Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye

Current Biology

Volumn 10, Issue 16, 2000, Pages 979-988

  Fanto, Manolis ^a,b   Weber, Ursula ^a,c   Strutt, David I ^a,d   Mlodzik, Marek ^a,c  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA;

EID: 0034710614     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00645-X     Document Type: Article

References (44)

1. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
2. A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila
3. Characterisation of Rho GTPase family homologues in Drosophila melanogaster: Overexpressing RhoA in retinal cells causes a late developmental defect
4. Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis
5. CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium
6. The role of RhoA in tissue polarity and Frizzled signalling
7. Eye development: Notch lends a handedness
8. The genetics of epithelial polarity and pattern in the Drosophila retina
9. Planar polarity in the Drosophila eye: A multifaceted view of signaling specificity and cross-talk
10. Development of the Drosophila retina, a neurocrystalline lattice
11. Cellular interactions in the developing Drosophila eye
12. The beginning of pattern formation in the Drosophila compound eye: The morphogenetic furrow and the second mitotic wave
13. The genetic control of tissue polarity in Drosophila
14. A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster
15. Dishevelled is required during wingless signalling to establish both cell polarity and cell identity
16. Frizzled regulates mirror-symmetric pattern formation in the Drosophila eye
17. Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila
18. A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains
19. A new member of the frizzled family from Drosophila functions as a Wingless receptor
20. Wingless repression of Drosophila frizzled2 expression shapes the Wingless morphogen gradient in the wing
21. Frizzled and Frizzled2 play a partially redundant role in Wingless signaling and have similar requirements to Wingless in neurogenesis
22. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled2 act in the wingless pathway
23. Wingless signaling in the Drosophila embryo: Zygotic requirements and the role of the frizzled genes
24. Frizzled and DFrizzled-2 function as redundant receptors for wingless during Drosophila embryonic development
25. Differential requirement of Dishevelled provides signaling specificity in the Wingless and planar cell polarity signaling pathways
26. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
27. Dishevelled is a component of the frizzled signalling pathway in Drosophila
28. Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene
29. Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila
30. The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates
31. Linking cell-fate specification to planar polarity: Determination of the R3/R4 photoreceptors is a prerequisite for the interpretation of the Frizzled mediated polarity signal
32. The Drosophila STE20-like kinase Misshapen is required downstream of the Frizzled receptor in planar polarity signaling
33. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
34. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
35. Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila
36. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs
37. RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation
38. Hemipterous encodes a novel MAP kinase kinase required for epithelial cell sheet movement
39. Puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
40. Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye
41. Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye
42. Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye
43. Relationships between complex Delta expression and the specification of retinal cell fates during Drosophila eye development
44. Decoding vectorial information from a gradient: Sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye