Contribution of the Complement Control Protein Modules of C2 in C4b Binding Assessed by Analysis of C2/Factor B Chimeras

Journal of Immunology

Volumn 158, Issue 12, 1997, Pages 5958-5965

  Xu, Yuanyuan ^a   Volanakis, John E ^a,b  

^a The University of Alabama at Birmingham   (United States)

^b Dept of Medicine in Rheumatology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4B; EPITOPE; MONOCLONAL ANTIBODY;

ARTICLE; CHIMERA; COMPLEMENT CLASSICAL PATHWAY; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CHIMERA; COMPLEMENT C2; COMPLEMENT C3B; COMPLEMENT C4B; COMPLEMENT FACTOR B; COMPLEMENT PATHWAY, CLASSICAL; EPITOPES; HUMANS; MOLECULAR SEQUENCE DATA;

EID: 0031570468     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Smith, C. A., C.-W. Vogel, and H. J. Müller-Eberhard. 1984. MHC class III products: An electron microscopic study of the C3 convertases of human complement. J. Exp. Med. 159:324.
2. Bentley, D. R. 1986. Primary structure of human complement component C2: homology to two unrelated protein families. Biochem. J. 239:339.
3. Horiuchi, T., K. J. Macon, V. J. Kidd, and J. E. Volanakis. 1989. cDNA cloning and expression of human complement component C2. J. Immunol. 142:2105.
4. Klickstein, L. B., W. W. Wong, J. A. Smith, J. H. Weis, J. G. Wilson, and D. T. Fearon. 1987. Human C3b/C4b receptor (CR1): demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristic of C3/C4 binding proteins. J. Exp. Med. 165:1095.
5. Oglesby, T. J. M. Accavitti, and J. E. Volanakis. 1988. Evidence for a C4b binding site(s) on the C2b domain of C2. J. Immunol. 41:926.
6. Horiuchi, T., K. J. Macon, J. A. Engler, and J. E. Volanakis. 1991. Site-directed mutagenesis of the region around Cys-241 of complement component C2: evidence for a C4b binding site. J. Immunol. 147:584.
7. Colombatti, A., and P. Bonaldo. 1991. The superfamily of proteins with von Willebrand factor type A-like domains: one theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms. Blood 77:2305.
8. Polley, M. J., and H. J. Müller-Eberhard. 1967. Enhancement of the hemolytic activity of the second component of human complement by oxidation. J. Exp. Med. 126:1013.
9. Parkes, C., J. Gagnon, and M. A. Kerr. 1983. The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B. Biochem. J. 213:201.
10. Nagasawa, S., and R. M. Stroud. 1977. Cleavage of C2 by C1s into the antigenically distinct fragments C2a and C2b: demonstration of binding of C2b to C4b. Proc. Natl. Acad Sci. USA 74:2998.
11. Kerr, M. A. 1980. The human complement system: assembly of the classical pathway C3 convertase. Biochem. J. 189:173.
12. Sim, R. B., and S. J. Perkins. 1989. Molecular modelling of C3 and its ligands. Curr. Top. Microbiol. Immunol. 153:209.
13. Ahearn, J. M., and D. T. Fearon. 1989. Structure and function of the complement receptors, CR1 (CD35) and CR2 (CD21). Adv. Immunol. 46:183.
14. Liszewski, M., T. Farries, D. Lublin, I., Rooney, and J. Atkinson. 1996. Control of the complement system. Adv. Immunol. 61:201.
15. Norman, D. G., P. N. Barlow, M. Baron, A. T. Day, R. B. Sim, and I. D. Campbell. 1991. Three-dimensional structure of a complement control protein module in solution. J. Mol. Biol. 219:717.
16. Barlow, P. N., D. G. Norman, A. Steinkasserer, T. J. Horne, P. C. Driscoll, J. Pearce, and I. D. Campbell. 1992. Solution structure of the fifth repeat of factor H: a second example of the complement control protein module. Biochemistry 31:3626.
17. Tsukamoto, H., A. Tousson, R. B. Marchase, and J. E. Volanakis. 1996. Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNA. J. Immunol. 156:4901.
18. Tessier, D. C., and D. Y. Thomas. 1993. PCR-assisted large insertion/deletion mutagenesis. Biotechniques 15:498.
19. Horiuchi, T., S. Kim, M. Matsumoto, I. Watanabe, S. Fujita, and J. E. Volanakis. 1993. Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression. Mol. Immunol. 30:1587.
20. Zoller, M. J., and M. Smith. 1983. Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors. Methods Enzymol. 100:468.
21. Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488.
22. Kunkel, T. A., D. D. Moore, R. M. Myers, J. M. Greene, and B. Cormack. 1995. Mutagenesis of cloned DNA. In Current Protocols in Molecular Biology, Vol. 1. F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Strahl, eds. John Wiley & Sons, Inc., New York, p. 8.5.7.
23. Tabor, S., and C. C. Richardson. 1987. DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Proc. Natl. Acad. Sci. USA 84:4767.
24. Nagaki, K., K. Iida, and S. Inai. 1974. A new method for the preparation of EAC14 cell with human or guinea-pig serum. J. Immunol. Methods 5:307.
25. Sakai, K., and R. M. Stroud. 1974. The activation of C1s with purified C1r. Immunochemistry 11:191.
26. Ueda, A., J. F. Kearney, K. H. Roux, and J. E. Volanakis. 1987. Probing functional sites on complement protein B with monoclonal antibodies. J. Immunol. 138:1143.
27. Mathias, P., C. J. Carrillo, N. E. Zepf, N. R. Cooper, and R. T. Ogata. 1992. Mutants of complement component C3 cleaved by the C4-specitic C1s protease. Proc. Natl. Acad. Sci. USA 89:8125.
28. Hortin, G. L., T. C. Farries, J. P. Graham, and J. P. Atkinson. 1989. Sulfation of tyrosine residues increases activity of the fourth component of complement. Proc. Natl. Acad. Sci. USA 86:1338.
29. Ogata, R. T., N. R. Cooper, B. M. Bradt, P. Mathias, and M. A. Picchi. 1989. Murine complement component C4 and sex-limited protein: identification of amino acid residues essential for C4 function. Proc. Natl. Acad. Sci. USA 86: 5575.
30. Hourcade, D. E., L. M. Wagner, and T. J. Oglesby. 1995. Analysis of the short consensus repeats of human complement factor B by site-directed mutagenesis. J. Biol. Chem. 270:19716.
31. Martin, D. R., A. Yuryev, K. R Kalli, D. T. Fearon, and J. M. Ahearn. 1991. Determination of the structural basis for selective binding of Epstein-Barr virus to human complement receptor type 2. J. Exp. Med. 174:1299.
32. Molina, H., S. J. Perkins, J. Guthridge, J. Gorka, T. Kinoshita, and V. M. Holers. 1995. Characterization of complement receptor 2 (CR2, CD21) ligand binding site for C3. J. Immunol. 154:5426.
33. Tomana, M., M. Niemann, C. Garner, and J. E. Volanakis. 1985. Carbohydrate composition of the second, third and fifth components and factors B and D of human complement. Mol. Immunol. 22:107.