type 1 (CR1, CD35) and type 3 (CR3, CD11b/CD18) involve an acidic sequence at the N-terminus of C3 α′-chain. J. Immunol. 153:1994;5285-5302.
47. Tuckwell D. S., Xu Y. Y., Newham P., Humphries M. J., Volanakis J. E. Surface loops adjacent to the cation-binding site of the complement factor B von Willebrand Factor type A module determine C3b binding specificity. Biochemistry. 36:1997;6605-6613.
48. Ueda A., Kearney J. F., Roux K. H., Volanakis J. E. Probing functional sites on complement protein B with monoclonal antibodies. Evidence for C3b-binding sites on Ba. J. Immunol. 138:1987;1143-1149.
49. Ueda T., Rieu P., Brayer J., Arnaout M. A. Identification of the complement iC3b binding site in the β2 integrin CR3 (CD11b/CD18). Proc. Natl Acad. Sci. USA. 91:1994;10680-10684.
50. von Zabern I., Nolte R., Vogt W. Treatment of human complement components C4 and C3 with amines or chaotropic ions. Evidence of a functional and structural change that provides uncleaved C4 and C3 with properties of their soluble activated forms C4b and C3b. Scand. J. Immunol. 13:1981;413-431.
51. Williams S. C., Sim R. B. Dye-ligand affinity purification of human complement factor B and β-2 glycoprotein I. J. Immunol. Methods. 157:1993;25-30.
52. Williams S. C., Sim R. B. Binding sites involved in the formation of the C3 (H2O)-factor B complex of the alternative pathway of complement. Biochem. Soc. Trans. 22:1994;2S.
53. Williams S. C., Hinshelwood J., Perkins S. J., Sim R. B. Production and functional activity of a recombinant von Willebrand Factor (vWF-A) domain from human complement factor B. Biochem. J. 342:1999;625-632.